Published in Blood on January 12, 2012
Key roles of adjuvants in modern vaccines. Nat Med (2013) 2.62
Toward a refined definition of monocyte subsets. Front Immunol (2013) 1.45
Dengue virus infection induces expansion of a CD14(+)CD16(+) monocyte population that stimulates plasmablast differentiation. Cell Host Microbe (2014) 1.22
The immunobiology of toll-like receptor 4 agonists: from endotoxin tolerance to immunoadjuvants. Shock (2013) 1.12
Dendritic cell-targeted vaccines. Front Immunol (2014) 1.08
The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes. PLoS One (2013) 1.03
CD16+ monocytes control T-cell subset development in immune thrombocytopenia. Blood (2012) 0.99
Blood Monocytes and Their Subsets: Established Features and Open Questions. Front Immunol (2015) 0.99
Toll-like receptor 7/8 (TLR7/8) and TLR9 agonists cooperate to enhance HIV-1 envelope antibody responses in rhesus macaques. J Virol (2014) 0.98
Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood. Proc Natl Acad Sci U S A (2016) 0.93
Analysis of immunoglobulin transcripts and hypermutation following SHIV(AD8) infection and protein-plus-adjuvant immunization. Nat Commun (2015) 0.89
Local innate immune responses in the vaccine adjuvant-injected muscle. Clin Transl Immunology (2016) 0.89
Macrophage- and neutrophil-derived TNF-α instructs skin langerhans cells to prime antiviral immune responses. J Immunol (2014) 0.85
Human decidual macrophages and NK cells differentially express Toll-like receptors and display distinct cytokine profiles upon TLR stimulation. Front Microbiol (2014) 0.84
Sex Differences in monocytes and TLR4 associated immune responses; implications for systemic lupus erythematosus (SLE). J Immunother Appl (2014) 0.84
A Multiantigenic DNA Vaccine That Induces Broad Hepatitis C Virus-Specific T-Cell Responses in Mice. J Virol (2015) 0.81
Adjuvanting an SIV vaccine with TLR ligands encapsulated in nanoparticles induces persistent antibody responses and enhanced protection in TRIM5α restrictive macaques. J Virol (2016) 0.81
Primate immune responses to HIV-1 Env formulated in the saponin-based adjuvant AbISCO-100 in the presence or absence of TLR9 co-stimulation. Sci Rep (2015) 0.79
Resiquimod as an immunologic adjuvant for NY-ESO-1 protein vaccination in patients with high-risk melanoma. Cancer Immunol Res (2015) 0.78
Adjuvant-induced Human Monocyte Secretome Profiles Reveal Adjuvant- and Age-specific Protein Signatures. Mol Cell Proteomics (2016) 0.77
Adjuvants: tailoring humoral immune responses. Curr Opin HIV AIDS (2017) 0.76
Modulation of Innate Immune Responses via Covalently Linked TLR Agonists. ACS Cent Sci (2015) 0.76
Targeting a Neutralizing Epitope of HIV Envelope Gp120 by Immune Complex Vaccine. J AIDS Clin Res (2012) 0.76
Isolation, characterization, and functional analysis of ferret lymphatic endothelial cells. Vet Immunol Immunopathol (2014) 0.76
Induction of innate immune signatures following polyepitope protein-glycoprotein B-TLR4&9 agonist immunization generates multifunctional CMV-specific cellular and humoral immunity. Hum Vaccin Immunother (2014) 0.76
Transient decrease in human peripheral blood myeloid dendritic cells following influenza vaccination correlates with induction of serum antibody. Immunol Invest (2014) 0.75
Successful and Maladaptive T Cell Aging. Immunity (2017) 0.75
Host- and pathogen-derived adjuvant coatings on protein nanoparticle vaccines. Bioeng Transl Med (2017) 0.75
A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses. MBio (2017) 0.75
Microbial TLR Agonists and Humoral Immunopathogenesis in HIV Disease. Epidemiology (Sunnyvale) (2013) 0.75
Human innate responses and adjuvant activity of TLR ligands in vivo in mice reconstituted with a human immune system. Vaccine (2017) 0.75
Brucella Dysregulates Monocytes and Inhibits Macrophage Polarization through LC3-Dependent Autophagy. Front Immunol (2017) 0.75
A Toll-like receptor recognizes bacterial DNA. Nature (2000) 26.34
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol (2010) 24.08
Pattern recognition receptors and inflammation. Cell (2010) 21.05
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol (2002) 13.10
Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med (2001) 8.60
Monocyte-mediated defense against microbial pathogens. Annu Rev Immunol (2008) 7.21
Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans. Nat Immunol (2008) 7.18
Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol (2011) 6.96
Nomenclature of monocytes and dendritic cells in blood. Blood (2010) 6.63
Systems biology of vaccination for seasonal influenza in humans. Nat Immunol (2011) 6.09
Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors. Immunity (2010) 5.43
Programming the magnitude and persistence of antibody responses with innate immunity. Nature (2011) 5.18
Vaccine adjuvants: putting innate immunity to work. Immunity (2010) 5.02
The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4. Science (2007) 4.90
Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity. J Exp Med (2006) 4.23
Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens. J Exp Med (2010) 4.17
Neutrophils, from marrow to microbes. Immunity (2010) 3.97
Cracking the BAFF code. Nat Rev Immunol (2009) 3.95
Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells. J Exp Med (2010) 3.43
Immunological mechanisms of vaccination. Nat Immunol (2011) 3.35
Comparison of gene expression profiles between human and mouse monocyte subsets. Blood (2009) 3.15
New horizons in adjuvants for vaccine development. Trends Immunol (2008) 2.85
MF59 adjuvant enhances diversity and affinity of antibody-mediated immune response to pandemic influenza vaccines. Sci Transl Med (2011) 2.75
Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets. Blood (2011) 2.74
Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates. J Exp Med (2006) 2.70
SuperSAGE evidence for CD14++CD16+ monocytes as a third monocyte subset. Blood (2011) 2.66
HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates. Proc Natl Acad Sci U S A (2005) 2.61
AS04, an aluminum salt- and TLR4 agonist-based adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity. J Immunol (2009) 2.49
Development and characterization of synthetic glucopyranosyl lipid adjuvant system as a vaccine adjuvant. PLoS One (2011) 2.39
Dendritic cells in vivo: a key target for a new vaccine science. Immunity (2008) 2.31
CpG DNA as a vaccine adjuvant. Expert Rev Vaccines (2011) 2.17
Monocyte trafficking in acute and chronic inflammation. Trends Immunol (2011) 2.05
Molecular and cellular signatures of human vaccine adjuvants. Proc Natl Acad Sci U S A (2008) 2.02
New adjuvants for human vaccines. Curr Opin Immunol (2010) 1.98
Immunization with HIV-1 Gag protein conjugated to a TLR7/8 agonist results in the generation of HIV-1 Gag-specific Th1 and CD8+ T cell responses. J Immunol (2005) 1.75
Recent clinical experience with vaccines using MPL- and QS-21-containing adjuvant systems. Expert Rev Vaccines (2011) 1.75
Targeting TLRs expands the antibody repertoire in response to a malaria vaccine. Sci Transl Med (2011) 1.53
Vaccine discovery and translation of new vaccine technology. Lancet (2011) 1.51
Type I interferon signaling regulates Ly6C(hi) monocytes and neutrophils during acute viral pneumonia in mice. PLoS Pathog (2011) 1.48
Regulation of inflammatory monocyte/macrophage recruitment from the bone marrow during murine cytomegalovirus infection: role for type I interferons in localized induction of CCR2 ligands. J Immunol (2009) 1.40
Mechanism of action of licensed vaccine adjuvants. Vaccine (2009) 1.34
Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets. J Clin Invest (2011) 1.33
Adjuvanting a DNA vaccine with a TLR9 ligand plus Flt3 ligand results in enhanced cellular immunity against the simian immunodeficiency virus. J Exp Med (2007) 1.30
MF59 adjuvant: the best insurance against influenza strain diversity. Expert Rev Vaccines (2011) 1.25
Toll-like receptor agonists: are they good adjuvants? Cancer J (2010) 1.16
TLR4 engagement during TLR3-induced proinflammatory signaling in dendritic cells promotes IL-10-mediated suppression of antitumor immunity. Cancer Res (2011) 1.15
Inductive and suppressive networks regulate TLR9-dependent gene expression in vivo. J Leukoc Biol (2009) 1.12
Assessing the safety of adjuvanted vaccines. Sci Transl Med (2011) 1.01
TLR-7 and -8 agonists as vaccine adjuvants. Expert Rev Vaccines (2011) 0.88
Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol (2007) 7.64
Systems biology of vaccination for seasonal influenza in humans. Nat Immunol (2011) 6.09
Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine. Science (2010) 6.04
Programming the magnitude and persistence of antibody responses with innate immunity. Nature (2011) 5.18
Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity. J Exp Med (2006) 4.23
Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway. Nat Immunol (2008) 3.43
Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance. J Clin Invest (2006) 3.31
A Blueprint for HIV Vaccine Discovery. Cell Host Microbe (2012) 3.27
A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells. J Immunol (2004) 3.25
Analysis of in vivo dynamics of influenza virus infection in mice using a GFP reporter virus. Proc Natl Acad Sci U S A (2010) 3.17
Impairment of dendritic cells and adaptive immunity by anthrax lethal toxin. Nature (2003) 2.83
Cutting edge: impairment of dendritic cells and adaptive immunity by Ebola and Lassa viruses. J Immunol (2003) 2.75
Modulation of adaptive immunity with Toll-like receptors. Semin Immunol (2009) 2.56
Systems vaccinology. Immunity (2010) 2.36
Toll-like receptor 2-dependent induction of vitamin A-metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity. Nat Med (2009) 2.30
The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling. Nat Immunol (2010) 2.20
Dendritic cell control of tolerogenic responses. Immunol Rev (2011) 2.13
Antisense intronic non-coding RNA levels correlate to the degree of tumor differentiation in prostate cancer. Oncogene (2004) 2.02
Toll-like receptor expression and responsiveness of distinct murine splenic and mucosal B-cell subsets. PLoS One (2007) 1.82
Rapid and massive virus-specific plasmablast responses during acute dengue virus infection in humans. J Virol (2012) 1.74
Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adults. J Immunol (2011) 1.66
Retinoic acid-dependent regulation of immune responses by dendritic cells and macrophages. Semin Immunol (2008) 1.51
ERK1-/- mice exhibit Th1 cell polarization and increased susceptibility to experimental autoimmune encephalomyelitis. J Immunol (2006) 1.49
Hematopoietic cell types: prototype for a revised cell ontology. J Biomed Inform (2010) 1.48
Predicting network activity from high throughput metabolomics. PLoS Comput Biol (2013) 1.44
A versatile role of mammalian target of rapamycin in human dendritic cell function and differentiation. J Immunol (2010) 1.42
Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production. Proc Natl Acad Sci U S A (2010) 1.39
Chronic but not acute virus infection induces sustained expansion of myeloid suppressor cell numbers that inhibit viral-specific T cell immunity. Immunity (2013) 1.33
The science of adjuvants. Expert Rev Vaccines (2007) 1.31
Adjuvanting a DNA vaccine with a TLR9 ligand plus Flt3 ligand results in enhanced cellular immunity against the simian immunodeficiency virus. J Exp Med (2007) 1.30
Improving defences at the portal of HIV entry: mucosal and innate immunity. PLoS Med (2008) 1.27
Ebola virus-like particles produced in insect cells exhibit dendritic cell stimulating activity and induce neutralizing antibodies. Virology (2006) 1.23
Human dendritic cells respond to Porphyromonas gingivalis LPS by promoting a Th2 effector response in vitro. Eur J Immunol (2003) 1.21
Systems vaccinology: learning to compute the behavior of vaccine induced immunity. Wiley Interdiscip Rev Syst Biol Med (2011) 1.19
Gene signatures related to B-cell proliferation predict influenza vaccine-induced antibody response. Eur J Immunol (2013) 1.15
Dendritic cells at the host-pathogen interface. Nat Immunol (2006) 1.14
The intronic long noncoding RNA ANRASSF1 recruits PRC2 to the RASSF1A promoter, reducing the expression of RASSF1A and increasing cell proliferation. PLoS Genet (2013) 1.14
Inhibition of T helper 2-type responses, IgE production and eosinophilia by synthetic lipopeptides. Eur J Immunol (2003) 1.14
Fatal multiorgan failure due to yellow fever vaccine-associated viscerotropic disease. Vaccine (2007) 1.13
Conserved tissue expression signatures of intronic noncoding RNAs transcribed from human and mouse loci. Genomics (2008) 1.12
Multiple innate immune pathways contribute to the immunogenicity of recombinant adenovirus vaccine vectors. J Virol (2010) 1.11
Gene profiling of Chikungunya virus arthritis in a mouse model reveals significant overlap with rheumatoid arthritis. Arthritis Rheum (2012) 1.10
Androgen responsive intronic non-coding RNAs. BMC Biol (2007) 1.07
The stimulation of CD8+ T cells by dendritic cells pulsed with polyketal microparticles containing ion-paired protein antigen and poly(inosinic acid)-poly(cytidylic acid). Biomaterials (2008) 1.03
Hepatic stellate cells preferentially induce Foxp3+ regulatory T cells by production of retinoic acid. J Immunol (2013) 1.02
Systems vaccinology: its promise and challenge for HIV vaccine development. Curr Opin HIV AIDS (2012) 1.01
Repression of bacterial lipoprotein production by Francisella novicida facilitates evasion of innate immune recognition. Cell Microbiol (2012) 1.00
Origins of the Xylella fastidiosa prophage-like regions and their impact in genome differentiation. PLoS One (2008) 0.99
Probing the 'labyrinth' linking the innate and adaptive immune systems. Nat Immunol (2007) 0.99
Hexa-acylation and KDO(2)-glycosylation determine the specific immunostimulatory activity of Neisseria meningitidis lipid A for human monocyte derived dendritic cells. Vaccine (2005) 0.98
Systems biological approaches to measure and understand vaccine immunity in humans. Semin Immunol (2013) 0.98
Immunogenomics and systems biology of vaccines. Immunol Rev (2011) 0.97
The iron stimulon of Xylella fastidiosa includes genes for type IV pilus and colicin V-like bacteriocins. J Bacteriol (2008) 0.96
Cross-presentation: avoiding trafficking chaos? Nat Immunol (2008) 0.93
Immunity to viruses: learning from successful human vaccines. Immunol Rev (2013) 0.92
As antisense RNA gets intronic. OMICS (2005) 0.92
The gut feeling of Treg cells: IL-10 is the silver lining during colitis. Nat Immunol (2009) 0.90
Identifying gnostic predictors of the vaccine response. Curr Opin Immunol (2012) 0.89
The role of prophage in plant-pathogenic bacteria. Annu Rev Phytopathol (2013) 0.89
Division of labor and cooperation between dendritic cells. Nat Immunol (2006) 0.88
CD28-B7 interaction modulates short- and long-lived plasma cell function. J Immunol (2012) 0.88
Systems biology of vaccination in the elderly. Curr Top Microbiol Immunol (2013) 0.88
A shot in the arm for mast cells. Nat Med (2008) 0.85
Understanding the role of innate immunity in the mechanism of action of the live attenuated Yellow Fever Vaccine 17D. Adv Exp Med Biol (2007) 0.85
Systems vaccinomics: the road ahead for vaccinology. OMICS (2011) 0.83
Learning vaccinology from viral infections. J Exp Med (2011) 0.83
RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors. Biochem Biophys Res Commun (2004) 0.83
Mycobacterium tuberculosis impairs dendritic cell functions through the serine hydrolase Hip1. J Immunol (2014) 0.81
Restraining order for dendritic cells: all quiet on the fetal front. J Clin Invest (2009) 0.80
Peptide crosslinked micelles: a new strategy for the design and synthesis of peptide vaccines. Int J Nanomedicine (2006) 0.80
Systems biology in understanding HIV pathogenesis and guiding vaccine development. Curr Opin HIV AIDS (2012) 0.80
4th Aegean Conference on the Crossroads between Innate and Adaptive Immunity. Nat Immunol (2011) 0.78
Host-pathogen interactions in the 21st century. Curr Opin Immunol (2005) 0.78
An open-ended plea for the development of a global database of HIV vaccine responses. Curr Opin HIV AIDS (2012) 0.75
Linking genome and immunity. Curr Opin Immunol (2013) 0.75
Editorial overview. Curr Opin Virol (2011) 0.75