PubRank

Charles G Eberhart

Author PubWeight™ 219.78‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Medulloblastoma comprises four distinct molecular variants. J Clin Oncol 2010 8.06
2 Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol 2011 6.67
3 Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 2002 6.53
4 Altered telomeres in tumors with ATRX and DAXX mutations. Science 2011 4.60
5 Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. Nat Genet 2009 4.52
6 Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome. J Clin Oncol 2010 4.48
7 Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature 2012 4.13
8 Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. Cancer Res 2006 3.81
9 PIK3CA gene mutations in pediatric and adult glioblastoma multiforme. Mol Cancer Res 2006 3.72
10 Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation. Cancer Res 2005 3.63
11 Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma. Stem Cells 2007 3.47
12 NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts. Stem Cells 2010 3.42
13 Clonal selection drives genetic divergence of metastatic medulloblastoma. Nature 2012 2.96
14 Notch1 and notch2 have opposite effects on embryonal brain tumor growth. Cancer Res 2004 2.90
15 Notch3 gene amplification in ovarian cancer. Cancer Res 2006 2.66
16 The neurobiology of autism. Brain Pathol 2007 2.63
17 Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples. Acta Neuropathol 2011 2.53
18 Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. Nat Genet 2013 2.42
19 Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes. Am J Pathol 2011 2.41
20 Frequent gains at chromosome 7q34 involving BRAF in pilocytic astrocytoma. J Neuropathol Exp Neurol 2008 2.40
21 Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis. Cell 2002 2.37
22 Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities. J Neurosci 2007 2.31
23 The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. Genes Dev 2005 2.14
24 Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct. Acta Neuropathol 2011 2.01
25 Hypoxia increases the expression of stem-cell markers and promotes clonogenicity in glioblastoma neurospheres. Am J Pathol 2010 1.86
26 The Smo/Smo model: hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread. Cancer Res 2008 1.84
27 Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation. Mol Cell Biol 2006 1.83
28 A polymeric nanoparticle formulation of curcumin inhibits growth, clonogenicity and stem-like fraction in malignant brain tumors. Cancer Biol Ther 2011 1.76
29 Genomic amplification of orthodenticle homologue 2 in medulloblastomas. Cancer Res 2005 1.75
30 c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype. Proc Natl Acad Sci U S A 2011 1.75
31 Medulloblastoma stem cells. J Clin Oncol 2008 1.71
32 Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancer. Clin Cancer Res 2009 1.66
33 c-myc overexpression causes anaplasia in medulloblastoma. Cancer Res 2006 1.66
34 A mouse model of blast injury to brain: initial pathological, neuropathological, and behavioral characterization. J Neuropathol Exp Neurol 2011 1.62
35 BRAF activation induces transformation and then senescence in human neural stem cells: a pilocytic astrocytoma model. Clin Cancer Res 2011 1.61
36 BRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549:BRAF fusion variants. J Neuropathol Exp Neurol 2012 1.60
37 The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance. Clin Cancer Res 2010 1.58
38 Cytogenetic prognostication within medulloblastoma subgroups. J Clin Oncol 2014 1.56
39 Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors. Cancer Res 2008 1.51
40 Unfolded protein response in fuchs endothelial corneal dystrophy: a unifying pathogenic pathway? Am J Ophthalmol 2010 1.49
41 Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma. J Clin Oncol 2013 1.43
42 Three-dimensional amide proton transfer MR imaging of gliomas: Initial experience and comparison with gadolinium enhancement. J Magn Reson Imaging 2013 1.43
43 Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma. Genes Dev 2008 1.42
44 Isochromosome 17q is a negative prognostic factor in poor-risk childhood medulloblastoma patients. Clin Cancer Res 2005 1.40
45 A clinicopathologic series of primary graft failure after Descemet's stripping and automated endothelial keratoplasty. Ophthalmology 2008 1.40
46 Iris cross-sectional area decreases with pupil dilation and its dynamic behavior is a risk factor in angle closure. J Glaucoma 2009 1.35
47 TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma. Acta Neuropathol 2013 1.35
48 Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma. Acta Neuropathol 2012 1.33
49 Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1. Proc Natl Acad Sci U S A 2013 1.33
50 CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity. Acta Neuropathol 2014 1.28
51 5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft. Oncotarget 2013 1.28
52 Activation of canonical WNT/β-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition. Cancer Lett 2012 1.26
53 Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model. Proc Natl Acad Sci U S A 2010 1.25
54 Spectrum of pilomyxoid astrocytomas: intermediate pilomyxoid tumors. Am J Surg Pathol 2010 1.23
55 Decreased 5-hydroxymethylcytosine is associated with neural progenitor phenotype in normal brain and shorter survival in malignant glioma. PLoS One 2012 1.23
56 Embryonal tumors with abundant neuropil and true rosettes: a distinctive CNS primitive neuroectodermal tumor. Am J Surg Pathol 2009 1.23
57 Hedgehog signaling promotes medulloblastoma survival via Bc/II. Am J Pathol 2007 1.22
58 DNER, an epigenetically modulated gene, regulates glioblastoma-derived neurosphere cell differentiation and tumor propagation. Stem Cells 2009 1.20
59 Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase. J Biol Chem 2007 1.19
60 Comparison of medulloblastoma and normal neural transcriptomes identifies a restricted set of activated genes. Oncogene 2003 1.14
61 Epithelial downgrowth following Descemet's-stripping automated endothelial keratoplasty. Arch Ophthalmol 2008 1.14
62 BRAF duplications and MAPK pathway activation are frequent in gliomas of the optic nerve proper. J Neuropathol Exp Neurol 2012 1.14
63 Hypoxic retinal Muller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4. Proc Natl Acad Sci U S A 2013 1.12
64 hTERT gene amplification and increased mRNA expression in central nervous system embryonal tumors. Am J Pathol 2003 1.11
65 Functional and molecular interactions between the HGF/c-Met pathway and c-Myc in large-cell medulloblastoma. Lab Invest 2007 1.10
66 Yes-associated protein 1 is widely expressed in human brain tumors and promotes glioblastoma growth. J Neuropathol Exp Neurol 2011 1.10
67 Neoplastic cells are a rare component in human glioblastoma microvasculature. Oncotarget 2012 1.09
68 Krüppel-like family of transcription factor 9, a differentiation-associated transcription factor, suppresses Notch1 signaling and inhibits glioblastoma-initiating stem cells. Stem Cells 2011 1.09
69 Disseminated oligodendroglial-like leptomeningeal tumor of childhood: a distinctive clinicopathologic entity. Acta Neuropathol 2012 1.09
70 Nrf2 has a protective role against neuronal and capillary degeneration in retinal ischemia-reperfusion injury. Free Radic Biol Med 2011 1.08
71 RNA interference-mediated c-MYC inhibition prevents cell growth and decreases sensitivity to radio- and chemotherapy in childhood medulloblastoma cells. BMC Cancer 2009 1.08
72 LIN28A facilitates the transformation of human neural stem cells and promotes glioblastoma tumorigenesis through a pro-invasive genetic program. Oncotarget 2013 1.05
73 Molecular and morphologic correlates of the alternative lengthening of telomeres phenotype in high-grade astrocytomas. Brain Pathol 2012 1.04
74 Identification of astrocytoma associated genes including cell surface markers. BMC Cancer 2004 1.04
75 DNA fragmentation simulation method (FSM) and fragment size matching improve aCGH performance of FFPE tissues. PLoS One 2012 1.02
76 Notch signaling promotes growth and invasion in uveal melanoma. Clin Cancer Res 2012 1.01
77 Notch3 activation promotes invasive glioma formation in a tissue site-specific manner. Cancer Res 2011 1.01
78 Transforming growth factor-β signaling pathway activation in Keratoconus. Am J Ophthalmol 2011 1.00
79 Lhermitte-Duclos disease: a report of 31 cases with immunohistochemical analysis of the PTEN/AKT/mTOR pathway. J Neuropathol Exp Neurol 2005 1.00
80 Gene expression profiling of NF-1-associated and sporadic pilocytic astrocytoma identifies aldehyde dehydrogenase 1 family member L1 (ALDH1L1) as an underexpressed candidate biomarker in aggressive subtypes. J Neuropathol Exp Neurol 2008 1.00
81 Beta-amyloid, phospho-tau and alpha-synuclein deposits similar to those in the brain are not identified in the eyes of Alzheimer's and Parkinson's disease patients. Brain Pathol 2013 0.99
82 Regulation of sonic hedgehog-GLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2 and their epigenetic status in medulloblastoma and astrocytoma. BMC Cancer 2010 0.99
83 OTX2 represses myogenic and neuronal differentiation in medulloblastoma cells. Cancer Res 2012 0.98
84 Notch signaling in prostate cancer: a moving target. Prostate 2014 0.98
85 Gain of 1q is a potential univariate negative prognostic marker for survival in medulloblastoma. Clin Cancer Res 2007 0.98
86 NKX3.1 as a marker of prostatic origin in metastatic tumors. Am J Surg Pathol 2010 0.97
87 Genome wide copy number abnormalities in pediatric medulloblastomas as assessed by array comparative genome hybridization. Brain Pathol 2007 0.97
88 Coexpression of neuronatin splice forms promotes medulloblastoma growth. Neuro Oncol 2008 0.96
89 Activation of mTORC1/mTORC2 signaling in pediatric low-grade glioma and pilocytic astrocytoma reveals mTOR as a therapeutic target. Neuro Oncol 2013 0.95
90 beta2-adrenergic receptor activation and genetic polymorphisms in autism: data from dizygotic twins. J Child Neurol 2005 0.95
91 MicroRNA profiling in pediatric pilocytic astrocytoma reveals biologically relevant targets, including PBX3, NFIB, and METAP2. Neuro Oncol 2012 0.95
92 Hepatocyte growth factor and sonic Hedgehog expression in cerebellar neural progenitor cells costimulate medulloblastoma initiation and growth. Cancer Res 2008 0.94
93 Morphologic characteristics and immunohistochemical profile of diffuse intrinsic pontine gliomas. Am J Surg Pathol 2013 0.94
94 Neurobrucellosis presenting as leukoencephalopathy: the role of cytotoxic T lymphocytes. Arch Pathol Lab Med 2003 0.92
95 Tissue inhibitor of matrix metalloproteinase-3 levels in the extracellular matrix of lung, kidney, and eye increase with age. J Histochem Cytochem 2008 0.92
96 c-MYC expression sensitizes medulloblastoma cells to radio- and chemotherapy and has no impact on response in medulloblastoma patients. BMC Cancer 2011 0.92
97 Establishment of a human glioblastoma stemlike brainstem rodent tumor model. J Neurosurg Pediatr 2010 0.91
98 Ghrelin and the growth hormone secretagogue receptor constitute a novel autocrine pathway in astrocytoma motility. J Biol Chem 2006 0.91
99 Prolonged inhibition of glioblastoma xenograft initiation and clonogenic growth following in vivo Notch blockade. Clin Cancer Res 2013 0.91
100 Podocalyxin-like protein is expressed in glioblastoma multiforme stem-like cells and is associated with poor outcome. PLoS One 2013 0.91
101 Anti-proliferative activity of the quassinoid NBT-272 in childhood medulloblastoma cells. BMC Cancer 2007 0.90
102 Increased 5-hydroxymethylcytosine and decreased 5-methylcytosine are indicators of global epigenetic dysregulation in diffuse intrinsic pontine glioma. Acta Neuropathol Commun 2014 0.89
103 L450W and Q455K Col8a2 knock-in mouse models of Fuchs endothelial corneal dystrophy show distinct phenotypes and evidence for altered autophagy. Invest Ophthalmol Vis Sci 2013 0.88
104 Pathological and molecular advances in pediatric low-grade astrocytoma. Annu Rev Pathol 2012 0.87
105 Prevention of experimental cerebral vasospasm by intracranial delivery of a nitric oxide donor from a controlled-release polymer: toxicity and efficacy studies in rabbits and rats. Stroke 2002 0.86
106 A developmental defect in astrocytes inhibits programmed regression of the hyaloid vasculature in the mammalian eye. Eur J Cell Biol 2011 0.86
107 Critical role of zinc finger protein 521 in the control of growth, clonogenicity and tumorigenic potential of medulloblastoma cells. Oncotarget 2013 0.86
108 Just say no to ATOH: how HIC1 methylation might predispose medulloblastoma to lineage addiction. Cancer Res 2008 0.86
109 CD133/CD15 defines distinct cell subpopulations with differential in vitro clonogenic activity and stem cell-related gene expression profile in in vitro propagated glioblastoma multiforme-derived cell line with a PNET-like component. Folia Neuropathol 2012 0.85
110 5-Fluorouracil for epithelial downgrowth after Descemet stripping automated endothelial keratoplasty. Cornea 2013 0.84
111 Expression of p75NTR in fetal brain and medulloblastomas: evidence of a precursor cell marker and its persistence in neoplasia. J Neurooncol 2008 0.84
112 cMYC expression in infiltrating gliomas: associations with IDH1 mutations, clinicopathologic features and outcome. J Neurooncol 2013 0.84
113 Intraorbital meningiomas: a pathologic review using current World Health Organization criteria. Arch Pathol Lab Med 2010 0.83
114 RNA binding protein RBM14 promotes radio-resistance in glioblastoma by regulating DNA repair and cell differentiation. Oncotarget 2014 0.83
115 Epigenetic silencing of multiple genes in primary CNS lymphoma. Int J Cancer 2006 0.83
116 A role for Jag2 in promoting uveal melanoma dissemination and growth. Invest Ophthalmol Vis Sci 2013 0.83
117 Differential DNA methylation identified in the blood and retina of AMD patients. Epigenetics 2015 0.83
118 Chronic hypotony associated with the Boston type 1 keratoprosthesis. Am J Ophthalmol 2012 0.83
119 A glioblastoma neurosphere line with alternative lengthening of telomeres. Acta Neuropathol 2013 0.82
120 Disrupting NOTCH Slows Diffuse Intrinsic Pontine Glioma Growth, Enhances Radiation Sensitivity, and Shows Combinatorial Efficacy With Bromodomain Inhibition. J Neuropathol Exp Neurol 2015 0.82
121 Growth properties of SF188/V+ human glioma in rats in vivo observed by magnetic resonance imaging. J Neurooncol 2012 0.81
122 Endothelial cell microRNA expression in human late-onset Fuchs' dystrophy. Invest Ophthalmol Vis Sci 2014 0.81
123 Expression of stabilized beta-catenin in differentiated neurons of transgenic mice does not result in tumor formation. BMC Cancer 2002 0.81
124 Tissue microarray analysis of cyclin-dependent kinase inhibitors p21 and p16 in Fuchs dystrophy. Cornea 2013 0.81
125 Endothelial cell whole genome expression analysis in a mouse model of early-onset Fuchs' endothelial corneal dystrophy. Invest Ophthalmol Vis Sci 2013 0.81
126 The chromatin-modifying protein HMGA2 promotes atypical teratoid/rhabdoid cell tumorigenicity. J Neuropathol Exp Neurol 2015 0.81
127 Ultrasound features of orbital granular cell tumor. Ophthal Plast Reconstr Surg 2009 0.80
128 Canonical TGF-β pathway activity is a predictor of SHH-driven medulloblastoma survival and delineates putative precursors in cerebellar development. Brain Pathol 2012 0.80
129 Human hedgehog interacting protein expression and promoter methylation in medulloblastoma cell lines and primary tumor samples. J Neurooncol 2010 0.80
130 Biologic risk stratification of medulloblastoma: the real time is now. J Clin Oncol 2004 0.80
131 Nature versus nurture in glioblastoma: microenvironment and genetics can both drive mesenchymal transcriptional signature. Am J Pathol 2012 0.80
132 NY-ESO-1 expression in meningioma suggests a rationale for new immunotherapeutic approaches. Cancer Immunol Res 2013 0.79
133 Ocular MECP2 protein expression in patients with and without Rett syndrome. Pediatr Neurol 2010 0.79
134 WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma. Acta Neuropathol Commun 2014 0.79
135 Combination of paclitaxel thermal gel depot with temozolomide and radiotherapy significantly prolongs survival in an experimental rodent glioma model. J Neurooncol 2012 0.79
136 Rhabdoid meningioma: cytopathologic findings in cerebrospinal fluid. Diagn Cytopathol 2003 0.79
137 Isolated endogenous Nocardia endophthalmitis after immunosuppression. J Ophthalmic Inflamm Infect 2012 0.79
138 Diagnosis of intravascular lymphoma by a novel biopsy site. Ophthalmology 2010 0.78
139 Ectopic recurrence of craniopharyngioma after an interhemispheric transcallosal approach: case report. Neurosurgery 2002 0.78
140 High-risk medulloblastoma: does c-myc amplification overrule histopathology? Pediatr Blood Cancer 2010 0.78
141 No increase in IgG4-positive plasma cells in limbal Rosai-Dorfman disease. Cornea 2014 0.78
142 The application of surgical cordectomy in the management of an intramedullary-extramedullary atypical meningioma: case report and literature review. J Spinal Disord Tech 2005 0.78
143 Pharmacologic Wnt Inhibition Reduces Proliferation, Survival, and Clonogenicity of Glioblastoma Cells. J Neuropathol Exp Neurol 2015 0.78
144 Evaluation of the effects of circular Descemet's membrane incision on the biomechanical, topographic and optical properties of rabbit corneas. Clin Experiment Ophthalmol 2011 0.78
145 Methylome alterations "mark" new therapeutic opportunities in glioblastoma. Cancer Cell 2012 0.77
146 Genetic profiling by single-nucleotide polymorphism-based array analysis defines three distinct subtypes of orbital meningioma. Brain Pathol 2014 0.77
147 Epilepsy and temporal lobe injury after skull base proton beam therapy. J Clin Neurosci 2009 0.76
148 A novel polymer gel for the delivery of local therapies to intracranial tumors: In vivo safety evaluation. J Biomed Mater Res A 2011 0.76
149 Design and analysis of keratoconus tissue microarrays. Cornea 2014 0.76
150 Notch signaling activation in pediatric low-grade astrocytoma. J Neuropathol Exp Neurol 2015 0.76
151 A model of a patient-derived IDH1 mutant anaplastic astrocytoma with alternative lengthening of telomeres. J Neurooncol 2014 0.76
152 Effects of Zeng Sheng Ping/ACAPHA on malignant brain tumor growth and Notch signaling. Anticancer Res 2012 0.75
153 Scleral penetration of an unusually aggressive case of a retinal hemangioblastoma. Can J Ophthalmol 2013 0.75
154 Mass confusion in a 30-year-old man. J Neuroophthalmol 2014 0.75
155 Endothelial Cdkn1a (p21) overexpression and accelerated senescence in a mouse model of Fuchs endothelial corneal dystrophy. Invest Ophthalmol Vis Sci 2012 0.75
156 Intraocular tuberculosis presenting as a large anterior chamber mass. Ocul Immunol Inflamm 2014 0.75
157 A mouse model of MYCN-driven retinoblastoma reveals MYCN-independent tumor reemergence. J Clin Invest 2017 0.75
158 Delayed Superficial Migration of Retained Hyaluronic Acid Years Following Periocular Injection. Ophthal Plast Reconstr Surg 2015 0.75
159 Persistent intermediate uveitis associated with latent manifestation of facial large B-cell non-Hodgkin lymphoma. Ocul Immunol Inflamm 2009 0.75
160 The effect of neurosphere culture conditions on the cellular metabolism of glioma cells. Folia Neuropathol 2015 0.75