Published in J Pharmacol Exp Ther on March 20, 2012
Neurosteroid interactions with synaptic and extrasynaptic GABA(A) receptors: regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network excitability. Psychopharmacology (Berl) (2013) 1.14
Neuroendocrine considerations in the treatment of men and women with epilepsy. Lancet Neurol (2013) 1.13
Neuroactive steroids for the treatment of status epilepticus. Epilepsia (2013) 0.94
Estrous cycle regulation of extrasynaptic δ-containing GABA(A) receptor-mediated tonic inhibition and limbic epileptogenesis. J Pharmacol Exp Ther (2013) 0.92
Perimenstrual-like hormonal regulation of extrasynaptic δ-containing GABAA receptors mediating tonic inhibition and neurosteroid sensitivity. J Neurosci (2014) 0.91
Neuroendocrine aspects of catamenial epilepsy. Horm Behav (2012) 0.90
Neurosteroids and their role in sex-specific epilepsies. Neurobiol Dis (2014) 0.87
Finasteride inhibits the disease-modifying activity of progesterone in the hippocampus kindling model of epileptogenesis. Epilepsy Behav (2012) 0.87
Clinical Potential of Neurosteroids for CNS Disorders. Trends Pharmacol Sci (2016) 0.87
Neurosteroid Structure-Activity Relationships for Functional Activation of Extrasynaptic δGABAA Receptors. J Pharmacol Exp Ther (2016) 0.86
GABAergic neuroactive steroids and resting-state functional connectivity in postpartum depression: a preliminary study. J Psychiatr Res (2013) 0.86
Role of hormones and neurosteroids in epileptogenesis. Front Cell Neurosci (2013) 0.84
Catamenial Epilepsy: Discovery of an Extrasynaptic Molecular Mechanism for Targeted Therapy. Front Cell Neurosci (2016) 0.81
Antiseizure Activity of Midazolam in Mice Lacking δ-Subunit Extrasynaptic GABA(A) Receptors. J Pharmacol Exp Ther (2015) 0.80
Seizure facilitating activity of the oral contraceptive ethinyl estradiol. Epilepsy Res (2016) 0.76
Sex differences in the anticonvulsant activity of neurosteroids. J Neurosci Res (2017) 0.75
PR-independent neurosteroid regulation of α2-GABA-A receptors in the hippocampus subfields. Brain Res (2017) 0.75
Catamenial-like seizure exacerbation in mice with targeted ablation of extrasynaptic δGABA-a receptors in the brain. J Neurosci Res (2017) 0.75
Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol (1972) 16.34
Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors. Proc Natl Acad Sci U S A (2003) 4.33
Ovarian cycle-linked changes in GABA(A) receptors mediating tonic inhibition alter seizure susceptibility and anxiety. Nat Neurosci (2005) 4.17
GABA(A) receptor alpha4 subunit suppression prevents withdrawal properties of an endogenous steroid. Nature (1998) 4.09
A permanent change in brain function resulting from daily electrical stimulation. Exp Neurol (1969) 3.89
Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice. Proc Natl Acad Sci U S A (1999) 2.88
A new benzodiazepine pharmacology. J Pharmacol Exp Ther (2002) 2.75
GABA(A)R plasticity during pregnancy: relevance to postpartum depression. Neuron (2008) 2.55
Enhanced neurosteroid potentiation of ternary GABA(A) receptors containing the delta subunit. J Neurosci (2002) 2.49
Three patterns of catamenial epilepsy. Epilepsia (1997) 2.29
Altered expression of the delta subunit of the GABAA receptor in a mouse model of temporal lobe epilepsy. J Neurosci (2004) 2.25
Seizure exacerbation associated with inhibition of progesterone metabolism. Ann Neurol (2003) 2.12
The influence of gonadal hormones on neuronal excitability, seizures, and epilepsy in the female. Epilepsia (2006) 2.06
Preferential coassembly of alpha4 and delta subunits of the gamma-aminobutyric acidA receptor in rat thalamus. Mol Pharmacol (1999) 1.96
Functional characterization of human gamma-aminobutyric acidA receptors containing the alpha 4 subunit. Mol Pharmacol (1996) 1.88
The influence of subunit composition on the interaction of neurosteroids with GABA(A) receptors. Neuropharmacology (2002) 1.85
Altered localization of GABA(A) receptor subunits on dentate granule cell dendrites influences tonic and phasic inhibition in a mouse model of epilepsy. J Neurosci (2007) 1.69
Endogenous neurosteroid synthesis modulates seizure frequency. Ann Neurol (2010) 1.68
Neurosteroid synthesis-mediated regulation of GABA(A) receptors: relevance to the ovarian cycle and stress. J Neurosci (2007) 1.68
Neurosteroid binding sites on GABA(A) receptors. Pharmacol Ther (2007) 1.64
Neurosteroid regulation of GABA(A) receptors: Focus on the alpha4 and delta subunits. Pharmacol Ther (2007) 1.50
Anticonvulsant activity of progesterone and neurosteroids in progesterone receptor knockout mice. J Pharmacol Exp Ther (2004) 1.41
Short-term exposure to a neuroactive steroid increases alpha4 GABA(A) receptor subunit levels in association with increased anxiety in the female rat. Brain Res (2001) 1.36
Frequency of catamenial seizure exacerbation in women with localization-related epilepsy. Ann Neurol (2004) 1.34
Short-term steroid treatment increases delta GABAA receptor subunit expression in rat CA1 hippocampus: pharmacological and behavioral effects. Neuropharmacology (2005) 1.33
Novel compounds selectively enhance delta subunit containing GABA A receptors and increase tonic currents in thalamus. Neuropharmacology (2008) 1.32
Neurosteroid withdrawal model of perimenstrual catamenial epilepsy. Epilepsia (2001) 1.29
The role of neurosteroids in the pathophysiology and treatment of catamenial epilepsy. Epilepsy Res (2009) 1.27
Diminished neurosteroid sensitivity of synaptic inhibition and altered location of the alpha4 subunit of GABA(A) receptors in an animal model of epilepsy. J Neurosci (2007) 1.26
Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy. Epilepsia (2001) 1.21
Diminished allopregnanolone enhancement of GABA(A) receptor currents in a rat model of chronic temporal lobe epilepsy. J Physiol (2001) 1.13
Neurosteroid administration and withdrawal alter GABAA receptor kinetics in CA1 hippocampus of female rats. J Physiol (2005) 1.10
Neurosteroid replacement therapy for catamenial epilepsy. Neurotherapeutics (2009) 1.09
Neurosteroid withdrawal regulates GABA-A receptor α4-subunit expression and seizure susceptibility by activation of progesterone receptor-independent early growth response factor-3 pathway. Neuroscience (2010) 1.09
Allopregnanolone synthesis in cerebellar granule cells: roles in regulation of GABA(A) receptor expression and function during progesterone treatment and withdrawal. Mol Pharmacol (2000) 1.07
Progesterone withdrawal I: pro-convulsant effects. Brain Res (1998) 1.03
Neuroendocrinological aspects of epilepsy: important issues and trends in future research. Epilepsy Behav (2011) 1.01
Laterality and location influence catamenial seizure expression in women with partial epilepsy. Neurology (2009) 1.01
Role of anticonvulsant and antiepileptogenic neurosteroids in the pathophysiology and treatment of epilepsy. Front Endocrinol (Lausanne) (2011) 1.01
Development and persistence of limbic epileptogenesis are impaired in mice lacking progesterone receptors. J Neurosci (2011) 0.99
Studies on neurosteroids XXV. Influence of a 5alpha-reductase inhibitor, finasteride, on rat brain neurosteroid levels and metabolism. Biol Pharm Bull (2008) 0.95
Seizure susceptibility in intact and ovariectomized female rats treated with the convulsant pilocarpine. Exp Neurol (2005) 0.94
Reduced serum level of THDOC, an anticonvulsant steroid, in women with perimenstrual catamenial epilepsy. Epilepsia (2008) 0.93
Menstrual cycle worsening of epileptic seizures in women with symptomatic focal epilepsy. Arq Neuropsiquiatr (2005) 0.91
GABAergic transmission in temporal lobe epilepsy: the role of neurosteroids. Exp Neurol (2011) 0.91
The optimization of TaqMan real-time RT-PCR assay for transcriptional profiling of GABA-A receptor subunit plasticity. J Neurosci Methods (2009) 0.87
Variation of seizure frequency with ovulatory status of menstrual cycles. Epilepsia (2011) 0.86
Human menopausal and pregnant mare serum gonadotrophins in murine superovulation regimens for transgenic applications. Theriogenology (2007) 0.82
Changes in GABA(A) receptor gene expression induced by withdrawal of, but not by long-term exposure to, ganaxolone in cultured rat cerebellar granule cells. J Pharmacol Exp Ther (2002) 0.80
Finasteride treatment and neuroactive steroid formation. Prague Med Rep (2009) 0.78