Published in Structure on February 08, 2012
Notch signaling at a glance. J Cell Sci (2013) 1.76
Notch1 mutations are drivers of oral tumorigenesis. Cancer Prev Res (Phila) (2014) 1.58
Structure and function of the CSL-KyoT2 corepressor complex: a negative regulator of Notch signaling. Structure (2013) 1.51
Mutations in NOTCH1 cause Adams-Oliver syndrome. Am J Hum Genet (2014) 1.26
Hydrogen exchange mass spectrometry: are we out of the quicksand? J Am Soc Mass Spectrom (2012) 1.23
Applications of hydrogen/deuterium exchange MS from 2012 to 2014. Anal Chem (2014) 1.16
A grid-enabled web service for low-resolution crystal structure refinement. Acta Crystallogr D Biol Crystallogr (2012) 1.06
Protein lysine acetylation by p300/CBP. Chem Rev (2015) 1.02
The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force. Dev Cell (2017) 0.98
Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases. Sci Signal (2013) 0.82
A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinase. J Mol Biol (2014) 0.80
Conformational insight into multi-protein signaling assemblies by hydrogen-deuterium exchange mass spectrometry. Curr Opin Struct Biol (2016) 0.78
Structure and Function of the Su(H)-Hairless Repressor Complex, the Major Antagonist of Notch Signaling in Drosophila melanogaster. PLoS Biol (2016) 0.78
UXT potentiates angiogenesis by attenuating Notch signaling. Development (2015) 0.77
Setting the Stage for Notch: The Drosophila Su(H)-Hairless Repressor Complex. PLoS Biol (2016) 0.76
Structure-based predictions broadly link transcription factor mutations to gene expression changes in cancers. Nucleic Acids Res (2014) 0.76
Structure-function analysis of RBP-J-interacting and tubulin-associated (RITA) reveals regions critical for repression of Notch target genes. J Biol Chem (2017) 0.75
In notch, one ANK repeat is not like the other. Structure (2012) 0.75
The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res (2016) 0.75
NOTCH 1 Mutation in a Patient with Spontaneous and Recurrent Dissections of Extracranial Arteries. Front Neurol (2017) 0.75
Phaser crystallographic software. J Appl Crystallogr (2007) 108.34
Notch signaling: cell fate control and signal integration in development. Science (1999) 28.83
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science (2004) 18.84
The mutational landscape of head and neck squamous cell carcinoma. Science (2011) 16.88
The canonical Notch signaling pathway: unfolding the activation mechanism. Cell (2009) 14.72
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature (2011) 13.18
Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol (2006) 13.12
Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science (2011) 11.12
Super-resolution biomolecular crystallography with low-resolution data. Nature (2010) 6.14
Determination of amide hydrogen exchange by mass spectrometry: a new tool for protein structure elucidation. Protein Sci (1993) 5.85
A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia. Nature (2011) 5.78
A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1. Mol Cell (2000) 5.56
A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. Mol Cell (2000) 5.53
Hydrogen exchange mass spectrometry for the analysis of protein dynamics. Mass Spectrom Rev (2005) 5.23
Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Mol Cell Biol (2003) 4.43
Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell (2006) 4.28
Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. Mol Cell (2004) 3.85
Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA. Cell (2006) 3.42
Protein folding studied using hydrogen-exchange labeling and two-dimensional NMR. Annu Rev Biophys Biomol Struct (1992) 3.34
Combining efficient conformational sampling with a deformable elastic network model facilitates structure refinement at low resolution. Structure (2007) 3.16
Semi-automated data processing of hydrogen exchange mass spectra using HX-Express. J Am Soc Mass Spectrom (2006) 2.92
Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex. Genes Dev (2002) 2.64
p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro. Mol Cell Biol (2002) 2.29
High-speed and high-resolution UPLC separation at zero degrees Celsius. Anal Chem (2008) 2.27
Conformational changes in proteins probed by hydrogen-exchange electrospray-ionization mass spectrometry. Rapid Commun Mass Spectrom (1991) 2.22
An experimentally determined protein folding energy landscape. Proc Natl Acad Sci U S A (2004) 2.06
Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex. J Biol Chem (2003) 2.02
Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription. Proc Natl Acad Sci U S A (2007) 1.98
The utility of hydrogen/deuterium exchange mass spectrometry in biopharmaceutical comparability studies. J Pharm Sci (2010) 1.90
Mechanistic insights into Notch receptor signaling from structural and biochemical studies. Curr Top Dev Biol (2010) 1.87
Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA. EMBO J (2004) 1.78
Exchange of hydrogen atoms in insulin with deuterium atoms in aqueous solutions. Biochim Biophys Acta (1954) 1.49
RAM-induced allostery facilitates assembly of a notch pathway active transcription complex. J Biol Chem (2008) 1.45
Quantitative dissection of the Notch:CSL interaction: insights into the Notch-mediated transcriptional switch. J Mol Biol (2006) 1.36
Mass spectrometric measurement of protein amide hydrogen exchange rates of apo- and holo-myoglobin. Protein Sci (1994) 1.35
Mutational and energetic studies of Notch 1 transcription complexes. J Mol Biol (2007) 1.35
Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes. Nat Struct Mol Biol (2010) 1.33
The notch ankyrin domain folds via a discrete, centralized pathway. Structure (2006) 1.26
The effects of conformational heterogeneity on the binding of the Notch intracellular domain to effector proteins: a case of biologically tuned disorder. Biochem Soc Trans (2008) 1.25
The Notch transcription activation complex makes its move. Cell (2006) 1.12
The crystal structure of a partial mouse Notch-1 ankyrin domain: repeats 4 through 7 preserve an ankyrin fold. Protein Sci (2005) 1.04
Thermodynamic analysis of the CSL x Notch interaction: distribution of binding energy of the Notch RAM region to the CSL beta-trefoil domain and the mode of competition with the viral transactivator EBNA2. J Biol Chem (2009) 1.00
Transcriptional repression in the Notch pathway: thermodynamic characterization of CSL-MINT (Msx2-interacting nuclear target protein) complexes. J Biol Chem (2011) 0.98
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science (2004) 18.84
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature (2009) 7.05
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev (2006) 6.19
Lipid-protein interactions in double-layered two-dimensional AQP0 crystals. Nature (2005) 5.44
Hydrogen exchange mass spectrometry for the analysis of protein dynamics. Mass Spectrom Rev (2005) 5.23
Direct inhibition of the NOTCH transcription factor complex. Nature (2009) 4.82
Molecular model for a complete clathrin lattice from electron cryomicroscopy. Nature (2004) 4.48
Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Mol Cell Biol (2003) 4.43
Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28. J Biol Chem (2008) 4.40
Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell (2006) 4.28
Structure and function of an essential component of the outer membrane protein assembly machine. Science (2007) 3.85
Structure of a complex of the ATPase SecA and the protein-translocation channel. Nature (2008) 3.73
Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature (2010) 3.39
Notch signaling in leukemia. Annu Rev Pathol (2008) 3.21
Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. Proc Natl Acad Sci U S A (2011) 3.10
Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes. Mol Cell Biol (2006) 2.94
Aquaporin-0 membrane junctions reveal the structure of a closed water pore. Nature (2004) 2.94
Semi-automated data processing of hydrogen exchange mass spectra using HX-Express. J Am Soc Mass Spectrom (2006) 2.92
Structural basis for autoinhibition of Notch. Nat Struct Mol Biol (2007) 2.89
Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity (2007) 2.88
Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies. J Pathol (2010) 2.58
Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation. Nat Struct Biol (2002) 2.56
Collaboration gets the most out of software. Elife (2013) 2.42
Molecular basis for interaction of let-7 microRNAs with Lin28. Cell (2011) 2.28
High-speed and high-resolution UPLC separation at zero degrees Celsius. Anal Chem (2008) 2.27
Identification and characterization of EX1 kinetics in H/D exchange mass spectrometry by peak width analysis. J Am Soc Mass Spectrom (2006) 2.25
Structure of human O-GlcNAc transferase and its complex with a peptide substrate. Nature (2011) 2.24
Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells. Proc Natl Acad Sci U S A (2011) 2.16
Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex. J Biol Chem (2003) 2.02
Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription. Proc Natl Acad Sci U S A (2007) 1.98
Structure of an LDLR-RAP complex reveals a general mode for ligand recognition by lipoprotein receptors. Mol Cell (2006) 1.94
Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1. Blood (2010) 1.92
The utility of hydrogen/deuterium exchange mass spectrometry in biopharmaceutical comparability studies. J Pharm Sci (2010) 1.90
Cooperation between fixed and low pH-inducible interfaces controls lipoprotein release by the LDL receptor. Mol Cell (2004) 1.89
Mechanistic insights into Notch receptor signaling from structural and biochemical studies. Curr Top Dev Biol (2010) 1.87
Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer. Cancer Cell (2013) 1.86
Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3. J Biol Chem (2008) 1.83
Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars. Nat Rev Drug Discov (2012) 1.80
Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats. Mol Cell Biol (2004) 1.78
Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A. Genes Dev (2009) 1.76
A role for the two-helix finger of the SecA ATPase in protein translocation. Nature (2008) 1.75
Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1. Mol Cell Biol (2006) 1.75
Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL. Blood (2008) 1.69
Crystal structure of a peptidoglycan glycosyltransferase suggests a model for processive glycan chain synthesis. Proc Natl Acad Sci U S A (2007) 1.68
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nat Commun (2012) 1.67
Protein structure determination by exhaustive search of Protein Data Bank derived databases. Proc Natl Acad Sci U S A (2010) 1.66
The molecular logic of Notch signaling--a structural and biochemical perspective. J Cell Sci (2008) 1.65
Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation. Structure (2011) 1.64
Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth. Proc Natl Acad Sci U S A (2011) 1.59
Post-translational modifications differentially affect IgG1 conformation and receptor binding. Mol Cell Proteomics (2010) 1.59
Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2. PLoS One (2009) 1.57
Targeting the Notch pathway: twists and turns on the road to rational therapeutics. J Clin Oncol (2012) 1.52
A quick guide to software licensing for the scientist-programmer. PLoS Comput Biol (2012) 1.51
Structure and physiologic function of the low-density lipoprotein receptor. Annu Rev Biochem (2005) 1.50
Origins of peptide selectivity and phosphoinositide binding revealed by structures of disabled-1 PTB domain complexes. Structure (2003) 1.48
Conformational disturbance in Abl kinase upon mutation and deregulation. Proc Natl Acad Sci U S A (2009) 1.47
Hydrogen exchange mass spectrometry: what is it and what can it tell us? Anal Bioanal Chem (2010) 1.46
T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling. Proc Natl Acad Sci U S A (2011) 1.41
Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors. PLoS One (2010) 1.41
Programming peptidomimetic syntheses by translating genetic codes designed de novo. Proc Natl Acad Sci U S A (2003) 1.38
Conformational analysis of membrane proteins in phospholipid bilayer nanodiscs by hydrogen exchange mass spectrometry. Anal Chem (2010) 1.36
Mutational and energetic studies of Notch 1 transcription complexes. J Mol Biol (2007) 1.35
NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers. Proc Natl Acad Sci U S A (2013) 1.34
Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor. Angew Chem Int Ed Engl (2013) 1.34
Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem (2008) 1.34
Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes. Nat Struct Mol Biol (2010) 1.33
Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance. Proc Natl Acad Sci U S A (2006) 1.30
Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization. Nat Struct Mol Biol (2011) 1.29
Src family kinases phosphorylate the Bcr-Abl SH3-SH2 region and modulate Bcr-Abl transforming activity. J Biol Chem (2006) 1.27
Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia. Blood (2010) 1.27
Hydrogen exchange mass spectrometry: are we out of the quicksand? J Am Soc Mass Spectrom (2012) 1.23
Amino acid backbone specificity of the Escherichia coli translation machinery. J Am Chem Soc (2004) 1.22
Characterization of IgG1 conformation and conformational dynamics by hydrogen/deuterium exchange mass spectrometry. Anal Chem (2009) 1.22
Ultra performance liquid chromatography (UPLC) further improves hydrogen/deuterium exchange mass spectrometry. J Am Soc Mass Spectrom (2006) 1.21
A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8. Science (2003) 1.21
The LDL receptor: how acid pulls the trigger. Trends Biochem Sci (2005) 1.20
Structural analysis of the contacts anchoring moenomycin to peptidoglycan glycosyltransferases and implications for antibiotic design. ACS Chem Biol (2008) 1.19
Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1. J Biol Chem (2013) 1.19
Extensive deuterium back-exchange in certain immobilized pepsin columns used for H/D exchange mass spectrometry. Anal Chem (2006) 1.18
Partial unfolding of diverse SH3 domains on a wide timescale. J Mol Biol (2006) 1.17
An examination of dynamics crosstalk between SH2 and SH3 domains by hydrogen/deuterium exchange and mass spectrometry. Protein Sci (2005) 1.17
Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1. Biochemistry (2003) 1.16
Applications of hydrogen/deuterium exchange MS from 2012 to 2014. Anal Chem (2014) 1.16
Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding. Blood (2010) 1.16
Activation of the Src family kinase Hck without SH3-linker release. J Biol Chem (2005) 1.14
A two-module region of the low-density lipoprotein receptor sufficient for formation of complexes with apolipoprotein E ligands. Biochemistry (2004) 1.14
Investigating solution-phase protein structure and dynamics by hydrogen exchange mass spectrometry. Curr Protoc Protein Sci (2009) 1.13
Allosteric loss-of-function mutations in HIV-1 Nef from a long-term non-progressor. J Mol Biol (2007) 1.12
Allosteric interactions between the myristate- and ATP-site of the Abl kinase. PLoS One (2011) 1.12
Optimizing peer review of software code. Science (2013) 1.09