Published in Immunity on March 01, 2012
Functions of NOD-Like Receptors in Human Diseases. Front Immunol (2013) 1.08
Structural mechanisms in NLR inflammasome signaling. Curr Opin Struct Biol (2014) 1.02
The expanding role of NLRs in antiviral immunity. Immunol Rev (2013) 0.96
Unsolved Mysteries in NLR Biology. Front Immunol (2013) 0.92
NOD-Like Receptors in Lung Diseases. Front Immunol (2013) 0.92
International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease. Pharmacol Rev (2015) 0.92
Recent progress in studies of arterivirus- and coronavirus-host interactions. Viruses (2012) 0.90
NLRs, inflammasomes, and viral infection. J Leukoc Biol (2012) 0.88
Intracellular detection of viral nucleic acids. Curr Opin Microbiol (2015) 0.88
Emerging significance of NLRs in inflammatory bowel disease. Inflamm Bowel Dis (2014) 0.86
Nod-like receptor X-1 is required for rhinovirus-induced barrier dysfunction in airway epithelial cells. J Virol (2014) 0.83
Structures of pattern recognition receptors reveal molecular mechanisms of autoinhibition, ligand recognition and oligomerization. Curr Opin Immunol (2013) 0.83
G Protein signaling modulator-3 inhibits the inflammasome activity of NLRP3. J Biol Chem (2014) 0.81
Consensus design of a NOD receptor leucine rich repeat domain with binding affinity for a muramyl dipeptide, a bacterial cell wall fragment. Protein Sci (2014) 0.81
Modeling-Enabled Characterization of Novel NLRX1 Ligands. PLoS One (2015) 0.79
NLRX1 has a tail to tell. Immunity (2012) 0.78
Holding the inflammatory system in check: NLRs keep it cool. F1000Prime Rep (2015) 0.77
How 'arm-twisting' by the inducer triggers activation of the MalT transcription factor, a typical signal transduction ATPase with numerous domains (STAND). Nucleic Acids Res (2015) 0.76
Beyond the inflammasome: regulatory NOD-like receptor modulation of the host immune response following virus exposure. J Gen Virol (2016) 0.76
Comparative Geometrical Analysis of Leucine-Rich Repeat Structures in the Nod-Like and Toll-Like Receptors in Vertebrate Innate Immunity. Biomolecules (2015) 0.75
Mitochondrial Regulation of Inflammasome Activation in Chronic Obstructive Pulmonary Disease. J Innate Immun (2015) 0.75
NLRX1 promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated translational inhibition mediated by PKR. Nat Immunol (2017) 0.75
Epithelial Cell Inflammasomes in Intestinal Immunity and Inflammation. Front Immunol (2017) 0.75
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88
Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr (1998) 169.28
Pathogen recognition and innate immunity. Cell (2006) 44.14
Automated MAD and MIR structure solution. Acta Crystallogr D Biol Crystallogr (1999) 41.65
Recognition of microorganisms and activation of the immune response. Nature (2007) 12.99
Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol (2009) 9.24
Determination of macromolecular structures from anomalous diffraction of synchrotron radiation. Science (1991) 7.79
The leucine-rich repeat as a protein recognition motif. Curr Opin Struct Biol (2001) 7.39
NOD-LRR proteins: role in host-microbial interactions and inflammatory disease. Annu Rev Biochem (2005) 6.18
NODs: intracellular proteins involved in inflammation and apoptosis. Nat Rev Immunol (2003) 5.07
A structural basis of the interactions between leucine-rich repeats and protein ligands. Nature (1995) 4.70
NLRX1 is a regulator of mitochondrial antiviral immunity. Nature (2008) 4.55
Structural basis of toll-like receptor 3 signaling with double-stranded RNA. Science (2008) 4.41
Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation. Mol Cell (2007) 4.33
Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain. Science (2002) 4.15
Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB. J Biol Chem (1999) 3.81
Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats. Nature (1994) 3.24
Function of Nod-like receptors in microbial recognition and host defense. Immunol Rev (2009) 3.20
The leucine-rich repeat structure. Cell Mol Life Sci (2008) 3.18
CATERPILLER: a novel gene family important in immunity, cell death, and diseases. Annu Rev Immunol (2005) 3.04
NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production. EMBO Rep (2008) 2.83
Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition. EMBO J (2004) 2.81
Plant NBS-LRR proteins in pathogen sensing and host defense. Nat Immunol (2006) 2.74
Structure of the apoptotic protease-activating factor 1 bound to ADP. Nature (2005) 2.63
NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways. Cell (2010) 2.49
Genetic analysis of resistance to viral infection. Nat Rev Immunol (2007) 2.47
Fluorescence polarization analysis of protein-DNA and protein-protein interactions. Mol Endocrinol (1996) 2.36
NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways. Immunity (2011) 2.29
Cutting edge: CATERPILLER: a large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains. J Immunol (2002) 2.18
NLRX1 negatively regulates TLR-induced NF-κB signaling by targeting TRAF6 and IKK. Immunity (2011) 2.10
The structural biology of Toll-like receptors. Structure (2011) 2.04
The Nod-like receptor (NLR) family: a tale of similarities and differences. PLoS One (2008) 1.99
Mechanism of ribonuclease inhibition by ribonuclease inhibitor protein based on the crystal structure of its complex with ribonuclease A. J Mol Biol (1996) 1.70
Cutting edge: NLRC5-dependent activation of the inflammasome. J Immunol (2010) 1.66
An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix. J Cell Sci (2009) 1.62
The crystal structure of rna1p: a new fold for a GTPase-activating protein. Mol Cell (1999) 1.34
NLRP1 influences the systemic sclerosis phenotype: a new clue for the contribution of innate immunity in systemic sclerosis-related fibrosing alveolitis pathogenesis. Ann Rheum Dis (2010) 1.19
A heterodimeric complex of the LRR proteins LRIM1 and APL1C regulates complement-like immunity in Anopheles gambiae. Proc Natl Acad Sci U S A (2010) 1.17
The missense variation Q705K in CIAS1/NALP3/NLRP3 gene and an NLRP1 haplotype are associated with celiac disease. Am J Gastroenterol (2011) 1.10
NOD-like receptors and human diseases. Microbes Infect (2007) 1.08
Identification of the critical residues involved in peptidoglycan detection by Nod1. J Biol Chem (2005) 1.05
NOD1 gene E266K polymorphism is associated with disease susceptibility but not with disease phenotype or NOD2/CARD15 in Hungarian patients with Crohn's disease. Dig Liver Dis (2007) 0.90
Association of NOD1 (CARD4) insertion/deletion polymorphism with susceptibility to IBD: a meta-analysis. World J Gastroenterol (2010) 0.88
Crystallization and crystal structure determination of ribonuclease A-ribonuclease inhibitor protein complex. Methods Mol Biol (2001) 0.77
Antibody recognition of a highly conserved influenza virus epitope. Science (2009) 11.26
Broad neutralization coverage of HIV by multiple highly potent antibodies. Nature (2011) 11.07
Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus. Science (2006) 10.04
HIV vaccine design and the neutralizing antibody problem. Nat Immunol (2004) 9.48
The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1-->2 mannose residues on the outer face of gp120. J Virol (2002) 7.82
Structure of a V3-containing HIV-1 gp120 core. Science (2005) 7.69
How TCRs bind MHCs, peptides, and coreceptors. Annu Rev Immunol (2006) 7.57
Printed covalent glycan array for ligand profiling of diverse glycan binding proteins. Proc Natl Acad Sci U S A (2004) 7.55
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9. Nature (2011) 7.20
Structure of the uncleaved human H1 hemagglutinin from the extinct 1918 influenza virus. Science (2004) 6.70
Antibody domain exchange is an immunological solution to carbohydrate cluster recognition. Science (2003) 6.68
Glycan microarray analysis of the hemagglutinins from modern and pandemic influenza viruses reveals different receptor specificities. J Mol Biol (2005) 6.17
Structural basis of preexisting immunity to the 2009 H1N1 pandemic influenza virus. Science (2010) 6.10
Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A (2002) 6.00
A highly conserved neutralizing epitope on group 2 influenza A viruses. Science (2011) 5.66
Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120. J Virol (2003) 5.59
Crystal structure of a soluble cleaved HIV-1 envelope trimer. Science (2013) 5.53
Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria. Nat Immunol (2006) 5.51
A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield. Science (2011) 5.44
A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity. J Virol (2005) 4.71
Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer. Science (2013) 4.61
Computational design of proteins targeting the conserved stem region of influenza hemagglutinin. Science (2011) 4.42
Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4. Science (2007) 4.35
Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41. Immunity (2005) 4.26
A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies. PLoS Pathog (2013) 4.23
New world bats harbor diverse influenza A viruses. PLoS Pathog (2013) 4.10
Protein production and purification. Nat Methods (2008) 3.97
Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. Science (2005) 3.72
Antibody vs. HIV in a clash of evolutionary titans. Proc Natl Acad Sci U S A (2005) 3.57
Rational HIV immunogen design to target specific germline B cell receptors. Science (2013) 3.55
Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses. Science (2012) 3.53
Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors. Nature (2008) 3.47
Highly conserved protective epitopes on influenza B viruses. Science (2012) 3.47
Exploration of uncharted regions of the protein universe. PLoS Biol (2009) 3.41
Structural rationale for the broad neutralization of HIV-1 by human monoclonal antibody 447-52D. Structure (2004) 3.31
A Blueprint for HIV Vaccine Discovery. Cell Host Microbe (2012) 3.27
Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes. Proc Natl Acad Sci U S A (2010) 3.24
A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis. Science (2011) 3.19
Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor. Nat Immunol (2005) 3.12
Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120. Nat Struct Mol Biol (2013) 3.11
Crystal structure of a bacterial cocaine esterase. Nat Struct Biol (2002) 3.06
Recent avian H5N1 viruses exhibit increased propensity for acquiring human receptor specificity. J Mol Biol (2008) 3.00
Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9. Proc Natl Acad Sci U S A (2013) 2.96
Glycan microarray technologies: tools to survey host specificity of influenza viruses. Nat Rev Microbiol (2006) 2.83
Genetic and phenotypic analyses of human immunodeficiency virus type 1 escape from a small-molecule CCR5 inhibitor. J Virol (2004) 2.80
HIV-1 and influenza antibodies: seeing antigens in new ways. Nat Immunol (2009) 2.80
Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1. Proc Natl Acad Sci U S A (2010) 2.77
Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans. PLoS Pathog (2013) 2.66
Structural characterization of the 1918 influenza virus H1N1 neuraminidase. J Virol (2008) 2.63
T cell activation by lipopeptide antigens. Science (2004) 2.59
Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12. Proc Natl Acad Sci U S A (2005) 2.50
Cross-neutralization of influenza A viruses mediated by a single antibody loop. Nature (2012) 2.44
Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures. Proc Natl Acad Sci U S A (2011) 2.38
Three-dimensional structural view of the central metabolic network of Thermotoga maritima. Science (2009) 2.33
Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. Proc Natl Acad Sci U S A (2012) 2.27
XtalPred: a web server for prediction of protein crystallizability. Bioinformatics (2007) 2.26
The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K. Science (2010) 2.26
Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A. Nat Immunol (2003) 2.20
Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity. J Exp Med (2005) 2.18
Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing. Nat Biotechnol (2012) 2.14
Comparative efficacy of neutralizing antibodies elicited by recombinant hemagglutinin proteins from avian H5N1 influenza virus. J Virol (2008) 2.14
Structural basis of steroid hormone perception by the receptor kinase BRI1. Nature (2011) 2.12
Structural basis of TLR5-flagellin recognition and signaling. Science (2012) 2.10
Contrasting IgG structures reveal extreme asymmetry and flexibility. J Mol Biol (2002) 2.10
Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation. Proc Natl Acad Sci U S A (2013) 2.10
Hepatitis C virus E2 envelope glycoprotein core structure. Science (2013) 2.06
Outcome of a workshop on applications of protein models in biomedical research. Structure (2009) 2.05
The junctional adhesion molecule JAML is a costimulatory receptor for epithelial gammadelta T cell activation. Science (2010) 2.02
The long third complementarity-determining region of the heavy chain is important in the activity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5. J Virol (2004) 2.02
The specificity of TCR/pMHC interaction. Curr Opin Immunol (2002) 1.99
The CD100 receptor interacts with its plexin B2 ligand to regulate epidermal γδ T cell function. Immunity (2012) 1.98
Antibody elbow angles are influenced by their light chain class. J Mol Biol (2006) 1.96
Structural basis of enhanced binding of extended and helically constrained peptide epitopes of the broadly neutralizing HIV-1 antibody 4E10. J Mol Biol (2006) 1.90
Organization of the influenza virus replication machinery. Science (2012) 1.89
Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis. Proc Natl Acad Sci U S A (2006) 1.88
The JCSG high-throughput structural biology pipeline. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 1.87
Molecular features of the broadly neutralizing immunoglobulin G1 b12 required for recognition of human immunodeficiency virus type 1 gp120. J Virol (2003) 1.84
The challenge of protein structure determination--lessons from structural genomics. Protein Sci (2007) 1.82
Crystal structure of a shark single-domain antibody V region in complex with lysozyme. Science (2004) 1.81
Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex. Science (2008) 1.79
Hyperglycosylated mutants of human immunodeficiency virus (HIV) type 1 monomeric gp120 as novel antigens for HIV vaccine design. J Virol (2003) 1.78
Functional balance of the hemagglutinin and neuraminidase activities accompanies the emergence of the 2009 H1N1 influenza pandemic. J Virol (2012) 1.76
Structural basis of hepatitis C virus neutralization by broadly neutralizing antibody HCV1. Proc Natl Acad Sci U S A (2012) 1.74
Crystal structures of mouse CD1d-iGb3 complex and its cognate Valpha14 T cell receptor suggest a model for dual recognition of foreign and self glycolipids. J Mol Biol (2008) 1.72
Structure-function analysis of the epitope for 4E10, a broadly neutralizing human immunodeficiency virus type 1 antibody. J Virol (2006) 1.71
COPII-dependent export of cystic fibrosis transmembrane conductance regulator from the ER uses a di-acidic exit code. J Cell Biol (2004) 1.70
Rapid refinement of crystallographic protein construct definition employing enhanced hydrogen/deuterium exchange MS. Proc Natl Acad Sci U S A (2004) 1.70
Secretory IgA N- and O-glycans provide a link between the innate and adaptive immune systems. J Biol Chem (2003) 1.68
The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies. PLoS Pathog (2013) 1.67
Anatomy of CD1-lipid antigen complexes. Nat Rev Immunol (2005) 1.67
Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d. Proc Natl Acad Sci U S A (2006) 1.66
Rapid and robust protection against cocaine-induced lethality in rats by the bacterial cocaine esterase. Mol Pharmacol (2006) 1.66
A conformational switch in human immunodeficiency virus gp41 revealed by the structures of overlapping epitopes recognized by neutralizing antibodies. J Virol (2009) 1.63
Geranylgeranyl switching regulates GDI-Rab GTPase recycling. Structure (2003) 1.63
Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses. Curr Opin Struct Biol (2010) 1.62
Structural characterization of the hemagglutinin receptor specificity from the 2009 H1N1 influenza pandemic. J Virol (2011) 1.62
Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity. Sci Transl Med (2011) 1.62
Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: a molecular basis for NKT cell activation. J Immunol (2005) 1.61