Published in Proc Natl Acad Sci U S A on April 30, 2002
Modeling cancer progression via pathway dependencies. PLoS Comput Biol (2008) 2.12
Intermolecular interactions of Sprouty proteins and their implications in development and disease. Mol Pharmacol (2009) 1.52
Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia. Proc Natl Acad Sci U S A (2003) 1.44
Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases. Biochim Biophys Acta (2012) 1.39
Tyrosine phosphorylation of Sprouty proteins regulates their ability to inhibit growth factor signaling: a dual feedback loop. Mol Biol Cell (2004) 1.24
Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells. Carcinogenesis (2010) 1.14
Sprouty 2 disturbs FGFR3 degradation in thanatophoric dysplasia type II: a severe form of human achondroplasia. Cell Signal (2008) 1.08
Regulation of EphB2 activation and cell repulsion by feedback control of the MAPK pathway. J Cell Biol (2008) 1.07
Sprouty 2 is an independent prognostic factor in breast cancer and may be useful in stratifying patients for trastuzumab therapy. PLoS One (2011) 1.05
Regulation of sprouty stability by Mnk1-dependent phosphorylation. Mol Cell Biol (2006) 1.03
Sprouty-2 controls c-Met expression and metastatic potential of colon cancer cells: sprouty/c-Met upregulation in human colonic adenocarcinomas. Oncogene (2010) 0.99
The role of the ubiquitination-proteasome pathway in breast cancer: ubiquitin mediated degradation of growth factor receptors in the pathogenesis and treatment of cancer. Breast Cancer Res (2002) 0.99
Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation. EMBO Rep (2005) 0.97
The developing story of Sprouty and cancer. Cancer Metastasis Rev (2014) 0.96
Sprouty is a negative regulator of transforming growth factor β-induced epithelial-to-mesenchymal transition and cataract. Mol Med (2012) 0.95
Regulation of cellular levels of Sprouty2 protein by prolyl hydroxylase domain and von Hippel-Lindau proteins. J Biol Chem (2011) 0.93
A novel role of Sprouty 2 in regulating cellular apoptosis. J Biol Chem (2007) 0.92
Mitogen-activated protein kinase signalling and ERK1/2 bistability in asthma. Clin Exp Allergy (2010) 0.91
HECT domain-containing E3 ubiquitin ligase Nedd4 interacts with and ubiquitinates Sprouty2. J Biol Chem (2009) 0.91
Sprouty/FGF signaling regulates the proximal-distal feather morphology and the size of dermal papillae. Dev Biol (2012) 0.91
Sprouty proteins are negative regulators of interferon (IFN) signaling and IFN-inducible biological responses. J Biol Chem (2012) 0.90
Fibroblast growth factors and epidermal growth factor cooperate with oocyte-derived members of the TGFbeta superfamily to regulate Spry2 mRNA levels in mouse cumulus cells. Biol Reprod (2009) 0.88
Establishment of extracellular signal-regulated kinase 1/2 bistability and sustained activation through Sprouty 2 and its relevance for epithelial function. Mol Cell Biol (2010) 0.88
hSef potentiates EGF-mediated MAPK signaling through affecting EGFR trafficking and degradation. Cell Signal (2007) 0.87
Sprouty4 regulates endothelial cell migration via modulating integrin β3 stability through c-Src. Angiogenesis (2013) 0.87
Down-regulation of Sprouty2 via p38 MAPK plays a key role in the induction of cellular apoptosis by tumor necrosis factor-alpha. Biochem Biophys Res Commun (2008) 0.87
Sprouty genes regulate proliferation and survival of human embryonic stem cells. Sci Rep (2013) 0.86
Sprouty4 is an endogenous negative modulator of TrkA signaling and neuronal differentiation induced by NGF. PLoS One (2012) 0.83
Intersectin 1 enhances Cbl ubiquitylation of epidermal growth factor receptor through regulation of Sprouty2-Cbl interaction. Mol Cell Biol (2011) 0.83
Negative Regulation of Receptor Tyrosine Kinase (RTK) Signaling: A Developing Field. Biomark Insights (2007) 0.82
Receptor tyrosine kinase ubiquitylation involves the dynamic regulation of Cbl-Spry2 by intersectin 1 and the Shp2 tyrosine phosphatase. Mol Cell Biol (2013) 0.81
hCG-induced Sprouty2 mediates amphiregulin-stimulated COX-2/PGE2 up-regulation in human granulosa cells: a potential mechanism for the OHSS. Sci Rep (2016) 0.77
SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150. Oncogene (2015) 0.76
Sprouty2 Drives Drug Resistance and Proliferation in Glioblastoma. Mol Cancer Res (2015) 0.76
Sprouty2 regulates endochondral bone formation by modulation of RTK and BMP signaling. Bone (2016) 0.75
Novel Function of Sprouty4 as a Regulator of Stemness and Differentiation of Embryonic Stem Cells. Balsaenggwa Saengsig (2016) 0.75
Sprouty2 Protein Regulates Hypoxia-inducible Factor-α (HIFα) Protein Levels and Transcription of HIFα-responsive Genes. J Biol Chem (2016) 0.75
Genome-wide gene expression analysis of chemoresistant pulmonary carcinoid cells. Lung Cancer (Auckl) (2010) 0.75
Cell signaling by receptor tyrosine kinases. Cell (2000) 18.16
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science (1999) 7.60
c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor. Genes Dev (1998) 5.31
sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. Cell (1998) 4.40
Feedback control of intercellular signalling in development. Nature (2000) 4.04
Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed. Development (1999) 3.84
Sprouty, an intracellular inhibitor of Ras signaling. Cell (1999) 2.51
Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7. J Biol Chem (1999) 2.21
The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor. J Biol Chem (1999) 2.13
Mammalian sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells. J Cell Biol (2001) 2.02
Cell determination strategies in the Drosophila eye. Development (1997) 1.95
Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesis. Mech Dev (2001) 1.94
Sprouty is a general inhibitor of receptor tyrosine kinase signaling. Development (1999) 1.92
The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha. Proc Natl Acad Sci U S A (1998) 1.89
Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila. Development (1999) 1.84
Conserved function of mSpry-2, a murine homolog of Drosophila sprouty, which negatively modulates respiratory organogenesis. Curr Biol (1999) 1.75
Multiple positive and negative regulators of signaling by the EGF-receptor. Curr Opin Cell Biol (1999) 1.73
Differential activation of the Rac pathway by Ha-Ras and K-Ras. J Biol Chem (2001) 1.72
The function of the Drosophila fat facets deubiquitinating enzyme in limiting photoreceptor cell number is intimately associated with endocytosis. Development (2000) 1.61
The evolutionarily conserved N-terminal region of Cbl is sufficient to enhance down-regulation of the epidermal growth factor receptor. J Biol Chem (2000) 1.60
Xenopus Sprouty2 inhibits FGF-mediated gastrulation movements but does not affect mesoderm induction and patterning. Genes Dev (2001) 1.55
Inhibition of angiogenesis by a mouse sprouty protein. J Biol Chem (2000) 1.54
D-cbl, a negative regulator of the Egfr pathway, is required for dorsoventral patterning in Drosophila oogenesis. Cell (2000) 1.48
Identification of a dominant negative mutant of Sprouty that potentiates fibroblast growth factor- but not epidermal growth factor-induced ERK activation. J Biol Chem (2001) 1.44
Interactions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development. Mol Cell Biol (1997) 1.43
Evidence for direct interaction between Sprouty and Cbl. J Biol Chem (2000) 1.37
The C terminus of sprouty is important for modulation of cellular migration and proliferation. J Biol Chem (2001) 1.28
Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain. J Biol Chem (2000) 1.11
Ras signal transduction pathway in Drosophila eye development. Cold Spring Harb Symp Quant Biol (1994) 0.94
RAS oncogenes: weaving a tumorigenic web. Nat Rev Cancer (2011) 6.45
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature (2013) 4.71
Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome. Nat Genet (2006) 4.68
Redox-dependent downregulation of Rho by Rac. Nat Cell Biol (2003) 4.46
Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis. Cancer Cell (2004) 4.23
Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia. Cancer Cell (2012) 4.16
Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos. Nat Cell Biol (2007) 3.68
Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS. Cell (2003) 3.66
Modulation of signalling by Sprouty: a developing story. Nat Rev Mol Cell Biol (2004) 3.46
The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol (2002) 3.08
Direct coupling of the cell cycle and cell death machinery by E2F. Nat Cell Biol (2002) 3.00
Membrane-dependent signal integration by the Ras activator Son of sevenless. Nat Struct Mol Biol (2008) 2.82
Regulating the regulator: post-translational modification of RAS. Nat Rev Mol Cell Biol (2011) 2.81
In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha. J Clin Invest (2009) 2.53
Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors. Nature (2007) 2.43
Structural analysis of autoinhibition in the Ras activator Son of sevenless. Cell (2004) 2.38
Role of boundary conditions in an experimental model of epithelial wound healing. Am J Physiol Cell Physiol (2006) 2.01
An orthosteric inhibitor of the Ras-Sos interaction. Nat Chem Biol (2011) 1.91
MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells. J Exp Med (2012) 1.82
Differential modification of Ras proteins by ubiquitination. Mol Cell (2006) 1.80
Regulation of ras signaling dynamics by Sos-mediated positive feedback. Curr Biol (2006) 1.70
Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells. Cancer Cell (2010) 1.58
A Ras-induced conformational switch in the Ras activator Son of sevenless. Proc Natl Acad Sci U S A (2006) 1.57
hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl. Curr Biol (2003) 1.52
Ras/MAPK signaling from endomembranes. Mol Oncol (2009) 1.51
A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen. Gastroenterology (2006) 1.48
Suppression of Ras-stimulated transformation by the JNK signal transduction pathway. Genes Dev (2003) 1.48
Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells. Clin Cancer Res (2008) 1.43
The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways. Proc Natl Acad Sci U S A (2008) 1.42
Distinct populations of metastases-enabling myeloid cells expand in the liver of mice harboring invasive and preinvasive intra-abdominal tumor. J Leukoc Biol (2009) 1.37
Prevention of radiation-induced oral cavity mucositis by plasmid/liposome delivery of the human manganese superoxide dismutase (SOD2) transgene. Radiat Res (2003) 1.35
The structural basis for the transition from Ras-GTP to Ras-GDP. Proc Natl Acad Sci U S A (2002) 1.32
Design, synthesis, and biological evaluation of new-generation taxoids. J Med Chem (2008) 1.29
Feedback regulation of Ras signaling by Rabex-5-mediated ubiquitination. Curr Biol (2010) 1.27
Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis. Nat Commun (2012) 1.26
Oncogenic K-ras drives cell cycle progression and phenotypic conversion of primary pancreatic duct epithelial cells. Cancer Res (2004) 1.23
The two hats of SOS. Sci STKE (2002) 1.22
Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless. Proc Natl Acad Sci U S A (2010) 1.22
VEGF exerts an angiogenesis-independent function in cancer cells to promote their malignant progression. Cancer Res (2012) 1.21
Structure of the G60A mutant of Ras: implications for the dominant negative effect. J Biol Chem (2005) 1.21
Computational docking and solution x-ray scattering predict a membrane-interacting role for the histone domain of the Ras activator son of sevenless. Proc Natl Acad Sci U S A (2005) 1.20
Pancreatic duct epithelial cell isolation and cultivation in two-dimensional and three-dimensional culture systems. Methods Enzymol (2006) 1.19
Chronic pancreatitis, pancreatic adenocarcinoma and the black box in-between. Cell Res (2005) 1.13
Tandem histone folds in the structure of the N-terminal segment of the ras activator Son of Sevenless. Structure (2003) 1.12
Spatial regulation of EGFR signaling by Sprouty2. Curr Biol (2007) 1.09
EZH2 couples pancreatic regeneration to neoplastic progression. Genes Dev (2012) 1.07
Pulmonary irradiation-induced expression of VCAM-I and ICAM-I is decreased by manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy. Biol Blood Marrow Transplant (2002) 1.05
Regulation of sprouty stability by Mnk1-dependent phosphorylation. Mol Cell Biol (2006) 1.03
Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas. Blood (2009) 1.03
Fibronectin growth factor-binding domains are required for fibroblast survival. J Invest Dermatol (2010) 1.02
Regulation of RAS oncogenicity by acetylation. Proc Natl Acad Sci U S A (2012) 1.02
Allosteric gating of Son of sevenless activity by the histone domain. Proc Natl Acad Sci U S A (2010) 0.98
The pleckstrin homology (PH) domain-interacting protein couples the insulin receptor substrate 1 PH domain to insulin signaling pathways leading to mitogenesis and GLUT4 translocation. Mol Cell Biol (2002) 0.98
Ras and Rac as activators of reactive oxygen species (ROS). Methods Mol Biol (2002) 0.98
Signaling endosomes: seeing is believing. Curr Opin Cell Biol (2010) 0.95
Characterization of a Ras mutant with identical GDP- and GTP-bound structures . Biochemistry (2009) 0.89
Spry2 expression correlates with BRAF mutation in thyroid cancer. Surgery (2010) 0.88
Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression. J Clin Invest (2013) 0.88
Quantitative analysis of cell signaling and drug action via mass spectrometry-based systems level phosphoproteomics. Proteomics (2009) 0.87
Autoinhibition of Sos by intramolecular interactions. Front Biosci (2002) 0.84
Ras oncogene and inflammation: partners in crime. Cell Cycle (2005) 0.83
Microdissection and culture of murine pancreatic ductal epithelial cells. Methods Mol Biol (2013) 0.81
Analysis of Ras:RasGEF interactions by phage display and static multi-angle light scattering. Methods (2005) 0.81
Perturbation of cytoskeleton dynamics by the opposing effects of Rac1 and Rac1b. Small GTPases (2010) 0.79
Clinical and therapeutic implications of Sprouty2 feedback dysregulation in BRAF V600E-mutation-positive papillary thyroid cancer. Surgery (2013) 0.79
Raf-1 and squamous cell carcinoma: Rok-ing the boat. Cancer Cell (2009) 0.78
Mapping cellular routes of Ras: a ubiquitin trail. Cell Cycle (2006) 0.77
Escorting Ras. Small GTPases (2012) 0.76
Profiling protein tyrosine phosphorylation: a quantitative 45-plex peptide-based immunoassay. J Biomol Screen (2008) 0.75
Biochemical and biophysical analyses of Ras modification by ubiquitin. Methods Enzymol (2008) 0.75