Published in J Neurosci on December 01, 2002
The science of stroke: mechanisms in search of treatments. Neuron (2010) 6.14
New avenues of exploration for erythropoietin. JAMA (2005) 3.23
Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use. Lancet Neurol (2009) 2.98
Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis. J Exp Med (2003) 2.37
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC Med Genomics (2009) 2.36
Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo. Proc Natl Acad Sci U S A (2003) 1.88
Role of erythropoietin in the brain. Crit Rev Oncol Hematol (2007) 1.50
Neurological diseases as primary gliopathies: a reassessment of neurocentrism. ASN Neuro (2012) 1.50
A systematic review and meta-analysis of erythropoietin in experimental stroke. J Cereb Blood Flow Metab (2009) 1.45
Hypoxic preconditioning protects against ischemic brain injury. NeuroRx (2004) 1.44
Survival and proliferative roles of erythropoietin beyond the erythroid lineage. Expert Rev Mol Med (2008) 1.36
Metabolic downregulation: a key to successful neuroprotection? Stroke (2008) 1.33
Targeting astrocytes for stroke therapy. Neurotherapeutics (2010) 1.25
Development of an ischemic tolerance model in a PC12 cell line. J Cereb Blood Flow Metab (2005) 1.25
Erythropoietin: a multimodal neuroprotective agent. Exp Transl Stroke Med (2009) 1.14
IL-1β stimulates COX-2 dependent PGE₂ synthesis and CGRP release in rat trigeminal ganglia cells. PLoS One (2011) 1.13
Diverse roles of the vasculature within the neural stem cell niche. Regen Med (2009) 1.09
Acute neuroprotective synergy of erythropoietin and insulin-like growth factor I. Proc Natl Acad Sci U S A (2004) 1.08
Science review: recombinant human erythropoietin in critical illness: a role beyond anemia? Crit Care (2004) 1.07
Protective conditioning of the brain: expressway or roadblock? J Physiol (2011) 1.05
Hypoxia inducible factor-1: its potential role in cerebral ischemia. Cell Mol Neurobiol (2012) 1.05
Neuroprotection for stroke: current status and future perspectives. Int J Mol Sci (2012) 1.04
Hemoglobin expression and regulation in glaucoma: insights into retinal ganglion cell oxygenation. Invest Ophthalmol Vis Sci (2009) 1.03
Erythropoietin improves histological and functional outcomes after traumatic brain injury in mice in the absence of the neural erythropoietin receptor. J Neurotrauma (2010) 1.03
Multifunctional actions of approved and candidate stroke drugs. Neurotherapeutics (2009) 1.03
A hematopoietic growth factor, thrombopoietin, has a proapoptotic role in the brain. Proc Natl Acad Sci U S A (2005) 1.03
Erythropoietin Receptor Signaling Through STAT3 Is Required For Glioma Stem Cell Maintenance. Genes Cancer (2010) 1.03
Preconditioning-induced ischemic tolerance: a window into endogenous gearing for cerebroprotection. Exp Transl Stroke Med (2010) 1.03
Systemic adeno-associated virus-mediated gene therapy preserves retinal ganglion cells and visual function in DBA/2J glaucomatous mice. Hum Gene Ther (2011) 1.02
Neuroprotection: lessons from hibernators. Comp Biochem Physiol B Biochem Mol Biol (2012) 1.02
Inhibition of NGF deprivation-induced death by low oxygen involves suppression of BIMEL and activation of HIF-1. J Cell Biol (2005) 1.00
Optimal neuroprotection by erythropoietin requires elevated expression of its receptor in neurons. Proc Natl Acad Sci U S A (2009) 0.99
The effect of erythropoietin on normal and neoplastic cells. Biologics (2012) 0.98
Selective overexpression of excitatory amino acid transporter 2 (EAAT2) in astrocytes enhances neuroprotection from moderate but not severe hypoxia-ischemia. Neuroscience (2008) 0.98
Neuroprotective effect of herpes simplex virus-mediated gene transfer of erythropoietin in hyperglycemic dorsal root ganglion neurons. Brain (2009) 0.97
Signal transducers and activators of transcription 5 contributes to erythropoietin-mediated neuroprotection against hippocampal neuronal death after transient global cerebral ischemia. Neurobiol Dis (2006) 0.97
Pharmacological preconditioning with erythropoietin attenuates the organ injury and dysfunction induced in a rat model of hemorrhagic shock. Dis Model Mech (2012) 0.97
Hemoglobin induces inflammation after preterm intraventricular hemorrhage by methemoglobin formation. J Neuroinflammation (2013) 0.94
Glucose utilization is essential for hypoxia-inducible factor 1 alpha-dependent phosphorylation of c-Jun. Mol Cell Biol (2004) 0.93
General anesthetics inhibit erythropoietin induction under hypoxic conditions in the mouse brain. PLoS One (2011) 0.93
PRAS40 is an integral regulatory component of erythropoietin mTOR signaling and cytoprotection. PLoS One (2012) 0.92
Acute anoxia stimulates proliferation in adult neural stem cells from the rat brain. Exp Brain Res (2008) 0.92
Tumor necrosis factor α primes cerebral endothelial cells for erythropoietin-induced angiogenesis. J Cereb Blood Flow Metab (2010) 0.92
Erythropoietin signaling promotes oligodendrocyte development following prenatal systemic hypoxic-ischemic brain injury. Pediatr Res (2013) 0.91
Erythropoietin: still on the neuroprotection road. Ther Adv Neurol Disord (2012) 0.90
JAK2/Y343/STAT5 signaling axis is required for erythropoietin-mediated protection against ischemic injury in primary renal tubular epithelial cells. Am J Physiol Renal Physiol (2008) 0.90
Pharmacologic preconditioning: translating the promise. Transl Stroke Res (2010) 0.89
Histone acetylation and CREB binding protein are required for neuronal resistance against ischemic injury. PLoS One (2014) 0.89
Erythropoietin increases endothelial biosynthesis of tetrahydrobiopterin by activation of protein kinase B alpha/Akt1. Hypertension (2008) 0.89
The asparaginyl endopeptidase legumain after experimental stroke. J Cereb Blood Flow Metab (2010) 0.88
Absence of the alpha v beta 3 integrin dictates the time-course of angiogenesis in the hypoxic central nervous system: accelerated endothelial proliferation correlates with compensatory increases in alpha 5 beta 1 integrin expression. J Cereb Blood Flow Metab (2010) 0.88
Erythropoetin as a novel agent with pleiotropic effects against acute lung injury. Eur J Clin Pharmacol (2010) 0.87
Hypoxic Conditioning as a New Therapeutic Modality. Front Pediatr (2015) 0.87
Pre-conditioning induces the precocious differentiation of neonatal astrocytes to enhance their neuroprotective properties. ASN Neuro (2011) 0.86
The role of the ubiquitin proteasome system in ischemia and ischemic tolerance. Neuroscientist (2009) 0.86
Nitric oxide prevents axonal degeneration by inducing HIF-1-dependent expression of erythropoietin. Proc Natl Acad Sci U S A (2011) 0.86
Vascular growth factors in neuropsychiatry. Cell Mol Life Sci (2013) 0.86
Carbon monoxide and the CNS: challenges and achievements. Br J Pharmacol (2014) 0.86
Erythropoietin in brain development and beyond. Anat Res Int (2012) 0.86
The Janus-faced effects of hypoxia on astrocyte function. Neuroscientist (2009) 0.85
Protecting mitochondrial bioenergetic function during resuscitation from cardiac arrest. Crit Care Clin (2012) 0.85
The neurobiology of erythropoietin. Cell Mol Neurobiol (2011) 0.84
Noninvasive strategies to promote functional recovery after stroke. Neural Plast (2013) 0.84
Erythropoietin-induced neuroprotection requires cystine glutamate exchanger activity. Brain Res (2010) 0.83
Tissue inhibitor of matrix metalloproteinase-1 mediates erythropoietin-induced neuroprotection in hypoxia ischemia. Neurobiol Dis (2011) 0.83
The neuroprotective effect of recombinant human erythropoietin via an antiapoptotic mechanism on hypoxic-ischemic brain injury in neonatal rats. Korean J Pediatr (2010) 0.82
Breakthrough in cardiac arrest: reports from the 4th Paris International Conference. Ann Intensive Care (2015) 0.81
Mechanisms and Functional Significance of Stroke-Induced Neurogenesis. Front Neurosci (2015) 0.81
Ginkgolide B preconditioning protects neurons against ischaemia-induced apoptosis. J Cell Mol Med (2010) 0.80
NADPH oxidase-2: linking glucose, acidosis, and excitotoxicity in stroke. Antioxid Redox Signal (2015) 0.80
Acidosis-induced zinc-dependent death of cultured cerebellar granule neurons. Cell Mol Neurobiol (2010) 0.80
Decreased extracellular adenosine levels lead to loss of hypoxia-induced neuroprotection after repeated episodes of exposure to hypoxia. PLoS One (2013) 0.80
Expression of erythropoietin in the spinal cord of lewis rats with experimental autoimmune encephalomyelitis. J Clin Neurol (2009) 0.80
Expression pattern of the thrombopoietin receptor (Mpl) in the murine central nervous system. BMC Dev Biol (2010) 0.79
A critical review of mechanisms regulating remote preconditioning-induced brain protection. J Appl Physiol (1985) (2015) 0.79
Ras family small GTPase-mediated neuroprotective signaling in stroke. Cent Nerv Syst Agents Med Chem (2011) 0.79
The mitochondria-targeted antioxidants and remote kidney preconditioning ameliorate brain damage through kidney-to-brain cross-talk. PLoS One (2012) 0.79
Ischemic tolerance as an active and intrinsic neuroprotective mechanism. Handb Clin Neurol (2009) 0.78
A functional role of the cyclin-dependent kinase inhibitor 1 (p21(WAF1/CIP1)) for neuronal preconditioning. J Cereb Blood Flow Metab (2013) 0.78
Dynamics of major histocompatibility complex class II-positive cells in the postischemic brain--influence of levodopa treatment. J Neuroinflammation (2014) 0.78
Ginkgolide B Protects Neurons from Ischemic Injury by Inhibiting the Expression of RTP801. Cell Mol Neurobiol (2015) 0.77
Intranasal deferoxamine attenuates synapse loss via up-regulating the P38/HIF-1α pathway on the brain of APP/PS1 transgenic mice. Front Aging Neurosci (2015) 0.77
No evidence for protective erythropoietin alpha signalling in rat hepatocytes. BMC Gastroenterol (2009) 0.77
Exploiting metabolic differences in glioma therapy. Curr Drug Discov Technol (2012) 0.77
The erythropoietin receptor is not required for the development, function, and aging of rods and cells in the retinal periphery. Mol Vis (2014) 0.77
Post-ischemic continuous infusion of erythropoeitin enhances recovery of lost memory function after global cerebral ischemia in the rat. BMC Neurosci (2013) 0.77
Erythropoietin in stroke therapy: friend or foe. Curr Med Chem (2015) 0.76
Tolerogenic effect of fiber tract injury: reduced EAE severity following entorhinal cortex lesion. Exp Brain Res (2006) 0.75
Brief low [Mg(2+)]o-induced Ca(2+) spikes inhibit subsequent prolonged exposure-induced excitotoxicity in cultured rat hippocampal neurons. Korean J Physiol Pharmacol (2015) 0.75
Peri-infarct flow transients predict outcome in rat focal brain ischemia. Neuroscience (2012) 0.75
Neuroprotective effects of erythropoietin against hypoxic injury via modulation of the mitogen-activated protein kinase pathway and apoptosis. Korean J Pediatr (2017) 0.75
Erythropoietin reduces experimental autoimmune encephalomyelitis severity via neuroprotective mechanisms. J Neuroinflammation (2017) 0.75
Bi-directionally protective communication between neurons and astrocytes under ischemia. Redox Biol (2017) 0.75
Preconditioning in Neuroprotection: From Hypoxia to Ischemia. Prog Neurobiol (2017) 0.75
The erythropoietin-derived peptide MK-X and erythropoietin have neuroprotective effects against ischemic brain damage. Cell Death Dis (2017) 0.75
Cerebrospinal fluid neuron specific enolase, interleukin-1β and erythropoietin concentrations in children after seizures. Childs Nerv Syst (2017) 0.75
Erythropoietin increases neuronal NDPKA expression, and NDPKA up-regulation as well as exogenous application protects cortical neurons from in vitro ischemia-related insults. Cell Mol Neurobiol (2014) 0.75
The prolyl 4-hydroxylase inhibitor GSK360A decreases post-stroke brain injury and sensory, motor, and cognitive behavioral deficits. PLoS One (2017) 0.75
Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions. Nat Neurosci (2007) 6.23
Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat Med (2002) 5.50
Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Nat Med (2005) 4.42
Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation. J Exp Med (2003) 3.89
Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality. Stroke (2008) 3.87
Central nervous system injury-induced immune deficiency syndrome. Nat Rev Neurosci (2005) 3.45
Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans. J Clin Invest (2010) 3.41
Good laboratory practice: preventing introduction of bias at the bench. Stroke (2008) 3.27
Heterogeneity of CNS myeloid cells and their roles in neurodegeneration. Nat Neurosci (2011) 3.06
Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach. Stroke (2008) 2.98
Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use. Lancet Neurol (2009) 2.98
Stroke-induced immunodepression: experimental evidence and clinical relevance. Stroke (2007) 2.76
CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system. Brain (2009) 2.59
Bone marrow-derived progenitor cells modulate vascular reendothelialization and neointimal formation: effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition. Arterioscler Thromb Vasc Biol (2002) 2.54
Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitis. J Clin Invest (2002) 2.50
Preventive antibacterial therapy in acute ischemic stroke: a randomized controlled trial. PLoS One (2008) 2.39
Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease. J Neurosci (2011) 2.31
Improving outcome after stroke: overcoming the translational roadblock. Cerebrovasc Dis (2008) 2.26
Physical activity improves long-term stroke outcome via endothelial nitric oxide synthase-dependent augmentation of neovascularization and cerebral blood flow. Circ Res (2006) 2.21
Sulfonylureas improve outcome in patients with type 2 diabetes and acute ischemic stroke. Stroke (2007) 2.10
Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage. Brain (2009) 2.06
The immunology of acute stroke. Nat Rev Neurol (2012) 2.06
Tolerance against ischemic neuronal injury can be induced by volatile anesthetics and is inducible NO synthase dependent. Stroke (2002) 2.00
Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain. Proc Natl Acad Sci U S A (2010) 1.91
Toll-like receptor 2 mediates CNS injury in focal cerebral ischemia. J Neuroimmunol (2007) 1.85
Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney. Kidney Int (2004) 1.84
Recognition of pneumococcal peptidoglycan: an expanded, pivotal role for LPS binding protein. Immunity (2003) 1.81
Interferon gamma: a crucial role in the function of induced regulatory T cells in vivo. Trends Immunol (2006) 1.81
Stroke and the immune system: from pathophysiology to new therapeutic strategies. Lancet Neurol (2011) 1.77
Controlled growth of tetrapod-branched inorganic nanocrystals. Nat Mater (2003) 1.76
Stroke research priorities for the next decade--A representative view of the European scientific community. Cerebrovasc Dis (2006) 1.75
Marrow-derived cells as vehicles for delivery of gene therapy to pulmonary epithelium. Am J Respir Cell Mol Biol (2002) 1.70
Mechanisms of stroke protection by physical activity. Ann Neurol (2003) 1.67
Hypoxia-induced stroke tolerance in the mouse is mediated by erythropoietin. Stroke (2003) 1.65
Circulating monocytes engraft in the brain, differentiate into microglia and contribute to the pathology following meningitis in mice. Brain (2006) 1.63
Estrogen increases bone marrow-derived endothelial progenitor cell production and diminishes neointima formation. Circulation (2003) 1.61
Pathophysiology of stroke: lessons from animal models. Metab Brain Dis (2004) 1.61
Role of glial cells in cerebral ischemia. Glia (2005) 1.58
Tickets to the brain: role of CCR2 and CX3CR1 in myeloid cell entry in the CNS. J Neuroimmunol (2010) 1.57
Prospective assessment of antidonor cellular alloreactivity is a tool for guidance of immunosuppression in kidney transplantation. Kidney Int (2013) 1.54
Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injury. FASEB J (2005) 1.54
Reprint: Good laboratory practice: preventing introduction of bias at the bench. J Cereb Blood Flow Metab (2008) 1.47
Desferrioxamine induces delayed tolerance against cerebral ischemia in vivo and in vitro. J Cereb Blood Flow Metab (2002) 1.44
Cellular immunodepression preceding infectious complications after acute ischemic stroke in humans. Cerebrovasc Dis (2007) 1.42
Molecular and cellular mechanisms of ecstasy-induced neurotoxicity: an overview. Mol Neurobiol (2009) 1.42
Roller culture of free-floating retinal slices: a new system of organotypic cultures of adult rat retina. Ophthalmic Res (2006) 1.42
Neuroprotective role of astrocytes in cerebral ischemia: focus on ischemic preconditioning. Glia (2005) 1.40
Stroke propagates bacterial aspiration to pneumonia in a model of cerebral ischemia. Stroke (2006) 1.39
IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous system. Brain (2011) 1.37
Rosuvastatin, a new HMG-CoA reductase inhibitor, upregulates endothelial nitric oxide synthase and protects from ischemic stroke in mice. Brain Res (2002) 1.36
Systematic survey of the design, statistical analysis, and reporting of studies published in the 2008 volume of the Journal of Cerebral Blood Flow and Metabolism. J Cereb Blood Flow Metab (2010) 1.35
Modeling stroke in mice - middle cerebral artery occlusion with the filament model. J Vis Exp (2011) 1.33
Lymph nodal prion replication and neuroinvasion in mice devoid of follicular dendritic cells. Proc Natl Acad Sci U S A (2002) 1.33
SUMO2/3 conjugation is an endogenous neuroprotective mechanism. J Cereb Blood Flow Metab (2011) 1.32
Bacterial programmed cell death of cerebral endothelial cells involves dual death pathways. J Clin Invest (2005) 1.32
Body weight after stroke: lessons from the obesity paradox. Stroke (2011) 1.31
Endogenous neuroprotection: mitochondria as gateways to cerebral preconditioning? Neuropharmacology (2008) 1.31
Impact of hepatic rearterialization on reperfusion injury and outcome after mouse liver transplantation. Transplantation (2003) 1.31
Endothelin-1 potently induces Leão's cortical spreading depression in vivo in the rat: a model for an endothelial trigger of migrainous aura? Brain (2002) 1.30
TLR2 mediates neuroinflammation and neuronal damage. J Immunol (2007) 1.26
Sugar for the brain: the role of glucose in physiological and pathological brain function. Trends Neurosci (2013) 1.25
Cutting Edge: Immunological consequences and trafficking of human regulatory macrophages administered to renal transplant recipients. J Immunol (2011) 1.25
International, multicenter randomized preclinical trials in translational stroke research: it's time to act. J Cereb Blood Flow Metab (2012) 1.24
Neurovascular coupling in rat brain operates independent of hemoglobin deoxygenation. J Cereb Blood Flow Metab (2009) 1.24
Genetic screening for Niemann-Pick disease type C in adults with neurological and psychiatric symptoms: findings from the ZOOM study. Hum Mol Genet (2013) 1.24
Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells. Blood (2011) 1.24
Development of a clinical score (A2DS2) to predict pneumonia in acute ischemic stroke. Stroke (2012) 1.22
Serial analysis of gene expression identifies metallothionein-II as major neuroprotective gene in mouse focal cerebral ischemia. J Neurosci (2002) 1.22
Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase. J Clin Invest (2004) 1.22
Inhibition of histone deacetylation protects wildtype but not gelsolin-deficient mice from ischemic brain injury. Exp Neurol (2007) 1.21
Preventive antibacterial treatment improves the general medical and neurological outcome in a mouse model of stroke. Stroke (2003) 1.21
Isoflurane induced prolonged protection against cerebral ischemia in mice: a redox sensitive mechanism? Neuroreport (2002) 1.20
Triptans reduce the inflammatory response in bacterial meningitis. J Cereb Blood Flow Metab (2002) 1.20
Foxp3+ Helios+ regulatory T cells are expanded in active systemic lupus erythematosus. Ann Rheum Dis (2012) 1.18
Thoracoscopic thymectomy with the da Vinci robotic system for myasthenia gravis. Ann N Y Acad Sci (2008) 1.17