Published in Stem Cells on November 09, 2006
Reproducible, ultra high-throughput formation of multicellular organization from single cell suspension-derived human embryonic stem cell aggregates. PLoS One (2008) 3.08
Investigating synapse formation and function using human pluripotent stem cell-derived neurons. Proc Natl Acad Sci U S A (2011) 1.52
Differentiation of human embryonic stem cells to regional specific neural precursors in chemically defined medium conditions. PLoS One (2008) 1.36
Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity. PLoS One (2009) 1.24
Concise review: Kidney stem/progenitor cells: differentiate, sort out, or reprogram? Stem Cells (2010) 1.23
Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state. Nat Commun (2011) 1.20
Molecular stages of rapid and uniform neuralization of human embryonic stem cells. Cell Death Differ (2009) 1.19
Cell transplantation strategies for retinal repair. Prog Brain Res (2009) 1.14
Differentiation of neural lineage cells from human pluripotent stem cells. Methods (2008) 1.13
Human embryonic stem cell differentiation toward regional specific neural precursors. Stem Cells (2009) 1.10
Neonatal desensitization allows long-term survival of neural xenotransplants without immunosuppression. Nat Methods (2009) 1.07
Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms. Cell Death Differ (2011) 1.06
Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen. Nat Protoc (2011) 1.01
Standardized generation and differentiation of neural precursor cells from human pluripotent stem cells. Stem Cell Rev (2013) 0.96
Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells. BMC Neurosci (2009) 0.96
Derivation of neural precursor cells from human ES cells at 3% O(2) is efficient, enhances survival and presents no barrier to regional specification and functional differentiation. Cell Death Differ (2011) 0.94
Myelin repair: the role of stem and precursor cells in multiple sclerosis. Philos Trans R Soc Lond B Biol Sci (2008) 0.93
Physiological normoxia and absence of EGF is required for the long-term propagation of anterior neural precursors from human pluripotent cells. PLoS One (2014) 0.92
Genetic approach to track neural cell fate decisions using human embryonic stem cells. Protein Cell (2014) 0.86
Human embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegeneration. Mol Neurobiol (2010) 0.85
Transplantation of neural stem cells clonally derived from embryonic stem cells promotes recovery after murine spinal cord injury. Stem Cells Dev (2015) 0.85
Temporal and epigenetic regulation of neurodevelopmental plasticity. Philos Trans R Soc Lond B Biol Sci (2008) 0.85
Experimental and therapeutic opportunities for stem cells in multiple sclerosis. Int J Mol Sci (2012) 0.84
Differentiation of pluripotent stem cells into striatal projection neurons: a pure MSN fate may not be sufficient. Front Cell Neurosci (2014) 0.83
Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis. J Neurochem (2012) 0.83
Formation of well-defined embryoid bodies from dissociated human induced pluripotent stem cells using microfabricated cell-repellent microwell arrays. Sci Rep (2014) 0.83
Culture conditions affect cardiac differentiation potential of human pluripotent stem cells. PLoS One (2012) 0.83
Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuroprotective pathways and therapeutics in neurodegeneration. Br J Clin Pharmacol (2013) 0.82
NMDA receptor-dependent glutamate excitotoxicity in human embryonic stem cell-derived neurons. Neurosci Lett (2013) 0.82
Therapeutic potentials of human embryonic stem cells in Parkinson's disease. Neurotherapeutics (2008) 0.78
Nitric oxide signaling and neural stem cell differentiation in peripheral nerve regeneration. Eplasty (2010) 0.77
Stem cells for spinal cord injury: Strategies to inform differentiation and transplantation. Biotechnol Bioeng (2016) 0.77
Generating Diverse Spinal Motor Neuron Subtypes from Human Pluripotent Stem Cells. Stem Cells Int (2015) 0.76
An efficient system for selection and culture of Schwann cells from adult rat peripheral nerves. Cytotechnology (2015) 0.75
Assembling Kidney Tissues from Cells: The Long Road from Organoids to Organs. Front Cell Dev Biol (2015) 0.75
Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med (2007) 17.06
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet (2009) 7.16
Characterizing the RNA targets and position-dependent splicing regulation by TDP-43. Nat Neurosci (2011) 5.24
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet (2013) 4.62
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. Ann Neurol (2011) 3.52
Bayesian refinement of association signals for 14 loci in 3 common diseases. Nat Genet (2012) 3.31
Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel. Science (2004) 3.28
Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study. Lancet Neurol (2012) 3.15
Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis. Hum Mol Genet (2006) 3.13
Improving the translational hit of experimental treatments in multiple sclerosis. Mult Scler (2010) 2.73
A high-density screen for linkage in multiple sclerosis. Am J Hum Genet (2005) 2.50
The role of the CD58 locus in multiple sclerosis. Proc Natl Acad Sci U S A (2009) 2.38
Lung organogenesis. Curr Top Dev Biol (2010) 2.30
Robust, persistent transgene expression in human embryonic stem cells is achieved with AAVS1-targeted integration. Stem Cells (2007) 2.20
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability. Proc Natl Acad Sci U S A (2012) 2.14
Case reports in The Lancet. Lancet (2003) 2.03
A second major histocompatibility complex susceptibility locus for multiple sclerosis. Ann Neurol (2007) 1.99
Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor. Eur J Hum Genet (2009) 1.97
Signaling pathways controlling pluripotency and early cell fate decisions of human induced pluripotent stem cells. Stem Cells (2009) 1.96
Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's disease. Ann Neurol (2007) 1.95
IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H). J Clin Invest (2009) 1.87
Embryonic stem cell-derived neural progenitors display temporal restriction to neural patterning. Stem Cells (2006) 1.82
Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature (2013) 1.79
Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development. Cell Res (2011) 1.76
Mice lacking the giant protocadherin mFAT1 exhibit renal slit junction abnormalities and a partially penetrant cyclopia and anophthalmia phenotype. Mol Cell Biol (2003) 1.76
Dopamine from the brain promotes spinal motor neuron generation during development and adult regeneration. Dev Cell (2013) 1.74
Allele-specific RNA interference rescues the long-QT syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes. Eur Heart J (2013) 1.69
Confounding underlies the apparent month of birth effect in multiple sclerosis. Ann Neurol (2013) 1.62
A highly enriched niche of precursor cells with neuronal and glial potential within the hair follicle dermal papilla of adult skin. Stem Cells (2007) 1.60
FUS-SMN protein interactions link the motor neuron diseases ALS and SMA. Cell Rep (2012) 1.50
Efficient generation of neural precursors from adult human skin: astrocytes promote neurogenesis from skin-derived stem cells. Lancet (2004) 1.50
Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy. Proc Natl Acad Sci U S A (2013) 1.49
Functional live cell imaging of the pulmonary neuroepithelial body microenvironment. Am J Respir Cell Mol Biol (2008) 1.48
The genetic analysis of multiple sclerosis in Europeans: concepts and design. J Neuroimmunol (2003) 1.47
Oligodendrocytes promote neuronal survival and axonal length by distinct intracellular mechanisms: a novel role for oligodendrocyte-derived glial cell line-derived neurotrophic factor. J Neurosci (2003) 1.45
A genome wide linkage disequilibrium screen in Parkinson's disease. J Neurol (2005) 1.41
Human autoimmunity after lymphocyte depletion is caused by homeostatic T-cell proliferation. Proc Natl Acad Sci U S A (2013) 1.38
Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells. Brain (2007) 1.31
Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping. Hum Mol Genet (2004) 1.29
Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity. PLoS One (2009) 1.24
Integrin activation promotes axon growth on inhibitory chondroitin sulfate proteoglycans by enhancing integrin signaling. J Neurosci (2011) 1.23
Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning. Proc Natl Acad Sci U S A (2010) 1.22
Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis. Nat Genet (2010) 1.16
Neural differentiation of mouse embryonic stem cells in chemically defined medium. Brain Res Bull (2005) 1.13
Mechanism of inhibition by hydrogen sulfide of native and recombinant BKCa channels. Respir Physiol Neurobiol (2010) 1.12
The calcium-sensing receptor beyond extracellular calcium homeostasis: conception, development, adult physiology, and disease. Annu Rev Physiol (2011) 1.12
FGF-dependent generation of oligodendrocytes by a hedgehog-independent pathway. Development (2003) 1.11
Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells". Sci Transl Med (2013) 1.11
Association of the truncating splice site mutation in BTNL2 with multiple sclerosis is secondary to HLA-DRB1*15. Hum Mol Genet (2005) 1.10
Recurrent myelitis and optic neuritis in a 29-year-old woman. Lancet Neurol (2005) 1.09
Multipotent skin-derived precursors: from biology to clinical translation. Curr Opin Biotechnol (2009) 1.09
A whole genome screen for linkage disequilibrium in multiple sclerosis confirms disease associations with regions previously linked to susceptibility. Brain (2002) 1.09
Enhancing and diminishing gene function in human embryonic stem cells. Stem Cells (2004) 1.07
Human stem cell-derived neurons: a system to study human tau function and dysfunction. PLoS One (2010) 1.07
Cell-mediated neuroprotection in a mouse model of human tauopathy. J Neurosci (2010) 1.07
Neonatal desensitization allows long-term survival of neural xenotransplants without immunosuppression. Nat Methods (2009) 1.07
Selective ablation of olfactory receptor neurons without functional impairment of vomeronasal receptor neurons in OMP-ntr transgenic mice. Eur J Neurosci (2002) 1.06
Automated mechanical passaging: a novel and efficient method for human embryonic stem cell expansion. Stem Cells (2006) 1.02
CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis. Hum Mol Genet (2010) 1.01
Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis. Eur J Hum Genet (2006) 1.00
Prevalence and natural history of pain in adults with multiple sclerosis: systematic review and meta-analysis. Pain (2012) 1.00
Induction of Olig2 precursors by FGF involves BMP signalling blockade at the Smad level. PLoS One (2008) 0.99
Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility. Hum Genet (2010) 0.99
High yields of oligodendrocyte lineage cells from human embryonic stem cells at physiological oxygen tensions for evaluation of translational biology. Stem Cell Reports (2013) 0.99
Regulation of mouse lung development by the extracellular calcium-sensing receptor, CaR. J Physiol (2008) 0.99
A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01. PLoS One (2010) 0.98
Decreased iNOS synthesis mediates dexamethasone-induced protection of neurons from inflammatory injury in vitro. Eur J Neurosci (2003) 0.98
Hypoxic modulation of Ca2+ signaling in human venous endothelial cells. Multiple roles for reactive oxygen species. J Biol Chem (2005) 0.97
Osteogenic differentiation of human bone marrow stromal cells in hydroxyapatite-loaded microsphere-based scaffolds. Tissue Eng Part A (2011) 0.97
Differential generation of oligodendrocytes from human and rodent embryonic spinal cord neural precursors. Glia (2004) 0.97
Thrombotic microangiopathy associated with interferon beta. N Engl J Med (2014) 0.97
A novel role for Sema3A in neuroprotection from injury mediated by activated microglia. J Neurosci (2006) 0.96
What wires together dies together: verbs, actions and neurodegeneration in motor neuron disease. Cortex (2011) 0.95