Breathing: rhythmicity, plasticity, chemosensitivity.

Looking for inspiration: new perspectives on respiratory rhythm. Nat Rev Neurosci (2006) 4.70

The sudden infant death syndrome. N Engl J Med (2009) 3.97

Distinct rhythm generators for inspiration and expiration in the juvenile rat. J Physiol (2005) 2.94

Genetic analysis of crawling and swimming locomotory patterns in C. elegans. Proc Natl Acad Sci U S A (2008) 2.92

Photostimulation of retrotrapezoid nucleus phox2b-expressing neurons in vivo produces long-lasting activation of breathing in rats. J Neurosci (2009) 2.36

Peripheral chemoreceptor inputs to retrotrapezoid nucleus (RTN) CO2-sensitive neurons in rats. J Physiol (2006) 2.31

A human mutation in Phox2b causes lack of CO2 chemosensitivity, fatal central apnea, and specific loss of parafacial neurons. Proc Natl Acad Sci U S A (2008) 2.19

Central pathways of pulmonary and lower airway vagal afferents. J Appl Physiol (1985) (2006) 2.17

General anesthesia and altered states of arousal: a systems neuroscience analysis. Annu Rev Neurosci (2011) 2.15

Medullary serotonergic neurones and adjacent neurones that express neurokinin-1 receptors are both involved in chemoreception in vivo. J Physiol (2004) 2.09

Central respiratory chemoreception. J Comp Neurol (2010) 2.06

Understanding the rhythm of breathing: so near, yet so far. Annu Rev Physiol (2012) 2.01

Raphé neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P. J Neurosci (2009) 1.88

Sleep-disordered breathing after targeted ablation of preBötzinger complex neurons. Nat Neurosci (2005) 1.88

A carbon dioxide avoidance behavior is integrated with responses to ambient oxygen and food in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2008) 1.83

Connexin hemichannel-mediated CO2-dependent release of ATP in the medulla oblongata contributes to central respiratory chemosensitivity. J Physiol (2010) 1.81

Central chemoreception is a complex system function that involves multiple brain stem sites. J Appl Physiol (1985) (2008) 1.78

The 2008 Carl Ludwig Lecture: retrotrapezoid nucleus, CO2 homeostasis, and breathing automaticity. J Appl Physiol (1985) (2008) 1.70

Neuromodulation by extracellular ATP and P2X receptors in the CNS. Neuron (2012) 1.70

A role for TASK-1 (KCNK3) channels in the chemosensory control of breathing. J Neurosci (2008) 1.69

Adenosine and ATP link PCO2 to cortical excitability via pH. Neuron (2005) 1.68

Genetic identification of an embryonic parafacial oscillator coupling to the preBötzinger complex. Nat Neurosci (2009) 1.64

The serotonin axis: Shared mechanisms in seizures, depression, and SUDEP. Epilepsia (2011) 1.59

Medullary serotonin neurons and central CO2 chemoreception. Respir Physiol Neurobiol (2009) 1.56

Retrotrapezoid nucleus and central chemoreception. J Physiol (2008) 1.54

Synaptic activity-independent persistent plasticity in endogenously active mammalian motoneurons. Proc Natl Acad Sci U S A (2004) 1.49

Selective lesion of retrotrapezoid Phox2b-expressing neurons raises the apnoeic threshold in rats. J Physiol (2008) 1.46

Ventilatory and cardiovascular responses to hypercapnia and hypoxia in multiple-system atrophy. Arch Neurol (2010) 1.43

Neuromodulation and the orchestration of the respiratory rhythm. Respir Physiol Neurobiol (2008) 1.40

Daily intermittent hypoxia augments spinal BDNF levels, ERK phosphorylation and respiratory long-term facilitation. Exp Neurol (2009) 1.39

Tracheal occlusion conditioning causes stress, anxiety and neural state changes in conscious rats. Exp Physiol (2012) 1.39

Task2 potassium channels set central respiratory CO2 and O2 sensitivity. Proc Natl Acad Sci U S A (2010) 1.36

Tonic signaling from O₂ sensors sets neural circuit activity and behavioral state. Nat Neurosci (2012) 1.34

Response of membrane potential and intracellular pH to hypercapnia in neurons and astrocytes from rat retrotrapezoid nucleus. Am J Physiol Regul Integr Comp Physiol (2005) 1.34

Reconfiguration of the pontomedullary respiratory network: a computational modeling study with coordinated in vivo experiments. J Neurophysiol (2008) 1.34

Central chemoreceptors and sympathetic vasomotor outflow. J Physiol (2006) 1.32

Projections of preBötzinger complex neurons in adult rats. J Comp Neurol (2010) 1.30

Temperature, oxygen, and salt-sensing neurons in C. elegans are carbon dioxide sensors that control avoidance behavior. Neuron (2011) 1.30

The chemical neuroanatomy of breathing. Respir Physiol Neurobiol (2008) 1.30

Contributions of 5-HT neurons to respiratory control: neuromodulatory and trophic effects. Respir Physiol Neurobiol (2008) 1.29

Reactive oxygen species and respiratory plasticity following intermittent hypoxia. Respir Physiol Neurobiol (2008) 1.27

Respiratory long-term facilitation following intermittent hypoxia requires reactive oxygen species formation. Neuroscience (2008) 1.26

Simultaneous inhibition of caudal medullary raphe and retrotrapezoid nucleus decreases breathing and the CO2 response in conscious rats. J Physiol (2006) 1.26

Sodium leak channels in neuronal excitability and rhythmic behaviors. Neuron (2011) 1.25

Determinants of frequency long-term facilitation following acute intermittent hypoxia in vagotomized rats. Respir Physiol Neurobiol (2008) 1.24

CO2-dependent opening of connexin 26 and related β connexins. J Physiol (2010) 1.22

Locus coeruleus noradrenergic neurons and CO2 drive to breathing. Pflugers Arch (2007) 1.22

Tuning and playing a motor rhythm: how metabotropic glutamate receptors orchestrate generation of motor patterns in the mammalian central nervous system. J Physiol (2006) 1.21

Focal CO2 dialysis in raphe obscurus does not stimulate ventilation but enhances the response to focal CO2 dialysis in the retrotrapezoid nucleus. J Appl Physiol (1985) (2008) 1.20

On the peripheral and central chemoreception and control of breathing: an emerging role of ATP. J Physiol (2005) 1.19

Intermittent hypoxia induces functional recovery following cervical spinal injury. Respir Physiol Neurobiol (2009) 1.19

PHYSIOLOGY. Regulation of breathing by CO₂ requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons. Science (2015) 1.17

Episodic spinal serotonin receptor activation elicits long-lasting phrenic motor facilitation by an NADPH oxidase-dependent mechanism. J Physiol (2009) 1.17

Photostimulation of Phox2b medullary neurons activates cardiorespiratory function in conscious rats. Am J Respir Crit Care Med (2010) 1.17

Sensory feedback control of mammalian vocalizations. Behav Brain Res (2007) 1.16

Neonatal maturation of the hypercapnic ventilatory response and central neural CO2 chemosensitivity. Respir Physiol Neurobiol (2005) 1.16

Inhibitory input from slowly adapting lung stretch receptors to retrotrapezoid nucleus chemoreceptors. J Physiol (2007) 1.14

NADPH oxidase activity is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation. J Physiol (2009) 1.14

Retrotrapezoid nucleus and parafacial respiratory group. Respir Physiol Neurobiol (2010) 1.12

Phrenic long-term facilitation requires NMDA receptors in the phrenic motonucleus in rats. J Physiol (2005) 1.12

Cholinergic neurotransmission in the preBötzinger Complex modulates excitability of inspiratory neurons and regulates respiratory rhythm. Neuroscience (2005) 1.11

Pre-Bötzinger complex receives glutamatergic innervation from galaninergic and other retrotrapezoid nucleus neurons. J Comp Neurol (2012) 1.11

Retrotrapezoid nucleus, respiratory chemosensitivity and breathing automaticity. Respir Physiol Neurobiol (2009) 1.10

Simulated apnoeas induce serotonin-dependent respiratory long-term facilitation in rats. J Physiol (2008) 1.10

Severe acute intermittent hypoxia elicits phrenic long-term facilitation by a novel adenosine-dependent mechanism. J Appl Physiol (1985) (2012) 1.10

Catecholamine neurones in rats modulate sleep, breathing, central chemoreception and breathing variability. J Physiol (2005) 1.10

Hypoglossal neuropathology and respiratory activity in pompe mice. Front Physiol (2011) 1.10

The respiratory neuromuscular system in Pompe disease. Respir Physiol Neurobiol (2013) 1.09

Regulation of breathing and autonomic outflows by chemoreceptors. Compr Physiol (2014) 1.09

Anesthetic activation of central respiratory chemoreceptor neurons involves inhibition of a THIK-1-like background K(+) current. J Neurosci (2010) 1.09

Spinal adenosine A2(A) receptor inhibition enhances phrenic long term facilitation following acute intermittent hypoxia. J Physiol (2009) 1.08

Release of ATP and glutamate in the nucleus tractus solitarii mediate pulmonary stretch receptor (Breuer-Hering) reflex pathway. J Physiol (2008) 1.08

Pain-facilitating medullary neurons contribute to opioid-induced respiratory depression. J Neurophysiol (2012) 1.07

Phox2b-expressing retrotrapezoid neurons are intrinsically responsive to H+ and CO2. J Neurosci (2013) 1.06

Central and peripheral chemoreceptors evoke distinct responses in simultaneously recorded neurons of the raphé-pontomedullary respiratory network. Philos Trans R Soc Lond B Biol Sci (2009) 1.06

The role of serotonin in respiratory function and dysfunction. Respir Physiol Neurobiol (2010) 1.05

Spinal plasticity following intermittent hypoxia: implications for spinal injury. Ann N Y Acad Sci (2010) 1.05

The disruption of central CO2 chemosensitivity in a mouse model of Rett syndrome. Am J Physiol Cell Physiol (2011) 1.05

Breathing with phox2b. Philos Trans R Soc Lond B Biol Sci (2009) 1.05

The polymorphic and contradictory aspects of intermittent hypoxia. Am J Physiol Lung Cell Mol Physiol (2014) 1.04

Carotid body chemosensory responses in mice deficient of TASK channels. J Gen Physiol (2010) 1.04

Respiratory modulation of premotor cardiac vagal neurons in the brainstem. Respir Physiol Neurobiol (2010) 1.04

Central chemoreceptors: locations and functions. Compr Physiol (2012) 1.04

Computational models and emergent properties of respiratory neural networks. Compr Physiol (2012) 1.04

Mechanisms of CO2/H+ chemoreception by respiratory rhythm generator neurons in the medulla from newborn rats in vitro. J Physiol (2006) 1.03

Formation and maintenance of ventilatory long-term facilitation require NMDA but not non-NMDA receptors in awake rats. J Appl Physiol (1985) (2008) 1.03

Spinal 5-HT7 receptor activation induces long-lasting phrenic motor facilitation. J Physiol (2011) 1.03

Phrenic long-term facilitation after acute intermittent hypoxia requires spinal ERK activation but not TrkB synthesis. J Appl Physiol (1985) (2012) 1.02

Serotonin transporter knockout mice have a reduced ventilatory response to hypercapnia (predominantly in males) but not to hypoxia. J Physiol (2008) 1.02

Ageing and gonadectomy have similar effects on hypoglossal long-term facilitation in male Fischer rats. J Physiol (2004) 1.02

Central chemoreception in wakefulness and sleep: evidence for a distributed network and a role for orexin. J Appl Physiol (1985) (2010) 1.02

Neural control of phrenic motoneuron discharge. Respir Physiol Neurobiol (2011) 1.02

Repetitive acute intermittent hypoxia increases expression of proteins associated with plasticity in the phrenic motor nucleus. Exp Neurol (2012) 1.01

Alpha4* nicotinic receptors in preBotzinger complex mediate cholinergic/nicotinic modulation of respiratory rhythm. J Neurosci (2008) 1.00

Normal breathing pattern and arterial blood gases in awake and sleeping goats after near total destruction of the presumed pre-Botzinger complex and the surrounding region. J Appl Physiol (1985) (2008) 1.00

Loss of transforming growth factor-beta 2 leads to impairment of central synapse function. Neural Dev (2008) 1.00

Similarities and differences in mechanisms of phrenic and hypoglossal motor facilitation. Respir Physiol Neurobiol (2011) 1.00

Chapter 3--networks within networks: the neuronal control of breathing. Prog Brain Res (2011) 1.00

Chemosensory pathways in the brainstem controlling cardiorespiratory activity. Philos Trans R Soc Lond B Biol Sci (2009) 0.99

Redefining the components of central CO2 chemosensitivity--towards a better understanding of mechanism. J Physiol (2011) 0.98

Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med (2002) 14.26

AMPA receptor trafficking and synaptic plasticity. Annu Rev Neurosci (2002) 13.09

The molecular biology of memory storage: a dialogue between genes and synapses. Science (2001) 11.85

Pre-Bötzinger complex: a brainstem region that may generate respiratory rhythm in mammals. Science (1991) 8.26

Prevalence of sleep-disordered breathing in women: effects of gender. Am J Respir Crit Care Med (2001) 5.94

Principles of rhythmic motor pattern generation. Physiol Rev (1996) 5.22

Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor. Science (1997) 4.03

Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the preBötzinger complex. Science (1999) 3.58

S-nitrosothiols signal the ventilatory response to hypoxia. Nature (2001) 3.26

PreBötzinger complex and pacemaker neurons: hypothesized site and kernel for respiratory rhythm generation. Annu Rev Physiol (1998) 3.06

Normal breathing requires preBötzinger complex neurokinin-1 receptor-expressing neurons. Nat Neurosci (2001) 3.05

Primary afferent tachykinins are required to experience moderate to intense pain. Nature (1998) 2.97

Altered nociception, analgesia and aggression in mice lacking the receptor for substance P. Nature (1998) 2.90

Time domains of the hypoxic ventilatory response. Respir Physiol (1998) 2.67

Invited review: Intermittent hypoxia and respiratory plasticity. J Appl Physiol (1985) (2001) 2.60

Neuroplasticity in respiratory motor control. J Appl Physiol (1985) (2003) 2.55

Central chemosensitivity and the reaction theory. J Physiol (1982) 2.49

Hypoxia-induced long-term facilitation of respiratory activity is serotonin dependent. Respir Physiol (1996) 2.49

Neuronal pacemaker for breathing visualized in vitro. Nature (1999) 2.49

Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha. Proc Natl Acad Sci U S A (2002) 2.35

Brainstem network controlling descending drive to phrenic motoneurons in rat. J Comp Neurol (1994) 2.30

Reconfiguration of the neural network controlling multiple breathing patterns: eupnea, sighs and gasps [see comment]. Nat Neurosci (2000) 2.28

The neurotrophin hypothesis for synaptic plasticity. Trends Neurosci (2000) 2.18

Phrenic long-term facilitation requires spinal serotonin receptor activation and protein synthesis. J Neurosci (2002) 2.17

Cellular mechanisms underlying modulation of breathing pattern in mammals. Ann N Y Acad Sci (1989) 2.16

Chronic intermittent hypoxia elicits serotonin-dependent plasticity in the central neural control of breathing. J Neurosci (2001) 2.15

LTP leads to rapid surface expression of NMDA but not AMPA receptors in adult rat CA1. Nat Neurosci (2002) 2.14

Opioid-induced quantal slowing reveals dual networks for respiratory rhythm generation. Neuron (2003) 2.12

Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation. Science (1995) 2.12

The crossed phrenic phenomenon: a model for plasticity in the respiratory pathways following spinal cord injury. J Appl Physiol (1985) (2003) 2.02

Tst-1/Oct-6/SCIP regulates a unique step in peripheral myelination and is required for normal respiration. Genes Dev (1996) 2.02

Neurokinin-1 receptor-immunoreactive neurons of the ventral respiratory group in the rat. J Comp Neurol (2001) 2.00

Phrenic long-term facilitation requires 5-HT receptor activation during but not following episodic hypoxia. J Appl Physiol (1985) (2001) 1.97

Activity-dependent release of endogenous brain-derived neurotrophic factor from primary sensory neurons detected by ELISA in situ. J Neurosci (2000) 1.97

Medullary serotonergic network deficiency in the sudden infant death syndrome: review of a 15-year study of a single dataset. J Neuropathol Exp Neurol (2001) 1.94

Prolonged stimulation of respiration by endogenous central serotonin. Respir Physiol (1980) 1.91

Persistent sodium current, membrane properties and bursting behavior of pre-bötzinger complex inspiratory neurons in vitro. J Neurophysiol (2002) 1.88

Long term facilitation of phrenic motor output. Respir Physiol (2000) 1.88

CO2, brainstem chemoreceptors and breathing. Prog Neurobiol (1999) 1.85

Time-dependent phrenic nerve responses to carotid afferent activation: intact vs. decerebellate rats. Am J Physiol (1993) 1.84

Episodic but not continuous hypoxia elicits long-term facilitation of phrenic motor output in rats. J Physiol (2000) 1.83

Respiratory rhythm: an emergent network property? Neuron (2002) 1.82

Prolonged stimulation of respiration by a new central neural mechanism. Respir Physiol (1980) 1.79

Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice. Biophys J (2000) 1.79

Studying rhythmogenesis of breathing: comparison of in vivo and in vitro models. Trends Neurosci (2001) 1.74

Serotonergic modulation of ventilation and upper airway stability in obese Zucker rats. Am J Respir Crit Care Med (2001) 1.73

Widespread sites of brain stem ventilatory chemoreceptors. J Appl Physiol (1985) (1993) 1.67

Ventilatory long-term facilitation in unanesthetized rats. J Appl Physiol (1985) (2001) 1.66

Electrical coupling and excitatory synaptic transmission between rhythmogenic respiratory neurons in the preBötzinger complex. J Neurosci (2000) 1.65

Substance P-saporin lesion of neurons with NK1 receptors in one chemoreceptor site in rats decreases ventilation and chemosensitivity. J Physiol (2002) 1.65

Opioid-resistant respiratory pathway from the preinspiratory neurones to abdominal muscles: in vivo and in vitro study in the newborn rat. J Physiol (2002) 1.64

Respiratory network function in the isolated brainstem-spinal cord of newborn rats. Prog Neurobiol (1999) 1.62

Long-term facilitation of upper airway muscle activities in vagotomized and vagally intact cats. J Appl Physiol (1985) (1997) 1.62

Respiratory rhythm generation and synaptic inhibition of expiratory neurons in pre-Bötzinger complex: differential roles of glycinergic and GABAergic neural transmission. J Neurophysiol (1997) 1.60

Neural organization and evolution of thermal regulation in mammals. Science (1978) 1.59

Synaptic inhibition in the isolated respiratory network of neonatal rats. Eur J Neurosci (1998) 1.58

Expression of c-fos in the rat brainstem after exposure to hypoxia and to normoxic and hyperoxic hypercapnia. J Comp Neurol (1997) 1.56

TASK-1 is a highly modulated pH-sensitive 'leak' K(+) channel expressed in brainstem respiratory neurons. Respir Physiol (2001) 1.53

Acidosis-stimulated neurons of the medullary raphe are serotonergic. J Neurophysiol (2001) 1.51

Reorganization of pontine rhythmogenic neuronal networks in Krox-20 knockout mice. Neuron (1996) 1.49

CO2 dialysis in nucleus tractus solitarius region of rat increases ventilation in sleep and wakefulness. J Appl Physiol (1985) (2002) 1.46

Mice lacking brain-derived neurotrophic factor exhibit visceral sensory neuron losses distinct from mice lacking NT4 and display a severe developmental deficit in control of breathing. J Neurosci (1996) 1.46

Oxygen sensing during intermittent hypoxia: cellular and molecular mechanisms. J Appl Physiol (1985) (2001) 1.46

Molecular mechanisms underlying a unique intermediate phase of memory in aplysia. Neuron (2001) 1.43

Chemosensitive serotonergic neurons are closely associated with large medullary arteries. Nat Neurosci (2002) 1.43

Central chemosensitivity, sleep, and wakefulness. Respir Physiol (2001) 1.43

CO2 dialysis in the medullary raphe of the rat increases ventilation in sleep. J Appl Physiol (1985) (2001) 1.42

Interaction between amount and pattern of training in the induction of intermediate- and long-term memory for sensitization in aplysia. Learn Mem (2002) 1.40

Long-term facilitation in obstructive sleep apnea patients during NREM sleep. J Appl Physiol (1985) (2001) 1.40

Serotonergic raphe neurons express TASK channel transcripts and a TASK-like pH- and halothane-sensitive K+ conductance. J Neurosci (2002) 1.39

Neurokinin-1 receptor-expressing cells of the ventral respiratory group are functionally heterogeneous and predominantly glutamatergic. J Neurosci (2002) 1.39

Models of respiratory rhythm generation in the pre-Bötzinger complex. III. Experimental tests of model predictions. J Neurophysiol (2001) 1.39

Impaired spatial learning and hyperactivity in developing rats exposed to intermittent hypoxia. Pediatr Res (2002) 1.39

Rnx deficiency results in congenital central hypoventilation. Nat Genet (2000) 1.39

Chemosensitivity of serotonergic neurons in the rostral ventral medulla. Respir Physiol (2001) 1.38

Role of intracellular and extracellular pH in the chemosensitive response of rat locus coeruleus neurones. J Physiol (2002) 1.38

Cervical dorsal rhizotomy enhances serotonergic innervation of phrenic motoneurons and serotonin-dependent long-term facilitation of respiratory motor output in rats. J Neurosci (1998) 1.38

CO2 decreases membrane conductance and depolarizes neurons in the nucleus tractus solitarii. Exp Brain Res (1989) 1.37

Long-term facilitation of ventilation in humans during NREM sleep. Sleep (1998) 1.36

Chemosensitive medullary neurones in the brainstem--spinal cord preparation of the neonatal rat. J Physiol (1996) 1.35

Expression of hypoglossal long-term facilitation differs between substrains of Sprague-Dawley rat. Physiol Genomics (2001) 1.34

Selective lesioning of the cat pre-Bötzinger complex in vivo eliminates breathing but not gasping. J Physiol (1998) 1.32

CO(2) microdialysis in retrotrapezoid nucleus of the rat increases breathing in wakefulness but not in sleep. J Appl Physiol (1985) (1999) 1.32

Pre-Bötzinger neurons with preinspiratory discharges "in vivo" express NK1 receptors in the rat. J Neurophysiol (2001) 1.30

Developmental plasticity in respiratory control. J Appl Physiol (1985) (2003) 1.30

Altered respiratory motor drive after spinal cord injury: supraspinal and bilateral effects of a unilateral lesion. J Neurosci (2001) 1.29

Respiration-modulated membrane potential and chemosensitivity of locus coeruleus neurones in the in vitro brainstem-spinal cord of the neonatal rat. J Physiol (1998) 1.29

Neuronal mechanisms of respiratory rhythm generation: an approach using in vitro preparation. Jpn J Physiol (1997) 1.28

Increased normoxic ventilation induced by repetitive hypoxia in conscious dogs. J Appl Physiol (1985) (1992) 1.28

Respiratory plasticity: differential actions of continuous and episodic hypoxia and hypercapnia. Respir Physiol (2001) 1.26

Control of Upper Airway Motoneurons During REM Sleep. News Physiol Sci (1998) 1.25

Effects of unilateral lesions of retrotrapezoid nucleus on breathing in awake rats. J Appl Physiol (1985) (1997) 1.24

Firing properties of respiratory rhythm generating neurons in the absence of synaptic transmission in rat medulla in vitro. Exp Brain Res (1989) 1.24

Abnormal phrenic motoneuron activity and morphology in neonatal monoamine oxidase A-deficient transgenic mice: possible role of a serotonin excess. J Neurosci (2000) 1.24

Opioid action on respiratory neuron activity of the isolated respiratory network in newborn rats. Anesthesiology (2001) 1.23

Early postnatal maturation of GABAA-mediated inhibition in the brainstem respiratory rhythm-generating network of the mouse. Eur J Neurosci (2000) 1.23

Decreased muscarinic receptor binding in the arcuate nucleus in sudden infant death syndrome. Science (1995) 1.21

Brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor are required simultaneously for survival of dopaminergic primary sensory neurons in vivo. J Neurosci (2001) 1.21

Long term facilitation of respiratory motor output decreases with age in male rats. J Physiol (2001) 1.19

CO2 dialysis in one chemoreceptor site, the RTN: stimulus intensity and sensitivity in the awake rat. Respir Physiol Neurobiol (2002) 1.19

BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia. Nat Neurosci (2003) 2.79

Brainstem serotonergic deficiency in sudden infant death syndrome. JAMA (2010) 2.55

Phrenic long-term facilitation requires spinal serotonin receptor activation and protein synthesis. J Neurosci (2002) 2.17

The brainstem and serotonin in the sudden infant death syndrome. Annu Rev Pathol (2009) 2.03

Spinal synaptic enhancement with acute intermittent hypoxia improves respiratory function after chronic cervical spinal cord injury. J Neurosci (2005) 2.01

Is there a link between intermittent hypoxia-induced respiratory plasticity and obstructive sleep apnoea? Exp Physiol (2006) 1.95

Daily intermittent hypoxia enhances walking after chronic spinal cord injury: a randomized trial. Neurology (2013) 1.73

Synaptic pathways to phrenic motoneurons are enhanced by chronic intermittent hypoxia after cervical spinal cord injury. J Neurosci (2003) 1.68

Failed heart rate recovery at a critical age in 5-HT-deficient mice exposed to episodic anoxia: implications for SIDS. J Appl Physiol (1985) (2011) 1.67

Essential role of Phox2b-expressing ventrolateral brainstem neurons in the chemosensory control of inspiration and expiration. J Neurosci (2010) 1.62

Recovery of phrenic activity and ventilation after cervical spinal hemisection in rats. J Appl Physiol (1985) (2005) 1.55

Maternal dietary tryptophan deficiency alters cardiorespiratory control in rat pups. J Appl Physiol (1985) (2010) 1.51

Short-term modulation of the exercise ventilatory response in young men. J Appl Physiol (1985) (2007) 1.49

Exercise increases hippocampal neurogenesis to high levels but does not improve spatial learning in mice bred for increased voluntary wheel running. Behav Neurosci (2003) 1.48

Spinal adenosine A2a receptor activation elicits long-lasting phrenic motor facilitation. J Neurosci (2008) 1.46

Intermittent hypoxia induces phrenic long-term facilitation in carotid-denervated rats. J Appl Physiol (1985) (2002) 1.42

Repetitive intermittent hypoxia induces respiratory and somatic motor recovery after chronic cervical spinal injury. J Neurosci (2012) 1.40

Daily intermittent hypoxia augments spinal BDNF levels, ERK phosphorylation and respiratory long-term facilitation. Exp Neurol (2009) 1.39

Episodic stimulation of alpha1-adrenoreceptors induces protein kinase C-dependent persistent changes in motoneuronal excitability. J Neurosci (2007) 1.30

Multiple pathways to long-lasting phrenic motor facilitation. Adv Exp Med Biol (2010) 1.30

Medullary serotonergic neurones modulate the ventilatory response to hypercapnia, but not hypoxia in conscious rats. J Physiol (2005) 1.29

Determinants of frequency long-term facilitation following acute intermittent hypoxia in vagotomized rats. Respir Physiol Neurobiol (2008) 1.24

Intermittent hypoxia and stem cell implants preserve breathing capacity in a rodent model of amyotrophic lateral sclerosis. Am J Respir Crit Care Med (2012) 1.20

Exposure to acute intermittent hypoxia augments somatic motor function in humans with incomplete spinal cord injury. Neurorehabil Neural Repair (2011) 1.20

Intermittent hypoxia induces functional recovery following cervical spinal injury. Respir Physiol Neurobiol (2009) 1.19

Cervical spinal cord injury upregulates ventral spinal 5-HT2A receptors. J Neurotrauma (2005) 1.18

Okadaic acid-sensitive protein phosphatases constrain phrenic long-term facilitation after sustained hypoxia. J Neurosci (2008) 1.18

Antagonism of orexin receptor-1 in the retrotrapezoid nucleus inhibits the ventilatory response to hypercapnia predominantly in wakefulness. J Physiol (2009) 1.18

Long-term effects of the perinatal environment on respiratory control. J Appl Physiol (1985) (2008) 1.18

7,8-dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndrome. J Appl Physiol (1985) (2011) 1.14

Antagonism of orexin receptors significantly lowers blood pressure in spontaneously hypertensive rats. J Physiol (2013) 1.11

Severe acute intermittent hypoxia elicits phrenic long-term facilitation by a novel adenosine-dependent mechanism. J Appl Physiol (1985) (2012) 1.10

Simulated apnoeas induce serotonin-dependent respiratory long-term facilitation in rats. J Physiol (2008) 1.10

Sex steroid hormones and the neural control of breathing. Respir Physiol Neurobiol (2003) 1.08

Spinal vascular endothelial growth factor induces phrenic motor facilitation via extracellular signal-regulated kinase and Akt signaling. J Neurosci (2011) 1.07

Severe spontaneous bradycardia associated with respiratory disruptions in rat pups with fewer brain stem 5-HT neurons. Am J Physiol Regul Integr Comp Physiol (2009) 1.06

Spinal plasticity following intermittent hypoxia: implications for spinal injury. Ann N Y Acad Sci (2010) 1.05

Inhibition of medullary raphe serotonergic neurons has age-dependent effects on the CO2 response in newborn piglets. J Appl Physiol (1985) (2004) 1.04

Hypoxia-induced phrenic long-term facilitation: emergent properties. Ann N Y Acad Sci (2013) 1.01

Repetitive acute intermittent hypoxia increases expression of proteins associated with plasticity in the phrenic motor nucleus. Exp Neurol (2012) 1.01

Exercise-induced changes in hippocampal brain-derived neurotrophic factor and neurotrophin-3: effects of rat strain. Brain Res (2003) 0.98

Postnatal loss of brainstem serotonin neurones compromises the ability of neonatal rats to survive episodic severe hypoxia. J Physiol (2011) 0.98

Bradycardia in serotonin-deficient Pet-1-/- mice: influence of respiratory dysfunction and hyperthermia over the first 2 postnatal weeks. Am J Physiol Regul Integr Comp Physiol (2010) 0.96

Chronic cervical spinal sensory denervation reveals ineffective spinal pathways to phrenic motoneurons in the rat. Neurosci Lett (2002) 0.96

Cervical spinal erythropoietin induces phrenic motor facilitation via extracellular signal-regulated protein kinase and Akt signaling. J Neurosci (2012) 0.95

Lipopolysaccharide attenuates phrenic long-term facilitation following acute intermittent hypoxia. Respir Physiol Neurobiol (2011) 0.94

Muscimol inhibition of medullary raphé neurons decreases the CO2 response and alters sleep in newborn piglets. Respir Physiol Neurobiol (2002) 0.94

Developmental aspects of the upper airway: report from an NHLBI Workshop, March 5-6, 2009. Proc Am Thorac Soc (2009) 0.92

Early postnatal chronic intermittent hypoxia modifies hypoxic respiratory responses and long-term phrenic facilitation in adult rats. Am J Physiol Regul Integr Comp Physiol (2006) 0.92

Sudden and unexpected death in early life: proceedings of a symposium in honor of Dr. Henry F. Krous. Forensic Sci Med Pathol (2012) 0.91

Chronic fluoxetine microdialysis into the medullary raphe nuclei of the rat, but not systemic administration, increases the ventilatory response to CO2. J Appl Physiol (1985) (2004) 0.89

Ventilatory effects of muscimol microdialysis into the rostral medullary raphé region of conscious rats. Respir Physiol Neurobiol (2005) 0.89

Reduced respiratory neural activity elicits phrenic motor facilitation. Respir Physiol Neurobiol (2010) 0.89

Respiratory long-term facilitation: too much or too little of a good thing? Adv Exp Med Biol (2008) 0.88

Respiratory plasticity after perinatal hyperoxia is not prevented by antioxidant supplementation. Respir Physiol Neurobiol (2007) 0.88

Differences in time-dependent hypoxic phrenic responses among inbred rat strains. J Appl Physiol (1985) (2004) 0.88

Brainstem serotonin deficiency in the neonatal period: autonomic dysregulation during mild cold stress. J Physiol (2011) 0.88

Common mechanisms of compensatory respiratory plasticity in spinal neurological disorders. Respir Physiol Neurobiol (2013) 0.86

Back to the future: carbon dioxide chemoreceptors in the mammalian brain. Nat Neurosci (2004) 0.86

Glial activation in the spinal ventral horn caudal to cervical injury. Respir Physiol Neurobiol (2011) 0.85

Subtle alterations in breathing and heart rate control in the 5-HT1A receptor knockout mouse in early postnatal development. J Appl Physiol (1985) (2012) 0.85

Short-term modulation of the exercise ventilatory response in younger and older women. Respir Physiol Neurobiol (2011) 0.83

Carotid sinus nerve responses and ventilatory acclimatization to hypoxia in adult rats following 2 weeks of postnatal hyperoxia. Respir Physiol Neurobiol (2005) 0.82

Spinal vascular endothelial growth factor (VEGF) and erythropoietin (EPO) induced phrenic motor facilitation after repetitive acute intermittent hypoxia. Respir Physiol Neurobiol (2012) 0.82

Activity-dependent plasticity in descending synaptic inputs to respiratory spinal motoneurons. Respir Physiol Neurobiol (2002) 0.82

Increased GABA(A) receptor ε-subunit expression on ventral respiratory column neurons protects breathing during pregnancy. PLoS One (2012) 0.81

Egr2-neurons control the adult respiratory response to hypercapnia. Brain Res (2012) 0.81

Short- and long-term modulation of the exercise ventilatory response. Med Sci Sports Exerc (2010) 0.81

Role of synaptic inhibition in turtle respiratory rhythm generation. J Physiol (2002) 0.81

Central CO2 chemoreception in cardiorespiratory control. J Appl Physiol (1985) (2010) 0.81

Short-term modulation of the exercise ventilatory response in older men. Respir Physiol Neurobiol (2010) 0.79

Adenosine 2A receptor inhibition enhances intermittent hypoxia-induced diaphragm but not intercostal long-term facilitation. J Neurotrauma (2014) 0.78

Development of brainstem 5-HT1A receptor-binding sites in serotonin-deficient mice. J Neurochem (2013) 0.77

Exercise training effects on hypoxic and hypercapnic ventilatory responses in mice selected for increased voluntary wheel running. Exp Physiol (2013) 0.77

Overview: the neurochemistry of respiratory control. Respir Physiol Neurobiol (2008) 0.77

Caffeine improves the ability of serotonin-deficient (Pet-1-/-) mice to survive episodic asphyxia. Pediatr Res (2012) 0.77

Respiratory plasticity after perinatal hypercapnia in rats. Respir Physiol Neurobiol (2005) 0.77

Reply from Aihua Li, Charles C. T. Hindmarch, Eugene E. Nattie and Julian F. R. Paton. J Physiol (2013) 0.76

Breathing mechanics during exercise with added dead space reflect mechanisms of ventilatory control. Respir Physiol Neurobiol (2009) 0.76

Acoustic plethysmography measures breathing in unrestrained neonatal mice. J Appl Physiol (1985) (2007) 0.76

Clinical challenges to ventilatory control. Respir Physiol Neurobiol (2013) 0.75

Breathing in thin air: acclimatization to altitude in ducks. Respir Physiol Neurobiol (2004) 0.75

Carotid chemoafferent plasticity in adult rats following developmental hyperoxia. Respir Physiol Neurobiol (2005) 0.75