Published in Proc Natl Acad Sci U S A on January 17, 2012
Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients. J Clin Invest (2014) 1.60
A mutation in a ganglioside biosynthetic enzyme, ST3GAL5, results in salt & pepper syndrome, a neurocutaneous disorder with altered glycolipid and glycoprotein glycosylation. Hum Mol Genet (2013) 0.93
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Ganglioside biochemistry. ISRN Biochem (2012) 0.89
Systemic blockade of sialylation in mice with a global inhibitor of sialyltransferases. J Biol Chem (2014) 0.86
Reducing FLI1 levels in the MRL/lpr lupus mouse model impacts T cell function by modulating glycosphingolipid metabolism. PLoS One (2013) 0.86
Lck, Membrane Microdomains, and TCR Triggering Machinery: Defining the New Rules of Engagement. Front Immunol (2012) 0.85
Role of glycosphingolipids in dendritic cell-mediated HIV-1 trans-infection. Adv Exp Med Biol (2013) 0.84
Lower Affinity T Cells are Critical Components and Active Participants of the Immune Response. Front Immunol (2015) 0.80
Relative roles of GM1 ganglioside, N-acylneuraminic acids, and α2β1 integrin in mediating rotavirus infection. J Virol (2014) 0.79
Imbalance in fatty-acid-chain length of gangliosides triggers Alzheimer amyloid deposition in the precuneus. PLoS One (2015) 0.77
CD8+ T Cells Mediate Female-Dominant IL-4 Production and Airway Inflammation in Allergic Asthma. PLoS One (2015) 0.76
TALEN mediated targeted editing of GM2/GD2-synthase gene modulates anchorage independent growth by reducing anoikis resistance in mouse tumor cells. Sci Rep (2015) 0.76
FLI1 Levels Impact CXCR3 Expression and Renal Infiltration of T Cells and Renal Glycosphingolipid Metabolism in the MRL/lpr Lupus Mouse Strain. J Immunol (2015) 0.75
Quantitative Proteomic Analysis of Escherichia coli Heat-Labile Toxin B Subunit (LTB) with Enterovirus 71 (EV71) Subunit VP1. Int J Mol Sci (2016) 0.75
Expression machinery of GM4: the excess amounts of GM3/GM4S synthase (ST3GAL5) are necessary for GM4 synthesis in mammalian cells. Glycoconj J (2013) 0.75
Functional rafts in cell membranes. Nature (1997) 38.89
The B7 family revisited. Annu Rev Immunol (2005) 13.51
Functional anatomy of T cell activation and synapse formation. Annu Rev Immunol (2010) 3.01
Location is everything: lipid rafts and immune cell signaling. Annu Rev Immunol (2001) 2.86
Mammalian glycosylation in immunity. Nat Rev Immunol (2008) 2.74
Functions of T cells in asthma: more than just T(H)2 cells. Nat Rev Immunol (2010) 2.62
Segregation of leading-edge and uropod components into specific lipid rafts during T cell polarization. Proc Natl Acad Sci U S A (2001) 2.55
Asialo GM1(+) CD8(+) T cells play a critical role in costimulation blockade-resistant allograft rejection. J Clin Invest (1999) 2.26
Antigen-induced translocation of PKC-theta to membrane rafts is required for T cell activation. Nat Immunol (2001) 2.18
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Structure and function of glycosphingolipids and sphingolipids: recollections and future trends. Biochim Biophys Acta (2007) 1.62
Altered lipid raft-associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus. J Clin Invest (2004) 1.52
The cell biology of glycosphingolipids. Semin Cell Dev Biol (2004) 1.50
Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions. Proc Natl Acad Sci U S A (2005) 1.43
CD4 receptor localized to non-raft membrane microdomains supports HIV-1 entry. Identification of a novel raft localization marker in CD4. J Biol Chem (2003) 1.39
Activation of murine CD4+ and CD8+ T lymphocytes leads to dramatic remodeling of N-linked glycans. J Immunol (2006) 1.34
Preparation of the active isomer of 1-phenyl-2-decanoylamino-3-morpholino-1-propanol, inhibitor of murine glucocerebroside synthetase. J Lipid Res (1987) 1.33
Organization of plasma membrane functional rafts upon T cell activation. Eur J Immunol (2001) 1.27
Emerging paradigms of T-cell co-stimulation. Curr Opin Immunol (2004) 1.22
Increasing functional avidity of TCR-redirected T cells by removing defined N-glycosylation sites in the TCR constant domain. J Exp Med (2009) 1.21
Evidence for the existence of ganglioside-enriched plasma membrane domains in human peripheral lymphocytes. J Lipid Res (1997) 1.16
Plasma membrane segregation during T cell activation: probing the order of domains. Curr Opin Immunol (2007) 1.04
Formation of a central supramolecular activation cluster is not required for activation of naive CD8+ T cells. Proc Natl Acad Sci U S A (2004) 1.03
Cross-linking of cell surface ganglioside GM1 induces the selective apoptosis of mature CD8+ T lymphocytes. Int Immunol (1996) 1.03
Lipid rafts and T-lymphocyte function: implications for autoimmunity. FEBS Lett (2008) 1.02
Mice lacking ganglioside GM3 synthase exhibit complete hearing loss due to selective degeneration of the organ of Corti. Proc Natl Acad Sci U S A (2009) 0.98
Quantitative differences in lipid raft components between murine CD4+ and CD8+ T cells. BMC Immunol (2004) 0.98
Overview of asthma; the place of the T cell. Curr Opin Pharmacol (2010) 0.97
Highly sensitive localization analysis of gangliosides and sulfatides including structural isomers in mouse cerebellum sections by combination of laser microdissection and hydrophilic interaction liquid chromatography/electrospray ionization mass spectrometry with theoretically expanded multiple reaction monitoring. Rapid Commun Mass Spectrom (2010) 0.94
CD4 raft association and signaling regulate molecular clustering at the immunological synapse site. J Immunol (2004) 0.94
Sex-related splenocyte function in a murine model of allergic asthma. Clin Exp Allergy (2008) 0.92
Human CD8+ T cells do not require the polarization of lipid rafts for activation and proliferation. Proc Natl Acad Sci U S A (2002) 0.92
Association of GM3 with Zap-70 induced by T cell activation in plasma membrane microdomains: GM3 as a marker of microdomains in human lymphocytes. J Biol Chem (2002) 0.92
Reduction of glycosphingolipid levels in lipid rafts affects the expression state and function of glycosylphosphatidylinositol-anchored proteins but does not impair signal transduction via the T cell receptor. J Biol Chem (2003) 0.90
Lowering glycosphingolipid levels in CD4+ T cells attenuates T cell receptor signaling, cytokine production, and differentiation to the Th17 lineage. J Biol Chem (2011) 0.90
Structure and function of lipid rafts in human activated T cells. Int Immunol (2005) 0.89
Anti-HER-2/neu immune responses are induced before the development of clinical tumors but declined following tumorigenesis in HER-2/neu transgenic mice. Cancer Res (2004) 0.88
CD8+ T cell apoptosis induced by Escherichia coli heat-labile enterotoxin B subunit occurs via a novel pathway involving NF-kappaB-dependent caspase activation. Eur J Immunol (2002) 0.87
Reducing glycosphingolipid biosynthesis in airway cells partially ameliorates disease manifestations in a mouse model of asthma. Int Immunol (2010) 0.83
CD8 Raft localization is induced by its assembly into CD8alpha beta heterodimers, Not CD8alpha alpha homodimers. J Biol Chem (2007) 0.83
Inhibition of sphingolipid synthesis impairs cellular activation, cytokine production and proliferation in human lymphocytes. Biochem Pharmacol (2005) 0.82
Differential antibody binding to the surface alphabetaTCR.CD3 complex of CD4+ and CD8+ T lymphocytes is conserved in mammals and associated with differential glycosylation. Int Immunol (2008) 0.81
p56lck, LFA-1 and PI3K but not SHP-2 interact with GM1- or GM3-enriched microdomains in a CD4-p56lck association-dependent manner. Biochem J (2007) 0.81
Increased expression of ganglioside GM1 in peripheral CD4+ T cells correlates soluble form of CD30 in Systemic Lupus Erythematosus patients. J Biomed Biotechnol (2010) 0.80
IV3 alpha (NeuGc alpha 2-8NeuGc)-Gg4Cer is restricted to CD4+ T cells producing interleukin-2 and a small population of mature thymocytes in mice. J Biol Chem (1995) 0.79
A new ganglioside showing choleragenoid-binding activity in mouse spleen. J Biochem (1987) 0.79
Expression of glycosphingolipids in lymph nodes of mice lacking TNF receptor 1: biochemical and flow cytometry analysis. Carbohydr Res (2004) 0.77
Lysosomal glycosphingolipid recognition by NKT cells. Science (2004) 7.31
Essential role for sphingosine kinases in neural and vascular development. Mol Cell Biol (2005) 3.59
Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice. J Clin Invest (2003) 2.79
Comparison of the methods for profiling glycoprotein glycans--HUPO Human Disease Glycomics/Proteome Initiative multi-institutional study. Glycobiology (2007) 2.71
The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis. J Biol Chem (2004) 2.62
G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation. Blood (2003) 2.27
ADAMTS13 gene deletion aggravates ischemic brain damage: a possible neuroprotective role of ADAMTS13 by ameliorating postischemic hypoperfusion. Blood (2009) 1.89
N-glycolylneuraminic acid deficiency in mice: implications for human biology and evolution. Mol Cell Biol (2007) 1.87
Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance. Proc Natl Acad Sci U S A (2007) 1.79
Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau. Proc Natl Acad Sci U S A (2002) 1.66
Germinal center marker GL7 probes activation-dependent repression of N-glycolylneuraminic acid, a sialic acid species involved in the negative modulation of B-cell activation. Mol Cell Biol (2007) 1.63
Hypoxia induces adhesion molecules on cancer cells: A missing link between Warburg effect and induction of selectin-ligand carbohydrates. Proc Natl Acad Sci U S A (2004) 1.50
Systemic inflammation in glucocerebrosidase-deficient mice with minimal glucosylceramide storage. J Clin Invest (2002) 1.45
The involvement of glucocorticoids in psychological stress-induced exacerbations of experimental allergic asthma. Int Arch Allergy Immunol (2014) 1.43
Screening for proteinuria in cats using a conventional dipstick test after removal of cauxin from urine with a Lens culinaris agglutinin lectin tip. Vet J (2010) 1.43
Evaluation of dengue NS1 antigen detection for diagnosis in public health laboratories, São Paulo State, 2009. Rev Inst Med Trop Sao Paulo (2011) 1.40
Hypoxic culture induces expression of sialin, a sialic acid transporter, and cancer-associated gangliosides containing non-human sialic acid on human cancer cells. Cancer Res (2006) 1.34
Inhibition of reactive astrocytes with fluorocitrate retards neurovascular remodeling and recovery after focal cerebral ischemia in mice. J Cereb Blood Flow Metab (2009) 1.27
Dengue virus type 4 phylogenetics in Brazil 2011: looking beyond the veil. PLoS Negl Trop Dis (2011) 1.26
Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo. Biochim Biophys Acta (2006) 1.26
Delayed treatment with minocycline ameliorates neurologic impairment through activated microglia expressing a high-mobility group box1-inhibiting mechanism. Stroke (2008) 1.25
Dynamic modification of sphingomyelin in lipid microdomains controls development of obesity, fatty liver, and type 2 diabetes. J Biol Chem (2011) 1.22
Impaired social interaction and reduced anxiety-related behavior in vasopressin V1a receptor knockout mice. Behav Brain Res (2006) 1.22
DES2 protein is responsible for phytoceramide biosynthesis in the mouse small intestine. Biochem J (2004) 1.19
Mayaro virus: imported cases of human infection in São Paulo State, Brazil. Rev Inst Med Trop Sao Paulo (2007) 1.18
Hantavirus pulmonary syndrome, central plateau, southeastern, and southern Brazil. Emerg Infect Dis (2009) 1.17
Novel class of glycosphingolipids involved in male fertility. J Biol Chem (2005) 1.16
Neuroprotective effects of quercetin and rutin on spatial memory impairment in an 8-arm radial maze task and neuronal death induced by repeated cerebral ischemia in rats. J Pharmacol Sci (2007) 1.14
Mental and physical fatigue-related biochemical alterations. Nutrition (2008) 1.14
Cannabidiol potentiates pharmacological effects of Delta(9)-tetrahydrocannabinol via CB(1) receptor-dependent mechanism. Brain Res (2007) 1.14
Allogeneic injection of fetal membrane-derived mesenchymal stem cells induces therapeutic angiogenesis in a rat model of hind limb ischemia. Stem Cells (2008) 1.14
Evaluation of an enzyme-linked immunosorbent assay based on Araraquara virus recombinant nucleocapsid protein. Am J Trop Med Hyg (2009) 1.13
St. Louis encephalitis virus: first isolation from a human in São Paulo State, Brazil. Rev Inst Med Trop Sao Paulo (2005) 1.13
Allergic airway hyperresponsiveness, inflammation, and remodeling do not develop in phosphoinositide 3-kinase gamma-deficient mice. J Allergy Clin Immunol (2009) 1.11
Magnetic resonance imaging shows delayed ischemic striatal neurodegeneration. Ann Neurol (2003) 1.11
Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism. Stroke (2005) 1.09
Detection of a new yellow fever virus lineage within the South American genotype I in Brazil. J Med Virol (2010) 1.08
Human epidermal glucosylceramides are major precursors of stratum corneum ceramides. J Invest Dermatol (2002) 1.07
Are N-glycolylneuraminic acid (Hanganutziu-Deicher) antigens important in pig-to-human xenotransplantation? Xenotransplantation (2004) 1.06
Distal myopathy with rimmed vacuoles: impaired O-glycan formation in muscular glycoproteins. Am J Pathol (2005) 1.05
Regulation of insect steroid hormone biosynthesis by innervating peptidergic neurons. Proc Natl Acad Sci U S A (2006) 1.04
Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism. Neuroreport (2004) 1.04
A major urinary protein of the domestic cat regulates the production of felinine, a putative pheromone precursor. Chem Biol (2006) 1.03
Delta9-tetrahydrocannabinol (Delta9-THC) prevents cerebral infarction via hypothalamic-independent hypothermia. Life Sci (2007) 0.99
Analysis of glycopeptides using lectin affinity chromatography with MALDI-TOF mass spectrometry. Anal Chem (2008) 0.99
Mice lacking ganglioside GM3 synthase exhibit complete hearing loss due to selective degeneration of the organ of Corti. Proc Natl Acad Sci U S A (2009) 0.98
Repeated administration of Yokukansan inhibits DOI-induced head-twitch response and decreases expression of 5-hydroxytryptamine (5-HT)2A receptors in the prefrontal cortex. Prog Neuropsychopharmacol Biol Psychiatry (2008) 0.98
Intracerebral microinjections of delta 9-tetrahydrocannabinol: search for the impairment of spatial memory in the eight-arm radial maze in rats. Brain Res (2002) 0.97
Threshold in stage-specific embryonic glycotypes uncovered by a full portrait of dynamic N-glycan expression during cell differentiation. Mol Cell Proteomics (2009) 0.96
Self-enhancement of hepatitis C virus replication by promotion of specific sphingolipid biosynthesis. PLoS Pathog (2012) 0.96
Lymph node macrophages, but not spleen macrophages, express high levels of unmasked sialoadhesin: implication for the adhesive properties of macrophages in vivo. Glycobiology (2002) 0.95
Ganglioside GM3 inhibits VEGF/VEGFR-2-mediated angiogenesis: direct interaction of GM3 with VEGFR-2. Glycobiology (2008) 0.95
Regulation of the transport and protein levels of the inositol phosphorylceramide mannosyltransferases Csg1 and Csh1 by the Ca2+-binding protein Csg2. J Biol Chem (2007) 0.94
Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance. Neuropharmacology (2007) 0.94
Reemergence of yellow fever: detection of transmission in the State of São Paulo, Brazil, 2008. Rev Soc Bras Med Trop (2011) 0.94
Reduced motor and sensory functions and emotional response in GM3-only mice: emergence from early stage of life and exacerbation with aging. Behav Brain Res (2008) 0.93
Inhibition of TPA-induced NF-kappaB nuclear translocation and production of NO and PGE2 by the anti-rheumatic gold compounds. J Pharm Pharmacol (2003) 0.93
ADAMTS13 gene deletion enhances plasma high-mobility group box1 elevation and neuroinflammation in brain ischemia-reperfusion injury. Neurol Sci (2012) 0.92
Selective depletion of mouse kidney proximal straight tubule cells causes acute kidney injury. Transgenic Res (2011) 0.92
V1a receptor knockout mice exhibit impairment of spatial memory in an eight-arm radial maze. Neurosci Lett (2004) 0.91
Cortical neuronal and glial pathology in TgTauP301L transgenic mice: neuronal degeneration, memory disturbance, and phenotypic variation. Am J Pathol (2006) 0.91
Cannabidiol prevents a post-ischemic injury progressively induced by cerebral ischemia via a high-mobility group box1-inhibiting mechanism. Neuropharmacology (2008) 0.91
Reduction of glycosphingolipid levels in lipid rafts affects the expression state and function of glycosylphosphatidylinositol-anchored proteins but does not impair signal transduction via the T cell receptor. J Biol Chem (2003) 0.90
[Yellow fever: reemerging in the state of Sao Paulo, Brazil, 2009]. Rev Saude Publica (2013) 0.90
Antipsychotics improve Delta9-tetrahydrocannabinol-induced impairment of the prepulse inhibition of the startle reflex in mice. Pharmacol Biochem Behav (2006) 0.90
Colonic epithelial cells express specific ligands for mucosal macrophage immunosuppressive receptors siglec-7 and -9. J Immunol (2012) 0.89
Altered depression-related behavior and neurochemical changes in serotonergic neurons in mutant R406W human tau transgenic mice. Brain Res (2005) 0.89
Decreased acetylcholine release is correlated to memory impairment in the Tg2576 transgenic mouse model of Alzheimer's disease. Brain Res (2008) 0.89
Combination treatment of neonatal rats with hypoxia-ischemia and endotoxin induces long-lasting memory and learning impairment that is associated with extended cerebral damage. Am J Obstet Gynecol (2004) 0.89
Inhibition of sphingomyelinase activity helps to prevent neuron death caused by ischemic stress. Neurochem Int (2004) 0.89
Structure and function of lipid rafts in human activated T cells. Int Immunol (2005) 0.89