PubRank

Stephen C Blacklow

Author PubWeight™ 130.54‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004 18.84
2 c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev 2006 6.19
3 Direct inhibition of the NOTCH transcription factor complex. Nature 2009 4.82
4 Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Mol Cell Biol 2003 4.43
5 Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell 2006 4.28
6 Notch signaling in leukemia. Annu Rev Pathol 2008 3.21
7 Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. Proc Natl Acad Sci U S A 2011 3.10
8 Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes. Mol Cell Biol 2006 2.94
9 Structural basis for autoinhibition of Notch. Nat Struct Mol Biol 2007 2.89
10 Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity 2007 2.88
11 Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies. J Pathol 2010 2.58
12 Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation. Nat Struct Biol 2002 2.56
13 Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells. Proc Natl Acad Sci U S A 2011 2.16
14 Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex. J Biol Chem 2003 2.02
15 Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription. Proc Natl Acad Sci U S A 2007 1.98
16 Structure of an LDLR-RAP complex reveals a general mode for ligand recognition by lipoprotein receptors. Mol Cell 2006 1.94
17 Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1. Blood 2010 1.92
18 Cooperation between fixed and low pH-inducible interfaces controls lipoprotein release by the LDL receptor. Mol Cell 2004 1.89
19 Mechanistic insights into Notch receptor signaling from structural and biochemical studies. Curr Top Dev Biol 2010 1.87
20 Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer. Cancer Cell 2013 1.86
21 Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3. J Biol Chem 2008 1.83
22 Conformational locking upon cooperative assembly of notch transcription complexes. Structure 2012 1.79
23 Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats. Mol Cell Biol 2004 1.78
24 Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A. Genes Dev 2009 1.76
25 Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1. Mol Cell Biol 2006 1.75
26 Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL. Blood 2008 1.69
27 The molecular logic of Notch signaling--a structural and biochemical perspective. J Cell Sci 2008 1.65
28 Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation. Structure 2011 1.64
29 Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth. Proc Natl Acad Sci U S A 2011 1.59
30 Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2. PLoS One 2009 1.57
31 Targeting the Notch pathway: twists and turns on the road to rational therapeutics. J Clin Oncol 2012 1.52
32 Structure and physiologic function of the low-density lipoprotein receptor. Annu Rev Biochem 2005 1.50
33 Origins of peptide selectivity and phosphoinositide binding revealed by structures of disabled-1 PTB domain complexes. Structure 2003 1.48
34 T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling. Proc Natl Acad Sci U S A 2011 1.41
35 Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors. PLoS One 2010 1.41
36 Programming peptidomimetic syntheses by translating genetic codes designed de novo. Proc Natl Acad Sci U S A 2003 1.38
37 Mutational and energetic studies of Notch 1 transcription complexes. J Mol Biol 2007 1.35
38 NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers. Proc Natl Acad Sci U S A 2013 1.34
39 Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes. Nat Struct Mol Biol 2010 1.33
40 The mature avian leukosis virus subgroup A envelope glycoprotein is metastable, and refolding induced by the synergistic effects of receptor binding and low pH is coupled to infection. J Virol 2004 1.33
41 Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia. Blood 2010 1.27
42 Amino acid backbone specificity of the Escherichia coli translation machinery. J Am Chem Soc 2004 1.22
43 A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8. Science 2003 1.21
44 The LDL receptor: how acid pulls the trigger. Trends Biochem Sci 2005 1.20
45 Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1. J Biol Chem 2013 1.19
46 Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1. Biochemistry 2003 1.16
47 Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding. Blood 2010 1.16
48 A two-module region of the low-density lipoprotein receptor sufficient for formation of complexes with apolipoprotein E ligands. Biochemistry 2004 1.14
49 Notch dimerization is required for leukemogenesis and T-cell development. Genes Dev 2010 1.06
50 A grid-enabled web service for low-resolution crystal structure refinement. Acta Crystallogr D Biol Crystallogr 2012 1.06
51 De novo genetic codes and pure translation display. Methods 2005 1.04
52 Epstein-Barr virus nuclear protein 3C binds to the N-terminal (NTD) and beta trefoil domains (BTD) of RBP/CSL; only the NTD interaction is essential for lymphoblastoid cell growth. Virology 2011 0.98
53 Requirement for natively unstructured regions of mesoderm development candidate 2 in promoting low-density lipoprotein receptor-related protein 6 maturation. Biochemistry 2007 0.97
54 The SCAN domain of ZNF174 is a dimer. J Biol Chem 2001 0.94
55 Notch and MAML-1 complexation do not detectably alter the DNA binding specificity of the transcription factor CSL. PLoS One 2010 0.93
56 Notch signaling as a therapeutic target. Curr Opin Chem Biol 2002 0.93
57 Pure translation display. Anal Biochem 2004 0.91
58 Phosphoinositide binding by the disabled-1 PTB domain is necessary for membrane localization and Reelin signal transduction. J Biol Chem 2005 0.90
59 The dual-function disabled-1 PTB domain exhibits site independence in binding phosphoinositide and peptide ligands. Biochemistry 2004 0.87
60 Folding and binding integrity of variants of a prototype ligand-binding module from the LDL receptor possessing multiple alanine substitutions. Biochemistry 2005 0.87
61 Biased multicomponent reactions to develop novel bromodomain inhibitors. J Med Chem 2014 0.87
62 Unfolding of the RAP-D3 helical bundle facilitates dissociation of RAP-receptor complexes. Biochemistry 2008 0.86
63 Global defects in the expression and function of the low density lipoprotein receptor (LDLR) associated with two familial hypercholesterolemia mutations resulting in misfolding of the LDLR epidermal growth factor-AB pair. J Biol Chem 2004 0.82
64 Insights into Notch3 activation and inhibition mediated by antibodies directed against its negative regulatory region. J Mol Biol 2013 0.79
65 Catching the common cold. Nat Struct Mol Biol 2004 0.78
66 An intramolecular spin of the LDL receptor beta propeller. Structure 2003 0.77
67 A new niche for Notch on Deltex? Structure 2005 0.75
68 Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation. PLoS One 2011 0.75
69 Analyzing the nuclear complexes of Notch signaling by electrophoretic mobility shift assay. Methods Mol Biol 2014 0.75
70 Diffuse Staining for Activated NOTCH1 Correlates With NOTCH1 Mutation Status and is Associated With Worse Outcome in Adenoid Cystic Carcinoma. Am J Surg Pathol 2017 0.75