Published in PLoS One on February 23, 2012
Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. Am J Hum Genet (2013) 1.26
The developing story of Sprouty and cancer. Cancer Metastasis Rev (2014) 0.96
MiR-21 is an Ngf-modulated microRNA that supports Ngf signaling and regulates neuronal degeneration in PC12 cells. Neuromolecular Med (2014) 0.87
Diva/BclB regulates differentiation by inhibiting NDPKB/Nm23H2-mediated neuronal differentiation in PC-12 cells. BMC Neurosci (2012) 0.75
Sprouty2 and -4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage. Hippocampus (2015) 0.75
The guanine nucleotide-binding switch in three dimensions. Science (2001) 9.34
Trk receptors: roles in neuronal signal transduction. Annu Rev Biochem (2003) 8.83
Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci (2006) 7.18
sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. Cell (1998) 4.40
Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci (2001) 3.53
Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway. Nat Cell Biol (2002) 3.35
Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling. Trends Cell Biol (2005) 3.14
Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1. Nat Cell Biol (2003) 2.71
Negative receptor signalling. Curr Opin Cell Biol (2003) 2.68
Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype. Nat Genet (2007) 2.55
Selectivity in neurotrophin signaling: theme and variations. Annu Rev Neurosci (2003) 2.21
Mammalian sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells. J Cell Biol (2001) 2.02
Mammalian sprouty proteins inhibit cell growth and differentiation by preventing ras activation. J Biol Chem (2001) 1.89
Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila. Development (1999) 1.84
Inhibition of angiogenesis by a mouse sprouty protein. J Biol Chem (2000) 1.54
Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops. Curr Biol (2003) 1.50
Sprouty2 inhibits the Ras/MAP kinase pathway by inhibiting the activation of Raf. J Biol Chem (2001) 1.46
Identification of a dominant negative mutant of Sprouty that potentiates fibroblast growth factor- but not epidermal growth factor-induced ERK activation. J Biol Chem (2001) 1.44
Lrig1 is an endogenous inhibitor of Ret receptor tyrosine kinase activation, downstream signaling, and biological responses to GDNF. J Neurosci (2008) 1.43
Role of neurotrophin signalling in the differentiation of neurons from dorsal root ganglia and sympathetic ganglia. Cell Tissue Res (2009) 1.41
Evidence for direct interaction between Sprouty and Cbl. J Biol Chem (2000) 1.37
The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins. Proc Natl Acad Sci U S A (2002) 1.33
SPRED1 mutations (Legius syndrome): another clinically useful genotype for dissecting the neurofibromatosis type 1 phenotype. J Med Genet (2009) 1.32
Tyrosine phosphorylation of Sprouty proteins regulates their ability to inhibit growth factor signaling: a dual feedback loop. Mol Biol Cell (2004) 1.24
A Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulation. J Biol Chem (2006) 1.13
Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1. Eur J Biochem (2002) 1.13
Sprouty2 inhibits BDNF-induced signaling and modulates neuronal differentiation and survival. Cell Death Differ (2007) 1.08
Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1. Cell Cycle (2003) 1.07
Sprouty proteins inhibit receptor-mediated activation of phosphatidylinositol-specific phospholipase C. Mol Biol Cell (2010) 1.06
Sprouty2 regulates growth and differentiation of human neuroblastoma cells through RET tyrosine kinase. Cancer Sci (2007) 1.03
Nerve growth factor signals through TrkA, phosphatidylinositol 3-kinase, and Rac1 to inactivate RhoA during the initiation of neuronal differentiation of PC12 cells. J Biol Chem (2002) 1.02
Positive and negative interactions of GDNF, NTN and ART in developing sensory neuron subpopulations, and their collaboration with neurotrophins. Development (2000) 1.00
Sprouty regulates cell migration by inhibiting the activation of Rac1 GTPase. Biochem Biophys Res Commun (2004) 0.95
Characterisation of a new regulator of BDNF signalling, Sprouty3, involved in axonal morphogenesis in vivo. Development (2010) 0.94
Sprouty-4 negatively regulates cell spreading by inhibiting the kinase activity of testicular protein kinase. Biochem J (2005) 0.94
Tiam1 as a signaling mediator of nerve growth factor-dependent neurite outgrowth. PLoS One (2010) 0.93
Sprouty4 negatively regulates protein kinase C activation by inhibiting phosphatidylinositol 4,5-biphosphate hydrolysis. Oncogene (2009) 0.91
Negative Regulation of Receptor Tyrosine Kinase (RTK) Signaling: A Developing Field. Biomark Insights (2007) 0.82
Sprouty: a controversial role in receptor tyrosine kinase signalling pathways. Biochem Soc Trans (2003) 0.82
The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands. Cell (2003) 3.09
Target-derived GFRalpha1 as an attractive guidance signal for developing sensory and sympathetic axons via activation of Cdk5. Neuron (2002) 1.92
Lrig1 is an endogenous inhibitor of Ret receptor tyrosine kinase activation, downstream signaling, and biological responses to GDNF. J Neurosci (2008) 1.43
GDNF and GFRalpha: a versatile molecular complex for developing neurons. Trends Neurosci (2008) 1.42
Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor. Proc Natl Acad Sci U S A (2005) 1.33
GDNF and GFRalpha1 promote formation of neuronal synapses by ligand-induced cell adhesion. Nat Neurosci (2007) 1.33
GDNF is a chemoattractant factor for neuronal precursor cells in the rostral migratory stream. Mol Cell Neurosci (2005) 1.00
Disruption of EphA/ephrin-a signaling in the nigrostriatal system reduces dopaminergic innervation and dissociates behavioral responses to amphetamine and cocaine. Mol Cell Neurosci (2004) 0.99
Na+-mediated coupling between AMPA receptors and KNa channels shapes synaptic transmission. Proc Natl Acad Sci U S A (2008) 0.94
Tiam1 as a signaling mediator of nerve growth factor-dependent neurite outgrowth. PLoS One (2010) 0.93
Peptidergic influences on proliferation, migration, and placement of neural progenitors in the adult mouse forebrain. Proc Natl Acad Sci U S A (2008) 0.90
New insights into the control of neurotrophic growth factor receptor signaling: implications for nervous system development and repair. J Neurochem (2012) 0.86
NPY and its involvement in axon guidance, neurogenesis, and feeding. Nutrition (2008) 0.86
Pea3 transcription factor family members Etv4 and Etv5 mediate retrograde signaling and axonal growth of DRG sensory neurons in response to NGF. J Neurosci (2013) 0.83
Negative Regulation of Receptor Tyrosine Kinase (RTK) Signaling: A Developing Field. Biomark Insights (2007) 0.82
Disruption of the GDNF binding site in NCAM dissociates ligand binding and homophilic cell adhesion. J Biol Chem (2007) 0.81
Neurotrophin-4 mediated TrkB activation reinforces morphine-induced analgesia. Nat Neurosci (2003) 0.78
The GTPase-activating protein Rap1GAP: a new player to modulate Ret signaling. Cell Res (2010) 0.75