Published in Cell Host Microbe on January 19, 2012
Human milk oligosaccharides protect bladder epithelial cells against uropathogenic Escherichia coli invasion and cytotoxicity. J Infect Dis (2013) 2.18
Urinary tract infections: epidemiology, mechanisms of infection and treatment options. Nat Rev Microbiol (2015) 2.06
Dysregulation of Escherichia coli α-hemolysin expression alters the course of acute and persistent urinary tract infection. Proc Natl Acad Sci U S A (2015) 1.62
Natural killer cell-mediated host defense against uropathogenic E. coli is counteracted by bacterial hemolysinA-dependent killing of NK cells. Cell Host Microbe (2013) 1.01
Cytotoxic necrotizing factor 1 and hemolysin from uropathogenic Escherichia coli elicit different host responses in the murine bladder. Infect Immun (2012) 0.93
Inhibition of Cyclooxygenase-2 Prevents Chronic and Recurrent Cystitis. EBioMedicine (2014) 0.93
The RTX pore-forming toxin α-hemolysin of uropathogenic Escherichia coli: progress and perspectives. Future Microbiol (2013) 0.93
Clinical features of bacterial vaginosis in a murine model of vaginal infection with Gardnerella vaginalis. PLoS One (2013) 0.92
Uropathogenic Escherichia coli superinfection enhances the severity of mouse bladder infection. PLoS Pathog (2015) 0.90
Metabolomic analysis of siderophore cheater mutants reveals metabolic costs of expression in uropathogenic Escherichia coli. J Proteome Res (2014) 0.87
How to make it in the urinary tract: a tutorial by Escherichia coli. PLoS Pathog (2012) 0.85
Virulence and Fitness Determinants of Uropathogenic Escherichia coli. Microbiol Spectr (2015) 0.85
FNR regulates expression of important virulence factors contributing to pathogenicity of uropathogenic Escherichia coli. Infect Immun (2014) 0.84
Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets. Blood (2012) 0.83
Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection. PLoS Pathog (2015) 0.82
UPEC hemolysin: more than just for making holes. Cell Host Microbe (2012) 0.81
Establishment and Characterization of UTI and CAUTI in a Mouse Model. J Vis Exp (2015) 0.80
Role for telomerase in Listeria monocytogenes infection. Infect Immun (2012) 0.79
Pathogenesis of human diffusely adhering Escherichia coli expressing Afa/Dr adhesins (Afa/Dr DAEC): current insights and future challenges. Clin Microbiol Rev (2014) 0.79
Subversion of Host Innate Immunity by Uropathogenic Escherichia coli. Pathogens (2016) 0.79
Campylobacter jejuni Increases Flagellar Expression and Adhesion of Noninvasive Escherichia coli: Effects on Enterocytic Toll-Like Receptor 4 and CXCL-8 Expression. Infect Immun (2015) 0.78
Role of pore-forming toxins in neonatal sepsis. Clin Dev Immunol (2013) 0.78
A conserved PapB family member, TosR, regulates expression of the uropathogenic Escherichia coli RTX nonfimbrial adhesin TosA while conserved LuxR family members TosE and TosF suppress motility. Infect Immun (2014) 0.78
Strengths and Limitations of Model Systems for the Study of Urinary Tract Infections and Related Pathologies. Microbiol Mol Biol Rev (2016) 0.78
Bacterial lysis liberates the neutrophil migration suppressor YbcL from the periplasm of uropathogenic Escherichia coli. Infect Immun (2014) 0.77
Uropathogenic Escherichia coli modulates innate immunity to suppress Th1-mediated inflammatory responses during infectious epididymitis. Infect Immun (2013) 0.77
Molecular Characterization of the Vacuolating Autotransporter Toxin in Uropathogenic Escherichia coli. J Bacteriol (2016) 0.77
Uropathogenic E. coli Exploit CEA to Promote Colonization of the Urogenital Tract Mucosa. PLoS Pathog (2016) 0.76
Purine biosynthesis metabolically constrains intracellular survival of uropathogenic E. coli. Infect Immun (2016) 0.76
DFI-seq identification of environment-specific gene expression in uropathogenic Escherichia coli. BMC Microbiol (2017) 0.75
Uropathogenic Escherichia coli Releases Extracellular Vesicles That Are Associated with RNA. PLoS One (2016) 0.75
Neutrophils and Immunity: From Bactericidal Action to Being Conquered. J Immunol Res (2017) 0.75
LIPOPOLYSACCHARIDE DOMAINS MODULATE UROVIRULENCE. Infect Immun (2016) 0.75
Immunity to uropathogens: the emerging roles of inflammasomes. Nat Rev Urol (2017) 0.75
Structure of a bacterial toxin-activating acyltransferase. Proc Natl Acad Sci U S A (2015) 0.75
Bacterial pathogenesis: UPEC helps host to exfoliate. Nat Rev Microbiol (2012) 0.75
Invasion of Host Cells and Tissues by Uropathogenic Bacteria. Microbiol Spectr (2016) 0.75
The role of the prostate in male fertility, health and disease. Nat Rev Urol (2016) 0.75
Switching Rho GTPase activation into effective antibacterial defenses requires the caspase-1/IL-1beta signaling axis. Small GTPases (2015) 0.75
Association of O-Antigen Serotype with the Magnitude of Initial Systemic Cytokine Responses and Persistence in the Urinary Tract. J Bacteriol (2016) 0.75
Immunomodulation in the canine endometrium by uteropathogenic Escherichia coli. Vet Res (2016) 0.75
Uropathogenic Escherichia coli-Associated Exotoxins. Microbiol Spectr (2016) 0.75
Induction and evasion of host defenses by type 1-piliated uropathogenic Escherichia coli. Science (1998) 8.16
Virulence factors in Escherichia coli urinary tract infection. Clin Microbiol Rev (1991) 7.11
Intracellular bacterial biofilm-like pods in urinary tract infections. Science (2003) 7.10
Haemolysin contributes to virulence of extra-intestinal E. coli infections. Nature (1981) 5.83
Pyelonephritogenic Escherichia coli and killing of cultured human renal proximal tubular epithelial cells: role of hemolysin in some strains. Infect Immun (1990) 4.94
Establishment of a persistent Escherichia coli reservoir during the acute phase of a bladder infection. Infect Immun (2001) 4.82
Escherichia coli hemolysin may damage target cell membranes by generating transmembrane pores. Infect Immun (1986) 3.94
Escherichia coli alpha-hemolysin: characteristics and probable role in pathogenicity. Microbiol Rev (1984) 3.66
Paxillin comes of age. J Cell Sci (2008) 3.57
Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder. Nature (2011) 3.15
CNF1 exploits the ubiquitin-proteasome machinery to restrict Rho GTPase activation for bacterial host cell invasion. Cell (2002) 2.77
Effect of Escherichia coli alpha-hemolysin on human peripheral leukocyte function in vitro. Infect Immun (1982) 2.61
Molecular regulation of urothelial renewal and host defenses during infection with uropathogenic Escherichia coli. J Biol Chem (2001) 2.34
beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer. Cancer Cell (2002) 2.33
Effect of Escherichia coli alpha-hemolysin on human peripheral leukocyte viability in vitro. Infect Immun (1982) 2.29
The repeat domain of Escherichia coli haemolysin (HlyA) is responsible for its Ca2+-dependent binding to erythrocytes. Mol Gen Genet (1988) 2.29
Serine peptidases: classification, structure and function. Cell Mol Life Sci (2008) 2.17
Activation of the unfolded protein response is required for defenses against bacterial pore-forming toxin in vivo. PLoS Pathog (2008) 2.16
RTX proteins: a highly diverse family secreted by a common mechanism. FEMS Microbiol Rev (2010) 2.13
Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics. Antimicrob Agents Chemother (2010) 2.05
Integrin-mediated host cell invasion by type 1-piliated uropathogenic Escherichia coli. PLoS Pathog (2007) 2.01
Histone modifications induced by a family of bacterial toxins. Proc Natl Acad Sci U S A (2007) 1.86
Human-restricted bacterial pathogens block shedding of epithelial cells by stimulating integrin activation. Science (2010) 1.68
Caspases - an update. Comp Biochem Physiol B Biochem Mol Biol (2008) 1.65
Activation of caspases measured in situ by binding of fluorochrome-labeled inhibitors of caspases (FLICA): correlation with DNA fragmentation. Exp Cell Res (2000) 1.64
Modulation of NF-κB signalling by microbial pathogens. Nat Rev Microbiol (2011) 1.64
Suppression of bladder epithelial cytokine responses by uropathogenic Escherichia coli. Infect Immun (2005) 1.55
Actin-gated intracellular growth and resurgence of uropathogenic Escherichia coli. Cell Microbiol (2006) 1.53
Global functional analyses of cellular responses to pore-forming toxins. PLoS Pathog (2011) 1.52
Bone morphogenetic protein 4 signaling regulates epithelial renewal in the urinary tract in response to uropathogenic infection. Cell Host Microbe (2009) 1.51
Acylation of Escherichia coli hemolysin: a unique protein lipidation mechanism underlying toxin function. Microbiol Mol Biol Rev (1998) 1.49
Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment. Nature (2009) 1.45
Staphylococcal alpha-toxin elicits hypertension in isolated rabbit lungs. Evidence for thromboxane formation and the role of extracellular calcium. J Clin Invest (1984) 1.43
Cytotoxic necrotizing factor type 1 of uropathogenic Escherichia coli kills cultured human uroepithelial 5637 cells by an apoptotic mechanism. Infect Immun (2000) 1.40
Pore-forming toxins and cellular non-immune defenses (CNIDs). Curr Opin Microbiol (2007) 1.40
Listeria monocytogenes transiently alters mitochondrial dynamics during infection. Proc Natl Acad Sci U S A (2011) 1.38
Alpha-hemolysin contributes to the pathogenicity of piliated digalactoside-binding Escherichia coli in the kidney: efficacy of an alpha-hemolysin vaccine in preventing renal injury in the BALB/c mouse model of pyelonephritis. Infect Immun (1991) 1.35
Covert operations of uropathogenic Escherichia coli within the urinary tract. Traffic (2005) 1.35
RAB-5- and RAB-11-dependent vesicle-trafficking pathways are required for plasma membrane repair after attack by bacterial pore-forming toxin. Cell Host Microbe (2011) 1.35
Escherichia coli mediated urinary tract infections: are there distinct uropathogenic E. coli (UPEC) pathotypes? FEMS Microbiol Lett (2005) 1.32
Alpha-hemolysin from Escherichia coli uses endogenous amplification through P2X receptor activation to induce hemolysis. Proc Natl Acad Sci U S A (2009) 1.30
Modulation of host innate immune response in the bladder by uropathogenic Escherichia coli. Infect Immun (2007) 1.29
Hemolysin of uropathogenic Escherichia coli evokes extensive shedding of the uroepithelium and hemorrhage in bladder tissue within the first 24 hours after intraurethral inoculation of mice. Infect Immun (2008) 1.28
Pore-forming toxins induce multiple cellular responses promoting survival. Cell Microbiol (2011) 1.28
Inactivation of host Akt/protein kinase B signaling by bacterial pore-forming toxins. Mol Biol Cell (2008) 1.26
Cytocidal effects of Escherichia coli hemolysin on human T lymphocytes. Infect Immun (1993) 1.25
Use of zebrafish to probe the divergent virulence potentials and toxin requirements of extraintestinal pathogenic Escherichia coli. PLoS Pathog (2009) 1.21
Enterokinase (enteropeptidase): comparative aspects. Trends Biochem Sci (1989) 1.11
Invasion of epithelial cells and proteolysis of cellular focal adhesion components by distinct types of Porphyromonas gingivalis fimbriae. Infect Immun (2006) 1.09
Uropathogenic Escherichia coli invades host cells via an HDAC6-modulated microtubule-dependent pathway. J Biol Chem (2008) 1.09
Association of RTX toxins with erythrocytes. Infect Immun (1996) 1.09
Why Escherichia coli alpha-hemolysin induces calcium oscillations in mammalian cells--the pore is on its own. FASEB J (2006) 1.07
Attenuation of human neutrophil migration and function by uropathogenic bacteria. Microbes Infect (2011) 1.07
Novel three-dimensional organoid model for evaluation of the interaction of uropathogenic Escherichia coli with terminally differentiated human urothelial cells. Infect Immun (2006) 1.06
E. coli virulence factor hemolysin induces neutrophil apoptosis and necrosis/lysis in vitro and necrosis/lysis and lung injury in a rat pneumonia model. Am J Physiol Lung Cell Mol Physiol (2005) 1.05
Interaction of the bacterial protein toxin alpha-haemolysin with model membranes: protein binding does not always lead to lytic activity. FEBS Lett (1995) 1.04
Aerolysin induces G-protein activation and Ca2+ release from intracellular stores in human granulocytes. J Biol Chem (1998) 1.01
Uropathogenic Escherichia coli dominantly suppress the innate immune response of bladder epithelial cells by a lipopolysaccharide- and Toll-like receptor 4-independent pathway. Microbes Infect (2007) 0.97
Human mesotrypsin defies natural trypsin inhibitors: from passive resistance to active destruction. Protein Pept Lett (2005) 0.95
Keratinocytes synthesize enteropeptidase and multiple forms of trypsinogen during terminal differentiation. J Invest Dermatol (2009) 0.94
Role of MAPK p38 in the cellular responses to pore-forming toxins. Peptides (2010) 0.93
Escherichia coli alpha-haemolysin induces focal leaks in colonic epithelium: a novel mechanism of bacterial translocation. Cell Microbiol (2007) 0.92
Contribution of Escherichia coli alpha-hemolysin to bacterial virulence and to intraperitoneal alterations in peritonitis. Infect Immun (2000) 0.92
In situ activation of caspases and serine proteases during apoptosis detected by affinity labeling their enzyme active centers with fluorochrome-tagged inhibitors. Exp Hematol (2002) 0.88
The emerging role of serine proteases in apoptosis. Biochem Soc Trans (2007) 0.85
Calcium-dependent conformation of E. coli alpha-haemolysin. Implications for the mechanism of membrane insertion and lysis. Biochim Biophys Acta (1998) 0.85
Relevance of fatty acid covalently bound to Escherichia coli alpha-hemolysin and membrane microdomains in the oligomerization process. J Biol Chem (2009) 0.84
Role of alpha-hemolysin for the in vitro phagocytosis and intracellular killing of Escherichia coli. Zentralbl Bakteriol (1989) 0.79
Carbon monoxide prevents apoptosis induced by uropathogenic Escherichia coli toxins. Pediatr Nephrol (2005) 0.79
Origins and virulence mechanisms of uropathogenic Escherichia coli. Exp Mol Pathol (2008) 2.81
Molecular regulation of urothelial renewal and host defenses during infection with uropathogenic Escherichia coli. J Biol Chem (2001) 2.34
Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics. Antimicrob Agents Chemother (2010) 2.05
Integrin-mediated host cell invasion by type 1-piliated uropathogenic Escherichia coli. PLoS Pathog (2007) 2.01
Urinary tract infections: current and emerging management strategies. Clin Infect Dis (2013) 1.85
Impact of the RNA chaperone Hfq on the fitness and virulence potential of uropathogenic Escherichia coli. Infect Immun (2008) 1.65
Actin-gated intracellular growth and resurgence of uropathogenic Escherichia coli. Cell Microbiol (2006) 1.53
CD14- and Toll-like receptor-dependent activation of bladder epithelial cells by lipopolysaccharide and type 1 piliated Escherichia coli. Infect Immun (2003) 1.38
Covert operations of uropathogenic Escherichia coli within the urinary tract. Traffic (2005) 1.35
Inactivation of host Akt/protein kinase B signaling by bacterial pore-forming toxins. Mol Biol Cell (2008) 1.26
Toxin-antitoxin systems are important for niche-specific colonization and stress resistance of uropathogenic Escherichia coli. PLoS Pathog (2012) 1.22
Use of zebrafish to probe the divergent virulence potentials and toxin requirements of extraintestinal pathogenic Escherichia coli. PLoS Pathog (2009) 1.21
Clathrin, AP-2, and the NPXY-binding subset of alternate endocytic adaptors facilitate FimH-mediated bacterial invasion of host cells. Cell Microbiol (2008) 1.12
Uropathogenic Escherichia coli invades host cells via an HDAC6-modulated microtubule-dependent pathway. J Biol Chem (2008) 1.09
Bacterial landlines: contact-dependent signaling in bacterial populations. Curr Opin Microbiol (2009) 1.07
Polyamine-mediated resistance of uropathogenic Escherichia coli to nitrosative stress. J Bacteriol (2006) 1.04
Roles of putative type II secretion and type IV pilus systems in the virulence of uropathogenic Escherichia coli. PLoS One (2009) 1.00
The RTX pore-forming toxin α-hemolysin of uropathogenic Escherichia coli: progress and perspectives. Future Microbiol (2013) 0.93
The Cpx stress response system potentiates the fitness and virulence of uropathogenic Escherichia coli. Infect Immun (2013) 0.92
Conditioning of uropathogenic Escherichia coli for enhanced colonization of host. Infect Immun (2009) 0.90
Combining quantitative genetic footprinting and trait enrichment analysis to identify fitness determinants of a bacterial pathogen. PLoS Genet (2013) 0.87
Adenylate cyclase and the cyclic AMP receptor protein modulate stress resistance and virulence capacity of uropathogenic Escherichia coli. Infect Immun (2012) 0.85
Contact-dependent inhibition: bacterial brakes and secret handshakes. Trends Microbiol (2006) 0.83
The repeat-in-toxin family member TosA mediates adherence of uropathogenic Escherichia coli and survival during bacteremia. Infect Immun (2011) 0.83
Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets. Blood (2012) 0.83
A phyletically rare gene promotes the niche-specific fitness of an E. coli pathogen during bacteremia. PLoS Pathog (2013) 0.80
Flushing bacteria out of the bladder. Nat Med (2007) 0.79
Uropathogenic Escherichia coli induces serum amyloid a in mice following urinary tract and systemic inoculation. PLoS One (2012) 0.78
Reply to Kaye and Sobel. Clin Infect Dis (2013) 0.77
Invasion of Host Cells and Tissues by Uropathogenic Bacteria. Microbiol Spectr (2016) 0.75