PubRank

Siddharthan Chandran

Author PubWeight™ 68.76‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Characterizing the RNA targets and position-dependent splicing regulation by TDP-43. Nat Neurosci 2011 5.24
2 Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study. Lancet Neurol 2012 3.15
3 Improving the translational hit of experimental treatments in multiple sclerosis. Mult Scler 2010 2.73
4 Robust, persistent transgene expression in human embryonic stem cells is achieved with AAVS1-targeted integration. Stem Cells 2007 2.20
5 Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability. Proc Natl Acad Sci U S A 2012 2.14
6 Signaling pathways controlling pluripotency and early cell fate decisions of human induced pluripotent stem cells. Stem Cells 2009 1.96
7 Embryonic stem cell-derived neural progenitors display temporal restriction to neural patterning. Stem Cells 2006 1.82
8 Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development. Cell Res 2011 1.76
9 Dopamine from the brain promotes spinal motor neuron generation during development and adult regeneration. Dev Cell 2013 1.74
10 A highly enriched niche of precursor cells with neuronal and glial potential within the hair follicle dermal papilla of adult skin. Stem Cells 2007 1.60
11 FUS-SMN protein interactions link the motor neuron diseases ALS and SMA. Cell Rep 2012 1.50
12 Efficient generation of neural precursors from adult human skin: astrocytes promote neurogenesis from skin-derived stem cells. Lancet 2004 1.50
13 Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy. Proc Natl Acad Sci U S A 2013 1.49
14 Oligodendrocytes promote neuronal survival and axonal length by distinct intracellular mechanisms: a novel role for oligodendrocyte-derived glial cell line-derived neurotrophic factor. J Neurosci 2003 1.45
15 Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells. Brain 2007 1.31
16 A scaleable and defined system for generating neural stem cells from human embryonic stem cells. Stem Cells 2006 1.26
17 Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity. PLoS One 2009 1.24
18 Integrin activation promotes axon growth on inhibitory chondroitin sulfate proteoglycans by enhancing integrin signaling. J Neurosci 2011 1.23
19 Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning. Proc Natl Acad Sci U S A 2010 1.22
20 Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells". Sci Transl Med 2013 1.11
21 The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments. Trials 2011 1.09
22 Multipotent skin-derived precursors: from biology to clinical translation. Curr Opin Biotechnol 2009 1.09
23 Cell-mediated neuroprotection in a mouse model of human tauopathy. J Neurosci 2010 1.07
24 Human stem cell-derived neurons: a system to study human tau function and dysfunction. PLoS One 2010 1.07
25 Automated mechanical passaging: a novel and efficient method for human embryonic stem cell expansion. Stem Cells 2006 1.02
26 Prevalence and natural history of pain in adults with multiple sclerosis: systematic review and meta-analysis. Pain 2012 1.00
27 High yields of oligodendrocyte lineage cells from human embryonic stem cells at physiological oxygen tensions for evaluation of translational biology. Stem Cell Reports 2013 0.99
28 Induction of Olig2 precursors by FGF involves BMP signalling blockade at the Smad level. PLoS One 2008 0.99
29 Thrombotic microangiopathy associated with interferon beta. N Engl J Med 2014 0.97
30 A novel role for Sema3A in neuroprotection from injury mediated by activated microglia. J Neurosci 2006 0.96
31 What wires together dies together: verbs, actions and neurodegeneration in motor neuron disease. Cortex 2011 0.95
32 Maturation of AMPAR composition and the GABAAR reversal potential in hPSC-derived cortical neurons. J Neurosci 2014 0.94
33 An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss. J Neuroimmunol 2008 0.93
34 Using induced pluripotent stem cells (iPSC) to model human neuromuscular connectivity: promise or reality? J Anat 2011 0.87
35 Verbal fluency as a rapid screening test for cognitive impairment in progressive multiple sclerosis. J Neurol Neurosurg Psychiatry 2011 0.87
36 Different pathways for iNOS-mediated toxicity in vitro dependent on neuronal maturation and NMDA receptor expression. J Neurochem 2002 0.86
37 Origins of gliogenic stem cell populations within adult skin and bone marrow. Stem Cells Dev 2010 0.86
38 Evidence for abnormal tau phosphorylation in early aggressive multiple sclerosis. Acta Neuropathol 2009 0.86
39 Human embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegeneration. Mol Neurobiol 2010 0.85
40 Neural precursor cells cultured at physiologically relevant oxygen tensions have a survival advantage following transplantation. Stem Cells Transl Med 2013 0.85
41 Experimental and therapeutic opportunities for stem cells in multiple sclerosis. Int J Mol Sci 2012 0.84
42 Abnormal tau phosphorylation in primary progressive multiple sclerosis. Acta Neuropathol 2010 0.83
43 Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis. J Neurochem 2012 0.83
44 Validation of the Edinburgh Cognitive and Behavioural Amyotrophic Lateral Sclerosis Screen (ECAS): A cognitive tool for motor disorders. Amyotroph Lateral Scler Frontotemporal Degener 2015 0.82
45 NMDA receptor-dependent glutamate excitotoxicity in human embryonic stem cell-derived neurons. Neurosci Lett 2013 0.82
46 Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuroprotective pathways and therapeutics in neurodegeneration. Br J Clin Pharmacol 2013 0.82
47 Neuroprotective effect of oligodendrocyte precursor cell transplantation in a long-term model of periventricular leukomalacia. Am J Pathol 2009 0.81
48 Focal immune-mediated white matter demyelination reveals an age-associated increase in axonal vulnerability and decreased remyelination efficiency. Am J Pathol 2012 0.80
49 Mesenchymal stem cells lack efficacy in the treatment of experimental autoimmune neuritis despite in vitro inhibition of T-cell proliferation. PLoS One 2012 0.79
50 Neurodegeneration progresses despite complete elimination of clinical relapses in a mouse model of multiple sclerosis. Acta Neuropathol Commun 2013 0.79
51 Minimally manipulated oligodendrocyte precursor cells retain exclusive commitment to the oligodendrocyte lineage following transplantation into intact and injured hippocampus. Eur J Neurosci 2007 0.78
52 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) presenting with sudden sensorineural hearing loss. J Laryngol Otol 2005 0.77
53 Using human pluripotent stem cells to study post-transcriptional mechanisms of neurodegenerative diseases. Brain Res 2012 0.77
54 Patterns of cognitive dysfunction in progressive MS. Behav Neurol 2013 0.76
55 Postnatal astrocytes promote neural induction from adult human bone marrow-derived stem cells. J Hematother Stem Cell Res 2003 0.76
56 Unpicking neurodegeneration in a dish with human pluripotent stem cells: one cell type at a time. Cell Cycle 2013 0.75
57 Can stem cells repair the brain. Trans Med Soc Lond 2014 0.75
58 Tissue, cell and pathway engineering. Curr Opin Biotechnol 2009 0.75
59 Corrigendum to "Genetic epidemiology of motor neuron disease-associated variants in the Scottish population." [Neurobiol. Aging 51 (2017) 178.e11-178.e20]. Neurobiol Aging 2017 0.75
60 Management of sialorrhoea in motor neuron disease: a survey of current UK practice. Amyotroph Lateral Scler Frontotemporal Degener 2013 0.75