Published in Cell Cycle on February 15, 2012
Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2. Mol Cell Biol (2013) 0.97
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Successful β cells islet regeneration in streptozotocin-induced diabetic baboons using ultrasound-targeted microbubble gene therapy with cyclinD2/CDK4/GLP1. Cell Cycle (2014) 0.86
Nucleic acid delivery with microbubbles and ultrasound. Adv Drug Deliv Rev (2014) 0.86
Cyclin D2 is a GATA4 cofactor in cardiogenesis. Proc Natl Acad Sci U S A (2014) 0.86
Overexpression of E2F3 promotes proliferation of functional human β cells without induction of apoptosis. Cell Cycle (2013) 0.82
A genetic mouse model for progressive ablation and regeneration of insulin producing beta-cells. Cell Cycle (2014) 0.78
Deletion of β-Arrestin2 in mice limited pancreatic beta-cell expansion under metabolic stress through activation of JNK pathway. Mol Med (2016) 0.75
ANGPTL8 reverses established adriamycin cardiomyopathy by stimulating adult cardiac progenitor cells. Oncotarget (2016) 0.75
The cell cycle as a brake for β-cell regeneration from embryonic stem cells. Stem Cell Res Ther (2016) 0.75
Utilization of diagnostic ultrasound and intravenous lipid-encapsulated perfluorocarbons in non-invasive targeted cardiovascular therapeutics. J Ther Ultrasound (2016) 0.75
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Islet-derived stem cells from adult rats participate in the repair of islet damage. J Mol Histol (2012) 0.75
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes (2003) 16.62
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Very slow turnover of beta-cells in aged adult mice. Diabetes (2005) 4.54
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Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth. Mol Cell Biol (2005) 3.50
Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages. Nat Biotechnol (2004) 3.36
Projecting the future diabetes population size and related costs for the U.S. Diabetes Care (2009) 3.34
New sources of pancreatic beta-cells. Nat Biotechnol (2005) 3.11
Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance. J Clin Invest (2007) 2.81
The replication of beta cells in normal physiology, in disease and for therapy. Nat Clin Pract Endocrinol Metab (2007) 2.72
Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells. Science (2004) 2.67
The adult mouse and human pancreas contain rare multipotent stem cells that express insulin. Cell Stem Cell (2011) 2.31
Molecular control of cell cycle progression in the pancreatic beta-cell. Endocr Rev (2006) 2.30
Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6. Diabetes (2010) 2.12
Induction of beta-cell proliferation and retinoblastoma protein phosphorylation in rat and human islets using adenovirus-mediated transfer of cyclin-dependent kinase-4 and cyclin D1. Diabetes (2004) 1.81
Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells. J Clin Invest (2007) 1.78
Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo. Diabetes (2009) 1.70
GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis. Cell Metab (2010) 1.64
Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology. Proc Natl Acad Sci U S A (2006) 1.57
Type 2 diabetes and the aging pancreatic beta cell. Aging (Albany NY) (2011) 1.39
p27 Regulates the transition of beta-cells from quiescence to proliferation. Diabetes (2006) 1.39
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Growth factors and beta cell replication. Int J Biochem Cell Biol (2005) 1.34
Cyclin D2 protein stability is regulated in pancreatic beta-cells. Mol Endocrinol (2009) 1.25
Multiple functions of D-type cyclins can antagonize pRb-mediated suppression of proliferation. Cell Cycle (2005) 1.23
Telomerase deficiency impairs glucose metabolism and insulin secretion. Aging (Albany NY) (2010) 1.17
Beta-cell growth: an unusual paradigm of organogenesis that is cyclin D2/Cdk4 dependent. Cell Cycle (2006) 1.17
Regeneration of pancreatic islets in vivo by ultrasound-targeted gene therapy. Gene Ther (2010) 1.12
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Reversal of streptozotocin-induced diabetes in rats by gene therapy with betacellulin and pancreatic duodenal homeobox-1. Gene Ther (2007) 1.02
Minireview: pancreatic progenitor cells--recent studies. Endocrinology (2008) 0.99
Glucagon-like peptide-1 plasmid construction and delivery for the treatment of type 2 diabetes. Mol Ther (2005) 0.99
Too many breaks (brakes): pancreatic β-cell senescence leads to diabetes. Cell Cycle (2011) 0.89
Efficient, glucose responsive and islet-specific transgene expression by a modified rat insulin promoter. Gene Ther (2009) 0.85
Epithelial-to-mesenchymal transition in pancreatic islet beta cells. Cell Cycle (2010) 0.84
Human islet-derived precursor cells can cycle between epithelial clusters and mesenchymal phenotypes. J Cell Mol Med (2008) 0.77
Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography. J Am Soc Echocardiogr (2003) 11.88
Prospective trial of combined transcatheter arterial chemoembolization and three-dimensional conformal radiotherapy for portal vein tumor thrombus in patients with unresectable hepatocellular carcinoma. Int J Radiat Oncol Biol Phys (2003) 2.34
Monitoring response to anticancer therapy by targeting microbubbles to tumor vasculature. Clin Cancer Res (2007) 2.19
Thinking outside the "box"-the ultrasound contrast controversy. J Am Coll Cardiol (2007) 2.06
Ultrasound-targeted microbubble destruction can repeatedly direct highly specific plasmid expression to the heart. Circulation (2003) 2.03
A new cell-permeable peptide allows successful allogeneic islet transplantation in mice. Nat Med (2004) 2.01
Recommendations for a standardized report for adult transthoracic echocardiography: a report from the American Society of Echocardiography's Nomenclature and Standards Committee and Task Force for a Standardized Echocardiography Report. J Am Soc Echocardiogr (2002) 1.98
Influence of mitral regurgitation repair on survival in the surgical treatment for ischemic heart failure trial. Circulation (2012) 1.91
Echocardiographic indices do not reliably track changes in left-sided filling pressure in healthy subjects or patients with heart failure with preserved ejection fraction. Circ Cardiovasc Imaging (2011) 1.86
Effect of ADAM28 on carcinoma cell metastasis by cleavage of von Willebrand factor. J Natl Cancer Inst (2012) 1.76
Use of ultrasound contrast agents for gene or drug delivery in cardiovascular medicine. J Am Coll Cardiol (2005) 1.61
A suggested roadmap for cardiovascular ultrasound research for the future. J Am Soc Echocardiogr (2011) 1.60
Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology. Proc Natl Acad Sci U S A (2006) 1.57
Optimization of ultrasound parameters for cardiac gene delivery of adenoviral or plasmid deoxyribonucleic acid by ultrasound-targeted microbubble destruction. J Am Coll Cardiol (2003) 1.54
Established preoperative risk factors do not predict long-term survival in isolated coronary artery bypass grafting patients. Ann Thorac Surg (2012) 1.44
Dramatically different phenotypic expressions of hypertrophic cardiomyopathy in male cousins undergoing cardiac transplantation with identical disease-causing gene mutation. Am J Cardiol (2013) 1.43
Augmentation of cardiac protein delivery using ultrasound targeted microbubble destruction. Ultrasound Med Biol (2005) 1.23
DNA-loaded albumin microbubbles enhance ultrasound-mediated transfection in vitro. Ultrasound Med Biol (2002) 1.22
Seven consecutive successful clinical islet isolations with pancreatic ductal injection. Cell Transplant (2009) 1.21
ADAM12 is selectively overexpressed in human glioblastomas and is associated with glioblastoma cell proliferation and shedding of heparin-binding epidermal growth factor. Am J Pathol (2004) 1.21
Large human islets secrete less insulin per islet equivalent than smaller islets in vitro. Islets (2011) 1.20
Targeting vascular endothelium with avidin microbubbles. Ultrasound Med Biol (2005) 1.19
Valvular heart disease: aortic regurgitation. Circulation (2005) 1.19
Neutrophil-derived matrix metalloproteinase 9 triggers acute aortic dissection. Circulation (2012) 1.18
Improving efficacy of clinical islet transplantation with iodixanol-based islet purification, thymoglobulin induction, and blockage of IL-1β and TNF-α. Cell Transplant (2011) 1.18
Ductal injection of preservation solution increases islet yields in islet isolation and improves islet graft function. Cell Transplant (2008) 1.16
SUIT, secretory units of islets in transplantation: An index for therapeutic management of islet transplanted patients and its application to type 2 diabetes. Diabetes Res Clin Pract (2006) 1.16
Cardiomyocyte-specific endothelin A receptor knockout mice have normal cardiac function and an unaltered hypertrophic response to angiotensin II and isoproterenol. Mol Cell Biol (2003) 1.15
Iodixanol-controlled density gradient during islet purification improves recovery rate in human islet isolation. Transplantation (2009) 1.07
ADAM28 is overexpressed in human breast carcinomas: implications for carcinoma cell proliferation through cleavage of insulin-like growth factor binding protein-3. Cancer Res (2006) 1.07
Induction of pancreatic stem/progenitor cells into insulin-producing cells by adenoviral-mediated gene transfer technology. Cell Transplant (2006) 1.06
BETA2/NeuroD protein can be transduced into cells due to an arginine- and lysine-rich sequence. Diabetes (2005) 1.05
A case report of giant cell myocarditis and myositis observed during the clinical course of invasive thymoma associated with myasthenia gravis. Keio J Med (2004) 1.05
Dynamic perifusion to maintain and assess isolated pancreatic islets. Diabetes Technol Ther (2002) 1.04
Reductive surgery plus percutaneous isolated hepatic perfusion for multiple advanced hepatocellular carcinoma. Ann Surg (2004) 1.03
ADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan. J Biol Chem (2004) 1.02
Overexpression of SIP1 and downregulation of E-cadherin predict delayed neck metastasis in stage I/II oral tongue squamous cell carcinoma after partial glossectomy. Ann Surg Oncol (2011) 1.02
A single recessive gene controls cadmium translocation in the cadmium hyperaccumulating rice cultivar Cho-Ko-Koku. Theor Appl Genet (2009) 1.01
Distinction in gene expression profiles of oligodendrogliomas with and without allelic loss of 1p. Oncogene (2002) 1.01
Role of vascular endothelial growth factor-A in development of abdominal aortic aneurysm. Cardiovasc Res (2011) 1.01
Low-temperature preservation of isolated islets is superior to conventional islet culture before islet transplantation. Transplantation (2010) 1.01
Anticoagulant-induced pseudothrombocytopenia occurring after transcatheter arterial embolization for hepatocellular carcinoma. Jpn J Clin Oncol (2006) 1.00
Immunohistochemical detection of the lymphatic marker podoplanin in diverse types of human cancer cells using a novel antibody. Int J Oncol (2007) 1.00
Fresh islets are more effective for islet transplantation than cultured islets. Cell Transplant (2012) 1.00
Evaluation of osmolality of density gradient for human islet purification. Cell Transplant (2012) 0.99
Loss of function of the candidate tumor suppressor prox1 by RNA mutation in human cancer cells. Neoplasia (2006) 0.97
Resveratrol prevents the development of abdominal aortic aneurysm through attenuation of inflammation, oxidative stress, and neovascularization. Atherosclerosis (2011) 0.97
"Downgrading" of gastric varices with multiple collateral veins in balloon-occluded retrograde transvenous obliteration. J Vasc Interv Radiol (2005) 0.97
Mitral "annular" calcium forming a complete circle "O" causing mitral stenosis in association with a stenotic congenitally bicuspid aortic valve and severe coronary artery disease. Am J Geriatr Cardiol (2006) 0.96
Effective islet isolation method with extremely high islet yields from adult pigs. Cell Transplant (2005) 0.96
Protein transduction technology: a novel therapeutic perspective. Acta Med Okayama (2006) 0.96
Bioeffects of myocardial contrast microbubble destruction by echocardiography. Echocardiography (2002) 0.96
A new mouse model for intraportal islet transplantation with limited hepatic lobe as a graft site. Transplantation (2006) 0.95
Myocardial contractile reserve by dobutamine stress echocardiography predicts improvement in ejection fraction with beta-blockade in patients with heart failure: the Beta-Blocker Evaluation of Survival Trial (BEST). Circulation (2003) 0.95
Primary carcinoid tumor in a polycystic kidney. Pathol Int (2003) 0.94
Variables associated with islet yield in autologous islet cell transplantation for chronic pancreatitis. Proc (Bayl Univ Med Cent) (2010) 0.94
Analysis of donor- and isolation-related variables from non-heart-beating donors (NHBDs) using the Kyoto islet isolation method. Cell Transplant (2008) 0.94
Reestablishment of microenvironment is necessary to maintain in vitro and in vivo human islet function. Cell Transplant (2008) 0.93
Assessment of islet quality following international shipping of more than 10,000 km. Cell Transplant (2010) 0.93
Characterization of human pancreatic progenitor cells. Cell Transplant (2010) 0.93
Comparison of ulinastatin, gabexate mesilate, and nafamostat mesilate in preservation solution for islet isolation. Cell Transplant (2012) 0.92
SUITO index for evaluation of efficacy of single donor islet transplantation. Cell Transplant (2009) 0.92
Ductal injection of JNK inhibitors before pancreas preservation prevents islet apoptosis and improves islet graft function. Hum Gene Ther (2009) 0.92
ADAM28 is activated by MMP-7 (matrilysin-1) and cleaves insulin-like growth factor binding protein-3. Biochem Biophys Res Commun (2004) 0.92
Autoimmune chronic pancreatitis with IgG4-related pancreatic pseudocyst in a patient undergoing total pancreatectomy followed by autologous islet transplantation: a case report. Pancreas (2013) 0.91
Amelioration of diabetes in mice after single-donor islet transplantation using the controlled release of gelatinized FGF-2. Cell Transplant (2006) 0.90
Expression of heparanase in renal cell carcinomas: implications for tumor invasion and prognosis. Clin Cancer Res (2008) 0.90
Pulmonary hypertension and thalidomide therapy in multiple myeloma. Br J Haematol (2005) 0.90
ADAM28 is overexpressed in human non-small cell lung carcinomas and correlates with cell proliferation and lymph node metastasis. Int J Cancer (2006) 0.90
Correlation of released HMGB1 levels with the degree of islet damage in mice and humans and with the outcomes of islet transplantation in mice. Cell Transplant (2012) 0.90
Effect on right ventricular volume of percutaneous Amplatzer closure of atrial septal defect in adults. Am J Cardiol (2005) 0.90
Non-invasive coronary angiography using multislice computed tomography. Heart (2005) 0.90
Cell permeable peptide of JNK inhibitor prevents islet apoptosis immediately after isolation and improves islet graft function. Am J Transplant (2005) 0.89
Comparison of modified Celsior solution and M-kyoto solution for pancreas preservation in human islet isolation. Cell Transplant (2010) 0.89
Isolation and propagation of a human CD133(-) colon tumor-derived cell line with tumorigenic and angiogenic properties. Cell Transplant (2010) 0.89
Secretory unit of islet in transplantation (SUIT) and engrafted islet rate (EIR) indexes are useful for evaluating single islet transplantation. Cell Transplant (2008) 0.89
Mechanism of PDX-1 protein transduction. Biochem Biophys Res Commun (2005) 0.89
In vivo targeted delivery of ANGPTL8 gene for beta cell regeneration in rats. Diabetologia (2015) 0.89
Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice. Diabetes (2007) 0.89
Bone repair by transplantation of hTERT-immortalized human mesenchymal stem cells in mice. Transplantation (2009) 0.88
Safety of ultrasound contrast agents in patients with known or suspected cardiac shunts. Am J Cardiol (2013) 0.88
Endovascular obliteration of bleeding duodenal varices in patients with liver cirrhosis. Eur Radiol (2005) 0.88
Grading severity of mitral regurgitation by echocardiography: science or art? JACC Cardiovasc Imaging (2010) 0.88
Tumor necrosis factor-α converting enzyme is a key mediator of abdominal aortic aneurysm development. Atherosclerosis (2011) 0.88
Progress in Clinical Encapsulated Islet Xenotransplantation. Transplantation (2016) 0.88
Interests in beta-cell replacement therapies among Japanese patients with type 1 diabetes. Diabetes Res Clin Pract (2010) 0.87