Neuroinflammation: a common pathway in CNS diseases as mediated at the blood-brain barrier.

PubWeight™: 0.99‹?› | Rank: Top 15%

🔗 View Article (PMC 3707010)

Published in Neuroimmunomodulation on January 11, 2012

Authors

Michelle A Erickson1, Kenji Dohi, William A Banks

Author Affiliations

1: Geriatrics Research Education and Clinical Center, Puget Sound Health Care System, Seattle, Wash., USA.

Articles citing this

Cytokine aberrations in autism spectrum disorder: a systematic review and meta-analysis. Mol Psychiatry (2014) 1.17

IL-6 regulation of synaptic function in the CNS. Neuropharmacology (2014) 0.91

Why is neuroimmunopharmacology crucial for the future of addiction research? Neuropharmacology (2013) 0.89

The nature, significance, and glucagon-like peptide-1 analog treatment of brain insulin resistance in Alzheimer's disease. Alzheimers Dement (2014) 0.88

Metabolic syndrome and the immunological affair with the blood-brain barrier. Front Immunol (2015) 0.85

Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition. Mediators Inflamm (2015) 0.82

Effects of interleukin-6 on the expression of tight junction proteins in isolated cerebral microvessels from yearling and adult sheep. Neuroimmunomodulation (2013) 0.82

Transplanted neural stem cells modulate regulatory T, γδ T cells and corresponding cytokines after intracerebral hemorrhage in rats. Int J Mol Sci (2014) 0.82

Interactions between the microbiota, immune and nervous systems in health and disease. Nat Neurosci (2017) 0.81

Betulinic acid regulates generation of neuroinflammatory mediators responsible for tissue destruction in multiple sclerosis in vitro. Acta Pharmacol Sin (2013) 0.80

Theranostic quantum dots for crossing blood-brain barrier in vitro and providing therapy of HIV-associated encephalopathy. Front Pharmacol (2013) 0.80

Exposure to vehicle emissions results in altered blood brain barrier permeability and expression of matrix metalloproteinases and tight junction proteins in mice. Part Fibre Toxicol (2013) 0.80

Brain insulin resistance in Alzheimer's disease and its potential treatment with GLP-1 analogs. Neurodegener Dis Manag (2014) 0.80

Nanoscale Particulate Matter from Urban Traffic Rapidly Induces Oxidative Stress and Inflammation in Olfactory Epithelium with Concomitant Effects on Brain. Environ Health Perspect (2016) 0.79

Neuroprotective effect of 6-paradol in focal cerebral ischemia involves the attenuation of neuroinflammatory responses in activated microglia. PLoS One (2015) 0.77

Cytokine and Growth Factor Activation In Vivo and In Vitro after Spinal Cord Injury. Mediators Inflamm (2016) 0.77

Some hormone, cytokine and chemokine levels that change across lifespan vary by cognitive status in male Fischer 344 rats. Brain Behav Immun (2015) 0.77

Characterizing blood-brain barrier perturbations after exposure to human triglyceride-rich lipoprotein lipolysis products using MRI in a rat model. Magn Reson Med (2015) 0.76

A Study of TNF Pathway Activation in Schizophrenia and Bipolar Disorder in Plasma and Brain Tissue. Schizophr Bull (2017) 0.76

Neuropil pruning in Early-Course Schizophrenia: Immunological, Clinical, and Neurocognitive Correlates. Biol Psychiatry Cogn Neurosci Neuroimaging (2016) 0.75

Transitory loss of glia and the subsequent modulation in inflammatory cytokines/chemokines regulate paracellular claudin-5 expression in endothelial cells. J Neuroimmunol (2015) 0.75

Interferon-γ blocks signalling through PDGFRβ in human brain pericytes. J Neuroinflammation (2016) 0.75

Nutritional and Nanotechnological Modulators of Microglia. Front Immunol (2016) 0.75

The Immunomodulatory Effects of Plant Extracts and Plant Secondary Metabolites on Chronic Neuroinflammation and Cognitive Aging: A Mechanistic and Empirical Review. Front Pharmacol (2017) 0.75

Immunomodulation by classical conditioning in NZB/W (F1) mice: Lifespan and diurnal variation. Sleep Sci (2016) 0.75

Indomethacin Increases Neurogenesis across Age Groups and Improves Delayed Probe Trial Difference Scores in Middle-Aged Rats. Front Aging Neurosci (2017) 0.75

The nervous and the immune systems: conspicuous physiological analogies. J Comp Physiol A Neuroethol Sens Neural Behav Physiol (2014) 0.75

Articles cited by this

(truncated to the top 100)

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science (2002) 49.51

The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron (2008) 10.19

Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron (2006) 6.38

Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell (1993) 6.05

Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia (2007) 5.67

RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat Med (2003) 5.14

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest (2000) 5.07

LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron (2004) 4.29

Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends Neurosci (2005) 3.84

A systematic review of brain injury epidemiology in Europe. Acta Neurochir (Wien) (2006) 3.75

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J Clin Invest (1996) 3.75

Signal transduction to hypoxia-inducible factor 1. Biochem Pharmacol (2002) 3.73

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J Clin Invest (1998) 3.66

LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies. Physiol Rev (2008) 3.46

Cytokine-induced sickness behavior. Brain Behav Immun (2003) 2.70

Blood-brain barrier breakdown as a therapeutic target in traumatic brain injury. Nat Rev Neurol (2010) 2.56

The role of microglia in amyloid clearance from the AD brain. J Neural Transm (Vienna) (2010) 2.21

Release of cytokines by brain endothelial cells: A polarized response to lipopolysaccharide. Brain Behav Immun (2005) 2.18

Modulation of immune response by head injury. Injury (2007) 2.16

Murine tumor necrosis factor alpha is transported from blood to brain in the mouse. J Neuroimmunol (1993) 2.08

Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia. FASEB J (2004) 2.00

ABC transporters and the blood-brain barrier. Curr Pharm Des (2004) 1.92

Alpha4-integrin-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels. J Clin Invest (2001) 1.90

Stimulation of neonatal and adult brain neurogenesis by subcutaneous injection of basic fibroblast growth factor. J Neurosci (1999) 1.83

Mechanisms of the blood-brain barrier disruption in HIV-1 infection. Cell Mol Neurobiol (2005) 1.81

Detrimental and beneficial effects of injury-induced inflammation and cytokine expression in the nervous system. Adv Exp Med Biol (2002) 1.78

Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. Characterization and comparison with tumor necrosis factor. J Clin Invest (1991) 1.77

Tumor necrosis factor alpha and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrier. Mol Pharmacol (2006) 1.76

The immune system and memory consolidation: a role for the cytokine IL-1beta. Neurosci Biobehav Rev (2001) 1.74

Cytokine-to-brain communication: a review & analysis of alternative mechanisms. Life Sci (1995) 1.68

Combination therapies for traumatic brain injury: prospective considerations. J Neurotrauma (2009) 1.67

Rapid modulation of P-glycoprotein-mediated transport at the blood-brain barrier by tumor necrosis factor-alpha and lipopolysaccharide. Mol Pharmacol (2005) 1.54

Interleukin-1beta in immune cells of the abdominal vagus nerve: a link between the immune and nervous systems? J Neurosci (1999) 1.53

A coat of many colors: neuroimmune crosstalk in human immunodeficiency virus infection. Neuron (2009) 1.48

Haemophilus influenzae lipopolysaccharide-induced blood brain barrier permeability during experimental meningitis in the rat. J Clin Invest (1988) 1.47

Review: leucocyte-endothelial cell crosstalk at the blood-brain barrier: a prerequisite for successful immune cell entry to the brain. Neuropathol Appl Neurobiol (2011) 1.47

Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid β-peptide elimination from the brain. J Neurochem (2010) 1.47

The role of hypoxia-inducible factor-1α, aquaporin-4, and matrix metalloproteinase-9 in blood-brain barrier disruption and brain edema after traumatic brain injury. J Neurosurg (2010) 1.46

Rapid regulation of P-glycoprotein at the blood-brain barrier by endothelin-1. Mol Pharmacol (2004) 1.42

Highly activated CD8(+) T cells in the brain correlate with early central nervous system dysfunction in simian immunodeficiency virus infection. J Immunol (2001) 1.42

Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury. J Neuroinflammation (2010) 1.40

The blood-brain barrier, chemokines and multiple sclerosis. Biochim Biophys Acta (2010) 1.40

Diapedesis of mononuclear cells across cerebral venules during experimental autoimmune encephalomyelitis leaves tight junctions intact. Acta Neuropathol (2004) 1.39

Pathology and new players in the pathogenesis of brain edema. Acta Neuropathol (2009) 1.39

The adhesion molecule ICAM-1 and its regulation in relation with the blood-brain barrier. J Neuroimmunol (2002) 1.38

Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration. J Neurosci (2010) 1.38

Immune surveillance of mouse brain perivascular spaces by blood-borne macrophages. Eur J Neurosci (2001) 1.33

Lipopolysaccharide alters the blood-brain barrier transport of amyloid beta protein: a mechanism for inflammation in the progression of Alzheimer's disease. Brain Behav Immun (2009) 1.32

Penetration of interleukin-6 across the murine blood-brain barrier. Neurosci Lett (1994) 1.32

Adiponectin does not cross the blood-brain barrier but modifies cytokine expression of brain endothelial cells. Diabetes (2006) 1.27

Differential permeability of the BBB in acute EAE: enhanced transport of TNT-alpha. Am J Physiol (1996) 1.26

TNFalpha transport across the blood-brain barrier is abolished in receptor knockout mice. Exp Neurol (2002) 1.24

Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle. Fluids Barriers CNS (2011) 1.21

The blood-central nervous system barriers actively control immune cell entry into the central nervous system. Curr Pharm Des (2008) 1.19

Testing the neurovascular hypothesis of Alzheimer's disease: LRP-1 antisense reduces blood-brain barrier clearance, increases brain levels of amyloid-beta protein, and impairs cognition. J Alzheimers Dis (2009) 1.17

HIV-1 gp120 induces cytokine expression, leukocyte adhesion, and transmigration across the blood-brain barrier: modulatory effects of STAT1 signaling. Microvasc Res (2008) 1.17

Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood. Neurobiol Aging (2002) 1.16

Expression of endothelial adhesion molecules and recruitment of neutrophils after traumatic brain injury in rats. J Leukoc Biol (1997) 1.16

Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway. J Biol Chem (2009) 1.16

Inflammatory changes and breakdown of microvascular integrity in early human immunodeficiency virus dementia. J Neurovirol (2004) 1.15

Adsorptive endocytosis of HIV-1gp120 by blood-brain barrier is enhanced by lipopolysaccharide. Exp Neurol (1999) 1.15

Bidirectional transport of interleukin-1 alpha across the blood-brain barrier. Brain Res Bull (1989) 1.15

Exposure of tumor necrosis factor-alpha to luminal membrane of bovine brain capillary endothelial cells cocultured with astrocytes induces a delayed increase of permeability and cytoplasmic stress fiber formation of actin. J Neurosci Res (1995) 1.13

Production of the cytokines interleukin 1 and 6 by murine brain microvessel endothelium and smooth muscle pericytes. J Neuroimmunol (1993) 1.12

Intravenous human interleukin-1alpha impairs memory processing in mice: dependence on blood-brain barrier transport into posterior division of the septum. J Pharmacol Exp Ther (2001) 1.12

Lymphocyte migration into the central nervous system: implication of ICAM-1 signalling at the blood-brain barrier. Vascul Pharmacol (2002) 1.12

Regulation of BCRP (ABCG2) and P-glycoprotein (ABCB1) by cytokines in a model of the human blood-brain barrier. Cell Mol Neurobiol (2009) 1.11

Brain endothelial cell production of a neuroprotective cytokine, interleukin-6, in response to noxious stimuli. Brain Res (1999) 1.10

The role of neuroinflammation on the pathogenesis of Parkinson's disease. BMB Rep (2010) 1.07

Brain CD8+ and cytotoxic T lymphocytes are associated with, and may be specific for, human immunodeficiency virus type 1 encephalitis in patients with acquired immunodeficiency syndrome. J Neurovirol (2006) 1.06

T lymphocyte trafficking: a novel target for neuroprotection in traumatic brain injury. J Neurotrauma (2007) 1.05

Requirements for passage of T lymphocytes across non-inflamed retinal microvessels. J Neuroimmunol (2003) 1.03

TNF activates P-glycoprotein in cerebral microvascular endothelial cells. Cell Physiol Biochem (2007) 1.03

E- and P-selectin are not required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL mice. J Immunol (2007) 1.02

Nitric oxide isoenzymes regulate lipopolysaccharide-enhanced insulin transport across the blood-brain barrier. Endocrinology (2008) 1.01

Transforming growth factor-beta1 upregulates the tight junction and P-glycoprotein of brain microvascular endothelial cells. Cell Mol Neurobiol (2004) 1.00

Cessation of blood-to-brain influx of interleukin-15 during development of EAE. J Cereb Blood Flow Metab (2009) 1.00

Regulation of major efflux transporters under inflammatory conditions at the blood-brain barrier in vitro. J Neurochem (2009) 0.99

Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by the p38 mitogen-activated protein kinase pathway. Exp Neurol (2008) 0.98

Lipopolysaccharide impairs blood-brain barrier P-glycoprotein function in mice through prostaglandin- and nitric oxide-independent pathways. J Neuroimmune Pharmacol (2008) 0.97

Neuroinflammation activates Mdr1b efflux transport through NFkappaB: promoter analysis in BBB endothelia. Cell Physiol Biochem (2008) 0.96

Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: implications for Aβ accumulation in AD brain. Free Radic Biol Med (2010) 0.95

Influence of the pro-inflammatory cytokines on P-glycoprotein expression and functionality. J Pharm Pharm Sci (2004) 0.95

Blood-brain barrier dysfunction in cats following recombinant interleukin-2 infusion. Cancer Res (1987) 0.94

Sodium dodecylsulphate induces a breach in the blood-brain barrier and enables a West Nile virus variant to penetrate into mouse brain. Brain Res (1989) 0.94

Cytokine transport across the injured blood-spinal cord barrier. Curr Pharm Des (2008) 0.93

Saturable entry of leukemia inhibitory factor from blood to the central nervous system. J Neuroimmunol (2000) 0.92

The role of cerebral vascular NFkappaB in LPS-induced inflammation: differential regulation of efflux transporter and transporting cytokine receptors. Cell Physiol Biochem (2010) 0.90

Evidence that N-acetylcysteine inhibits TNF-alpha-induced cerebrovascular endothelin-1 upregulation via inhibition of mitogen- and stress-activated protein kinase. Free Radic Biol Med (2006) 0.90

Molecular characterization of IL-32 in human endothelial cells. Cytokine (2009) 0.90

Entry of EGF into brain is rapid and saturable. Peptides (1999) 0.90

TNFalpha trafficking in cerebral vascular endothelial cells. J Neuroimmunol (2007) 0.90

Influence of tumor necrosis factor-alpha on the expression and function of P-glycoprotein in an immortalised rat brain capillary endothelial cell line, GPNT. Biochem Pharmacol (2003) 0.90

Irradiation does not compromise or exacerbate the innate immune response in the brains of mice that were transplanted with bone marrow stem cells. Stem Cells (2007) 0.89

HIV-1-induced production of endothelin-1 in an in vitro model of the human blood-brain barrier. Neuroreport (2002) 0.88

Interleukin-2 does not cross the blood-brain barrier by a saturable transport system. Brain Res Bull (1994) 0.87

Downregulation of LRP1 [correction of LPR1] at the blood-brain barrier in streptozotocin-induced diabetic mice. Neuropharmacology (2009) 0.86

Permeability of the mouse blood-brain barrier to murine interleukin-2: predominance of a saturable efflux system. Brain Behav Immun (2004) 0.85

Selective transport of blood-borne interleukin-1 alpha into the posterior division of the septum of the mouse brain. Brain Res (1995) 0.82

Peripheral injection of lipopolysaccharide prevents brain recruitment of leukocytes induced by central injection of interleukin-1. Neuroscience (2005) 0.82

Articles by these authors

(truncated to the top 100)

Ghrelin controls hippocampal spine synapse density and memory performance. Nat Neurosci (2006) 4.25

Glucagon-like peptide-1 receptor is involved in learning and neuroprotection. Nat Med (2003) 3.57

Clinical depression and inflammatory risk markers for coronary heart disease. Am J Cardiol (2002) 2.67

Brain-immune communication pathways. Brain Behav Immun (2007) 2.50

Release of cytokines by brain endothelial cells: A polarized response to lipopolysaccharide. Brain Behav Immun (2005) 2.18

Strategies to advance translational research into brain barriers. Lancet Neurol (2008) 2.16

Effects of leptin on memory processing. Peptides (2005) 1.97

Developmentally regulated mannose 6-phosphate receptor-mediated transport of a lysosomal enzyme across the blood-brain barrier. Proc Natl Acad Sci U S A (2004) 1.97

Obesity and hypertriglyceridemia produce cognitive impairment. Endocrinology (2008) 1.94

Obesity-prone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onset. Am J Physiol Regul Integr Comp Physiol (2003) 1.82

The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice. J Neurochem (2003) 1.67

Pathways linking depression, adiposity, and inflammatory markers in healthy young adults. Brain Behav Immun (2003) 1.60

The effects of animal-assisted therapy on loneliness in an elderly population in long-term care facilities. J Gerontol A Biol Sci Med Sci (2002) 1.51

Peroxisome proliferator-activated receptor-gamma-mediated positive energy balance in the rat is associated with reduced sympathetic drive to adipose tissues and thyroid status. Endocrinology (2008) 1.47

Blood-brain barrier dysfunction as a cause and consequence of Alzheimer's disease. J Cereb Blood Flow Metab (2013) 1.45

Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6. Proc Natl Acad Sci U S A (2006) 1.39

HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells. Brain Res (2005) 1.39

Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity. Endocrinology (2002) 1.36

Permeability of the blood-brain barrier to a novel satiety molecule nesfatin-1. Peptides (2007) 1.35

Pharmacological profiles of peptide drug candidates for the treatment of Alzheimer's disease. J Biol Chem (2003) 1.34

Lipopolysaccharide alters the blood-brain barrier transport of amyloid beta protein: a mechanism for inflammation in the progression of Alzheimer's disease. Brain Behav Immun (2009) 1.32

Adiponectin does not cross the blood-brain barrier but modifies cytokine expression of brain endothelial cells. Diabetes (2006) 1.27

Polypeptide point modifications with fatty acid and amphiphilic block copolymers for enhanced brain delivery. Bioconjug Chem (2005) 1.26

Animal-assisted therapy and loneliness in nursing homes: use of robotic versus living dogs. J Am Med Dir Assoc (2008) 1.23

Epinephrine enhances lysosomal enzyme delivery across the blood brain barrier by up-regulation of the mannose 6-phosphate receptor. Proc Natl Acad Sci U S A (2007) 1.18

Angiotensin II modulates BBB permeability via activation of the AT(1) receptor in brain endothelial cells. J Cereb Blood Flow Metab (2009) 1.17

Testing the neurovascular hypothesis of Alzheimer's disease: LRP-1 antisense reduces blood-brain barrier clearance, increases brain levels of amyloid-beta protein, and impairs cognition. J Alzheimers Dis (2009) 1.17

Brain microvascular pericytes are immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in response to lipopolysaccharide. J Neuroinflammation (2011) 1.16

Decreased levels of PSD95 and two associated proteins and increased levels of BCl2 and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: Insights into their potential roles for loss of synapses and memory, accumulation of Abeta, and neurodegeneration in a prodromal stage of Alzheimer's disease. J Neurosci Res (2010) 1.15

Cytokine and chemokine responses in serum and brain after single and repeated injections of lipopolysaccharide: multiplex quantification with path analysis. Brain Behav Immun (2011) 1.15

Mannose 6-phosphate receptor-mediated transport of sulfamidase across the blood-brain barrier in the newborn mouse. Mol Ther (2008) 1.14

A novel antioxidant N-acetylcysteine amide prevents gp120- and Tat-induced oxidative stress in brain endothelial cells. Exp Neurol (2006) 1.12

Topiramate treatment protects blood-brain barrier pericytes from hyperglycemia-induced oxidative damage in diabetic mice. Endocrinology (2011) 1.11

Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a beta-sheet breaker peptide. FASEB J (2002) 1.11

Lipopolysaccharide impairs amyloid β efflux from brain: altered vascular sequestration, cerebrospinal fluid reabsorption, peripheral clearance and transporter function at the blood-brain barrier. J Neuroinflammation (2012) 1.09

Characterization of blood-brain barrier permeability to PYY3-36 in the mouse. J Pharmacol Exp Ther (2003) 1.08

Effects of orexin-A on memory processing. Peptides (2002) 1.07

N-Acetylcysteine amide protects against methamphetamine-induced oxidative stress and neurotoxicity in immortalized human brain endothelial cells. Brain Res (2009) 1.06

HIV proteins (gp120 and Tat) and methamphetamine in oxidative stress-induced damage in the brain: potential role of the thiol antioxidant N-acetylcysteine amide. Free Radic Biol Med (2010) 1.06

Starvation and triglycerides reverse the obesity-induced impairment of insulin transport at the blood-brain barrier. Endocrinology (2008) 1.05

Pegylated leptin antagonist is a potent orexigenic agent: preparation and mechanism of activity. Endocrinology (2009) 1.04

A physiological role for amyloid-beta protein:enhancement of learning and memory. J Alzheimers Dis (2010) 1.04

Antisense directed at the Abeta region of APP decreases brain oxidative markers in aged senescence accelerated mice. Brain Res (2004) 1.04

Pleiotropic functions of PACAP in the CNS: neuroprotection and neurodevelopment. Ann N Y Acad Sci (2006) 1.02

Transport across the blood-brain barrier of pluronic leptin. J Pharmacol Exp Ther (2010) 1.01

Highly active antiretroviral therapy drug combination induces oxidative stress and mitochondrial dysfunction in immortalized human blood-brain barrier endothelial cells. Free Radic Biol Med (2010) 1.01

Isolation of peptide transport system-6 from brain endothelial cells: therapeutic effects with antisense inhibition in Alzheimer and stroke models. J Cereb Blood Flow Metab (2008) 1.01

Role of PACAP in ischemic neural death. J Mol Neurosci (2008) 1.00

Effects of N-acetylcysteine amide (NACA), a novel thiol antioxidant against glutamate-induced cytotoxicity in neuronal cell line PC12. Brain Res (2005) 1.00

Effect of lipopolysaccharide on the transport of pituitary adenylate cyclase activating polypeptide across the blood-brain barrier. Exp Neurol (2005) 1.00

Increase in reactive oxygen metabolite level in acute exacerbations of asthma. Int Arch Allergy Immunol (2008) 0.99

Protein conjugation with amphiphilic block copolymers for enhanced cellular delivery. Bioconjug Chem (2008) 0.99

Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by the p38 mitogen-activated protein kinase pathway. Exp Neurol (2008) 0.98

Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF. J Neuroinflammation (2011) 0.98

Ghrelin-induced feeding is dependent on nitric oxide. Peptides (2003) 0.97

Lipopolysaccharide impairs blood-brain barrier P-glycoprotein function in mice through prostaglandin- and nitric oxide-independent pathways. J Neuroimmune Pharmacol (2008) 0.97

Loss of appendicular muscle mass and loss of muscle strength in young postmenopausal women. J Gerontol A Biol Sci Med Sci (2007) 0.97

Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration. Eur J Pharmacol (2010) 0.96

Proteomic identification of less oxidized brain proteins in aged senescence-accelerated mice following administration of antisense oligonucleotide directed at the Abeta region of amyloid precursor protein. Brain Res Mol Brain Res (2005) 0.96

Lipids and cognition. J Alzheimers Dis (2010) 0.96

Leptin and adiponectin levels in middle-aged postmenopausal women: associations with lifestyle habits, hormones, and inflammatory markers--a cross-sectional study. Metabolism (2006) 0.95

Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: implications for Aβ accumulation in AD brain. Free Radic Biol Med (2010) 0.95

Suppression of oxidative neuronal damage after transient middle cerebral artery occlusion in mice lacking interleukin-1. Neurosci Res (2003) 0.95

Higher C-reactive protein and soluble tumor necrosis factor receptor levels are associated with poor physical function and disability: a cross-sectional analysis of a cohort of late middle-aged African Americans. J Gerontol A Biol Sci Med Sci (2009) 0.95

Peripheral administration of antisense oligonucleotides targeting the amyloid-β protein precursor reverses AβPP and LRP-1 overexpression in the aged SAMP8 mouse brain. J Alzheimers Dis (2012) 0.94

Pharmacological inhibition of mitochondrial carbonic anhydrases protects mouse cerebral pericytes from high glucose-induced oxidative stress and apoptosis. J Pharmacol Exp Ther (2012) 0.94

Nitrative stress in cerebral endothelium is mediated by mGluR5 in hyperhomocysteinemia. J Cereb Blood Flow Metab (2011) 0.93

Alzheimer's disease through the eye of a mouse. Acceptance lecture for the 2001 Gayle A. Olson and Richard D. Olson prize. Peptides (2002) 0.92

Delivery of galanin-like peptide to the brain: targeting with intranasal delivery and cyclodextrins. J Pharmacol Exp Ther (2008) 0.92

Antagonists of growth hormone-releasing hormone cross the blood-brain barrier: a potential applicability to treatment of brain tumors. Proc Natl Acad Sci U S A (2005) 0.92

Cynical hostility, depressive symptoms, and the expression of inflammatory risk markers for coronary heart disease. J Behav Med (2003) 0.92

Effects of lipopolysaccharide on leptin transport across the blood-brain barrier. Brain Res (2004) 0.92

Extra virgin olive oil improves learning and memory in SAMP8 mice. J Alzheimers Dis (2012) 0.92

Proteomic analysis of specific brain proteins in aged SAMP8 mice treated with alpha-lipoic acid: implications for aging and age-related neurodegenerative disorders. Neurochem Int (2005) 0.91

Lower serum DHEAS levels are associated with a higher degree of physical disability and depressive symptoms in middle-aged to older African American women. Maturitas (2007) 0.91

Ovine proinflammatory cytokines cross the murine blood-brain barrier by a common saturable transport mechanism. Neuroimmunomodulation (2010) 0.91

Passage of vasoactive intestinal peptide across the blood-brain barrier. Peptides (2003) 0.90

Inflammation-induced dysfunction of the low-density lipoprotein receptor-related protein-1 at the blood-brain barrier: protection by the antioxidant N-acetylcysteine. Brain Behav Immun (2012) 0.89

Dietary components in the development of leptin resistance. Adv Nutr (2013) 0.89

Increased mitochondrial DNA oxidative damage after transient middle cerebral artery occlusion in mice. Neurosci Res (2007) 0.89

Human immunodeficiency virus-1 uses the mannose-6-phosphate receptor to cross the blood-brain barrier. PLoS One (2012) 0.88

Potentiation of lead-induced cell death in PC12 cells by glutamate: protection by N-acetylcysteine amide (NACA), a novel thiol antioxidant. Toxicol Appl Pharmacol (2006) 0.88

DHEAS improves learning and memory in aged SAMP8 mice but not in diabetic mice. Life Sci (2004) 0.88

Chronic ethanol consumption impairs learning and memory after cessation of ethanol. Alcohol Clin Exp Res (2005) 0.88

HIV-1-induced production of endothelin-1 in an in vitro model of the human blood-brain barrier. Neuroreport (2002) 0.88

High glucose-induced mitochondrial respiration and reactive oxygen species in mouse cerebral pericytes is reversed by pharmacological inhibition of mitochondrial carbonic anhydrases: Implications for cerebral microvascular disease in diabetes. Biochem Biophys Res Commun (2013) 0.88

Rapid transport of CCL11 across the blood-brain barrier: regional variation and importance of blood cells. J Pharmacol Exp Ther (2014) 0.87

Conjugates of superoxide dismutase 1 with amphiphilic poly(2-oxazoline) block copolymers for enhanced brain delivery: synthesis, characterization and evaluation in vitro and in vivo. Mol Pharm (2012) 0.87

Predictors of serum testosterone and DHEAS in African-American men. Int J Androl (2008) 0.86

Role of PACAP in neural stem/progenitor cell and astrocyte--from neural development to neural repair. Curr Pharm Des (2011) 0.86

A pharmacologically active monoclonal antibody against the human melanocortin-4 receptor: effectiveness after peripheral and central administration. J Pharmacol Exp Ther (2010) 0.86

Mediation of chronic pain: not by neurons alone. Pain (2006) 0.86

Brain pericytes increase the lipopolysaccharide-enhanced transcytosis of HIV-1 free virus across the in vitro blood-brain barrier: evidence for cytokine-mediated pericyte-endothelial cell crosstalk. Fluids Barriers CNS (2013) 0.85

Reduced postischemic apoptosis in the hippocampus of mice deficient in interleukin-1. J Comp Neurol (2002) 0.85

SAMP8 mice have altered hippocampal gene expression in long term potentiation, phosphatidylinositol signaling, and endocytosis pathways. Neurobiol Aging (2013) 0.85

Effect of dietary n-3 polyunsaturated fatty acids on brain lipid fatty acid composition, learning ability, and memory of senescence-accelerated mouse. J Gerontol A Biol Sci Med Sci (2008) 0.84

Regional differences in PACAP transport across the blood-brain barrier in mice: a possible influence of strain, amyloid beta protein, and age. Peptides (2002) 0.84

Memories are made of this: recent advances in understanding cognitive impairments and dementia. J Gerontol A Biol Sci Med Sci (2003) 0.84

Blind mice are not impaired in T-maze footshock avoidance acquisition and retention. Physiol Behav (2002) 0.83

Transport of antisense across the blood-brain barrier. Methods Mol Med (2005) 0.83