Published in Endocrinology on March 01, 2002
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Long-acting glucagon-like peptide-1 receptor agonists have direct access to and effects on pro-opiomelanocortin/cocaine- and amphetamine-stimulated transcript neurons in the mouse hypothalamus. J Diabetes Investig (2016) 0.79
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The anti-tumor activity of a neutralizing nanobody targeting leptin receptor in a mouse model of melanoma. PLoS One (2014) 0.79
Effect of Leptin on In Vitro Nuclear Maturation and Apoptosis of Buffalo (Bubalus bubalis) Oocyte. Int J Fertil Steril (2014) 0.78
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A cholecystokinin-1 receptor agonist (CCK-8) mediates increased permeability of brain barriers to leptin. Br J Pharmacol (2008) 0.77
Benefits of leptin therapy in HIV patients. Indian J Endocrinol Metab (2012) 0.76
The in vitro effect of leptin on semen quality of water buffalo (Bubalus bubalis) bulls. Vet Res Forum (2013) 0.75
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Idiopathic intracranial hypertension, hormones, and 11β-hydroxysteroid dehydrogenases. J Pain Res (2016) 0.75
On the Molecular Evolution of Leptin, Leptin Receptor, and Endospanin. Front Endocrinol (Lausanne) (2017) 0.75
Endocrine regulation of bone and energy metabolism in hibernating mammals. Integr Comp Biol (2014) 0.75
Selective leptin insensitivity and alterations in female-reproductive patterns linked to hyperleptinemia during infancy. PLoS One (2013) 0.75
Loss of Leptin-Induced Modulation of Hippocampal Synaptic Trasmission and Signal Transduction in High-Fat Diet-Fed Mice. Front Cell Neurosci (2017) 0.75
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TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest (2006) 17.49
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Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab (2007) 9.34
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes Dev (2012) 5.71
Leptin regulation of the mesoaccumbens dopamine pathway. Neuron (2006) 4.53
Ghrelin controls hippocampal spine synapse density and memory performance. Nat Neurosci (2006) 4.25
Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology (2004) 4.10
Neurogenesis in the hypothalamus of adult mice: potential role in energy balance. Science (2005) 4.01
Glucagon-like peptide-1 receptor is involved in learning and neuroprotection. Nat Med (2003) 3.57
Obesity is a fibroblast growth factor 21 (FGF21)-resistant state. Diabetes (2010) 3.30
Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat Med (2004) 2.98
Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis. Endocrinology (2009) 2.89
Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus. J Bone Miner Res (2015) 2.74
Clinical depression and inflammatory risk markers for coronary heart disease. Am J Cardiol (2002) 2.67
Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin. Endocrinology (2003) 2.56
Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue. Diabetes (2007) 2.54
Attenuation of leptin and insulin signaling by SOCS proteins. Trends Endocrinol Metab (2006) 2.52
Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin. Diabetes (2006) 2.50
Brain-immune communication pathways. Brain Behav Immun (2007) 2.50
The gut and energy balance: visceral allies in the obesity wars. Science (2005) 2.24
Release of cytokines by brain endothelial cells: A polarized response to lipopolysaccharide. Brain Behav Immun (2005) 2.18
Strategies to advance translational research into brain barriers. Lancet Neurol (2008) 2.16
Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice. Diabetes (2004) 2.12
Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling. J Biol Chem (2004) 2.11
Variations in the FTO gene are associated with severe obesity in the Japanese. J Hum Genet (2008) 2.03
The adipocyte as an active participant in energy balance and metabolism. Gastroenterology (2007) 2.02
Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo. Endocrinology (2011) 2.00
Risk Stratification of Coronary Artery Disease in Asymptomatic Diabetic Subjects Using Multidetector Computed Tomography. Circ J (2015) 1.99
Effects of leptin on memory processing. Peptides (2005) 1.97
Developmentally regulated mannose 6-phosphate receptor-mediated transport of a lysosomal enzyme across the blood-brain barrier. Proc Natl Acad Sci U S A (2004) 1.97
Evidence for constitutive neural cell proliferation in the adult murine hypothalamus. J Comp Neurol (2007) 1.96
Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells. Cell Metab (2006) 1.96
Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice. J Clin Invest (2003) 1.95
Obesity and hypertriglyceridemia produce cognitive impairment. Endocrinology (2008) 1.94
Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function. J Clin Invest (2007) 1.91
Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice. J Clin Invest (2011) 1.89
Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice. Proc Natl Acad Sci U S A (2008) 1.83
Role of premature leptin surge in obesity resulting from intrauterine undernutrition. Cell Metab (2005) 1.83
Obesity-prone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onset. Am J Physiol Regul Integr Comp Physiol (2003) 1.82
Leptin-dependent control of glucose balance and locomotor activity by POMC neurons. Cell Metab (2009) 1.79
Regulated production of a peroxisome proliferator-activated receptor-gamma ligand during an early phase of adipocyte differentiation in 3T3-L1 adipocytes. J Biol Chem (2004) 1.75
Role of Rho-kinase in regulation of insulin action and glucose homeostasis. Cell Metab (2005) 1.73
Efficacy and safety of leptin-replacement therapy and possible mechanisms of leptin actions in patients with generalized lipodystrophy. J Clin Endocrinol Metab (2006) 1.68
The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice. J Neurochem (2003) 1.67
Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling. J Biol Chem (2009) 1.63
Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity. Cell Metab (2007) 1.63
Leptin and the control of food intake: neurons in the nucleus of the solitary tract are activated by both gastric distension and leptin. Endocrinology (2007) 1.62
PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo. Am J Physiol Endocrinol Metab (2007) 1.61
Transplanted hypothalamic neurons restore leptin signaling and ameliorate obesity in db/db mice. Science (2011) 1.60
Pathways linking depression, adiposity, and inflammatory markers in healthy young adults. Brain Behav Immun (2003) 1.60
Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice. J Immunol (2006) 1.58
Divergent regulation of proopiomelanocortin neurons by leptin in the nucleus of the solitary tract and in the arcuate hypothalamic nucleus. Diabetes (2006) 1.53
Dysregulation of adipose glutathione peroxidase 3 in obesity contributes to local and systemic oxidative stress. Mol Endocrinol (2008) 1.51
The effects of animal-assisted therapy on loneliness in an elderly population in long-term care facilities. J Gerontol A Biol Sci Med Sci (2002) 1.51
CDH13 Polymorphisms are Associated with Adiponectin Levels and Metabolic Syndrome Traits Independently of Visceral Fat Mass. J Atheroscler Thromb (2015) 1.50
Peroxisome proliferator-activated receptor-gamma-mediated positive energy balance in the rat is associated with reduced sympathetic drive to adipose tissues and thyroid status. Endocrinology (2008) 1.47
Blood-brain barrier dysfunction as a cause and consequence of Alzheimer's disease. J Cereb Blood Flow Metab (2013) 1.45
Evolution in health and medicine Sackler colloquium: Making evolutionary biology a basic science for medicine. Proc Natl Acad Sci U S A (2009) 1.45
Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype. Proc Natl Acad Sci U S A (2003) 1.41
Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity. Diabetes (2005) 1.40
beta-Arrestin2 regulates the differential response of cortical and trabecular bone to intermittent PTH in female mice. J Bone Miner Res (2004) 1.39
HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells. Brain Res (2005) 1.39
Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity. Diabetes (2002) 1.37
Permeability of the blood-brain barrier to a novel satiety molecule nesfatin-1. Peptides (2007) 1.35
Complex role of the vitamin D receptor and its ligand in adipogenesis in 3T3-L1 cells. J Biol Chem (2006) 1.35
Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts. Proc Natl Acad Sci U S A (2007) 1.35
Pharmacological profiles of peptide drug candidates for the treatment of Alzheimer's disease. J Biol Chem (2003) 1.34
Neuroscience. The fat-brain axis enters a new dimension. Science (2004) 1.33
Lipopolysaccharide alters the blood-brain barrier transport of amyloid beta protein: a mechanism for inflammation in the progression of Alzheimer's disease. Brain Behav Immun (2009) 1.32
Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance. Diabetes (2006) 1.30
Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight. Endocrinology (2008) 1.29
Human obesity and type 2 diabetes are associated with alterations in SREBP1 isoform expression that are reproduced ex vivo by tumor necrosis factor-alpha. Diabetes (2002) 1.29
Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas. Cell Metab (2006) 1.28
Adiponectin does not cross the blood-brain barrier but modifies cytokine expression of brain endothelial cells. Diabetes (2006) 1.27
Polypeptide point modifications with fatty acid and amphiphilic block copolymers for enhanced brain delivery. Bioconjug Chem (2005) 1.26
Animal-assisted therapy and loneliness in nursing homes: use of robotic versus living dogs. J Am Med Dir Assoc (2008) 1.23
Regulation of melanocortin-4 receptor signaling: agonist-mediated desensitization and internalization. Endocrinology (2003) 1.22
Adipose tissue-specific regulation of angiotensinogen in obese humans and mice: impact of nutritional status and adipocyte hypertrophy. Am J Hypertens (2010) 1.22
Possible involvement of the alpha1 isoform of 5'AMP-activated protein kinase in oxidative stress-stimulated glucose transport in skeletal muscle. Am J Physiol Endocrinol Metab (2004) 1.21
Osteopenia, decreased bone formation and impaired osteoblast development in Sox4 heterozygous mice. J Cell Sci (2007) 1.20
Divergent leptin signaling in proglucagon neurons of the nucleus of the solitary tract in mice and rats. Endocrinology (2007) 1.20
Epinephrine enhances lysosomal enzyme delivery across the blood brain barrier by up-regulation of the mannose 6-phosphate receptor. Proc Natl Acad Sci U S A (2007) 1.18
Adipocytokine orosomucoid integrates inflammatory and metabolic signals to preserve energy homeostasis by resolving immoderate inflammation. J Biol Chem (2010) 1.18
Angiotensin II modulates BBB permeability via activation of the AT(1) receptor in brain endothelial cells. J Cereb Blood Flow Metab (2009) 1.17
Testing the neurovascular hypothesis of Alzheimer's disease: LRP-1 antisense reduces blood-brain barrier clearance, increases brain levels of amyloid-beta protein, and impairs cognition. J Alzheimers Dis (2009) 1.17
Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARalpha-dependent manner. J Biol Chem (2010) 1.16
Brain microvascular pericytes are immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in response to lipopolysaccharide. J Neuroinflammation (2011) 1.16
Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. J Hum Genet (2009) 1.16
Cytokine and chemokine responses in serum and brain after single and repeated injections of lipopolysaccharide: multiplex quantification with path analysis. Brain Behav Immun (2011) 1.15
Mannose 6-phosphate receptor-mediated transport of sulfamidase across the blood-brain barrier in the newborn mouse. Mol Ther (2008) 1.14
High-fat diet impairs the effects of a single bout of endurance exercise on glucose transport and insulin sensitivity in rat skeletal muscle. Metabolism (2007) 1.13
A novel antioxidant N-acetylcysteine amide prevents gp120- and Tat-induced oxidative stress in brain endothelial cells. Exp Neurol (2006) 1.12
Topiramate treatment protects blood-brain barrier pericytes from hyperglycemia-induced oxidative damage in diabetic mice. Endocrinology (2011) 1.11