Published in Int J Cancer on March 28, 2012
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Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression. Cell Rep (2013) 1.56
Human discs large and scrib are localized at the same regions in colon mucosa and changes in their expression patterns are correlated with loss of tissue architecture during malignant progression. Int J Cancer (2006) 1.50
The hScrib/Dlg apico-basal control complex is differentially targeted by HPV-16 and HPV-18 E6 proteins. Oncogene (2005) 1.40
Interaction between the HPV E7 oncoprotein and the transcriptional coactivator p300. Oncogene (2003) 1.36
Structures of a human papillomavirus (HPV) E6 polypeptide bound to MAGUK proteins: mechanisms of targeting tumor suppressors by a high-risk HPV oncoprotein. J Virol (2007) 1.34
Activity of the human papillomavirus E6 PDZ-binding motif correlates with an enhanced morphological transformation of immortalized human keratinocytes. J Cell Sci (2003) 1.31
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HPV E6 specifically targets different cellular pools of its PDZ domain-containing tumour suppressor substrates for proteasome-mediated degradation. Oncogene (2004) 1.20
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Changes in expression of the human homologue of the Drosophila discs large tumour suppressor protein in high-grade premalignant cervical neoplasias. Carcinogenesis (2002) 1.12
Comparative analysis of the intracellular location of the high- and low-risk human papillomavirus oncoproteins. Virology (2002) 1.11
Regulation of human papillomavirus type 16 E7 activity through direct protein interaction with the E2 transcriptional activator. J Virol (2006) 1.11
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Regulation of the discs large tumor suppressor by a phosphorylation-dependent interaction with the beta-TrCP ubiquitin ligase receptor. J Biol Chem (2003) 1.04
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Differential expression of the human homologue of drosophila discs large oncosuppressor in histologic samples from human papillomavirus-associated lesions as a marker for progression to malignancy. Int J Cancer (2004) 1.03
Stabilization of HPV16 E6 protein by PDZ proteins, and potential implications for genome maintenance. Virology (2011) 1.02
Analysis of specificity determinants in the interactions of different HPV E6 proteins with their PDZ domain-containing substrates. Virology (2008) 1.02
HPV-16 E2 contributes to induction of HPV-16 late gene expression by inhibiting early polyadenylation. EMBO J (2012) 1.00
Degradation of hDlg and MAGIs by human papillomavirus E6 is E6-AP-independent. J Gen Virol (2004) 0.99
SNX17 facilitates infection with diverse papillomavirus types. J Virol (2012) 0.98
The stability of the human papillomavirus E6 oncoprotein is E6AP dependent. Virology (2009) 0.98
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Crosstalk between the human papillomavirus E2 transcriptional activator and the E6 oncoprotein. Oncogene (2005) 0.96
High-risk human papillomavirus E6 oncoproteins interact with 14-3-3ζ in a PDZ binding motif-dependent manner. J Virol (2012) 0.96
Redistribution of the discs large tumor suppressor protein during mitosis. Exp Cell Res (2003) 0.95
HPV E6 proteins interact with specific PML isoforms and allow distinctions to be made between different POD structures. Oncogene (2004) 0.94
The role of protein kinase A regulation of the E6 PDZ-binding domain during the differentiation-dependent life cycle of human papillomavirus type 18. J Virol (2013) 0.94
Cloning and functional analysis of the promoter region of the human Disc large gene. Gene (2008) 0.94
Inhibition of E6-induced degradation of its cellular substrates by novel blocking peptides. J Mol Biol (2004) 0.93
Chimaeric HPV E6 proteins allow dissection of the proteolytic pathways regulating different E6 cellular target proteins. Oncogene (2002) 0.92
Comparative analysis of transforming properties of E6 and E7 from different beta human papillomavirus types. J Virol (2011) 0.92
The human papillomavirus (HPV) E6* proteins from high-risk, mucosal HPVs can direct degradation of cellular proteins in the absence of full-length E6 protein. J Virol (2009) 0.92
The invasive capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF/RhoG activity. PLoS Pathog (2012) 0.92
Skip interacts with the retinoblastoma tumor suppressor and inhibits its transcriptional repression activity. Nucleic Acids Res (2002) 0.91
Analysis of the PDZ binding specificities of Influenza A virus NS1 proteins. Virol J (2011) 0.91
Mutational analysis of the discs large tumour suppressor identifies domains responsible for human papillomavirus type 18 E6-mediated degradation. J Gen Virol (2002) 0.91
Geographical distribution and oncogenic risk association of human papillomavirus type 58 E6 and E7 sequence variations. Int J Cancer (2012) 0.91
Modification of human papillomavirus minor capsid protein L2 by sumoylation. J Virol (2010) 0.90
E6 and E7 from human papillomavirus type 16 cooperate to target the PDZ protein Na/H exchange regulatory factor 1. J Virol (2011) 0.90
The Mdm2 ubiquitin ligase enhances transcriptional activity of human papillomavirus E2. J Virol (2008) 0.89
Ubiquitination and proteasome degradation of the E6 proteins of human papillomavirus types 11 and 18. J Gen Virol (2004) 0.89
Systematic analysis of the amino acid residues of human papillomavirus type 16 E7 conserved region 3 involved in dimerization and transformation. J Virol (2011) 0.89
The high-risk HPV E6 oncoprotein preferentially targets phosphorylated nuclear forms of hDlg. Virology (2009) 0.87
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Conserved region 3 of human papillomavirus 16 E7 contributes to deregulation of the retinoblastoma tumor suppressor. J Virol (2012) 0.87
Regulation of the hDlg/hScrib/Hugl-1 tumour suppressor complex. Exp Cell Res (2008) 0.87
Cleavage of MAGI-1, a tight junction PDZ protein, by caspases is an important step for cell-cell detachment in apoptosis. Apoptosis (2007) 0.86
CDK phosphorylation of the discs large tumour suppressor controls its localisation and stability. J Cell Sci (2008) 0.86
Cellular localization of MAGI-1 caspase cleavage products and their role in apoptosis. Biol Chem (2007) 0.85
Comparative transforming potential of different human papillomaviruses associated with non-melanoma skin cancer. Virology (2007) 0.85
Differential regulation of cell-cell contact, invasion and anoikis by hScrib and hDlg in keratinocytes. PLoS One (2012) 0.85
Regulation of the human papillomavirus type 18 E6/E6AP ubiquitin ligase complex by the HECT domain-containing protein EDD. J Virol (2011) 0.85
The role of inflammation in HPV infection of the Oesophagus. BMC Cancer (2013) 0.84
The E6E7 oncoproteins of cutaneous human papillomavirus type 38 interfere with the interferon pathway. Virology (2008) 0.83
A functional interaction between the MAGUK protein hDlg and the gap junction protein connexin 43 in cervical tumour cells. Biochem J (2012) 0.82
HPV E6 oncoprotein as a potential therapeutic target in HPV related cancers. Expert Opin Ther Targets (2013) 0.82
Regulation of translational efficiency by different splice variants of the Disc large 1 oncosuppressor 5'-UTR. FEBS J (2011) 0.82
Retinoblastoma-independent antiproliferative activity of novel intracellular antibodies against the E7 oncoprotein in HPV 16-positive cells. BMC Cancer (2011) 0.81
A novel interaction between hScrib and PP1γ downregulates ERK signaling and suppresses oncogene-induced cell transformation. PLoS One (2013) 0.81
hDLG/SAP97, a member of the MAGUK protein family, is a novel caspase target during cell-cell detachment in apoptosis. Biol Chem (2005) 0.81
Human papillomavirus-16 E7 protein inhibits the DNA interaction of the TATA binding transcription factor. J Cell Biochem (2002) 0.81
Interaction of HPV E6 oncoproteins with specific proteasomal subunits. Virology (2013) 0.80
Transformation assays for HPV oncoproteins. Methods Mol Med (2005) 0.79
Comparison of p53 and the PDZ domain containing protein MAGI-3 regulation by the E6 protein from high-risk human papillomaviruses. Virol J (2008) 0.79
The mechanism and implications of hScrib regulation of ERK. Small GTPases (2010) 0.79
The human papillomavirus E7 proteins associate with p190RhoGAP and alter its function. J Virol (2014) 0.78
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In vitro assays of substrate degradation induced by high-risk HPV E6 oncoproteins. Methods Mol Med (2005) 0.77
Disordered interactome of human papillomavirus. Curr Pharm Des (2014) 0.77
HPV proteins as targets for therapeutic intervention. Antivir Ther (2004) 0.77
Human papillomavirus infection, cancer & therapy. Indian J Med Res (2009) 0.76
Complementation of a p300/CBP defective-binding mutant of adenovirus E1a by human papillomavirus E6 proteins. J Gen Virol (2002) 0.76
Targeting the retinoblastoma protein by MC007L, gene product of the molluscum contagiosum virus: detection of a novel virus-cell interaction by a member of the poxviruses. J Virol (2008) 0.76