A liquid chromatography/tandem mass spectrometry method for measuring the in vivo incorporation of plasma free fatty acids into intramyocellular ceramides in humans.

PubWeight™: 1.10‹?› | Rank: Top 10%

🔗 View Article (PMC 3370409)

Published in Rapid Commun Mass Spectrom on May 15, 2012

Authors

Agnieszka U Blachnio-Zabielska1, Xuan-Mai T Persson, Christina Koutsari, Piotr Zabielski, Michael D Jensen

Author Affiliations

1: Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA.

Articles citing this

Influence of fish oil on skeletal muscle mitochondrial energetics and lipid metabolites during high-fat diet. Am J Physiol Endocrinol Metab (2013) 1.04

Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1α-dependent manner. J Lipid Res (2015) 0.89

Myocardial infarction differentially alters sphingolipid levels in plasma, erythrocytes and platelets of the rat. Basic Res Cardiol (2012) 0.89

Proinflammatory cytokines differentially regulate adipocyte mitochondrial metabolism, oxidative stress, and dynamics. Am J Physiol Endocrinol Metab (2014) 0.88

Exercise increases sphingoid base-1-phosphate levels in human blood and skeletal muscle in a time- and intensity-dependent manner. Eur J Appl Physiol (2014) 0.87

White Matter Lipids as a Ketogenic Fuel Supply in Aging Female Brain: Implications for Alzheimer's Disease. EBioMedicine (2015) 0.86

Impact of insulin deprivation and treatment on sphingolipid distribution in different muscle subcellular compartments of streptozotocin-diabetic C57Bl/6 mice. Am J Physiol Endocrinol Metab (2013) 0.86

Relative Contribution of Intramyocellular Lipid to Whole-Body Fat Oxidation Is Reduced With Age but Subsarcolemmal Lipid Accumulation and Insulin Resistance Are Only Associated With Overweight Individuals. Diabetes (2016) 0.85

Defining the role of DAG, mitochondrial function, and lipid deposition in palmitate-induced proinflammatory signaling and its counter-modulation by palmitoleate. J Lipid Res (2013) 0.85

Intramyocellular diacylglycerol concentrations and [U-¹³C]palmitate isotopic enrichment measured by LC/MS/MS. J Lipid Res (2013) 0.85

Training status diverges muscle diacylglycerol accumulation during free fatty acid elevation. Am J Physiol Endocrinol Metab (2014) 0.82

Increased bioactive lipids content in human subcutaneous and epicardial fat tissue correlates with insulin resistance. Lipids (2012) 0.82

Characterising the inhibitory actions of ceramide upon insulin signaling in different skeletal muscle cell models: a mechanistic insight. PLoS One (2014) 0.81

Hyperinsulinemia and skeletal muscle fatty acid trafficking. Am J Physiol Endocrinol Metab (2013) 0.80

Maternal plasma and amniotic fluid sphingolipids profiling in fetal Down syndrome. PLoS One (2015) 0.77

Sustained Action of Ceramide on the Insulin Signaling Pathway in Muscle Cells: IMPLICATION OF THE DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE. J Biol Chem (2015) 0.77

Mitochondrial substrate availability and its role in lipid-induced insulin resistance and proinflammatory signaling in skeletal muscle. Diabetes (2013) 0.77

Positive effects of voluntary running on metabolic syndrome-related disorders in non-obese hereditary hypertriacylglycerolemic rats. PLoS One (2015) 0.75

Training Does Not Alter Muscle Ceramide and Diacylglycerol in Offsprings of Type 2 Diabetic Patients Despite Improved Insulin Sensitivity. J Diabetes Res (2016) 0.75

Intramyocellular Ceramides - Sub-Cellular Concentrations and Fractional De Novo Synthesis in Postabsorptive Humans. Diabetes (2017) 0.75

Articles cited by this

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet (1963) 16.71

Cellular mechanisms of insulin resistance. J Clin Invest (2000) 12.61

Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia (1999) 8.17

Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. Methods (2006) 4.31

Fuel selection in human skeletal muscle in insulin resistance: a reexamination. Diabetes (2000) 4.19

Sphingolipidomics: high-throughput, structure-specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry. Methods (2005) 3.42

Radiation and ceramide-induced apoptosis. Oncogene (2003) 2.68

Quantitative analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole linear ion trap mass spectrometers. J Lipid Res (2008) 2.62

Intramuscular triglyceride and muscle insulin sensitivity: evidence for a relationship in nondiabetic subjects. Metabolism (1996) 2.11

Quantitative measurement of different ceramide species from crude cellular extracts by electrospray ionization tandem mass spectrometry (ESI-MS/MS). J Lipid Res (1999) 1.84

Measurement of very low stable isotope enrichments by gas chromatography/mass spectrometry: application to measurement of muscle protein synthesis. Metabolism (1997) 1.61

Simultaneous quantitative analysis of sphingoid base 1-phosphates in biological samples by o-phthalaldehyde precolumn derivatization after dephosphorylation with alkaline phosphatase. Anal Biochem (2002) 1.60

Sphingolipids in mammalian cell signalling. Cell Mol Life Sci (2001) 1.56

Relationship between insulin sensitivity and sphingomyelin signaling pathway in human skeletal muscle. Diabetes (2004) 1.56

Rapid measurement of plasma free fatty acid concentration and isotopic enrichment using LC/MS. J Lipid Res (2010) 1.50

Relationship between plasma free fatty acid, intramyocellular triglycerides and long-chain acylcarnitines in resting humans. J Physiol (2009) 1.41

Determination of ceramides and diglycerides by the diglyceride kinase assay. Anal Biochem (2001) 1.23

Quantification of ceramide species in biological samples by liquid chromatography electrospray ionization tandem mass spectrometry. Anal Biochem (2010) 1.15

Free fatty acid turnover measured using ultralow doses of [U-13C]palmitate. J Lipid Res (1997) 1.10

Role of MAPK in ceramide-induced cell death in primary cultured astrocytes from mouse embryonic brain. Neurotoxicology (2005) 1.02

Quantitative measurement of different ceramide species from crude cellular extracts by normal-phase high-performance liquid chromatography coupled to atmospheric pressure ionization mass spectrometry. Rapid Commun Mass Spectrom (2004) 0.97

Ceramide inhibition of chondrocyte proliferation and bone growth is IGF-I independent. J Endocrinol (2006) 0.89

Factors to consider in using [U-C]palmitate for analysis of sphingolipid biosynthesis by tandem mass spectrometry. J Lipid Res (2011) 0.82

Articles by these authors

Bariatric surgery: a systematic review and meta-analysis. JAMA (2004) 23.34

Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis. Am J Med (2009) 13.91

DHEA in elderly women and DHEA or testosterone in elderly men. N Engl J Med (2006) 7.90

Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study. Lancet (2006) 6.50

Interindividual variation in posture allocation: possible role in human obesity. Science (2005) 6.26

2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. J Am Coll Cardiol (2013) 5.24

2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. Circulation (2013) 5.02

Splanchnic lipolysis in human obesity. J Clin Invest (2004) 3.94

Roux-en-Y gastric bypass vs intensive medical management for the control of type 2 diabetes, hypertension, and hyperlipidemia: the Diabetes Surgery Study randomized clinical trial. JAMA (2013) 3.49

Fat tissue, aging, and cellular senescence. Aging Cell (2010) 3.34

Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns. Am J Physiol Endocrinol Metab (2006) 3.03

Normal weight obesity: a risk factor for cardiometabolic dysregulation and cardiovascular mortality. Eur Heart J (2009) 2.71

Mechanisms of the age-associated deterioration in glucose tolerance: contribution of alterations in insulin secretion, action, and clearance. Diabetes (2003) 2.53

Diagnostic performance of body mass index to detect obesity in patients with coronary artery disease. Eur Heart J (2007) 2.38

Normal-Weight Central Obesity: Implications for Total and Cardiovascular Mortality. Ann Intern Med (2015) 2.31

Obesity as a disease: a white paper on evidence and arguments commissioned by the Council of the Obesity Society. Obesity (Silver Spring) (2008) 2.23

Fat depot origin affects adipogenesis in primary cultured and cloned human preadipocytes. Am J Physiol Regul Integr Comp Physiol (2002) 2.23

Regional differences in cellular mechanisms of adipose tissue gain with overfeeding. Proc Natl Acad Sci U S A (2010) 2.17

Abundance of two human preadipocyte subtypes with distinct capacities for replication, adipogenesis, and apoptosis varies among fat depots. Am J Physiol Endocrinol Metab (2004) 2.16

Phospholipase A2 in the central nervous system: implications for neurodegenerative diseases. J Lipid Res (2003) 1.92

Direct free fatty acid uptake into human adipocytes in vivo: relation to body fat distribution. Diabetes (2007) 1.88

Subcutaneous adipocyte size and body fat distribution. Am J Clin Nutr (2008) 1.80

Effects of pioglitazone versus diet and exercise on metabolic health and fat distribution in upper body obesity. Diabetes Care (2003) 1.78

Energy expenditure, sex, and endogenous fuel availability in humans. J Clin Invest (2003) 1.62

A quick, reliable, and automated method for fat cell sizing. J Lipid Res (2003) 1.61

Storage of circulating free fatty acid in adipose tissue of postabsorptive humans: quantitative measures and implications for body fat distribution. Diabetes (2011) 1.53

Rapid measurement of plasma free fatty acid concentration and isotopic enrichment using LC/MS. J Lipid Res (2010) 1.50

Thematic review series: patient-oriented research. Free fatty acid metabolism in human obesity. J Lipid Res (2006) 1.48

Acute changes in lipoprotein subclasses during exercise. Metabolism (2013) 1.45

Relationship between plasma free fatty acid, intramyocellular triglycerides and long-chain acylcarnitines in resting humans. J Physiol (2009) 1.41

Gastric sensorimotor functions and hormone profile in normal weight, overweight, and obese people. Gastroenterology (2006) 1.39

Neuroprotective mechanisms of curcumin against cerebral ischemia-induced neuronal apoptosis and behavioral deficits. J Neurosci Res (2005) 1.38

Sex- and depot-dependent differences in adipogenesis in normal-weight humans. Obesity (Silver Spring) (2010) 1.37

Identification of altered metabolic pathways in plasma and CSF in mild cognitive impairment and Alzheimer's disease using metabolomics. PLoS One (2013) 1.36

Why are we shaped differently, and why does it matter? Am J Physiol Endocrinol Metab (2008) 1.35

Nonoxidative free fatty acid disposal is greater in young women than men. J Clin Endocrinol Metab (2010) 1.31

Fat depots, free fatty acids, and dyslipidemia. Nutrients (2013) 1.30

Sex-specific differences in leg fat uptake are revealed with a high-fat meal. Am J Physiol Endocrinol Metab (2006) 1.25

Leptin, insulin resistance, and liver fibrosis in human nonalcoholic fatty liver disease. J Hepatol (2004) 1.24

Basal and insulin-regulated free fatty acid and glucose metabolism in humans. Am J Physiol Endocrinol Metab (2007) 1.24

Higher muscle protein synthesis in women than men across the lifespan, and failure of androgen administration to amend age-related decrements. FASEB J (2008) 1.24

Preventing overestimation of pixels in computed tomography assessment of visceral fat. Obes Res (2004) 1.22

Plasma free fatty acid storage in subcutaneous and visceral adipose tissue in postabsorptive women. Diabetes (2008) 1.22

Secretory PLA2-IIA: a new inflammatory factor for Alzheimer's disease. J Neuroinflammation (2006) 1.20

Strength training and adiposity in premenopausal women: strong, healthy, and empowered study. Am J Clin Nutr (2007) 1.20

Effect of 2 years of testosterone replacement on insulin secretion, insulin action, glucose effectiveness, hepatic insulin clearance, and postprandial glucose turnover in elderly men. Diabetes Care (2007) 1.20

Meal fatty acid uptake in visceral fat in women. Diabetes (2007) 1.20

Leptin upregulates caveolin-1 expression: implications for development of atherosclerosis. Atherosclerosis (2010) 1.19

Measuring committed preadipocytes in human adipose tissue from severely obese patients by using adipocyte fatty acid binding protein. Am J Physiol Regul Integr Comp Physiol (2004) 1.16

Counterpoint: visceral adiposity is not causally related to insulin resistance. Diabetes Care (2005) 1.15

Single-gene detection and karyotyping using small-target fluorescence in situ hybridization on maize somatic chromosomes. Genetics (2007) 1.13

The influence of sex and obesity phenotype on meal fatty acid metabolism before and after weight loss. Am J Clin Nutr (2008) 1.13

Visceral and subcutaneous adipose tissue diacylglycerol acyltransferase activity in humans. Obesity (Silver Spring) (2009) 1.12

Sex differences in abdominal, gluteal, and thigh LPL activity. Am J Physiol Endocrinol Metab (2007) 1.10

Free fatty acid storage in human visceral and subcutaneous adipose tissue: role of adipocyte proteins. Diabetes (2011) 1.09

Storage rates of circulating free fatty acid into adipose tissue during eating or walking in humans. Diabetes (2012) 1.07

Regional fat deposition as a factor in FFA metabolism. Annu Rev Nutr (2007) 1.07

Growth hormone-induced insulin resistance is associated with increased intramyocellular triglyceride content but unaltered VLDL-triglyceride kinetics. Am J Physiol Endocrinol Metab (2006) 1.07

Insulin regulation of free fatty acid kinetics in adult cystic fibrosis patients with impaired glucose tolerance. Metabolism (2004) 1.05

Phospholipase A2 in astrocytes: responses to oxidative stress, inflammation, and G protein-coupled receptor agonists. Mol Neurobiol (2005) 1.04

Modest visceral fat gain causes endothelial dysfunction in healthy humans. J Am Coll Cardiol (2010) 1.04

A novel ELISA for measuring CD36 protein in human adipose tissue. J Lipid Res (2010) 1.04

Two years of treatment with dehydroepiandrosterone does not improve insulin secretion, insulin action, or postprandial glucose turnover in elderly men or women. Diabetes (2007) 1.04

Influence of fish oil on skeletal muscle mitochondrial energetics and lipid metabolites during high-fat diet. Am J Physiol Endocrinol Metab (2013) 1.04

Vascular response to angiotensin II in upper body obesity. Hypertension (2004) 1.02

Evidence of increased visceral obesity and reduced physical fitness in healthy insulin-resistant first-degree relatives of type 2 diabetic patients. Eur J Endocrinol (2004) 0.99

Effects of male hypogonadism on regional adipose tissue fatty acid storage and lipogenic proteins. PLoS One (2012) 0.98

Adipocyte mitochondrial function is reduced in human obesity independent of fat cell size. J Clin Endocrinol Metab (2013) 0.98

In vivo measurement of synthesis rate of multiple plasma proteins in humans. Am J Physiol Endocrinol Metab (2006) 0.97

Omental 11beta-hydroxysteroid dehydrogenase 1 correlates with fat cell size independently of obesity. Obesity (Silver Spring) (2007) 0.97

Relationship between postabsorptive respiratory exchange ratio and plasma free fatty acid concentrations. J Lipid Res (2009) 0.96

Effect of high fat diet enriched with unsaturated and diet rich in saturated fatty acids on sphingolipid metabolism in rat skeletal muscle. J Cell Physiol (2010) 0.95

Measuring VLDL-triglyceride turnover in humans using ex vivo-prepared VLDL tracer. J Lipid Res (2005) 0.95

Sphingolipid content of human adipose tissue: relationship to adiponectin and insulin resistance. Obesity (Silver Spring) (2012) 0.95

Measuring long-chain acyl-coenzyme A concentrations and enrichment using liquid chromatography/tandem mass spectrometry with selected reaction monitoring. Rapid Commun Mass Spectrom (2011) 0.94

Weekly changes in basal metabolic rate with eight weeks of overfeeding. Obesity (Silver Spring) (2006) 0.94

Myocardium of type 2 diabetic and obese patients is characterized by alterations in sphingolipid metabolic enzymes but not by accumulation of ceramide. J Lipid Res (2010) 0.93

Body fat distribution, adipocyte size, and metabolic characteristics of nondiabetic adults. J Clin Endocrinol Metab (2009) 0.93

Energy expenditure, insulin, and VLDL-triglyceride production in humans. J Lipid Res (2006) 0.93

Impact of body composition on very-low-density lipoprotein-triglycerides kinetics. Am J Physiol Endocrinol Metab (2008) 0.93

Alteration of gastric functions and candidate genes associated with weight reduction in response to sibutramine. Clin Gastroenterol Hepatol (2007) 0.92

Effects of free fatty acids and glycerol on splanchnic glucose metabolism and insulin extraction in nondiabetic humans. Diabetes (2002) 0.92

Effect of exercise duration on the key pathways of ceramide metabolism in rat skeletal muscles. J Cell Biochem (2008) 0.91

Diet/Exercise versus pioglitazone: effects of insulin sensitization with decreasing or increasing fat mass on adipokines and inflammatory markers. J Clin Endocrinol Metab (2006) 0.91

Effects of weight gain and weight loss on regional fat distribution. Am J Clin Nutr (2012) 0.91

Effects of pioglitazone versus glipizide on body fat distribution, body water content, and hemodynamics in type 2 diabetes. Diabetes Care (2006) 0.91

Recruitment and screening for a randomized trial investigating Roux-en-Y gastric bypass versus intensive medical management for treatment of type 2 diabetes. Obes Surg (2014) 0.91

Fatty acid metabolism in the elderly: effects of dehydroepiandrosterone and testosterone replacement in hormonally deficient men and women. J Clin Endocrinol Metab (2009) 0.90

Plasma sphingosine-1-phosphate concentration is reduced in patients with myocardial infarction. Med Sci Monit (2009) 0.90