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1
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N-Acetylcysteine reverses cocaine-induced metaplasticity.
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Nat Neurosci
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2009
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3.49
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2
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Glutamatergic substrates of drug addiction and alcoholism.
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Biochem Pharmacol
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2007
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3.06
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3
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Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use-dependent inhibitor of dopamine synthesis.
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Nat Med
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2010
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1.84
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4
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mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning.
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Neuropsychopharmacology
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2009
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1.80
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5
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Potent rewarding and reinforcing effects of the synthetic cathinone 3,4-methylenedioxypyrovalerone (MDPV).
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Addict Biol
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2012
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1.64
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6
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mGluR5 antagonism attenuates methamphetamine reinforcement and prevents reinstatement of methamphetamine-seeking behavior in rats.
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Neuropsychopharmacology
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2008
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1.57
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7
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Positive allosteric modulation of mGluR5 receptors facilitates extinction of a cocaine contextual memory.
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Biol Psychiatry
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2008
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1.43
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8
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The mGluR5 antagonist MPEP reduces the conditioned rewarding effects of cocaine but not other drugs of abuse.
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Synapse
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2003
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1.41
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9
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Ethanol facilitates glutamatergic transmission to dopamine neurons in the ventral tegmental area.
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Neuropsychopharmacology
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2008
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1.32
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10
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Decreased anxiety-like behavior, reduced stress hormones, and neurosteroid supersensitivity in mice lacking protein kinase Cepsilon.
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J Clin Invest
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2002
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1.31
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11
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Loss of object recognition memory produced by extended access to methamphetamine self-administration is reversed by positive allosteric modulation of metabotropic glutamate receptor 5.
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Neuropsychopharmacology
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2010
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1.25
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12
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Anxiogenic and aversive effects of corticotropin-releasing factor (CRF) in the bed nucleus of the stria terminalis in the rat: role of CRF receptor subtypes.
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Psychopharmacology (Berl)
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2006
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1.24
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13
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Suppression of heavy drinking and alcohol seeking by a selective ALDH-2 inhibitor.
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Alcohol Clin Exp Res
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2009
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1.13
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14
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Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models.
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J Neurosci
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2012
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1.13
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15
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Role of protein kinase C epsilon (PKCvarepsilon) in the reduction of ethanol reinforcement due to mGluR5 antagonism in the nucleus accumbens shell.
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Psychopharmacology (Berl)
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2009
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1.11
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16
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The Reinforcing and Rewarding Effects of Methylone, a Synthetic Cathinone Commonly Found in "Bath Salts"
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J Addict Res Ther
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2012
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1.10
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17
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mGluR5 positive allosteric modulation enhances extinction learning following cocaine self-administration.
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Behav Neurosci
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2011
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1.10
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18
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The glucocorticoid receptor antagonist mifepristone reduces ethanol intake in rats under limited access conditions.
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Psychoneuroendocrinology
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2004
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1.06
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19
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mGluR5 receptors in the basolateral amygdala and nucleus accumbens regulate cue-induced reinstatement of ethanol-seeking behavior.
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Pharmacol Biochem Behav
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2012
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1.05
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20
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The Effects of Maternal Separation on Adult Methamphetamine Self-Administration, Extinction, Reinstatement, and MeCP2 Immunoreactivity in the Nucleus Accumbens.
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Front Psychiatry
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2013
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1.03
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21
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Alcohol-seeking behavior is associated with increased glutamate transmission in basolateral amygdala and nucleus accumbens as measured by glutamate-oxidase-coated biosensors.
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Addict Biol
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2010
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1.02
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22
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Reinstatement of ethanol-seeking behavior following intravenous self-administration in Wistar rats.
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Alcohol Clin Exp Res
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2007
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1.01
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23
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Positive allosteric modulators of type 5 metabotropic glutamate receptors (mGluR5) and their therapeutic potential for the treatment of CNS disorders.
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Molecules
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2011
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0.99
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24
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Attenuation of methamphetamine seeking by the mGluR2/3 agonist LY379268 in rats with histories of restricted and escalated self-administration.
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Neuropharmacology
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2012
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0.97
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25
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A role for mGluR5 receptors in intravenous methamphetamine self-administration.
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Ann N Y Acad Sci
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2008
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0.95
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26
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Effect of the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP) on the acute locomotor stimulant properties of cocaine, D-amphetamine, and the dopamine reuptake inhibitor GBR12909 in mice.
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Psychopharmacology (Berl)
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2004
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0.92
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27
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Attenuation of reinstatement of methamphetamine-, sucrose-, and food-seeking behavior in rats by fenobam, a metabotropic glutamate receptor 5 negative allosteric modulator.
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Psychopharmacology (Berl)
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2012
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0.92
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28
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The anti-relapse compound acamprosate inhibits the development of a conditioned place preference to ethanol and cocaine but not morphine.
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Br J Pharmacol
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2003
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0.92
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29
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Positive Allosteric Modulation of mGluR5 Accelerates Extinction Learning but Not Relearning Following Methamphetamine Self-Administration.
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Front Pharmacol
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2012
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30
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Effects of adolescent exposure to cocaine on locomotor activity and extracellular dopamine and glutamate levels in nucleus accumbens of DBA/2J mice.
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Brain Res
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2007
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0.88
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31
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The corticotropin-releasing factor/urocortin system and alcohol.
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Alcohol Clin Exp Res
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2002
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32
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Pharmacotherapies for alcoholism: the old and the new.
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CNS Neurol Disord Drug Targets
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33
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The mGluR5 Positive Allosteric Modulator CDPPB Does Not Alter Extinction or Contextual Reinstatement of Methamphetamine-Seeking Behavior in Rats.
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J Addict Res Ther
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2011
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Role of the endogenous opioid system on the neuropsychopharmacological effects of ethanol: new insights about an old question.
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Alcohol Clin Exp Res
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2005
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0.86
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35
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Acamprosate attenuates cocaine- and cue-induced reinstatement of cocaine-seeking behavior in rats.
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Psychopharmacology (Berl)
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2007
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36
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Safety and efficacy of acamprosate for the treatment of alcohol dependence.
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Subst Abuse
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Ethanol consumption patterns and conditioned place preference in mice lacking preproenkephalin.
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Neurosci Lett
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2002
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The safety of disulfiram for the treatment of alcohol and cocaine dependence in randomized clinical trials: guidance for clinical practice.
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Expert Opin Drug Saf
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Changes in extracellular levels of glutamate in the nucleus accumbens after ethanol-induced behavioral sensitization in adolescent and adult mice.
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Alcohol
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mGluR5 positive allosteric modulation and its effects on MK-801 induced set-shifting impairments in a rat operant delayed matching/non-matching-to-sample task.
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Psychopharmacology (Berl)
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2014
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Similar ethanol drinking in adolescent and adult C57BL/6J mice after chronic ethanol exposure and withdrawal.
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Investigating Methamphetamine Craving Using the Extinction-Reinstatement Model in the Rat.
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Differential Modulation of Thresholds for Intracranial Self-Stimulation by mGlu5 Positive and Negative Allosteric Modulators: Implications for Effects on Drug Self-Administration.
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Front Pharmacol
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Intracranial stereotaxic cannulation for development of orthotopic glioblastoma allograft in Sprague-Dawley rats and histoimmunopathological characterization of the brain tumor.
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Neurochem Res
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Constitutive knockout of kalirin-7 leads to increased rates of cocaine self-administration.
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Mol Pharmacol
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Neurochemical and neurostructural plasticity in alcoholism.
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ACS Chem Neurosci
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Ethanol pre-exposure during adolescence or adulthood increases ethanol intake but ethanol-induced conditioned place preference is enhanced only when pre-exposure occurs in adolescence.
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Dev Psychobiol
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Combined antiretroviral therapy reduces brain viral load and pathological features of HIV encephalitis in a mouse model.
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Early life stress and chronic variable stress in adulthood interact to influence methamphetamine self-administration in male rats.
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Behav Pharmacol
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Early-life stress interactions with the epigenome: potential mechanisms driving vulnerability toward psychiatric illness.
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Behav Pharmacol
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Increases in doublecortin immunoreactivity in the dentate gyrus following extinction of heroin-seeking behavior.
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Neural Plast
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Transcriptional profiling of the rat frontal cortex following administration of the mGlu5 receptor antagonists MPEP and MTEP.
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A microdialysis study of extracellular levels of acamprosate and naltrexone in the rat brain following acute and repeated administration.
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