Purine nucleosides: endogenous neuroprotectants in hypoxic brain.

PubWeight™: 0.94‹?›

🔗 View Article (PMC 3499684)

Published in J Neurochem on March 14, 2012

Authors

Bettina Thauerer1, Stephanie Zur Nedden, Gabriele Baier-Bitterlich

Author Affiliations

1: Division of Neurobiochemistry, Biocenter Department, Medical University of Innsbruck, Innsbruck, Austria.

Articles cited by this

(truncated to the top 100)

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci U S A (1976) 21.06

Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science (2002) 14.50

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med (2007) 10.00

International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev (2001) 9.90

ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell (1991) 9.54

Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol (2010) 8.87

Adult neurogenesis in the mammalian brain: significant answers and significant questions. Neuron (2011) 8.06

Ischemic cell death in brain neurons. Physiol Rev (1999) 8.01

Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell (2010) 7.20

Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage. Nature (2002) 6.50

The science of stroke: mechanisms in search of treatments. Neuron (2010) 6.14

Adenosine regulates via two different types of receptors, the accumulation of cyclic AMP in cultured brain cells. J Neurochem (1979) 5.92

The extended protein kinase C superfamily. Biochem J (1998) 5.84

Apoptosis in the nervous system. Nature (2000) 5.82

HIF-1 and human disease: one highly involved factor. Genes Dev (2000) 5.41

Nomenclature and classification of purinoceptors. Pharmacol Rev (1994) 5.32

Mitogen-activated protein kinases in apoptosis regulation. Oncogene (2004) 4.76

Mitogen-activated protein kinases in synaptic plasticity and memory. Curr Opin Neurobiol (2004) 4.59

Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors. Annu Rev Immunol (2004) 4.28

The role and regulation of adenosine in the central nervous system. Annu Rev Neurosci (2001) 4.17

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors--an update. Pharmacol Rev (2011) 4.16

Extracellular metabolism of ATP and other nucleotides. Naunyn Schmiedebergs Arch Pharmacol (2000) 4.06

Molecular cloning and characterization of an adenosine receptor: the A3 adenosine receptor. Proc Natl Acad Sci U S A (1992) 3.91

Life with oxygen. Science (2007) 3.88

A new penumbra: transitioning from injury into repair after stroke. Nat Med (2008) 3.59

Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ (2007) 3.55

Inflammatory mediators and stroke: new opportunities for novel therapeutics. J Cereb Blood Flow Metab (1999) 3.48

Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptors. Nat Rev Immunol (2005) 3.21

Purinergic signalling in neuron-glia interactions. Nat Rev Neurosci (2006) 3.17

Intracellular signaling pathways activated by neurotrophic factors. Annu Rev Neurosci (1996) 2.98

A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice. J Neurosci (1999) 2.92

Purinergic signalling in the nervous system: an overview. Trends Neurosci (2008) 2.86

Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor. Proc Natl Acad Sci U S A (2001) 2.73

Adenosine in the central nervous system: release mechanisms and extracellular concentrations. J Neurochem (2001) 2.63

Brain ischemia and reperfusion: molecular mechanisms of neuronal injury. J Neurol Sci (2000) 2.56

Purinergic signalling and disorders of the central nervous system. Nat Rev Drug Discov (2008) 2.40

Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells. Biochem Pharmacol (2001) 2.31

Signalling from adenosine receptors to mitogen-activated protein kinases. Cell Signal (2003) 2.19

Actions of adenosine at its receptors in the CNS: insights from knockouts and drugs. Annu Rev Pharmacol Toxicol (2005) 2.19

Making new connections: role of ERK/MAP kinase signaling in neuronal plasticity. Neuron (1999) 2.17

MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia. Proc Natl Acad Sci U S A (1999) 2.16

Hypoxia-inducible factor 1: regulator of mitochondrial metabolism and mediator of ischemic preconditioning. Biochim Biophys Acta (2010) 2.00

Adenosine: an old drug newly discovered. Anesthesiology (2009) 1.99

cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells. J Biol Chem (1994) 1.98

Adenosine and brain function. Int Rev Neurobiol (2005) 1.97

Stroke Treatment Academic Industry Roundtable (STAIR) recommendations for maximizing the use of intravenous thrombolytics and expanding treatment options with intra-arterial and neuroprotective therapies. Stroke (2011) 1.92

Role of mitogen- and stress-activated kinases in ischemic injury. J Cereb Blood Flow Metab (2002) 1.91

Inosine induces axonal rewiring and improves behavioral outcome after stroke. Proc Natl Acad Sci U S A (2002) 1.88

Inosine reduces ischemic brain injury in rats. Stroke (2005) 1.83

Trophic effects of purines in neurons and glial cells. Prog Neurobiol (1999) 1.82

ERK activation upon hypoxia: involvement in HIF-1 activation. FEBS Lett (2000) 1.81

Stroke and the immune system: from pathophysiology to new therapeutic strategies. Lancet Neurol (2011) 1.77

Promoting axonal rewiring to improve outcome after stroke. Neurobiol Dis (2009) 1.77

T regulatory cells: hypoxia-adenosinergic suppression and re-direction of the immune response. Trends Immunol (2009) 1.74

Current status of neuroprotection for cerebral ischemia: synoptic overview. Stroke (2008) 1.72

CREB-mediated Bcl-2 protein expression after ischemic preconditioning. J Cereb Blood Flow Metab (2005) 1.60

Nucleoside transporters: from scavengers to novel therapeutic targets. Trends Pharmacol Sci (2006) 1.60

Expression of human equilibrative nucleoside transporter 1 in mouse neurons regulates adenosine levels in physiological and hypoxic-ischemic conditions. J Neurochem (2011) 1.59

Neuroprotection by adenosine in the brain: From A(1) receptor activation to A (2A) receptor blockade. Purinergic Signal (2005) 1.58

Trophic actions of extracellular nucleotides and nucleosides on glial and neuronal cells. Trends Neurosci (1996) 1.58

A2A adenosine receptors from rat striatum and rat pheochromocytoma PC12 cells: characterization with radioligand binding and by activation of adenylate cyclase. Mol Pharmacol (1992) 1.57

Structure and function of A1 adenosine receptors. FASEB J (1991) 1.57

Recent developments in adenosine receptor ligands and their potential as novel drugs. Biochim Biophys Acta (2010) 1.53

Immunomodulatory and neuroprotective effects of inosine. Trends Pharmacol Sci (2004) 1.53

The structure and function of PKN, a protein kinase having a catalytic domain homologous to that of PKC. J Biochem (2003) 1.51

Inosine binds to A3 adenosine receptors and stimulates mast cell degranulation. J Clin Invest (1997) 1.47

Neuronal cell death in neonatal hypoxia-ischemia. Ann Neurol (2011) 1.47

Inosine inhibits inflammatory cytokine production by a posttranscriptional mechanism and protects against endotoxin-induced shock. J Immunol (2000) 1.47

Role of extracellular signal regulated kinases 1 and 2 in neuronal survival. Eur J Biochem (2004) 1.44

Bioenergetics of cerebral ischemia: a cellular perspective. Neuropharmacology (2008) 1.43

G protein-dependent activation of phospholipase C by adenosine A3 receptors in rat brain. Mol Pharmacol (1995) 1.40

Emerging role for ERK as a key regulator of neuronal apoptosis. Sci STKE (2004) 1.39

Neuroprotective role of adenosine in cerebral ischaemia. Trends Pharmacol Sci (1992) 1.38

High-resolution real-time recording with microelectrode biosensors reveals novel aspects of adenosine release during hypoxia in rat hippocampal slices. J Neurochem (2003) 1.37

Inosine stimulates extensive axon collateral growth in the rat corticospinal tract after injury. Proc Natl Acad Sci U S A (1999) 1.35

Proteolytic activation of PKN by caspase-3 or related protease during apoptosis. Proc Natl Acad Sci U S A (1998) 1.31

Transgenic overexpression of adenosine kinase aggravates cell death in ischemia. J Cereb Blood Flow Metab (2006) 1.30

Membrane depolarization in PC-12 cells during hypoxia is regulated by an O2-sensitive K+ current. Am J Physiol (1996) 1.30

Stimulation of the mitogen-activated protein kinase via the A2A-adenosine receptor in primary human endothelial cells. J Biol Chem (1997) 1.30

Preferential inhibition of omega-conotoxin-sensitive presynaptic Ca2+ channels by adenosine autoreceptors. Nature (1993) 1.29

Adenosine receptors as drug targets. Exp Cell Res (2010) 1.27

Chronic activation of ERK and neurodegenerative diseases. Bioessays (2003) 1.26

Adenosine receptor signaling in the brain immune system. Trends Pharmacol Sci (2005) 1.25

The Drosophila Pkn protein kinase is a Rho/Rac effector target required for dorsal closure during embryogenesis. Genes Dev (1999) 1.24

Adenosine receptors. Neuropharmacology (1995) 1.24

Neuroprotection and stroke: time for a compromise. J Neurochem (2007) 1.23

Intracellular formation and release of adenosine from rat hippocampal slices evoked by electrical stimulation or energy depletion. Neurochem Int (1993) 1.21

Direct measurement of adenosine release during hypoxia in the CA1 region of the rat hippocampal slice. J Physiol (2000) 1.20

Upregulation of the enzyme chain hydrolyzing extracellular ATP after transient forebrain ischemia in the rat. J Neurosci (1998) 1.19

Mst3b, a purine-sensitive Ste20-like protein kinase, regulates axon outgrowth. Proc Natl Acad Sci U S A (2006) 1.19

Activation of mitogen-activated protein kinase by the A(2A)-adenosine receptor via a rap1-dependent and via a p21(ras)-dependent pathway. J Biol Chem (1999) 1.18

Apoptosis and neurologic disease. Am J Med (2000) 1.17

Aspects of the general biology of adenosine A2A signaling. Prog Neurobiol (2007) 1.17

The G(s)-coupled adenosine A(2B) receptor recruits divergent pathways to regulate ERK1/2 and p38. Exp Cell Res (2003) 1.17

Molecular biology of nucleoside transporters and their distributions and functions in the brain. Curr Top Med Chem (2011) 1.14

Neuroprotection mediated by glial cell line-derived neurotrophic factor: involvement of a reduction of NMDA-induced calcium influx by the mitogen-activated protein kinase pathway. J Neurosci (2001) 1.10

Mst3b, an Ste20-like kinase, regulates axon regeneration in mature CNS and PNS pathways. Nat Neurosci (2009) 1.10

Pathophysiology of perinatal brain damage. Brain Res Brain Res Rev (1999) 1.09

Apoptosis and necrosis in the newborn piglet brain following transient cerebral hypoxia-ischaemia. Neuropathol Appl Neurobiol (1997) 1.07

Rat cultured astrocytes release guanine-based purines in basal conditions and after hypoxia/hypoglycemia. Glia (1999) 1.06