Published in J Physiol on January 30, 2012
Adiponectin supplementation in pregnant mice prevents the adverse effects of maternal obesity on placental function and fetal growth. Proc Natl Acad Sci U S A (2015) 1.81
Regulation of nutrient transport across the placenta. J Pregnancy (2012) 1.32
The emerging role of mTORC1 signaling in placental nutrient-sensing. Placenta (2012) 1.12
Maternal-fetal nutrient transport in pregnancy pathologies: the role of the placenta. Int J Mol Sci (2014) 1.03
Placental transport in response to altered maternal nutrition. J Dev Orig Health Dis (2013) 0.96
Interleukin-1β inhibits insulin signaling and prevents insulin-stimulated system A amino acid transport in primary human trophoblasts. Mol Cell Endocrinol (2013) 0.96
Review: Adiponectin--the missing link between maternal adiposity, placental transport and fetal growth? Placenta (2012) 0.92
The role of placental nutrient sensing in maternal-fetal resource allocation. Biol Reprod (2014) 0.92
Role of placental nutrient sensing in developmental programming. Clin Obstet Gynecol (2013) 0.91
Maternal obesity and metabolic risk to the offspring: why lifestyle interventions may have not achieved the desired outcomes. Int J Obes (Lond) (2015) 0.90
Adiponectin inhibits insulin function in primary trophoblasts by PPARα-mediated ceramide synthesis. Mol Endocrinol (2014) 0.90
Placental Responses to Changes in the Maternal Environment Determine Fetal Growth. Front Physiol (2016) 0.88
Activation of SNAT1/SLC38A1 in human breast cancer: correlation with p-Akt overexpression. BMC Cancer (2013) 0.85
Patterns of adiponectin expression in term pregnancy: impact of obesity. J Clin Endocrinol Metab (2014) 0.84
Maternal magnesium deficiency in mice leads to maternal metabolic dysfunction and altered lipid metabolism with fetal growth restriction. Mol Med (2014) 0.77
Direct effects of leptin and adiponectin on peripheral reproductive tissues: a critical review. Mol Hum Reprod (2015) 0.77
Increased placental fatty acid transporter 6 and binding protein 3 expression and fetal liver lipid accumulation in a mouse model of obesity in pregnancy. Am J Physiol Regul Integr Comp Physiol (2015) 0.77
Knockout maternal adiponectin increases fetal growth in mice: potential role for trophoblast IGFBP-1. Diabetologia (2016) 0.77
Adipokines and the female reproductive tract. Int J Endocrinol (2014) 0.76
Maternal and cord blood adiponectin levels in relation to post-natal body size in infants in the first year of life: a prospective study. BMC Pregnancy Childbirth (2016) 0.75
The Relationship between Maternal Plasma Leptin and Adiponectin Concentrations and Newborn Adiposity. Nutrients (2017) 0.75
Activation of placental insulin and mTOR signaling in a mouse model of maternal obesity associated with fetal overgrowth. Am J Physiol Regul Integr Comp Physiol (2015) 0.75
The effect of androgen excess on maternal metabolism, placental function and fetal growth in obese dams. Sci Rep (2017) 0.75
Upstream and downstream of mTOR. Genes Dev (2004) 21.61
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med (2001) 16.51
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol (2007) 15.30
Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics (2005) 8.99
Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia (1993) 8.86
Adiponectin and adiponectin receptors. Endocr Rev (2005) 8.46
The influence of obesity and diabetes on the prevalence of macrosomia. Am J Obstet Gynecol (2004) 2.75
CATs and HATs: the SLC7 family of amino acid transporters. Pflugers Arch (2003) 2.69
Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family. Pflugers Arch (2003) 2.66
Down-regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein diet. J Physiol (2006) 2.27
Role of the placenta in fetal programming: underlying mechanisms and potential interventional approaches. Clin Sci (Lond) (2007) 2.23
A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes. Cell Metab (2005) 2.14
Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice. J Allergy Clin Immunol (2006) 2.05
Adiponectin ameliorates dyslipidemia induced by the human immunodeficiency virus protease inhibitor ritonavir in mice. Endocrinology (2003) 2.02
Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids. J Biol Chem (1999) 1.72
IFPA 2005 Award in Placentology Lecture. Human placental transport in altered fetal growth: does the placenta function as a nutrient sensor? -- a review. Placenta (2006) 1.69
Placental phenotypes of intrauterine growth. Pediatr Res (2005) 1.68
High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice. FASEB J (2008) 1.66
Placental transport of leucine and lysine is reduced in intrauterine growth restriction. Pediatr Res (1998) 1.65
Association between the activity of the system A amino acid transporter in the microvillous plasma membrane of the human placenta and severity of fetal compromise in intrauterine growth restriction. Pediatr Res (1997) 1.57
Leptin stimulates the activity of the system A amino acid transporter in human placental villous fragments. J Clin Endocrinol Metab (2003) 1.56
Mammalian target of rapamycin in the human placenta regulates leucine transport and is down-regulated in restricted fetal growth. J Physiol (2007) 1.49
Alterations in the activity of placental amino acid transporters in pregnancies complicated by diabetes. Diabetes (2002) 1.44
Modulation of adipokines and cytokines in gestational diabetes and macrosomia. J Clin Endocrinol Metab (2006) 1.44
Involvement of transporter recruitment as well as gene expression in the substrate-induced adaptive regulation of amino acid transport system A. Biochim Biophys Acta (2001) 1.43
Maternal hormones linking maternal body mass index and dietary intake to birth weight. Am J Clin Nutr (2008) 1.43
Amino acid (system A) transporter activity in microvillous membrane vesicles from the placentas of appropriate and small for gestational age babies. Pediatr Res (1993) 1.39
Adaptations in placental phenotype support fetal growth during undernutrition of pregnant mice. J Physiol (2009) 1.38
Regulation of amino acid transporters by glucose and growth factors in cultured primary human trophoblast cells is mediated by mTOR signaling. Am J Physiol Cell Physiol (2009) 1.38
Regulation of placental amino acid transporter activity by mammalian target of rapamycin. Am J Physiol Cell Physiol (2008) 1.38
SNAT4 isoform of system A amino acid transporter is expressed in human placenta. Am J Physiol Cell Physiol (2005) 1.35
Cardiac-specific overexpression of peroxisome proliferator-activated receptor-alpha causes insulin resistance in heart and liver. Diabetes (2005) 1.33
Intrauterine growth restriction is associated with a reduced activity of placental taurine transporters. Pediatr Res (1998) 1.31
Placental transport of leucine, phenylalanine, glycine, and proline in intrauterine growth-restricted pregnancies. J Clin Endocrinol Metab (2001) 1.31
Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells. Diabetologia (2004) 1.31
Adiponectin reduces plasma triglyceride by increasing VLDL triglyceride catabolism. Diabetes (2008) 1.28
Stimulation of AMP-activated protein kinase (AMPK) is associated with enhancement of Glut1-mediated glucose transport. Arch Biochem Biophys (2000) 1.25
Maternal protein restriction in the rat inhibits placental insulin, mTOR, and STAT3 signaling and down-regulates placental amino acid transporters. Endocrinology (2011) 1.23
Insulinlike growth factors. Their regulation of glucose and amino acid transport in placental trophoblasts isolated from first-trimester chorionic villi. J Reprod Med (1994) 1.22
Amino acid transporters in the human placenta. Pediatr Res (2001) 1.19
Akt-dependent and -independent survival signaling pathways utilized by insulin-like growth factor I. Mol Cell Biol (1998) 1.18
Full-length adiponectin attenuates insulin signaling and inhibits insulin-stimulated amino Acid transport in human primary trophoblast cells. Diabetes (2010) 1.15
The mechanisms and regulation of placental amino acid transport to the human foetus. J Neuroendocrinol (2008) 1.13
Adiponectin is reduced in gestational diabetes mellitus in normal weight women. Acta Obstet Gynecol Scand (2004) 1.13
Glucose transporter isoform 4 is expressed in the syncytiotrophoblast of first trimester human placenta. Hum Reprod (2004) 1.12
Amino acid transport by the cultured human placental trophoblast: effect of insulin on AIB transport. Am J Physiol (1992) 1.09
Expression and regulation of adiponectin and receptor in human and rat placenta. J Clin Endocrinol Metab (2005) 1.09
Facilitated transporters mediate net efflux of amino acids to the fetus across the basal membrane of the placental syncytiotrophoblast. J Physiol (2011) 1.05
The SNAT4 isoform of the system A amino acid transporter is functional in human placental microvillous plasma membrane. J Physiol (2008) 1.02
Determining the source of fetal adiponectin. J Reprod Med (2007) 1.02
Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule. Arch Pharm Res (2005) 0.97
Early treatment of the pregnant guinea pig with IGFs promotes placental transport and nutrient partitioning near term. Am J Physiol Endocrinol Metab (2006) 0.97
Characterization of an N-system amino acid transporter expressed in retina and its involvement in glutamine transport. J Biol Chem (2001) 0.96
High molecular mass multimer complexes and vascular expression contribute to high adiponectin in the fetus. J Clin Endocrinol Metab (2008) 0.96
Effect of insulin on glucose uptake and metabolism in the human placenta. J Clin Endocrinol Metab (1986) 0.95
Isolation of plasma membrane vesicles from mouse placenta at term and measurement of system A and system beta amino acid transporter activity. Placenta (2009) 0.91
SNAT expression in rat placenta. Placenta (2005) 0.88
Adiponectin attenuation of endocrine function within human term trophoblast cells. Endocrinology (2009) 0.87
Maternal obesity and familial history of diabetes have opposing effects on infant birth weight in women with mild glucose intolerance in pregnancy. J Matern Fetal Neonatal Med (2008) 0.86
Insulin and glucose modulate glucose transporter messenger ribonucleic acid expression and glucose uptake in trophoblasts isolated from first-trimester chorionic villi. Am J Obstet Gynecol (1995) 0.86
Relationship of adiponectin and resistin levels in umbilical serum, maternal serum and placenta with neonatal birth weight. Aust N Z J Obstet Gynaecol (2010) 0.80
Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature (2002) 5.62
CATs and HATs: the SLC7 family of amino acid transporters. Pflugers Arch (2003) 2.69
Down-regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein diet. J Physiol (2006) 2.27
Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population. Sci Transl Med (2009) 2.25
Role of the placenta in fetal programming: underlying mechanisms and potential interventional approaches. Clin Sci (Lond) (2007) 2.23
Mutations in glucose transporter 9 gene SLC2A9 cause renal hypouricemia. Am J Hum Genet (2008) 2.21
New insights into renal transport of urate. Curr Opin Rheumatol (2007) 2.07
Placental phenotypes of intrauterine growth. Pediatr Res (2005) 1.68
Transport of 99mTc-MAG3 via rat renal organic anion transporter 1. J Nucl Med (2004) 1.66
High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice. FASEB J (2008) 1.66
L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors. Int J Cancer (2006) 1.57
L-type amino-acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer. Pathol Int (2009) 1.57
Loss of parietal cell expression of Sonic hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells. Gastroenterology (2009) 1.55
Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules. J Pharmacol Sci (2004) 1.52
Mammalian target of rapamycin in the human placenta regulates leucine transport and is down-regulated in restricted fetal growth. J Physiol (2007) 1.49
Mutations in SLC6A19, encoding B0AT1, cause Hartnup disorder. Nat Genet (2004) 1.45
Alterations in the activity of placental amino acid transporters in pregnancies complicated by diabetes. Diabetes (2002) 1.44
Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition. Mol Pharmacol (2002) 1.44
Maternal hormones linking maternal body mass index and dietary intake to birth weight. Am J Clin Nutr (2008) 1.43
A novel role of the C-terminus of b 0,+ AT in the ER-Golgi trafficking of the rBAT-b 0,+ AT heterodimeric amino acid transporter. Biochem J (2009) 1.41
The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus. J Biol Chem (2004) 1.40
Activation of placental mTOR signaling and amino acid transporters in obese women giving birth to large babies. J Clin Endocrinol Metab (2012) 1.38
l-type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms. Cancer Sci (2008) 1.37
The SLC3 and SLC7 families of amino acid transporters. Mol Aspects Med (2013) 1.36
Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters. J Biol Chem (2003) 1.34
Organic anion transporter family: current knowledge. J Pharmacol Sci (2006) 1.34
Regulation of nutrient transport across the placenta. J Pregnancy (2012) 1.32
Placental mTOR links maternal nutrient availability to fetal growth. Biochem Soc Trans (2009) 1.30
Common dysfunctional variants in ABCG2 are a major cause of early-onset gout. Sci Rep (2013) 1.28
Mammalian target of rapamycin signalling modulates amino acid uptake by regulating transporter cell surface abundance in primary human trophoblast cells. J Physiol (2012) 1.23
Maternal protein restriction in the rat inhibits placental insulin, mTOR, and STAT3 signaling and down-regulates placental amino acid transporters. Endocrinology (2011) 1.23
Inhibition of L-type amino acid transporter 1 has antitumor activity in non-small cell lung cancer. Anticancer Res (2010) 1.20
Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter, sodium taurocholate cotransporting polypeptide (NTCP). Hepatology (2014) 1.19
LAT1 expression is closely associated with hypoxic markers and mTOR in resected non-small cell lung cancer. Am J Transl Res (2011) 1.16
Sodium-dependent phosphate cotransporter type 1 sequence polymorphisms in male patients with gout. Ann Rheum Dis (2009) 1.16
Full-length adiponectin attenuates insulin signaling and inhibits insulin-stimulated amino Acid transport in human primary trophoblast cells. Diabetes (2010) 1.15
Localization of Ang-1, -2, Tie-2, and VEGF expression at endothelial-pericyte interdigitation in rat angiogenesis. Lab Invest (2006) 1.15
Enhanced tumor growth elicited by L-type amino acid transporter 1 in human malignant glioma cells. Neurosurgery (2008) 1.14
L-type amino acid transporter 1 inhibitors inhibit tumor cell growth. Cancer Sci (2009) 1.13
Correlation of L-type amino acid transporter 1 and CD98 expression with triple negative breast cancer prognosis. Cancer Sci (2011) 1.11
Interleukin-6 in the maternal circulation reaches the rat fetus in mid-gestation. Pediatr Res (2006) 1.11
Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells. Biochim Biophys Acta (2002) 1.10
Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate. Hepatology (2007) 1.09
Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions. Biochem Biophys Res Commun (2004) 1.09
System L amino acid transporter inhibitor enhances anti-tumor activity of cisplatin in a head and neck squamous cell carcinoma cell line. Cancer Lett (2008) 1.08
Fluorine-18-alpha-methyltyrosine positron emission tomography for diagnosis and staging of lung cancer: a clinicopathologic study. Clin Cancer Res (2007) 1.07
The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location. Genomics (2002) 1.07
CD98 expression is associated with poor prognosis in resected non-small-cell lung cancer with lymph node metastases. Ann Surg Oncol (2009) 1.07
Amino acid transporter LAT3 is required for podocyte development and function. J Am Soc Nephrol (2009) 1.06
Expression of LAT1 predicts risk of progression of transitional cell carcinoma of the upper urinary tract. Virchows Arch (2007) 1.05
Dual-color imaging of nuclear-cytoplasmic dynamics, viability, and proliferation of cancer cells in the portal vein area. Cancer Res (2006) 1.04
Lysophosphatidylcholine enhances cytokine production of endothelial cells via induction of L-type amino acid transporter 1 and cell surface antigen 4F2. Arterioscler Thromb Vasc Biol (2004) 1.03
Modulation of renal apical organic anion transporter 4 function by two PDZ domain-containing proteins. J Am Soc Nephrol (2005) 1.03
Brief hyperglycaemia in the early pregnant rat increases fetal weight at term by stimulating placental growth and affecting placental nutrient transport. J Physiol (2007) 1.03
Transport of 3-fluoro-L-α-methyl-tyrosine by tumor-upregulated L-type amino acid transporter 1: a cause of the tumor uptake in PET. J Nucl Med (2012) 1.02
Functional characterization of rat organic anion transporter 5 (Slc22a19) at the apical membrane of renal proximal tubules. J Pharmacol Exp Ther (2005) 1.02
The ancillary proteins of HATs: SLC3 family of amino acid transporters. Pflugers Arch (2003) 1.02
Connexon-mediated cell adhesion drives microtissue self-assembly. FASEB J (2010) 1.01
The RNA interference of amino acid transporter LAT1 inhibits the growth of KB human oral cancer cells. Anticancer Res (2006) 1.00
BCH, an inhibitor of system L amino acid transporters, induces apoptosis in cancer cells. Biol Pharm Bull (2008) 1.00
Correlation of angiogenesis with 18F-FMT and 18F-FDG uptake in non-small cell lung cancer. Cancer Sci (2009) 0.98
Clinical significance of L-type amino acid transporter 1 expression as a prognostic marker and potential of new targeting therapy in biliary tract cancer. BMC Cancer (2013) 0.97
Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition. J Biol Chem (2002) 0.97
Enhancement of L-cystine transport activity and its relation to xCT gene induction at the blood-brain barrier by diethyl maleate treatment. J Pharmacol Exp Ther (2002) 0.97
Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule. Arch Pharm Res (2005) 0.97
L-type amino acid transporter 1 expression is a prognostic marker in patients with surgically resected stage I non-small cell lung cancer. Histopathology (2009) 0.96
Interleukin-1β inhibits insulin signaling and prevents insulin-stimulated system A amino acid transport in primary human trophoblasts. Mol Cell Endocrinol (2013) 0.96
Common variant of leucine-rich repeat-containing 16A (LRRC16A) gene is associated with gout susceptibility. Hum Cell (2013) 0.96
Identification of a novel Na+-independent acidic amino acid transporter with structural similarity to the member of a heterodimeric amino acid transporter family associated with unknown heavy chains. J Biol Chem (2002) 0.96
Down-regulation of placental mTOR, insulin/IGF-I signaling, and nutrient transporters in response to maternal nutrient restriction in the baboon. FASEB J (2013) 0.95
Hormonal regulation of glucose and system A amino acid transport in first trimester placental villous fragments. Am J Physiol Regul Integr Comp Physiol (2004) 0.95
Establishment of stable cell lines with high expression of heterodimers of human 4F2hc and human amino acid transporter LAT1 or LAT2 and delineation of their differential interaction with α-alkyl moieties. J Pharmacol Sci (2012) 0.95
Integrated physiology of proximal tubular organic anion transport. Curr Opin Nephrol Hypertens (2005) 0.95
Maternal androgen excess reduces placental and fetal weights, increases placental steroidogenesis, and leads to long-term health effects in their female offspring. Am J Physiol Endocrinol Metab (2012) 0.94
Clinicopathological significance of ASC amino acid transporter-2 expression in pancreatic ductal carcinoma. Histopathology (2014) 0.94
Identification of a novel voltage-driven organic anion transporter present at apical membrane of renal proximal tubule. J Biol Chem (2003) 0.94
Protein characterization of NA+-independent system L amino acid transporter 3 in mice: a potential role in supply of branched-chain amino acids under nutrient starvation. Am J Pathol (2007) 0.94
Maternal overweight induced by a diet with high content of saturated fat activates placental mTOR and eIF2alpha signaling and increases fetal growth in rats. Biol Reprod (2013) 0.94
L-type amino acid transporter 1 (LAT1) expression in malignant pleural mesothelioma. Anticancer Res (2011) 0.93
Roles of organic anion transporters in the renal excretion of perfluorooctanoic acid. Basic Clin Pharmacol Toxicol (2008) 0.93
Establishment and characterization of mammalian cell lines stably expressing human L-type amino acid transporters. J Pharmacol Sci (2008) 0.93
System L-amino acid transporters are differently expressed in rat astrocyte and C6 glioma cells. Neurosci Res (2004) 0.93