Engineering mammalian mucin-type O-glycosylation in plants.

PubWeight™: 0.94‹?›

🔗 View Article (PMC 3320939)

Published in J Biol Chem on February 14, 2012

Authors

Zhang Yang1, Damian P Drew, Bodil Jørgensen, Ulla Mandel, Søren S Bach, Peter Ulvskov, Steven B Levery, Eric P Bennett, Henrik Clausen, Bent L Petersen

Author Affiliations

1: Department of Genetics and Biotechnology, Faculty of Agricultural Sciences, Aarhus University, Flakkebjerg, 4200 Slagelse, Denmark.

Articles citing this

Two key polymorphisms in a newly discovered allele of the Vitis vinifera TPS24 gene are responsible for the production of the rotundone precursor α-guaiene. J Exp Bot (2015) 1.12

Functional identification of a hydroxyproline-o-galactosyltransferase specific for arabinogalactan protein biosynthesis in Arabidopsis. J Biol Chem (2013) 1.09

Expression of recombinant antibodies. Front Immunol (2013) 1.06

Engineering of sialylated mucin-type O-glycosylation in plants. J Biol Chem (2012) 0.99

Toward stable genetic engineering of human O-glycosylation in plants. Plant Physiol (2012) 0.87

Challenges in O-glycan engineering of plants. Front Plant Sci (2012) 0.87

Analytical technologies for identification and characterization of the plant N-glycoproteome. Front Plant Sci (2012) 0.86

Pan-phylum Comparison of Nematode Metabolic Potential. PLoS Negl Trop Dis (2015) 0.85

A gene responsible for prolyl-hydroxylation of moss-produced recombinant human erythropoietin. Sci Rep (2013) 0.82

Transient Glyco-Engineering to Produce Recombinant IgA1 with Defined N- and O-Glycans in Plants. Front Plant Sci (2016) 0.82

Plant-based solutions for veterinary immunotherapeutics and prophylactics. Vet Res (2014) 0.81

Engineering of human-type O-glycosylation in Nicotiana benthamiana plants. Bioengineered (2012) 0.78

Production and glyco-engineering of immunomodulatory helminth glycoproteins in plants. Sci Rep (2017) 0.77

Transient Expression of Secretory IgA In Planta is Optimal Using a Multi-Gene Vector and may be Further Enhanced by Improving Joining Chain Incorporation. Front Plant Sci (2016) 0.75

Exploring site-specific N-glycosylation of HEK293 and plant-produced human IgA isotypes. J Proteome Res (2017) 0.75

Articles cited by this

Identification of DNA sequences required for activity of the cauliflower mosaic virus 35S promoter. Nature (1985) 12.80

Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector. Nat Biotechnol (2004) 10.60

Retracted An enhanced transient expression system in plants based on suppression of gene silencing by the p19 protein of tomato bushy stunt virus. Plant J (2003) 9.35

Analysis of the aphthovirus 2A/2B polyprotein 'cleavage' mechanism indicates not a proteolytic reaction, but a novel translational effect: a putative ribosomal 'skip'. J Gen Virol (2001) 4.25

USER fusion: a rapid and efficient method for simultaneous fusion and cloning of multiple PCR products. Nucleic Acids Res (2007) 3.43

Advancing uracil-excision based cloning towards an ideal technique for cloning PCR fragments. Nucleic Acids Res (2006) 3.16

T and Tn, general carcinoma autoantigens. Science (1984) 3.10

The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line. Nat Biotechnol (2011) 2.87

Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family. Glycobiology (2011) 2.56

Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure. Plant Biotechnol J (2008) 2.49

Comprehensive analysis of glycosyltransferases in eukaryotic genomes for structural and functional characterization of glycans. Carbohydr Res (2009) 2.40

O-glycosylated cell wall proteins are essential in root hair growth. Science (2011) 2.34

Transporters of nucleotide sugars, ATP, and nucleotide sulfate in the endoplasmic reticulum and Golgi apparatus. Annu Rev Biochem (1998) 2.21

Cancer biomarkers defined by autoantibody signatures to aberrant O-glycopeptide epitopes. Cancer Res (2010) 1.79

Mucin-type O-glycosylation and its potential use in drug and vaccine development. Biochim Biophys Acta (2007) 1.70

Sialylated endogenous glycoconjugates in plant cells. Nat Biotechnol (2003) 1.64

Cloning and analysis of the Saccharomyces cerevisiae MNN9 and MNN1 genes required for complex glycosylation of secreted proteins. Proc Natl Acad Sci U S A (1994) 1.63

Purification and cDNA cloning of a human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase. J Biol Chem (1995) 1.60

Gene stacking in transgenic plants--the challenge for 21st century plant biotechnology. Plant Biotechnol J (2005) 1.55

Advances in the production of human therapeutic proteins in yeasts and filamentous fungi. Nat Biotechnol (2004) 1.54

Targeting of proteins derived from self-processing polyproteins containing multiple signal sequences. Traffic (2004) 1.54

In planta protein sialylation through overexpression of the respective mammalian pathway. J Biol Chem (2010) 1.52

Enhancement of therapeutic protein in vivo activities through glycoengineering. Nat Biotechnol (2003) 1.51

Role of the extensin superfamily in primary cell wall architecture. Plant Physiol (2011) 1.50

Chemoenzymatically synthesized multimeric Tn/STn MUC1 glycopeptides elicit cancer-specific anti-MUC1 antibody responses and override tolerance. Glycobiology (2005) 1.50

Extremely high-level and rapid transient protein production in plants without the use of viral replication. Plant Physiol (2008) 1.48

O-mannosyl glycans: from yeast to novel associations with human disease. Curr Opin Struct Biol (2003) 1.47

Membrane-anchored prolyl hydroxylase with an export signal from the endoplasmic reticulum. Plant J (2005) 1.47

O-glycosylation modulates proprotein convertase activation of angiopoietin-like protein 3: possible role of polypeptide GalNAc-transferase-2 in regulation of concentrations of plasma lipids. J Biol Chem (2010) 1.46

Pilot study of a heptavalent vaccine-keyhole limpet hemocyanin conjugate plus QS21 in patients with epithelial ovarian, fallopian tube, or peritoneal cancer. Clin Cancer Res (2007) 1.39

Identification of a novel cancer-specific immunodominant glycopeptide epitope in the MUC1 tandem repeat. Glycobiology (2006) 1.35

Cloning of a human UDP-N-acetyl-alpha-D-Galactosamine:polypeptide N-acetylgalactosaminyltransferase that complements other GalNAc-transferases in complete O-glycosylation of the MUC1 tandem repeat. J Biol Chem (1998) 1.34

Expression, purification, and biochemical characterization of WbpP, a new UDP-GlcNAc C4 epimerase from Pseudomonas aeruginosa serotype O6. J Biol Chem (2000) 1.32

Production of pharmaceutical-grade recombinant aprotinin and a monoclonal antibody product using plant-based transient expression systems. Plant Biotechnol J (2010) 1.30

Nucleotide sugar transporters of the Golgi apparatus. Curr Opin Struct Biol (2000) 1.28

Characterization of a second Arabidopsis thaliana prolyl 4-hydroxylase with distinct substrate specificity. J Biol Chem (2004) 1.26

Posttranslational modification of therapeutic proteins in plants. Curr Opin Plant Biol (2004) 1.24

Molecular characterization of two Arabidopsis thaliana glycosyltransferase mutants, rra1 and rra2, which have a reduced residual arabinose content in a polymer tightly associated with the cellulosic wall residue. Plant Mol Biol (2007) 1.24

Cloning and characterization of a low molecular weight prolyl 4-hydroxylase from Arabidopsis thaliana. Effective hydroxylation of proline-rich, collagen-like, and hypoxia-inducible transcription factor alpha-like peptides. J Biol Chem (2002) 1.22

Autoantibodies to aberrantly glycosylated MUC1 in early stage breast cancer are associated with a better prognosis. Breast Cancer Res (2011) 1.20

GlycoPEGylation of recombinant therapeutic proteins produced in Escherichia coli. Glycobiology (2006) 1.17

Quantifying the labeling and the levels of plant cell wall precursors using ion chromatography tandem mass spectrometry. Plant Physiol (2010) 1.08

Coordinate expression and independent subcellular targeting of multiple proteins from a single transgene. Plant Physiol (2004) 1.06

Sialic acid concentrations in plants are in the range of inadvertent contamination. Planta (2006) 1.06

Chlamydomonas reinhardtii has multiple prolyl 4-hydroxylases, one of which is essential for proper cell wall assembly. Plant Cell (2007) 1.04

Human and Drosophila UDP-galactose transporters transport UDP-N-acetylgalactosamine in addition to UDP-galactose. Eur J Biochem (2002) 1.04

Production of complex multiantennary N-glycans in Nicotiana benthamiana plants. Plant Physiol (2011) 1.01

Sub-compartmental organization of Golgi-resident N-glycan processing enzymes in plants. Mol Plant (2011) 1.00

Lectin domains of polypeptide GalNAc transferases exhibit glycopeptide binding specificity. J Biol Chem (2011) 0.98

Nucleotide-sugar transporters: structure, function and roles in vivo. Braz J Med Biol Res (2006) 0.97

Engineering of mucin-type human glycoproteins in yeast cells. Proc Natl Acad Sci U S A (2008) 0.95

Recombinant plant-expressed tumour-associated MUC1 peptide is immunogenic and capable of breaking tolerance in MUC1.Tg mice. Plant Biotechnol J (2011) 0.95

O-linked glycosylation in maize-expressed human IgA1. Glycobiology (2005) 0.93

Glycoprotein sialylation in plants? Nat Biotechnol (2004) 0.92

The role of nucleotide sugar transporters in development of eukaryotes. Semin Cell Dev Biol (2010) 0.91

Identification and characterization of in vitro galactosyltransferase activities involved in arabinogalactan-protein glycosylation in tobacco and Arabidopsis. Plant Physiol (2010) 0.91

Engineering of N. benthamiana L. plants for production of N-acetylgalactosamine-glycosylated proteins--towards development of a plant-based platform for production of protein therapeutics with mucin type O-glycosylation. BMC Biotechnol (2010) 0.90

Efficient antibody production upon suppression of O mannosylation in the yeast Ogataea minuta. Appl Environ Microbiol (2007) 0.89

Reduced immunogenicity of Arabidopsis hgl1 mutant N-glycans caused by altered accessibility of xylose and core fucose epitopes. J Biol Chem (2011) 0.86

Assay and heterologous expression in Pichia pastoris of plant cell wall type-II membrane anchored glycosyltransferases. Glycoconj J (2009) 0.86

Glutelin basic subunits have a mammalian mucin-type O-linked disaccharide side chain. Arch Biochem Biophys (1999) 0.85

Non-carbohydrate-mediated interaction of lectins with plant proteins. Adv Exp Med Biol (2011) 0.82

O-glycosylation of protein subpopulations in alcohol-extracted rice proteins. J Plant Physiol (2008) 0.80

Nucleotide sugars, nucleotide sulfate, and ATP transporters of the endoplasmic reticulum and Golgi apparatus. Ann N Y Acad Sci (1998) 0.79

Generation of glyco-engineered BY2 cell lines with decreased expression of plant-specific glycoepitopes. Protein Cell (2011) 0.79

Bioprospecting in plants for engineered proteins. Curr Opin Plant Biol (2005) 0.78

Articles by these authors

Lysosomal glycosphingolipid recognition by NKT cells. Science (2004) 7.31

Hemicelluloses. Annu Rev Plant Biol (2010) 5.42

The Selaginella genome identifies genetic changes associated with the evolution of vascular plants. Science (2011) 3.10

Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylation. J Biol Chem (2006) 2.68

T cell activation by lipopeptide antigens. Science (2004) 2.59

Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology. EMBO J (2013) 2.58

Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family. Glycobiology (2011) 2.56

Bacterial glycosidases for the production of universal red blood cells. Nat Biotechnol (2007) 2.41

O-glycosylated cell wall proteins are essential in root hair growth. Science (2011) 2.34

Glycosylation restores survival of chilled blood platelets. Science (2003) 2.18

Absence of intraepidermal glycosyltransferase ppGalNac-T3 expression in familial tumoral calcinosis. Am J Dermatopathol (2005) 2.09

Mining the O-glycoproteome using zinc-finger nuclease-glycoengineered SimpleCell lines. Nat Methods (2011) 1.92

Seromic profiling of colorectal cancer patients with novel glycopeptide microarray. Int J Cancer (2011) 1.84

Cancer biomarkers defined by autoantibody signatures to aberrant O-glycopeptide epitopes. Cancer Res (2010) 1.79

If homogalacturonan were a side chain of rhamnogalacturonan I. Implications for cell wall architecture. Plant Physiol (2003) 1.75

Mucin-type O-glycosylation and its potential use in drug and vaccine development. Biochim Biophys Acta (2007) 1.70

Location, location, location: new insights into O-GalNAc protein glycosylation. Trends Cell Biol (2010) 1.65

CYP79F1 and CYP79F2 have distinct functions in the biosynthesis of aliphatic glucosinolates in Arabidopsis. Plant J (2003) 1.63

The ST6GalNAc-I sialyltransferase localizes throughout the Golgi and is responsible for the synthesis of the tumor-associated sialyl-Tn O-glycan in human breast cancer. J Biol Chem (2005) 1.59

Chemoenzymatically synthesized multimeric Tn/STn MUC1 glycopeptides elicit cancer-specific anti-MUC1 antibody responses and override tolerance. Glycobiology (2005) 1.50

O-glycosylation modulates proprotein convertase activation of angiopoietin-like protein 3: possible role of polypeptide GalNAc-transferase-2 in regulation of concentrations of plasma lipids. J Biol Chem (2010) 1.46

Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in Drosophila. J Biol Chem (2002) 1.44

High-throughput screening of monoclonal antibodies against plant cell wall glycans by hierarchical clustering of their carbohydrate microarray binding profiles. Glycoconj J (2007) 1.41

A systematic study of site-specific GalNAc-type O-glycosylation modulating proprotein convertase processing. J Biol Chem (2011) 1.40

Pilot study of a heptavalent vaccine-keyhole limpet hemocyanin conjugate plus QS21 in patients with epithelial ovarian, fallopian tube, or peritoneal cancer. Clin Cancer Res (2007) 1.39

Site-specific protein O-glycosylation modulates proprotein processing - deciphering specific functions of the large polypeptide GalNAc-transferase gene family. Biochim Biophys Acta (2012) 1.36

Identification of a novel cancer-specific immunodominant glycopeptide epitope in the MUC1 tandem repeat. Glycobiology (2006) 1.35

Cyanogenic glucosides and plant-insect interactions. Phytochemistry (2004) 1.34

Hypomorphic mutations in PGAP2, encoding a GPI-anchor-remodeling protein, cause autosomal-recessive intellectual disability. Am J Hum Genet (2013) 1.34

Phosphorylation of MUC1 by Met modulates interaction with p53 and MMP1 expression. J Biol Chem (2008) 1.31

CD1d-restricted T cell activation by nonlipidic small molecules. Proc Natl Acad Sci U S A (2004) 1.30

Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes. Blood (2009) 1.28

Aberrant expression of mucin core proteins and o-linked glycans associated with progression of pancreatic cancer. Clin Cancer Res (2013) 1.28

UDP-glucose dehydrogenase plays multiple roles in the biology of the pathogenic fungus Cryptococcus neoformans. J Biol Chem (2004) 1.28

Mining the O-mannose glycoproteome reveals cadherins as major O-mannosylated glycoproteins. Proc Natl Acad Sci U S A (2013) 1.27

Tumor-associated Tn-MUC1 glycoform is internalized through the macrophage galactose-type C-type lectin and delivered to the HLA class I and II compartments in dendritic cells. Cancer Res (2007) 1.26

Initiation of GalNAc-type O-glycosylation in the endoplasmic reticulum promotes cancer cell invasiveness. Proc Natl Acad Sci U S A (2013) 1.26

Arabidopsis thaliana RGXT1 and RGXT2 encode Golgi-localized (1,3)-alpha-D-xylosyltransferases involved in the synthesis of pectic rhamnogalacturonan-II. Plant Cell (2006) 1.25

Molecular characterization of two Arabidopsis thaliana glycosyltransferase mutants, rra1 and rra2, which have a reduced residual arabinose content in a polymer tightly associated with the cellulosic wall residue. Plant Mol Biol (2007) 1.24

Role of the human ST6GalNAc-I and ST6GalNAc-II in the synthesis of the cancer-associated sialyl-Tn antigen. Cancer Res (2004) 1.23

Probing isoform-specific functions of polypeptide GalNAc-transferases using zinc finger nuclease glycoengineered SimpleCells. Proc Natl Acad Sci U S A (2012) 1.22

The lectin domains of polypeptide GalNAc-transferases exhibit carbohydrate-binding specificity for GalNAc: lectin binding to GalNAc-glycopeptide substrates is required for high density GalNAc-O-glycosylation. Glycobiology (2007) 1.21

Transcriptome analysis at four developmental stages of grape berry (Vitis vinifera cv. Shiraz) provides insights into regulated and coordinated gene expression. BMC Genomics (2012) 1.21

Chondroitin sulphate A (CSA)-binding of single recombinant Duffy-binding-like domains is not restricted to Plasmodium falciparum Erythrocyte Membrane Protein 1 expressed by CSA-binding parasites. Int J Parasitol (2009) 1.19

Identification of new cancer biomarkers based on aberrant mucin glycoforms by in situ proximity ligation. J Cell Mol Med (2012) 1.19

GlycoPEGylation of recombinant therapeutic proteins produced in Escherichia coli. Glycobiology (2006) 1.17

Over-expression of ST3Gal-I promotes mammary tumorigenesis. Glycobiology (2010) 1.14

Sensitive detection of isoglobo and globo series tetraglycosylceramides in human thymus by ion trap mass spectrometry. Glycobiology (2007) 1.14

Biophysical consequences of remodeling the neutral side chains of rhamnogalacturonan I in tubers of transgenic potatoes. Planta (2004) 1.14

The Cell Walls of Green Algae: A Journey through Evolution and Diversity. Front Plant Sci (2012) 1.11

Immunologic glycosphingolipidomics and NKT cell development in mouse thymus. J Proteome Res (2009) 1.11

XAX1 from glycosyltransferase family 61 mediates xylosyltransfer to rice xylan. Proc Natl Acad Sci U S A (2012) 1.09

A serial lectin approach to the mucin-type O-glycoproteome of Drosophila melanogaster S2 cells. Proteomics (2007) 1.09

Identification of a GH110 subfamily of alpha 1,3-galactosidases: novel enzymes for removal of the alpha 3Gal xenotransplantation antigen. J Biol Chem (2008) 1.07

A complementary bioinformatics approach to identify potential plant cell wall glycosyltransferase-encoding genes. Plant Physiol (2004) 1.06

Differential expression profiles of glycosphingolipids in human breast cancer stem cells vs. cancer non-stem cells. Proc Natl Acad Sci U S A (2013) 1.06

Direct interference with rhamnogalacturonan I biosynthesis in Golgi vesicles. Plant Physiol (2002) 1.05

Comparison of antigen constructs and carrier molecules for augmenting the immunogenicity of the monosaccharide epithelial cancer antigen Tn. Cancer Immunol Immunother (2004) 1.05

The glycosyltransferase repertoire of the spikemoss Selaginella moellendorffii and a comparative study of its cell wall. PLoS One (2012) 1.04

The origin and function of platelet glycosyltransferases. Blood (2012) 1.04

A β-glucuronosyltransferase from Arabidopsis thaliana involved in biosynthesis of type II arabinogalactan has a role in cell elongation during seedling growth. Plant J (2013) 1.04

Enhanced mass spectrometric mapping of the human GalNAc-type O-glycoproteome with SimpleCells. Mol Cell Proteomics (2013) 1.04

Involvement of O-glycosylation defining oncofetal fibronectin in epithelial-mesenchymal transition process. Proc Natl Acad Sci U S A (2011) 1.03