Published in Br J Clin Pharmacol on March 01, 2013
Metabolomics for Biomarker Discovery in Children With EoE | NCT03107819
Metabolomics: Applications and Promise in Mycobacterial Disease. Ann Am Thorac Soc (2015) 1.96
Metabolic profiling, a noninvasive approach for the detection of experimental colorectal neoplasia. Cancer Prev Res (Phila) (2012) 1.66
Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery. Drug Discov Today (2013) 1.03
An analysis of a 'community-driven' reconstruction of the human metabolic network. Metabolomics (2013) 0.90
NGAL and metabolomics: the single biomarker to reveal the metabolome alterations in kidney injury. Biomed Res Int (2013) 0.83
Pharmacometabolomics of l-carnitine treatment response phenotypes in patients with septic shock. Ann Am Thorac Soc (2015) 0.83
Gut Microbiota Profiling: Metabolomics Based Approach to Unravel Compounds Affecting Human Health. Front Microbiol (2016) 0.83
Urine metabolome profiling of immune-mediated inflammatory diseases. BMC Med (2016) 0.78
Nutraceuticals: is there good science behind the hype? Br J Clin Pharmacol (2013) 0.77
Personalized Medicine in Ocular Fibrosis: Myth or Future Biomarkers. Adv Wound Care (New Rochelle) (2016) 0.75
High-throughput and simultaneous quantitative analysis of homocysteine-methionine cycle metabolites and co-factors in blood plasma and cerebrospinal fluid by isotope dilution LC-MS/MS. Anal Bioanal Chem (2016) 0.75
Blood type biochemistry and human disease. Wiley Interdiscip Rev Syst Biol Med (2016) 0.75
Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Gastroenterology (2004) 14.78
HMDB: the Human Metabolome Database. Nucleic Acids Res (2007) 13.38
Steatohepatitis: a tale of two "hits"? Gastroenterology (1998) 13.21
Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature (2009) 12.58
Metabolite profiles and the risk of developing diabetes. Nat Med (2011) 12.22
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab (2009) 11.46
Gut flora in health and disease. Lancet (2003) 9.85
How host-microbial interactions shape the nutrient environment of the mammalian intestine. Annu Rev Nutr (2002) 8.31
Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts. Nat Protoc (2007) 5.92
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci U S A (2009) 5.86
Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology (2010) 5.35
Gut microorganisms, mammalian metabolism and personalized health care. Nat Rev Microbiol (2005) 5.35
Systems biology: Metabonomics. Nature (2008) 5.32
The cancer biomarker problem. Nature (2008) 4.64
Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry. Proc Natl Acad Sci U S A (2009) 4.13
Chemometrics in metabonomics. J Proteome Res (2007) 4.02
Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women. Diabetes Care (2009) 3.69
A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model. Mol Syst Biol (2007) 3.68
750 MHz 1H and 1H-13C NMR spectroscopy of human blood plasma. Anal Chem (1995) 3.61
Non-alcoholic steatohepatitis (NASH): a disease of emerging identity and importance. J Hepatol (1998) 3.57
Nonalcoholic fatty liver disease: pathology and pathogenesis. Annu Rev Pathol (2010) 3.36
Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans. J Clin Invest (2011) 3.23
A comprehensive urinary metabolomic approach for identifying kidney cancerr. Anal Biochem (2007) 3.14
Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting. PLoS One (2010) 2.84
Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes. J Exp Med (2008) 2.79
Mass spectrometry-based metabolic profiling reveals different metabolite patterns in invasive ovarian carcinomas and ovarian borderline tumors. Cancer Res (2006) 2.68
Acquired obesity is associated with changes in the serum lipidomic profile independent of genetic effects--a monozygotic twin study. PLoS One (2007) 2.38
Metabolomics reveals metabolic biomarkers of Crohn's disease. PLoS One (2009) 2.35
Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statement: Executive Summary. Crit Pathw Cardiol (2005) 2.31
Metabolomics in early Alzheimer's disease: identification of altered plasma sphingolipidome using shotgun lipidomics. PLoS One (2011) 2.30
Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women. PLoS One (2010) 2.14
Colonization-induced host-gut microbial metabolic interaction. MBio (2011) 2.04
Noninvasive assessment of hepatic lipid composition: Advancing understanding and management of fatty liver disorders. Hepatology (2008) 2.03
Increased risk of irritable bowel syndrome after bacterial gastroenteritis: cohort study. BMJ (1999) 1.99
Rapid and noninvasive metabonomic characterization of inflammatory bowel disease. J Proteome Res (2007) 1.99
Susceptibility of human metabolic phenotypes to dietary modulation. J Proteome Res (2006) 1.96
Metabonomics in ulcerative colitis: diagnostics, biomarker identification, and insight into the pathophysiology. J Proteome Res (2010) 1.84
Plasma metabolomic profile in nonalcoholic fatty liver disease. Metabolism (2010) 1.77
High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues. Nat Protoc (2010) 1.76
Inflammatory bowel disease: immunodiagnostics, immunotherapeutics, and ecotherapeutics. Gastroenterology (2001) 1.76
Plasma free amino acid profiling of five types of cancer patients and its application for early detection. PLoS One (2011) 1.73
A role for inflammation in irritable bowel syndrome? Gut (2002) 1.57
Mass spectrometric profiling of oxidized lipid products in human nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. J Lipid Res (2010) 1.53
Quantitative metabolomics by H-NMR and LC-MS/MS confirms altered metabolic pathways in diabetes. PLoS One (2010) 1.53
HPLC-MS-based methods for the study of metabonomics. J Chromatogr B Analyt Technol Biomed Life Sci (2005) 1.52
1H NMR metabonomics approach to the disease continuum of diabetic complications and premature death. Mol Syst Biol (2008) 1.51
Food patterns and components of the metabolic syndrome in men and women: a cross-sectional study within the Malmö Diet and Cancer cohort. Am J Epidemiol (2001) 1.51
Urinary metabolic phenotyping differentiates children with autism from their unaffected siblings and age-matched controls. J Proteome Res (2010) 1.50
Investigation of human blood plasma sample preparation for performing metabolomics using ultrahigh performance liquid chromatography/mass spectrometry. Anal Chem (2009) 1.35
Metabolomics of fecal extracts detects altered metabolic activity of gut microbiota in ulcerative colitis and irritable bowel syndrome. J Proteome Res (2011) 1.30
Liquid chromatography-mass spectrometry-based parallel metabolic profiling of human and mouse model serum reveals putative biomarkers associated with the progression of nonalcoholic fatty liver disease. J Proteome Res (2010) 1.29
Human metabolic phenotypes link directly to specific dietary preferences in healthy individuals. J Proteome Res (2007) 1.28
Characterization of inflammatory bowel disease with urinary metabolic profiling. Am J Gastroenterol (2009) 1.27
Noninvasive urinary metabonomic diagnosis of human bladder cancer. J Proteome Res (2010) 1.26
Metabolic shifts due to long-term caloric restriction revealed in nonhuman primates. Exp Gerontol (2009) 1.26
Gut microflora associated characteristics in children with celiac disease. Am J Gastroenterol (2005) 1.26
Application of biofluid 1H nuclear magnetic resonance-based metabonomic techniques for the analysis of the biochemical effects of dietary isoflavones on human plasma profile. Anal Biochem (2003) 1.24
The metabonomic signature of celiac disease. J Proteome Res (2009) 1.24
Panorganismal gut microbiome-host metabolic crosstalk. J Proteome Res (2009) 1.18
Transgenomic metabolic interactions in a mouse disease model: interactions of Trichinella spiralis infection with dietary Lactobacillus paracasei supplementation. J Proteome Res (2006) 1.16
Metabolome-wide association study identifies multiple biomarkers that discriminate north and south Chinese populations at differing risks of cardiovascular disease: INTERMAP study. J Proteome Res (2010) 1.15
Principal component directed partial least squares analysis for combining nuclear magnetic resonance and mass spectrometry data in metabolomics: application to the detection of breast cancer. Anal Chim Acta (2010) 1.13
Quantitative metabolomic profiling of serum and urine in DSS-induced ulcerative colitis of mice by (1)H NMR spectroscopy. J Proteome Res (2010) 1.10
Urinary excretion of N-methylhistamine as a marker of disease activity in inflammatory bowel disease. Am J Gastroenterol (2002) 1.10
An HR-MAS MR metabolomics study on breast tissues obtained with core needle biopsy. PLoS One (2011) 1.10
A review of the role of the gut microflora in irritable bowel syndrome and the effects of probiotics. Br J Nutr (2002) 1.09
Gender-dependent progression of systemic metabolic states in early childhood. Mol Syst Biol (2008) 1.08
Metabolic regulation in progression to autoimmune diabetes. PLoS Comput Biol (2011) 1.06
Metabolic profiling strategy for discovery of nutritional biomarkers: proline betaine as a marker of citrus consumption. Am J Clin Nutr (2010) 1.04
Exercise-induced changes in metabolic intermediates, hormones, and inflammatory markers associated with improvements in insulin sensitivity. Diabetes Care (2010) 1.04
Metabolism of the colonic mucosa in patients with inflammatory bowel diseases: an in vitro proton magnetic resonance spectroscopy study. Magn Reson Imaging (2008) 1.03
Metabolomic profiling to identify potential serum biomarkers for schizophrenia and risperidone action. J Proteome Res (2011) 1.03
Urinary metabolic profiles of inflammatory bowel disease in interleukin-10 gene-deficient mice. Anal Chem (2008) 1.01
Metabolic phenotyping of the Crohn's disease-like IBD etiopathology in the TNF(ΔARE/WT) mouse model. J Proteome Res (2011) 1.01
Metabolomic biomarkers: search, discovery and validation. Expert Rev Mol Diagn (2007) 0.99
Metabolome in schizophrenia and other psychotic disorders: a general population-based study. Genome Med (2011) 0.98
A metabolic system-wide characterisation of the pig: a model for human physiology. Mol Biosyst (2011) 0.98
Metabolic assessment of gradual development of moderate experimental colitis in IL-10 deficient mice. J Proteome Res (2009) 0.97
Using metabolomic analysis to understand inflammatory bowel diseases. Inflamm Bowel Dis (2011) 0.96
Metabolomic analysis identifies inflammatory and noninflammatory metabolic effects of genetic modification in a mouse model of Crohn's disease. J Proteome Res (2010) 0.96
A proton nuclear magnetic resonance metabonomics approach for biomarker discovery in nonalcoholic fatty liver disease. J Proteome Res (2011) 0.92
Identification of urinary biomarkers of colon inflammation in IL10-/- mice using Short-Column LCMS metabolomics. J Biomed Biotechnol (2010) 0.86
Metabolomics unveils urinary changes in subjects with metabolic syndrome following 12-week nut consumption. J Proteome Res (2011) 0.84
Topographical variation in murine intestinal metabolic profiles in relation to microbiome speciation and functional ecological activity. J Proteome Res (2009) 0.83
Metabolic phenotyping of genetically modified mice: An NMR metabonomic approach. Biochimie (2009) 0.83
Future therapies for inflammatory bowel disease. Curr Gastroenterol Rep (2003) 0.82
Similarity in the metabolic profile in macroscopically involved and un-involved colonic mucosa in patients with inflammatory bowel disease: an in vitro proton ((1)H) MR spectroscopy study. Magn Reson Imaging (2010) 0.82
Metabotyping of biofluids reveals stress-based differences in gut permeability in healthy individuals. J Proteome Res (2009) 0.78
Chemometric strategy for modeling metabolic biological space along the gastrointestinal tract and assessing microbial influences. Anal Chem (2010) 0.78
Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model. Mol Syst Biol (2008) 2.43
Metabolomics applied to exhaled breath condensate in childhood asthma. Am J Respir Crit Care Med (2007) 2.42
Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes. Mol Syst Biol (2008) 2.17
Colonization-induced host-gut microbial metabolic interaction. MBio (2011) 2.04
Precision of GE Lunar iDXA for the measurement of total and regional body composition in nonobese adults. J Clin Densitom (2012) 1.63
Methylation of ELOVL2 gene as a new epigenetic marker of age. Aging Cell (2012) 1.45
Investigation of human blood plasma sample preparation for performing metabolomics using ultrahigh performance liquid chromatography/mass spectrometry. Anal Chem (2009) 1.35
Human metabolic phenotypes link directly to specific dietary preferences in healthy individuals. J Proteome Res (2007) 1.28
Metabolic shifts due to long-term caloric restriction revealed in nonhuman primates. Exp Gerontol (2009) 1.26
Maladaptive intestinal epithelial responses to life stress may predispose healthy women to gut mucosal inflammation. Gastroenterology (2008) 1.22
Panorganismal gut microbiome-host metabolic crosstalk. J Proteome Res (2009) 1.18
Metabolic signatures of extreme longevity in northern Italian centenarians reveal a complex remodeling of lipids, amino acids, and gut microbiota metabolism. PLoS One (2013) 1.11
Stability and robustness of human metabolic phenotypes in response to sequential food challenges. J Proteome Res (2011) 1.10
Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model. Mol Syst Biol (2008) 1.10
Dietary modulation of gut functional ecology studied by fecal metabonomics. J Proteome Res (2010) 1.10
A whole-grain cereal-rich diet increases plasma betaine, and tends to decrease total and LDL-cholesterol compared with a refined-grain diet in healthy subjects. Br J Nutr (2011) 1.03
Metabolomics view on gut microbiome modulation by polyphenol-rich foods. J Proteome Res (2012) 1.03
Multivariate modeling strategy for intercompartmental analysis of tissue and plasma 1H NMR spectrotypes. J Proteome Res (2009) 1.02
Metabolic phenotyping of the Crohn's disease-like IBD etiopathology in the TNF(ΔARE/WT) mouse model. J Proteome Res (2011) 1.01
A metabolic system-wide characterisation of the pig: a model for human physiology. Mol Biosyst (2011) 0.98
Metabolic assessment of gradual development of moderate experimental colitis in IL-10 deficient mice. J Proteome Res (2009) 0.97
Reproducibility and relative validity of a food-frequency questionnaire for French-speaking Swiss adults. Food Nutr Res (2011) 0.93
Analysis of time-related metabolic fluctuations induced by ethionine in the rat. J Proteome Res (2007) 0.93
Metabotyping of Caenorhabditis elegans and their culture media revealed unique metabolic phenotypes associated to amino acid deficiency and insulin-like signaling. J Proteome Res (2011) 0.92
Metabolic effects of dark chocolate consumption on energy, gut microbiota, and stress-related metabolism in free-living subjects. J Proteome Res (2009) 0.92
Gut microbiota modulate the metabolism of brown adipose tissue in mice. J Proteome Res (2011) 0.92
Profiling techniques in nutrition and health research. Curr Opin Biotechnol (2008) 0.92
Precision of a new tool to measure visceral adipose tissue (VAT) using dual-energy X-Ray absorptiometry (DXA). Obesity (Silver Spring) (2013) 0.91
Early metabolic adaptation in C57BL/6 mice resistant to high fat diet induced weight gain involves an activation of mitochondrial oxidative pathways. J Proteome Res (2013) 0.89
Metabolomics perspectives in pediatric research. Pediatr Res (2013) 0.87
Metabolomic applications to decipher gut microbial metabolic influence in health and disease. Front Physiol (2012) 0.87
A protein-leucine supplement increases branched-chain amino acid and nitrogen turnover but not performance. Med Sci Sports Exerc (2012) 0.87
Alignment using variable penalty dynamic time warping. Anal Chem (2009) 0.86
Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity. Aging (Albany NY) (2014) 0.86
Topographical body fat distribution links to amino acid and lipid metabolism in healthy obese women [corrected]. PLoS One (2013) 0.85
Current status on genome-metabolome-wide associations: an opportunity in nutrition research. Genes Nutr (2012) 0.85
1H NMR-based metabonomic applications to decipher gut microbial metabolic influence on mammalian health. Magn Reson Chem (2011) 0.85
Automated SPE-RP-HPLC fractionation of biofluids combined to off-line NMR spectroscopy for biomarker identification in metabonomics. J Chromatogr B Analyt Technol Biomed Life Sci (2008) 0.84
Topographical variation in murine intestinal metabolic profiles in relation to microbiome speciation and functional ecological activity. J Proteome Res (2009) 0.83
Monitoring healthy metabolic trajectories with nutritional metabonomics. Nutrients (2009) 0.82
Quantitative analysis of plasma caffeic and ferulic acid equivalents by liquid chromatography tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci (2009) 0.82
Quantification of flavan-3-ols and phenolic acids in milk-based food products by reversed-phase liquid chromatography-tandem mass spectrometry. J Chromatogr A (2009) 0.81
A plasma global metabolic profiling approach applied to an exercise study monitoring the effects of glucose, galactose and fructose drinks during post-exercise recovery. J Chromatogr B Analyt Technol Biomed Life Sci (2010) 0.81
Quantification of alkylresorcinols in human plasma by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom (2010) 0.81
1H NMR-based protocol for the detection of adulterations of refined olive oil with refined hazelnut oil. J Agric Food Chem (2009) 0.81
Effects of increase in fish oil intake on intestinal eicosanoids and inflammation in a mouse model of colitis. Lipids Health Dis (2013) 0.80
Specific dietary preferences are linked to differing gut microbial metabolic activity in response to dark chocolate intake. J Proteome Res (2012) 0.80
Quantitative measurement of betaine and free choline in plasma, cereals and cereal products by isotope dilution LC-MS/MS. J Agric Food Chem (2010) 0.79
Identification of novel circulating coffee metabolites in human plasma by liquid chromatography-mass spectrometry. J Chromatogr A (2011) 0.79
Online hydrogen/deuterium exchange performed in the ion mobility cell of a hybrid mass spectrometer. Anal Chem (2009) 0.79
High-resolution quantitative metabolome analysis of urine by automated flow injection NMR. Anal Chem (2013) 0.78
Chemometric strategy for modeling metabolic biological space along the gastrointestinal tract and assessing microbial influences. Anal Chem (2010) 0.78
Nondairy creamer, but not milk, delays the appearance of coffee phenolic acid equivalents in human plasma. J Nutr (2009) 0.78
First identification of dimethoxycinnamic acids in human plasma after coffee intake by liquid chromatography-mass spectrometry. J Chromatogr A (2010) 0.78
The role of liquid chromatography and flow injection analyses coupled to isotope ratio mass spectrometry for studying human in vivo glucose metabolism. Rapid Commun Mass Spectrom (2011) 0.77
Weaning diet induces sustained metabolic phenotype shift in the pig and influences host response to Bifidobacterium lactis NCC2818. Gut (2012) 0.77
Isotopomics: a top-down systems biology approach for understanding dynamic metabolism in rats using [1,2-(13)C(2)] acetate. Anal Chem (2010) 0.76
Nutritional metabonomics: an approach to promote personalized health and wellness. Chimia (Aarau) (2011) 0.76
Blood plasma lipidomic signature of epicardial fat in healthy obese women. Obesity (Silver Spring) (2014) 0.75
Everyday eating experiences of chocolate and non-chocolate snacks impact postprandial anxiety, energy and emotional states. Nutrients (2012) 0.75
Differential effect of maternal diet supplementation with alpha-Linolenic adcid or n-3 long-chain polyunsaturated fatty acids on glial cell phosphatidylethanolamine and phosphatidylserine fatty acid profile in neonate rat brains. Nutr Metab (Lond) (2010) 0.75
Application of support vector machines to 1H NMR data of fish oils: methodology for the confirmation of wild and farmed salmon and their origins. Anal Bioanal Chem (2007) 0.75
The Scientific Challenge of Expanding the Frontiers of Nutrition. Nestle Nutr Inst Workshop Ser (2016) 0.75