Severe acute intermittent hypoxia elicits phrenic long-term facilitation by a novel adenosine-dependent mechanism.

PubWeight™: 1.10‹?› | Rank: Top 10%

🔗 View Article (PMC 3365407)

Published in J Appl Physiol (1985) on March 08, 2012

Authors

Nicole L Nichols1, Erica A Dale, Gordon S Mitchell

Author Affiliations

1: Department of Comparative Biosciences, University of Wisconsin, School of Veterinary Medicine, Madison, Wisconsin 53706, USA.

Articles citing this

Therapeutic potential of intermittent hypoxia: a matter of dose. Am J Physiol Regul Integr Comp Physiol (2014) 1.07

Phrenic long-term facilitation after acute intermittent hypoxia requires spinal ERK activation but not TrkB synthesis. J Appl Physiol (1985) (2012) 1.02

Hypoxia-induced phrenic long-term facilitation: emergent properties. Ann N Y Acad Sci (2013) 1.01

Repetitive acute intermittent hypoxia increases expression of proteins associated with plasticity in the phrenic motor nucleus. Exp Neurol (2012) 1.01

Intermittent hypoxia and neurorehabilitation. J Appl Physiol (1985) (2015) 0.98

The impact of arousal state, sex, and sleep apnea on the magnitude of progressive augmentation and ventilatory long-term facilitation. J Appl Physiol (1985) (2012) 0.98

Spinal 5-HT7 receptors and protein kinase A constrain intermittent hypoxia-induced phrenic long-term facilitation. Neuroscience (2013) 0.91

Intermittent hypoxia, respiratory plasticity and sleep apnea in humans: present knowledge and future investigations. Respir Physiol Neurobiol (2013) 0.88

Inactivity-induced respiratory plasticity: protecting the drive to breathe in disorders that reduce respiratory neural activity. Respir Physiol Neurobiol (2013) 0.86

Spinal atypical protein kinase C activity is necessary to stabilize inactivity-induced phrenic motor facilitation. J Neurosci (2012) 0.86

Daily acute intermittent hypoxia elicits functional recovery of diaphragm and inspiratory intercostal muscle activity after acute cervical spinal injury. Exp Neurol (2015) 0.85

Peripheral-central chemoreceptor interaction and the significance of a critical period in the development of respiratory control. Respir Physiol Neurobiol (2012) 0.82

Spinal 5-HT7 receptors induce phrenic motor facilitation via EPAC-mTORC1 signaling. J Neurophysiol (2015) 0.82

Spinal metaplasticity in respiratory motor control. Front Neural Circuits (2015) 0.82

Inactivity-induced phrenic and hypoglossal motor facilitation are differentially expressed following intermittent vs. sustained neural apnea. J Appl Physiol (1985) (2013) 0.81

Acute intermittent hypoxia induced phrenic long-term facilitation despite increased SOD1 expression in a rat model of ALS. Exp Neurol (2015) 0.81

Spinal TNF is necessary for inactivity-induced phrenic motor facilitation. J Physiol (2013) 0.80

Respiratory function after selective respiratory motor neuron death from intrapleural CTB-saporin injections. Exp Neurol (2014) 0.80

Acute intermittent optogenetic stimulation of nucleus tractus solitarius neurons induces sympathetic long-term facilitation. Am J Physiol Regul Integr Comp Physiol (2014) 0.80

Ventilatory long-term facilitation is evident after initial and repeated exposure to intermittent hypoxia in mice genetically depleted of brain serotonin. J Appl Physiol (1985) (2013) 0.80

Mammalian target of rapamycin is required for phrenic long-term facilitation following severe but not moderate acute intermittent hypoxia. J Neurophysiol (2015) 0.78

Adenosine 2A receptor inhibition enhances intermittent hypoxia-induced diaphragm but not intercostal long-term facilitation. J Neurotrauma (2014) 0.78

Quantitative assessment of integrated phrenic nerve activity. Respir Physiol Neurobiol (2015) 0.77

Enhanced recovery of breathing capacity from combined adenosine 2A receptor inhibition and daily acute intermittent hypoxia after chronic cervical spinal injury. Exp Neurol (2016) 0.77

Time Domains of the Hypoxic Ventilatory Response and Their Molecular Basis. Compr Physiol (2016) 0.76

Signalling mechanisms of long term facilitation of breathing with intermittent hypoxia. F1000Prime Rep (2013) 0.76

Activation of 5-hyrdoxytryptamine 7 receptors within the rat nucleus tractus solitarii modulates synaptic properties. Brain Res (2016) 0.75

Sustained Hypoxia Elicits Competing Spinal Mechanisms of Phrenic Motor Facilitation. J Neurosci (2016) 0.75

Adenosine-Dependent Phrenic Motor Facilitation is Inflammation Resistant. J Neurophysiol (2016) 0.75

Chronic Intermittent Hypoxia Differentially Impacts Different States of Inspiratory Activity at the Level of the preBötzinger Complex. Front Physiol (2017) 0.75

Mechanisms of enhanced phrenic long-term facilitation in SOD1(G93A) rats. J Neurosci (2017) 0.75

Articles cited by this

Breathing: rhythmicity, plasticity, chemosensitivity. Annu Rev Neurosci (2003) 4.82

BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia. Nat Neurosci (2003) 2.79

Time domains of the hypoxic ventilatory response. Respir Physiol (1998) 2.67

Neuroplasticity in respiratory motor control. J Appl Physiol (1985) (2003) 2.55

Hypoxia-induced long-term facilitation of respiratory activity is serotonin dependent. Respir Physiol (1996) 2.49

Phrenic long-term facilitation requires spinal serotonin receptor activation and protein synthesis. J Neurosci (2002) 2.17

Phrenic long-term facilitation requires 5-HT receptor activation during but not following episodic hypoxia. J Appl Physiol (1985) (2001) 1.97

Is there a link between intermittent hypoxia-induced respiratory plasticity and obstructive sleep apnoea? Exp Physiol (2006) 1.95

Prolonged stimulation of respiration by endogenous central serotonin. Respir Physiol (1980) 1.91

Long term facilitation of phrenic motor output. Respir Physiol (2000) 1.88

Time-dependent phrenic nerve responses to carotid afferent activation: intact vs. decerebellate rats. Am J Physiol (1993) 1.84

Episodic but not continuous hypoxia elicits long-term facilitation of phrenic motor output in rats. J Physiol (2000) 1.83

Neurotransmitters and neuromodulators controlling the hypoxic respiratory response in anaesthetized cats. J Physiol (1999) 1.82

Prolonged stimulation of respiration by a new central neural mechanism. Respir Physiol (1980) 1.79

Experimental protocols and preparations to study respiratory long term facilitation. Respir Physiol Neurobiol (2011) 1.71

Reactive oxygen species in the plasticity of respiratory behavior elicited by chronic intermittent hypoxia. J Appl Physiol (1985) (2003) 1.68

Release of ATP in the ventral medulla during hypoxia in rats: role in hypoxic ventilatory response. J Neurosci (2005) 1.54

Long-term facilitation of inspiratory intercostal nerve activity following carotid sinus nerve stimulation in cats. J Physiol (1994) 1.49

Spinal adenosine A2a receptor activation elicits long-lasting phrenic motor facilitation. J Neurosci (2008) 1.46

Adenosine released by astrocytes contributes to hypoxia-induced modulation of synaptic transmission. Glia (2007) 1.44

Intermittent hypoxia induces phrenic long-term facilitation in carotid-denervated rats. J Appl Physiol (1985) (2002) 1.42

Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation. Cell Tissue Res (2006) 1.38

High-resolution real-time recording with microelectrode biosensors reveals novel aspects of adenosine release during hypoxia in rat hippocampal slices. J Neurochem (2003) 1.37

Cross-talk between G(s)- and G(q)-coupled pathways in regulation of interleukin-4 by A(2B) adenosine receptors in human mast cells. Mol Pharmacol (2006) 1.33

Episodic stimulation of alpha1-adrenoreceptors induces protein kinase C-dependent persistent changes in motoneuronal excitability. J Neurosci (2007) 1.30

Multiple pathways to long-lasting phrenic motor facilitation. Adv Exp Med Biol (2010) 1.30

Respiratory long-term facilitation following intermittent hypoxia requires reactive oxygen species formation. Neuroscience (2008) 1.26

Intermittent hypoxia and respiratory plasticity in humans and other animals: does exposure to intermittent hypoxia promote or mitigate sleep apnoea? Exp Physiol (2008) 1.26

Determinants of frequency long-term facilitation following acute intermittent hypoxia in vagotomized rats. Respir Physiol Neurobiol (2008) 1.24

Direct measurement of adenosine release during hypoxia in the CA1 region of the rat hippocampal slice. J Physiol (2000) 1.20

Time-dependent hypoxic ventilatory responses in rats: effects of ketanserin and 5-carboxamidotryptamine. Am J Physiol (1999) 1.19

Okadaic acid-sensitive protein phosphatases constrain phrenic long-term facilitation after sustained hypoxia. J Neurosci (2008) 1.18

Sensing hypoxia in the carotid body: from stimulus to response. Essays Biochem (2007) 1.14

NADPH oxidase activity is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation. J Physiol (2009) 1.14

Simulated apnoeas induce serotonin-dependent respiratory long-term facilitation in rats. J Physiol (2008) 1.10

Spinal adenosine A2(A) receptor inhibition enhances phrenic long term facilitation following acute intermittent hypoxia. J Physiol (2009) 1.08

Identification of G protein-coupled signaling pathways in cardiac fibroblasts: cross talk between G(q) and G(s). Am J Physiol Cell Physiol (2000) 1.07

Integrated phrenic responses to carotid afferent stimulation in adult rats following perinatal hyperoxia. J Physiol (1997) 1.05

Serotonin 2A and 2B receptor-induced phrenic motor facilitation: differential requirement for spinal NADPH oxidase activity. Neuroscience (2011) 1.04

Up-regulation of endogenous RGS2 mediates cross-desensitization between Gs and Gq signaling in osteoblasts. J Biol Chem (2006) 1.04

Spinal 5-HT7 receptor activation induces long-lasting phrenic motor facilitation. J Physiol (2011) 1.03

Astrocytes and neurons: different roles in regulating adenosine levels. Neurol Res (2005) 1.00

Prolonged inhibition of respiration following acute hypoxia in glomectomized cats. Respir Physiol (1984) 0.96

Adenosine 5'-triphosphate release from the normoxic and hypoxic in vivo rat cerebral cortex. Neurosci Lett (1993) 0.96

Modulation of hypoglossal motoneuron excitability by intracellular signal transduction cascades. Respir Physiol Neurobiol (2005) 0.95

5-Hydroxytryptophan (5-HTP) augments spontaneous and evoked phrenic motoneuron discharge in spinalized rats. Neurosci Lett (1992) 0.88

Release of adenosine and other purines from hippocampal slices stimulated electrically or by hypoxia/hypoglycemia. Effect of chlormethiazole. Life Sci (1994) 0.85

Two long-lasting central respiratory responses following acute hypoxia in glomectomized cats. J Physiol (1988) 0.83

Carotid chemoafferent activity is not necessary for all phrenic long-term facilitation following acute intermittent hypoxia. Respir Physiol Neurobiol (2010) 0.83

Articles by these authors

Breathing: rhythmicity, plasticity, chemosensitivity. Annu Rev Neurosci (2003) 4.82

BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia. Nat Neurosci (2003) 2.79

Phrenic long-term facilitation requires spinal serotonin receptor activation and protein synthesis. J Neurosci (2002) 2.17

Spinal synaptic enhancement with acute intermittent hypoxia improves respiratory function after chronic cervical spinal cord injury. J Neurosci (2005) 2.01

Is there a link between intermittent hypoxia-induced respiratory plasticity and obstructive sleep apnoea? Exp Physiol (2006) 1.95

Daily intermittent hypoxia enhances walking after chronic spinal cord injury: a randomized trial. Neurology (2013) 1.73

Synaptic pathways to phrenic motoneurons are enhanced by chronic intermittent hypoxia after cervical spinal cord injury. J Neurosci (2003) 1.68

Recovery of phrenic activity and ventilation after cervical spinal hemisection in rats. J Appl Physiol (1985) (2005) 1.55

Short-term modulation of the exercise ventilatory response in young men. J Appl Physiol (1985) (2007) 1.49

Exercise increases hippocampal neurogenesis to high levels but does not improve spatial learning in mice bred for increased voluntary wheel running. Behav Neurosci (2003) 1.48

Spinal adenosine A2a receptor activation elicits long-lasting phrenic motor facilitation. J Neurosci (2008) 1.46

Intermittent hypoxia induces phrenic long-term facilitation in carotid-denervated rats. J Appl Physiol (1985) (2002) 1.42

Repetitive intermittent hypoxia induces respiratory and somatic motor recovery after chronic cervical spinal injury. J Neurosci (2012) 1.40

Daily intermittent hypoxia augments spinal BDNF levels, ERK phosphorylation and respiratory long-term facilitation. Exp Neurol (2009) 1.39

Episodic stimulation of alpha1-adrenoreceptors induces protein kinase C-dependent persistent changes in motoneuronal excitability. J Neurosci (2007) 1.30

Multiple pathways to long-lasting phrenic motor facilitation. Adv Exp Med Biol (2010) 1.30

Determinants of frequency long-term facilitation following acute intermittent hypoxia in vagotomized rats. Respir Physiol Neurobiol (2008) 1.24

Intermittent hypoxia and stem cell implants preserve breathing capacity in a rodent model of amyotrophic lateral sclerosis. Am J Respir Crit Care Med (2012) 1.20

Exposure to acute intermittent hypoxia augments somatic motor function in humans with incomplete spinal cord injury. Neurorehabil Neural Repair (2011) 1.20

Intermittent hypoxia induces functional recovery following cervical spinal injury. Respir Physiol Neurobiol (2009) 1.19

Cervical spinal cord injury upregulates ventral spinal 5-HT2A receptors. J Neurotrauma (2005) 1.18

Okadaic acid-sensitive protein phosphatases constrain phrenic long-term facilitation after sustained hypoxia. J Neurosci (2008) 1.18

Long-term effects of the perinatal environment on respiratory control. J Appl Physiol (1985) (2008) 1.18

7,8-dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndrome. J Appl Physiol (1985) (2011) 1.14

Simulated apnoeas induce serotonin-dependent respiratory long-term facilitation in rats. J Physiol (2008) 1.10

Sex steroid hormones and the neural control of breathing. Respir Physiol Neurobiol (2003) 1.08

Spinal vascular endothelial growth factor induces phrenic motor facilitation via extracellular signal-regulated kinase and Akt signaling. J Neurosci (2011) 1.07

Spinal plasticity following intermittent hypoxia: implications for spinal injury. Ann N Y Acad Sci (2010) 1.05

Hypoxia-induced phrenic long-term facilitation: emergent properties. Ann N Y Acad Sci (2013) 1.01

Repetitive acute intermittent hypoxia increases expression of proteins associated with plasticity in the phrenic motor nucleus. Exp Neurol (2012) 1.01

Exercise-induced changes in hippocampal brain-derived neurotrophic factor and neurotrophin-3: effects of rat strain. Brain Res (2003) 0.98

Chronic cervical spinal sensory denervation reveals ineffective spinal pathways to phrenic motoneurons in the rat. Neurosci Lett (2002) 0.96

Cervical spinal erythropoietin induces phrenic motor facilitation via extracellular signal-regulated protein kinase and Akt signaling. J Neurosci (2012) 0.95

Lipopolysaccharide attenuates phrenic long-term facilitation following acute intermittent hypoxia. Respir Physiol Neurobiol (2011) 0.94

Developmental aspects of the upper airway: report from an NHLBI Workshop, March 5-6, 2009. Proc Am Thorac Soc (2009) 0.92

Early postnatal chronic intermittent hypoxia modifies hypoxic respiratory responses and long-term phrenic facilitation in adult rats. Am J Physiol Regul Integr Comp Physiol (2006) 0.92

Reduced respiratory neural activity elicits phrenic motor facilitation. Respir Physiol Neurobiol (2010) 0.89

Respiratory plasticity after perinatal hyperoxia is not prevented by antioxidant supplementation. Respir Physiol Neurobiol (2007) 0.88

Respiratory long-term facilitation: too much or too little of a good thing? Adv Exp Med Biol (2008) 0.88

Differences in time-dependent hypoxic phrenic responses among inbred rat strains. J Appl Physiol (1985) (2004) 0.88

Common mechanisms of compensatory respiratory plasticity in spinal neurological disorders. Respir Physiol Neurobiol (2013) 0.86

Back to the future: carbon dioxide chemoreceptors in the mammalian brain. Nat Neurosci (2004) 0.86

Glial activation in the spinal ventral horn caudal to cervical injury. Respir Physiol Neurobiol (2011) 0.85

Short-term modulation of the exercise ventilatory response in younger and older women. Respir Physiol Neurobiol (2011) 0.83

Spinal vascular endothelial growth factor (VEGF) and erythropoietin (EPO) induced phrenic motor facilitation after repetitive acute intermittent hypoxia. Respir Physiol Neurobiol (2012) 0.82

Activity-dependent plasticity in descending synaptic inputs to respiratory spinal motoneurons. Respir Physiol Neurobiol (2002) 0.82

Carotid sinus nerve responses and ventilatory acclimatization to hypoxia in adult rats following 2 weeks of postnatal hyperoxia. Respir Physiol Neurobiol (2005) 0.82

Increased GABA(A) receptor ε-subunit expression on ventral respiratory column neurons protects breathing during pregnancy. PLoS One (2012) 0.81

Short- and long-term modulation of the exercise ventilatory response. Med Sci Sports Exerc (2010) 0.81

Role of synaptic inhibition in turtle respiratory rhythm generation. J Physiol (2002) 0.81

Short-term modulation of the exercise ventilatory response in older men. Respir Physiol Neurobiol (2010) 0.79

Adenosine 2A receptor inhibition enhances intermittent hypoxia-induced diaphragm but not intercostal long-term facilitation. J Neurotrauma (2014) 0.78

Respiratory plasticity after perinatal hypercapnia in rats. Respir Physiol Neurobiol (2005) 0.77

Overview: the neurochemistry of respiratory control. Respir Physiol Neurobiol (2008) 0.77

Exercise training effects on hypoxic and hypercapnic ventilatory responses in mice selected for increased voluntary wheel running. Exp Physiol (2013) 0.77

Breathing mechanics during exercise with added dead space reflect mechanisms of ventilatory control. Respir Physiol Neurobiol (2009) 0.76

Clinical challenges to ventilatory control. Respir Physiol Neurobiol (2013) 0.75

Breathing in thin air: acclimatization to altitude in ducks. Respir Physiol Neurobiol (2004) 0.75

Carotid chemoafferent plasticity in adult rats following developmental hyperoxia. Respir Physiol Neurobiol (2005) 0.75

Effect of Thoracic Epidural Anesthesia on Ventricular Excitability in a Porcine Model. Anesthesiology (2017) 0.75