OTX2 represses myogenic and neuronal differentiation in medulloblastoma cells.

PubWeight™: 0.98‹?› | Rank: Top 15%

🔗 View Article (PMID 22986744)

Published in Cancer Res on September 17, 2012

Authors

Ren-Yuan Bai1, Verena Staedtke, Hart G Lidov, Charles G Eberhart, Gregory J Riggins

Author Affiliations

1: Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA. rbai1@jhmi.edu

Articles citing this

The prenatal origins of cancer. Nat Rev Cancer (2014) 1.09

Sulforaphane and TRAIL induce a synergistic elimination of advanced prostate cancer stem-like cells. Int J Oncol (2014) 0.87

Brain Penetration and Efficacy of Different Mebendazole Polymorphs in a Mouse Brain Tumor Model. Clin Cancer Res (2015) 0.87

Clostridium novyi-NT can cause regression of orthotopically implanted glioblastomas in rats. Oncotarget (2015) 0.86

Effective treatment of diverse medulloblastoma models with mebendazole and its impact on tumor angiogenesis. Neuro Oncol (2014) 0.86

Microarray discovery of new OGT substrates: the medulloblastoma oncogene OTX2 is O-GlcNAcylated. J Am Chem Soc (2014) 0.84

MyoD is a tumor suppressor gene in medulloblastoma. Cancer Res (2013) 0.83

Gene expression analyses of the spatio-temporal relationships of human medulloblastoma subgroups during early human neurogenesis. PLoS One (2014) 0.81

Genetic and molecular alterations across medulloblastoma subgroups. J Mol Med (Berl) (2015) 0.81

A mouse model of human primitive neuroectodermal tumors resulting from microenvironmentally-driven malignant transformation of orthotopically transplanted radial glial cells. PLoS One (2015) 0.76

A Proteogenomic Approach to Understanding MYC Function in Metastatic Medulloblastoma Tumors. Int J Mol Sci (2016) 0.75

The ATRA-induced differentiation of medulloblastoma cells is enhanced with LOX/COX inhibitors: an analysis of gene expression. Cancer Cell Int (2014) 0.75

OTX2 expression contributes to proliferation and progression in Myc-amplified medulloblastoma. Am J Cancer Res (2017) 0.75

OTX2 Activity at Distal Regulatory Elements Shapes the Chromatin Landscape of Group 3 Medulloblastoma. Cancer Discov (2017) 0.75

Articles cited by this

REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. Cell (2005) 8.65

The genetic landscape of the childhood cancer medulloblastoma. Science (2010) 8.34

The circuitry of a master switch: Myod and the regulation of skeletal muscle gene transcription. Development (2005) 8.04

Subtypes of medulloblastoma have distinct developmental origins. Nature (2010) 5.94

NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis. Nat Genet (1998) 4.54

Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. Nat Genet (2009) 4.52

Regulation of neuronal traits by a novel transcriptional complex. Neuron (2001) 4.02

An amino-terminal fragment of GAL4 binds DNA as a dimer. J Mol Biol (1989) 3.65

Identification of potential target genes for the neuron-restrictive silencer factor. Proc Natl Acad Sci U S A (1996) 3.11

MSX1 cooperates with histone H1b for inhibition of transcription and myogenesis. Science (2004) 2.87

Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid. Cancer Res (2005) 2.35

Skeletal myogenic potential of human and mouse neural stem cells. Nat Neurosci (2000) 2.13

Large cell/anaplastic medulloblastomas and medullomyoblastomas: clinicopathological and genetic features. J Neurosurg (2001) 1.85

Medullomyoblastoma: a radiographic and clinicopathologic analysis of six cases and review of the literature. Cancer (2004) 1.84

OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas. Cancer Res (2009) 1.77

Genomic amplification of orthodenticle homologue 2 in medulloblastomas. Cancer Res (2005) 1.75

Embryonic activation of the myoD gene is regulated by a highly conserved distal control element. Development (1995) 1.69

Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity. Mol Cell Biol (1998) 1.68

Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain. Development (2004) 1.59

Otx1 and Otx2 define layers and regions in developing cerebral cortex and cerebellum. J Neurosci (1994) 1.57

Establishment and characterization of the human medulloblastoma cell line and transplantable xenograft D283 Med. J Neuropathol Exp Neurol (1985) 1.51

The regulation of MyoD gene expression: conserved elements mediate expression in embryonic axial muscle. Dev Biol (1995) 1.50

Understanding the cognitive impact on children who are treated for medulloblastoma. J Pediatr Psychol (2007) 1.42

OTX1 and OTX2 expression correlates with the clinicopathologic classification of medulloblastomas. J Neuropathol Exp Neurol (2006) 1.39

Molecular distinction between specification and differentiation in the myogenic basic helix-loop-helix transcription factor family. Mol Cell Biol (2001) 1.39

Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon. Development (2008) 1.28

Identification of a functional silencer element involved in neuron-specific expression of the synapsin I gene. Proc Natl Acad Sci U S A (1993) 1.28

Deletion at 14q22-23 indicates a contiguous gene syndrome comprising anophthalmia, pituitary hypoplasia, and ear anomalies. Am J Med Genet A (2006) 1.23

Molecular dissection reveals decreased activity and not dominant negative effect in human OTX2 mutants. J Mol Med (Berl) (2006) 1.18

Otx2 expression is restricted to dopaminergic neurons of the ventral tegmental area in the adult brain. Int J Dev Biol (2010) 1.16

OTX2 directly activates cell cycle genes and inhibits differentiation in medulloblastoma cells. Int J Cancer (2011) 1.11

Tetracycline analogues (doxycycline and COL-3) induce caspase-dependent and -independent apoptosis in human colon cancer cells. Int J Cancer (2006) 1.07

Expression of the Otx2 homeobox gene in the developing mammalian brain: embryonic and adult expression in the pineal gland. J Neurochem (2006) 1.05

Otx2 controls identity and fate of glutamatergic progenitors of the thalamus by repressing GABAergic differentiation. J Neurosci (2006) 1.01

Molecular diagnostics in embryonal brain tumors. Brain Pathol (2011) 1.00

Meis2 competes with the Groucho co-repressor Tle4 for binding to Otx2 and specifies tectal fate without induction of a secondary midbrain-hindbrain boundary organizer. Development (2009) 1.00

Effects of doxycycline on human prostate cancer cells in vitro. Cancer Lett (1998) 0.98

Regulation of cell cycle genes and induction of senescence by overexpression of OTX2 in medulloblastoma cell lines. Mol Cancer Res (2010) 0.96

Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors. Mol Cell Biol (2006) 0.91

Characterization of five new cell lines derived from human primitive neuroectodermal tumors of the central nervous system. Cancer Res (1994) 0.89

Otx1 and Otx2 in the development and evolution of the mammalian brain. EMBO J (1998) 0.89

Childhood medulloblastoma: current status of biology and treatment. CNS Drugs (2010) 0.87

Cloning and characterization of a novel MyoD enhancer-binding factor. Mech Dev (2007) 0.86

Evaluation of retinoic acid therapy for OTX2-positive medulloblastomas. Neuro Oncol (2010) 0.86

The role of otx2 in adult mesencephalic-diencephalic dopaminergic neurons. Mol Neurobiol (2010) 0.85

Aberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cells. PLoS One (2012) 0.83

The role of immunohistochemistry in medullomyoblastoma--a case series highlighting divergent differentiation. Diagn Pathol (2008) 0.81

Medulloblastoma with myogenic differentiation showing double immunopositivity for synaptophysin and myoglobin. Pathol Int (2009) 0.78

Fluorescence in situ hybridization of 12p in germ cell tumors using a bacterial artificial chromosome clone 12p probe on paraffin-embedded tissue: clinical test validation. Cancer Genet Cytogenet (2008) 0.78

Medullomyoblastoma: a histological, immunohistochemical, ultrastructural and molecular genetic study. Acta Neuropathol (1998) 0.76

Articles by these authors

Mutations of the BRAF gene in human cancer. Nature (2002) 65.42

An integrated genomic analysis of human glioblastoma multiforme. Science (2008) 51.36

IDH1 and IDH2 mutations in gliomas. N Engl J Med (2009) 32.41

High frequency of mutations of the PIK3CA gene in human cancers. Science (2004) 27.94

Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci Transl Med (2014) 8.36

The genetic landscape of the childhood cancer medulloblastoma. Science (2010) 8.34

Medulloblastoma comprises four distinct molecular variants. J Clin Oncol (2010) 8.06

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Proc Natl Acad Sci U S A (2013) 6.88

Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol (2011) 6.67

Medulloblastoma growth inhibition by hedgehog pathway blockade. Science (2002) 6.53

Altered telomeres in tumors with ATRX and DAXX mutations. Science (2011) 4.60

Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. Nat Genet (2009) 4.52

Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome. J Clin Oncol (2010) 4.48

An anatomy of normal and malignant gene expression. Proc Natl Acad Sci U S A (2002) 4.45

Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature (2012) 4.13

Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas. Oncotarget (2012) 3.88

Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. Cancer Res (2006) 3.81

PIK3CA gene mutations in pediatric and adult glioblastoma multiforme. Mol Cancer Res (2006) 3.72

Distinctive patterns of microRNA expression in primary muscular disorders. Proc Natl Acad Sci U S A (2007) 3.72

Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation. Cancer Res (2005) 3.63

Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma. Stem Cells (2007) 3.47

NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts. Stem Cells (2010) 3.42

Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. Cancer Res (2010) 3.30

Clonal selection drives genetic divergence of metastatic medulloblastoma. Nature (2012) 2.96

Notch1 and notch2 have opposite effects on embryonal brain tumor growth. Cancer Res (2004) 2.90

Notch3 gene amplification in ovarian cancer. Cancer Res (2006) 2.66

Comprehensive sampling of gene expression in human cell lines with massively parallel signature sequencing. Proc Natl Acad Sci U S A (2003) 2.64

The neurobiology of autism. Brain Pathol (2007) 2.63

Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists. Cancer Cell (2013) 2.62

Molecular markers in ductal carcinoma in situ of the breast. Mol Cancer Res (2003) 2.55

Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples. Acta Neuropathol (2011) 2.53

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. Nat Genet (2013) 2.42

Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes. Am J Pathol (2011) 2.41

Frequent gains at chromosome 7q34 involving BRAF in pilocytic astrocytoma. J Neuropathol Exp Neurol (2008) 2.40

Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas. Proc Natl Acad Sci U S A (2005) 2.38

Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis. Cell (2002) 2.37

A mouse atlas of gene expression: large-scale digital gene-expression profiles from precisely defined developing C57BL/6J mouse tissues and cells. Proc Natl Acad Sci U S A (2005) 2.35

Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities. J Neurosci (2007) 2.31

Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion. Cancer Res (2002) 2.23

The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. Genes Dev (2005) 2.14

Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct. Acta Neuropathol (2011) 2.01

Hypoxia increases the expression of stem-cell markers and promotes clonogenicity in glioblastoma neurospheres. Am J Pathol (2010) 1.86

The Smo/Smo model: hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread. Cancer Res (2008) 1.84

Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation. Mol Cell Biol (2006) 1.83

Gastric cancers overexpress S100A calcium-binding proteins. Cancer Res (2002) 1.81

The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags. Proc Natl Acad Sci U S A (2003) 1.79

A polymeric nanoparticle formulation of curcumin inhibits growth, clonogenicity and stem-like fraction in malignant brain tumors. Cancer Biol Ther (2011) 1.76

Genomic amplification of orthodenticle homologue 2 in medulloblastomas. Cancer Res (2005) 1.75

c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype. Proc Natl Acad Sci U S A (2011) 1.75

Medulloblastoma stem cells. J Clin Oncol (2008) 1.71

Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancer. Clin Cancer Res (2009) 1.66

c-myc overexpression causes anaplasia in medulloblastoma. Cancer Res (2006) 1.66

A mouse model of blast injury to brain: initial pathological, neuropathological, and behavioral characterization. J Neuropathol Exp Neurol (2011) 1.62

BRAF activation induces transformation and then senescence in human neural stem cells: a pilocytic astrocytoma model. Clin Cancer Res (2011) 1.61

BRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549:BRAF fusion variants. J Neuropathol Exp Neurol (2012) 1.60

Establishment and characterization of a primary human chordoma xenograft model. J Neurosurg (2012) 1.60

The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance. Clin Cancer Res (2010) 1.58

Cytogenetic prognostication within medulloblastoma subgroups. J Clin Oncol (2014) 1.56

A survey of glioblastoma genomic amplifications and deletions. J Neurooncol (2009) 1.52

Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors. Cancer Res (2008) 1.51

Unfolded protein response in fuchs endothelial corneal dystrophy: a unifying pathogenic pathway? Am J Ophthalmol (2010) 1.49

A preoperative diagnostic test that distinguishes benign from malignant thyroid carcinoma based on gene expression. J Clin Invest (2004) 1.48

Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma. J Clin Oncol (2013) 1.43

Three-dimensional amide proton transfer MR imaging of gliomas: Initial experience and comparison with gadolinium enhancement. J Magn Reson Imaging (2013) 1.43

Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma. Genes Dev (2008) 1.42

Long-term persistence of donor nuclei in a Duchenne muscular dystrophy patient receiving bone marrow transplantation. J Clin Invest (2002) 1.41

Glycoprotein nonmetastatic melanoma protein B, a potential molecular therapeutic target in patients with glioblastoma multiforme. Clin Cancer Res (2006) 1.41

Isochromosome 17q is a negative prognostic factor in poor-risk childhood medulloblastoma patients. Clin Cancer Res (2005) 1.40

A clinicopathologic series of primary graft failure after Descemet's stripping and automated endothelial keratoplasty. Ophthalmology (2008) 1.40

Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells. Oncotarget (2011) 1.39

Iris cross-sectional area decreases with pupil dilation and its dynamic behavior is a risk factor in angle closure. J Glaucoma (2009) 1.35

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma. Acta Neuropathol (2013) 1.35

Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma. Acta Neuropathol (2012) 1.33

Meningioma transcript profiles reveal deregulated Notch signaling pathway. Cancer Res (2005) 1.33

Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1. Proc Natl Acad Sci U S A (2013) 1.33

Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine. Oncotarget (2013) 1.31

CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity. Acta Neuropathol (2014) 1.28

5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft. Oncotarget (2013) 1.28

Activation of canonical WNT/β-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition. Cancer Lett (2012) 1.26

Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme. Neuro Oncol (2011) 1.26

Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model. Proc Natl Acad Sci U S A (2010) 1.25

Spectrum of pilomyxoid astrocytomas: intermediate pilomyxoid tumors. Am J Surg Pathol (2010) 1.23

Decreased 5-hydroxymethylcytosine is associated with neural progenitor phenotype in normal brain and shorter survival in malignant glioma. PLoS One (2012) 1.23

Embryonal tumors with abundant neuropil and true rosettes: a distinctive CNS primitive neuroectodermal tumor. Am J Surg Pathol (2009) 1.23

Hedgehog signaling promotes medulloblastoma survival via Bc/II. Am J Pathol (2007) 1.22

DNER, an epigenetically modulated gene, regulates glioblastoma-derived neurosphere cell differentiation and tumor propagation. Stem Cells (2009) 1.20

The impact of SNPs on the interpretation of SAGE and MPSS experimental data. Nucleic Acids Res (2004) 1.19

Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase. J Biol Chem (2007) 1.19

Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells. Mol Cancer Ther (2009) 1.18

Generation and analysis of melanoma SAGE libraries: SAGE advice on the melanoma transcriptome. Oncogene (2004) 1.18

Exomic sequencing of four rare central nervous system tumor types. Oncotarget (2013) 1.17

Comparison of medulloblastoma and normal neural transcriptomes identifies a restricted set of activated genes. Oncogene (2003) 1.14

Epithelial downgrowth following Descemet's-stripping automated endothelial keratoplasty. Arch Ophthalmol (2008) 1.14

BRAF duplications and MAPK pathway activation are frequent in gliomas of the optic nerve proper. J Neuropathol Exp Neurol (2012) 1.14