PubRank

Patrick Aloy

Author PubWeight™ 71.12‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Proteome survey reveals modularity of the yeast cell machinery. Nature 2006 20.77
2 Potential artefacts in protein-interaction networks. FEBS Lett 2002 2.24
3 3did: interacting protein domains of known three-dimensional structure. Nucleic Acids Res 2005 2.18
4 Unveiling the role of network and systems biology in drug discovery. Trends Pharmacol Sci 2010 2.06
5 A structural perspective on protein-protein interactions. Curr Opin Struct Biol 2004 1.98
6 Interactome3D: adding structural details to protein networks. Nat Methods 2012 1.89
7 A network medicine approach to human disease. FEBS Lett 2009 1.83
8 3did: identification and classification of domain-based interactions of known three-dimensional structure. Nucleic Acids Res 2010 1.71
9 3did Update: domain-domain and peptide-mediated interactions of known 3D structure. Nucleic Acids Res 2008 1.51
10 Contextual specificity in peptide-mediated protein interactions. PLoS One 2008 1.37
11 Structural insights into the target specificity of plant invertase and pectin methylesterase inhibitory proteins. Plant Cell 2004 1.33
12 Targeting and tinkering with interaction networks. Nat Chem Biol 2008 1.27
13 Ribonucleotide reductases: divergent evolution of an ancient enzyme. J Mol Evol 2002 1.26
14 Pushing structural information into the yeast interactome by high-throughput protein docking experiments. PLoS Comput Biol 2009 1.22
15 Three-dimensional modeling of protein interactions and complexes is going 'omics. Curr Opin Struct Biol 2011 1.21
16 Towards a detailed atlas of protein-protein interactions. Curr Opin Struct Biol 2013 1.19
17 3did: a catalog of domain-based interactions of known three-dimensional structure. Nucleic Acids Res 2013 1.14
18 Dynamic interactions of proteins in complex networks: a more structured view. FEBS J 2009 1.13
19 Interactome mapping suggests new mechanistic details underlying Alzheimer's disease. Genome Res 2010 1.02
20 Novel peptide-mediated interactions derived from high-resolution 3-dimensional structures. PLoS Comput Biol 2010 1.02
21 Systematic searches for molecular synapomorphies in model metazoan genomes give some support for Ecdysozoa after accounting for the idiosyncrasies of Caenorhabditis elegans. Evol Dev 2004 1.01
22 Analysis of chemical and biological features yields mechanistic insights into drug side effects. Chem Biol 2013 1.00
23 Uncovering new substrates for Aurora A kinase. EMBO Rep 2010 1.00
24 Recycling side-effects into clinical markers for drug repositioning. Genome Med 2012 0.99
25 Approved drug mimics of short peptide ligands from protein interaction motifs. J Chem Inf Model 2008 0.98
26 Towards a molecular characterisation of pathological pathways. FEBS Lett 2008 0.96
27 The role of structural disorder in the rewiring of protein interactions through evolution. Mol Cell Proteomics 2012 0.95
28 The proton-pump inhibitor lansoprazole enhances amyloid beta production. PLoS One 2013 0.91
29 Target selection for complex structural genomics. Curr Opin Struct Biol 2006 0.90
30 NetAligner--a network alignment server to compare complexes, pathways and whole interactomes. Nucleic Acids Res 2012 0.90
31 A novel framework for the comparative analysis of biological networks. PLoS One 2012 0.89
32 Towards Alzheimer's root cause: ECSIT as an integrating hub between oxidative stress, inflammation and mitochondrial dysfunction. Hypothetical role of the adapter protein ECSIT in familial and sporadic Alzheimer's disease pathogenesis. Bioessays 2012 0.88
33 A second-generation protein-protein interaction network of Helicobacter pylori. Mol Cell Proteomics 2014 0.86
34 Exploiting gene deletion fitness effects in yeast to understand the modular architecture of protein complexes under different growth conditions. BMC Syst Biol 2009 0.86
35 A systematic study of the energetics involved in structural changes upon association and connectivity in protein interaction networks. Structure 2011 0.83
36 Functional and structural analysis of C-terminal BRCA1 missense variants. PLoS One 2013 0.82
37 From protein interaction networks to novel therapeutic strategies. IUBMB Life 2012 0.82
38 Incorporating high-throughput proteomics experiments into structural biology pipelines: identification of the low-hanging fruits. Proteomics 2008 0.82
39 Systematic bioinformatics and experimental validation of yeast complexes reduces the rate of attrition during structural investigations. Structure 2010 0.82
40 Structural systems pharmacology: the role of 3D structures in next-generation drug development. Chem Biol 2013 0.81
41 On the analysis of protein-protein interactions via knowledge-based potentials for the prediction of protein-protein docking. Protein Sci 2011 0.80
42 A molecular interpretation of genetic interactions in yeast. FEBS Lett 2008 0.79
43 Structural similarity to bridge sequence space: finding new families on the bridges. Protein Sci 2005 0.79
44 Yeast mitochondrial protein-protein interactions reveal diverse complexes and disease-relevant functional relationships. J Proteome Res 2015 0.78
45 Revealing the molecular relationship between type 2 diabetes and the metabolic changes induced by a very-low-carbohydrate low-fat ketogenic diet. Nutr Metab (Lond) 2010 0.77
46 Predicting protein-protein interaction specificity through the integration of three-dimensional structural information and the evolutionary record of protein domains. Mol Biosyst 2010 0.76
47 Discovery and hypothesis generation through bioinformatics. Genome Biol 2006 0.75