Published in Proc Natl Acad Sci U S A on June 24, 1997
Mechanisms of human papillomavirus-induced oncogenesis. J Virol (2004) 3.95
Pathogenesis of human papillomaviruses in differentiating epithelia. Microbiol Mol Biol Rev (2004) 3.52
Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein. Proc Natl Acad Sci U S A (1997) 3.37
The landscape of human proteins interacting with viruses and other pathogens. PLoS Pathog (2008) 3.11
Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase. Mol Cell Biol (2000) 2.79
Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and high-risk papillomavirus E6 oncoproteins. Oncogene (2000) 2.20
The HTLV-1 Tax interactome. Retrovirology (2008) 2.02
The human papillomavirus type 16 E6 gene alone is sufficient to induce carcinomas in transgenic animals. J Virol (1999) 2.01
Enhancement of infectivity and persistence in vivo by HBZ, a natural antisense coded protein of HTLV-1. Blood (2006) 1.98
Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins. J Virol (2000) 1.97
The human papillomavirus type 16 E6 oncoprotein can down-regulate p53 activity by targeting the transcriptional coactivator CBP/p300. J Virol (1999) 1.94
The PDZ ligand domain of the human papillomavirus type 16 E6 protein is required for E6's induction of epithelial hyperplasia in vivo. J Virol (2003) 1.91
The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation. Mol Cell Biol (1999) 1.84
HPV E6 and MAGUK protein interactions: determination of the molecular basis for specific protein recognition and degradation. Oncogene (2001) 1.78
Papillomavirus E6 proteins. Virology (2008) 1.70
Interferon regulatory factor 3 is a cellular partner of rotavirus NSP1. J Virol (2002) 1.67
Oncogenic activities of human papillomaviruses. Virus Res (2009) 1.60
A novel and conserved protein-protein interaction domain of mammalian Lin-2/CASK binds and recruits SAP97 to the lateral surface of epithelia. Mol Cell Biol (2002) 1.54
Adenovirus type 5 E4 open reading frame 4 protein induces apoptosis in transformed cells. J Virol (1998) 1.54
Epithelial cell polarity: a major gatekeeper against cancer? Cell Death Differ (2011) 1.51
The human papillomavirus type 16 E6 oncoprotein activates mTORC1 signaling and increases protein synthesis. J Virol (2010) 1.49
Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells. Proc Natl Acad Sci U S A (2001) 1.47
Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein. Proc Natl Acad Sci U S A (2000) 1.38
Craniofacial dysmorphogenesis including cleft palate in mice with an insertional mutation in the discs large gene. Mol Cell Biol (2001) 1.38
Human papillomavirus oncoprotein E6 inactivates the transcriptional coactivator human ADA3. Mol Cell Biol (2002) 1.38
Characterization of PDZ-binding kinase, a mitotic kinase. Proc Natl Acad Sci U S A (2000) 1.36
Role of the PDZ domain-binding motif of the oncoprotein E6 in the pathogenesis of human papillomavirus type 31. J Virol (2004) 1.35
Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions. Biochem J (2001) 1.29
Comprehensive analysis of host cellular interactions with human papillomavirus E6 proteins identifies new E6 binding partners and reflects viral diversity. J Virol (2012) 1.28
Requirement of PDZ-containing proteins for cell cycle regulation and differentiation in the mouse lens epithelium. Mol Cell Biol (2003) 1.27
Human papillomavirus type 16 E6-induced degradation of E6TP1 correlates with its ability to immortalize human mammary epithelial cells. J Virol (2001) 1.23
CREB-2, a cellular CRE-dependent transcription repressor, functions in association with Tax as an activator of the human T-cell leukemia virus type 1 promoter. J Virol (1998) 1.23
Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressor. EMBO J (2006) 1.22
Cell polarity proteins: common targets for tumorigenic human viruses. Oncogene (2008) 1.22
Association of E6AP (UBE3A) with human papillomavirus type 11 E6 protein. Virology (2006) 1.22
Viral oncoprotein-induced mislocalization of select PDZ proteins disrupts tight junctions and causes polarity defects in epithelial cells. J Cell Sci (2005) 1.22
Cellular binding partners of the human papillomavirus E6 protein. Arch Virol (2008) 1.21
Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis. Retrovirology (2009) 1.21
Selective PDZ protein-dependent stimulation of phosphatidylinositol 3-kinase by the adenovirus E4-ORF1 oncoprotein. Oncogene (2003) 1.20
PDZ binding motif of HTLV-1 Tax promotes virus-mediated T-cell proliferation in vitro and persistence in vivo. Blood (2005) 1.19
Link of the unique oncogenic properties of adenovirus type 9 E4-ORF1 to a select interaction with the candidate tumor suppressor protein ZO-2. EMBO J (2001) 1.18
HPV 5 and 8 E6 abrogate ATR activity resulting in increased persistence of UVB induced DNA damage. PLoS Pathog (2012) 1.16
HTLV tax: a fascinating multifunctional co-regulator of viral and cellular pathways. Front Microbiol (2012) 1.16
A new crucial protein interaction element that targets the adenovirus E4-ORF1 oncoprotein to membrane vesicles. J Virol (2007) 1.15
A mutant of human papillomavirus type 16 E6 deficient in binding alpha-helix partners displays reduced oncogenic potential in vivo. J Virol (2002) 1.15
Human papillomavirus E6 triggers upregulation of the antiviral and cancer genomic DNA deaminase APOBEC3B. MBio (2014) 1.15
Degradation of tyrosine phosphatase PTPN3 (PTPH1) by association with oncogenic human papillomavirus E6 proteins. J Virol (2006) 1.14
Human T Lymphotropic Virus Type 1 (HTLV-1): Molecular Biology and Oncogenesis. Viruses (2010) 1.13
Induction of cell cycle arrest by human T-cell lymphotropic virus type 1 Tax in hematopoietic progenitor (CD34+) cells: modulation of p21cip1/waf1 and p27kip1 expression. J Virol (2005) 1.13
Emerging theme: cellular PDZ proteins as common targets of pathogenic viruses. J Virol (2011) 1.12
The large and small isoforms of human papillomavirus type 16 E6 bind to and differentially affect procaspase 8 stability and activity. J Virol (2007) 1.11
Tissue polarity-dependent control of mammary epithelial homeostasis and cancer development: an epigenetic perspective. J Mammary Gland Biol Neoplasia (2010) 1.11
Beta-HPV 5 and 8 E6 promote p300 degradation by blocking AKT/p300 association. PLoS Pathog (2011) 1.10
Human and primate tumour viruses use PDZ binding as an evolutionarily conserved mechanism of targeting cell polarity regulators. Oncogene (2008) 1.10
Signals that dictate nuclear localization of human papillomavirus type 16 oncoprotein E6 in living cells. J Virol (2003) 1.08
A carboxy-terminal region required by the adenovirus type 9 E4 ORF1 oncoprotein for transformation mediates direct binding to cellular polypeptides. J Virol (1997) 1.08
E6AP-dependent degradation of DLG4/PSD95 by high-risk human papillomavirus type 18 E6 protein. J Virol (2006) 1.08
The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity. Mol Cell Biol (2007) 1.07
The avian influenza virus NS1 ESEV PDZ binding motif associates with Dlg1 and Scribble to disrupt cellular tight junctions. J Virol (2011) 1.07
Viral oncogenes, noncoding RNAs, and RNA splicing in human tumor viruses. Int J Biol Sci (2010) 1.05
The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2. J Cell Biochem (2000) 1.03
Modulation of apoptosis by human papillomavirus (HPV) oncoproteins. Arch Virol (2006) 1.00
Early region 1 transforming functions are dispensable for mammary tumorigenesis by human adenovirus type 9. J Virol (1999) 1.00
Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes. Proc Natl Acad Sci U S A (2014) 0.99
HPV16 E7 oncogene expression in normal human epithelial cells causes molecular changes indicative of an epithelial to mesenchymal transition. Virology (2009) 0.99
Cell cycle regulation in the developing lens. Semin Cell Dev Biol (2006) 0.97
A non-oncogenic HPV 16 E6/E7 vaccine enhances treatment of HPV expressing tumors. Cancer Gene Ther (2012) 0.97
High-risk human papillomavirus E6 oncoproteins interact with 14-3-3ζ in a PDZ binding motif-dependent manner. J Virol (2012) 0.96
The HPV16 E6 oncoprotein causes prolonged receptor protein tyrosine kinase signaling and enhances internalization of phosphorylated receptor species. PLoS Pathog (2013) 0.94
The human papillomavirus 16 E6 protein can either protect or further sensitize cells to TNF: effect of dose. Cell Death Differ (2005) 0.94
Genetic evidence of a role for ATM in functional interaction between human T-cell leukemia virus type 1 Tax and p53. J Virol (2001) 0.94
Inactivation of tumor suppressor Dlg1 augments transformation of a T-cell line induced by human T-cell leukemia virus type 1 Tax protein. Retrovirology (2006) 0.93
WIF1 is a frequent target for epigenetic silencing in squamous cell carcinoma of the cervix. Carcinogenesis (2011) 0.93
Adenovirus E4orf6 oncoprotein modulates the function of the p53-related protein, p73. Proc Natl Acad Sci U S A (1998) 0.93
Human papillomavirus type 16 E2 and E6 are RNA-binding proteins and inhibit in vitro splicing of pre-mRNAs with suboptimal splice sites. Virology (2009) 0.93
Human viruses and cancer. Viruses (2014) 0.92
The invasive capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF/RhoG activity. PLoS Pathog (2012) 0.92
Biology of human papillomavirus-related oropharyngeal cancer. Semin Radiat Oncol (2012) 0.90
Human tumour viruses and the deregulation of cell polarity in cancer. Nat Rev Cancer (2012) 0.90
Determinants of stability for the E6 protein of papillomavirus type 16. J Mol Biol (2009) 0.89
Several E4 region functions influence mammary tumorigenesis by human adenovirus type 9. J Virol (2001) 0.89
HPV 5 and 8 E6 expression reduces ATM protein levels and attenuates LINE-1 retrotransposition. Virology (2013) 0.89
The critical protein interactions and structures that elicit growth deregulation in cancer and viral replication. Wiley Interdiscip Rev Syst Biol Med (2010) 0.88
The human adenovirus E4-ORF1 protein subverts discs large 1 to mediate membrane recruitment and dysregulation of phosphatidylinositol 3-kinase. PLoS Pathog (2014) 0.88
The ING4 Binding with p53 and Induced p53 Acetylation were Attenuated by Human Papillomavirus 16 E6. PLoS One (2013) 0.86
PDZ domains and viral infection: versatile potentials of HPV-PDZ interactions in relation to malignancy. Biomed Res Int (2013) 0.86
Biophysical characterization of the complex between human papillomavirus E6 protein and synapse-associated protein 97. J Biol Chem (2010) 0.85
Functionally distinct monomers and trimers produced by a viral oncoprotein. Oncogene (2007) 0.84
The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy. Viruses (2015) 0.84
Ras modifies proliferation and invasiveness of cells expressing human papillomavirus oncoproteins. J Virol (2008) 0.83
Requirement for Dlgh-1 in planar cell polarity and skeletogenesis during vertebrate development. PLoS One (2013) 0.83
Evolution of human papillomavirus carcinogenicity. Adv Virus Res (2010) 0.83
Regulation of the DLG tumor suppressor by β-catenin. Int J Cancer (2012) 0.83
Warts, cancer and ubiquitylation: lessons from the papillomaviruses. Trans Am Clin Climatol Assoc (2006) 0.82
Doxycycline-regulated 3T3-L1 preadipocyte cell line with inducible, stable expression of adenoviral E4orf1 gene: a cell model to study insulin-independent glucose disposal. PLoS One (2013) 0.82
Oncogenes and RNA splicing of human tumor viruses. Emerg Microbes Infect (2014) 0.82
Cancer-causing human papillomavirus E6 proteins display major differences in the phospho-regulation of their PDZ interactions. J Virol (2014) 0.81
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell (1992) 9.19
Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science (1995) 8.61
Recognition of unique carboxyl-terminal motifs by distinct PDZ domains. Science (1997) 8.16
Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases. Nature (1995) 5.54
The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions. Cell (1991) 5.30
Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein. Science (1996) 3.42
Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP. Nature (1996) 3.27
Dlg protein is required for junction structure, cell polarity, and proliferation control in Drosophila epithelia. J Cell Biol (1996) 3.24
DHR domains in syntrophins, neuronal NO synthases and other intracellular proteins. Trends Biochem Sci (1995) 3.06
HTLV-I Tax protein stimulation of DNA binding of bZIP proteins by enhancing dimerization. Science (1993) 3.05
Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1. Proc Natl Acad Sci U S A (1994) 2.41
Molecular characterization and spatial distribution of SAP97, a novel presynaptic protein homologous to SAP90 and the Drosophila discs-large tumor suppressor protein. J Neurosci (1995) 2.40
Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins. Neuron (1996) 2.39
Mutations in the APC gene and their implications for protein structure and function. Curr Opin Genet Dev (1995) 2.22
Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein. Science (1995) 2.20
PDZs and receptor/channel clustering: rounding up the latest suspects. Neuron (1996) 2.17
Constitutive activation of NF-kappa B is essential for transformation of rat fibroblasts by the human T-cell leukemia virus type I Tax protein. EMBO J (1996) 1.85
Exclusion of Int-6 from PML nuclear bodies by binding to the HTLV-I Tax oncoprotein. Science (1996) 1.72
Type I human T cell leukemia virus tax protein transforms rat fibroblasts through the cyclic adenosine monophosphate response element binding protein/activating transcription factor pathway. J Clin Invest (1991) 1.58
Adenovirus type 9 E4 open reading frame 1 encodes a transforming protein required for the production of mammary tumors in rats. J Virol (1994) 1.54
Tight junctions, membrane-associated guanylate kinases and cell signaling. Curr Opin Cell Biol (1995) 1.49
Human adenovirus type 9-induced rat mammary tumors. J Virol (1991) 1.43
Requirement for the adenovirus type 9 E4 region in production of mammary tumors. Science (1992) 1.41
Human adenovirus early region 4 open reading frame 1 genes encode growth-transforming proteins that may be distantly related to dUTP pyrophosphatase enzymes. J Virol (1997) 1.39
HTLV-I and HTLV-II Tax: differences in induction of micronuclei in cells and transcriptional activation of viral LTRs. Virology (1996) 1.35
Human adenovirus type 9 E4 open reading frame 1 encodes a cytoplasmic transforming protein capable of increasing the oncogenicity of CREF cells. J Virol (1996) 1.26
Mutant adenovirus type 9 E4 ORF1 genes define three protein regions required for transformation of CREF cells. J Virol (1997) 1.20
In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. Oncogene (1993) 4.03
Herpes simplex virus latent phase transcription facilitates in vivo reactivation. Virology (1990) 4.00
Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins. J Virol (2000) 1.97
Genetic and biological analyses of a herpes simplex virus intertypic recombinant reduced specifically for neurovirulence. J Virol (1987) 1.40
Two avirulent herpes simplex viruses generate lethal recombinants in vivo. Science (1986) 1.40
Human adenovirus early region 4 open reading frame 1 genes encode growth-transforming proteins that may be distantly related to dUTP pyrophosphatase enzymes. J Virol (1997) 1.39
Human adenovirus type 9 E4 open reading frame 1 encodes a cytoplasmic transforming protein capable of increasing the oncogenicity of CREF cells. J Virol (1996) 1.26
Mutant adenovirus type 9 E4 ORF1 genes define three protein regions required for transformation of CREF cells. J Virol (1997) 1.20
Link of the unique oncogenic properties of adenovirus type 9 E4-ORF1 to a select interaction with the candidate tumor suppressor protein ZO-2. EMBO J (2001) 1.18
Pathogenesis of a lethal mixed infection in mice with two nonneuroinvasive herpes simplex virus strains. J Virol (1988) 1.08
A carboxy-terminal region required by the adenovirus type 9 E4 ORF1 oncoprotein for transformation mediates direct binding to cellular polypeptides. J Virol (1997) 1.08
The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2. J Cell Biochem (2000) 1.03
Early region 1 transforming functions are dispensable for mammary tumorigenesis by human adenovirus type 9. J Virol (1999) 1.00
The effect of Hus1 on ionizing radiation sensitivity is associated with homologous recombination repair but is independent of nonhomologous end-joining. Oncogene (2006) 0.93
Loss of Hus1 sensitizes cells to etoposide-induced apoptosis by regulating BH3-only proteins. Oncogene (2008) 0.86
Functionally distinct monomers and trimers produced by a viral oncoprotein. Oncogene (2007) 0.84
Effect of temperature on sodium-calcium exchange in sarcolemma from mammalian and amphibian hearts. Biochim Biophys Acta (1991) 0.81
Lysophosphatidylcholine and sodium-calcium exchange in cardiac sarcolemma: comparison with ischemia. Am J Physiol (1991) 0.80
Sarcolemmal calcium transporters in myocardial ischemia. J Mol Cell Cardiol (1997) 0.77
The experience of AIDS: hypotheses based on pilot study interviews. J Palliat Care (1988) 0.75
5. Marriage and the family in the near future. In: The family and its future. Ciba Found Symp (1970) 0.75
Health-care-dollar bank account. CMAJ (1988) 0.75
The nature of case manager support. Hosp Community Psychiatry (1984) 0.75
Men and the family. Fam Process (1985) 0.75
Pacific Science Center. Science (1964) 0.75
Principles underlying a manual for parents whose children were killed by a drunk driver. Am J Orthopsychiatry (1987) 0.75
Is it possible to prepare for trauma? J Palliat Care (1988) 0.75