Radiation and ceramide-induced apoptosis.

An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models. Science (2008) 4.89

Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice. Nat Med (2005) 4.31

Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis. Cell (2012) 3.23

Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell (2008) 3.15

Platelets, petechiae, and preservation of the vascular wall. N Engl J Med (2008) 2.25

Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2. J Pharmacol Exp Ther (2010) 2.09

The pathogenesis and treatment of acid sphingomyelinase-deficient Niemann-Pick disease. J Inherit Metab Dis (2007) 1.94

Ceramide-orchestrated signalling in cancer cells. Nat Rev Cancer (2012) 1.79

LASS3 (longevity assurance homologue 3) is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity. Biochem J (2006) 1.54

Role of membrane sphingomyelin and ceramide in platform formation for Fas-mediated apoptosis. J Exp Med (2005) 1.46

Targeted induction of lung endothelial cell apoptosis causes emphysema-like changes in the mouse. J Biol Chem (2008) 1.44

New paradigms and future challenges in radiation oncology: an update of biological targets and technology. Sci Transl Med (2013) 1.35

Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms. Mol Pharmacol (2009) 1.29

AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells. J Lipid Res (2009) 1.23

Golgi fragmentation is associated with ceramide-induced cellular effects. Mol Biol Cell (2005) 1.21

Emergence of stereotactic body radiation therapy and its impact on current and future clinical practice. J Clin Oncol (2014) 1.21

Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling. Mol Cancer (2010) 1.21

RB1 dual role in proliferation and apoptosis: cell fate control and implications for cancer therapy. Oncotarget (2015) 1.20

Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer. Mol Ther (2008) 1.19

The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner. Cell Signal (2011) 1.15

Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery. PLoS One (2010) 1.13

A new mixed-backbone oligonucleotide against glucosylceramide synthase sensitizes multidrug-resistant tumors to apoptosis. PLoS One (2009) 1.11

Apoptotic sphingolipid signaling by ceramides in lung endothelial cells. Am J Respir Cell Mol Biol (2008) 1.11

A liquid chromatography/tandem mass spectrometry method for measuring the in vivo incorporation of plasma free fatty acids into intramyocellular ceramides in humans. Rapid Commun Mass Spectrom (2012) 1.10

Cancer treatment strategies targeting sphingolipid metabolism. Adv Exp Med Biol (2010) 1.09

Prevention and mitigation of acute radiation syndrome in mice by synthetic lipopeptide agonists of Toll-like receptor 2 (TLR2). PLoS One (2012) 1.07

Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. Mol Cell Biol (2006) 1.07

Spinal ceramide modulates the development of morphine antinociceptive tolerance via peroxynitrite-mediated nitroxidative stress and neuroimmune activation. J Pharmacol Exp Ther (2008) 1.07

Role of the autotaxin-lysophosphatidate axis in cancer resistance to chemotherapy and radiotherapy. Biochim Biophys Acta (2012) 1.04

Ceramide kinase promotes tumor cell survival and mammary tumor recurrence. Cancer Res (2014) 1.03

Oxidative lipidomics of γ-radiation-induced lung injury: mass spectrometric characterization of cardiolipin and phosphatidylserine peroxidation. Radiat Res (2011) 1.02

Cell-nonautonomous function of ceramidase in photoreceptor homeostasis. Neuron (2008) 1.02

Combined anticancer effects of sphingosine kinase inhibitors and sorafenib. Invest New Drugs (2010) 1.01

Glucosylceramide synthase, a factor in modulating drug resistance, is overexpressed in metastatic breast carcinoma. Int J Oncol (2011) 0.99

MEMS-enabled implantable drug infusion pumps for laboratory animal research, preclinical, and clinical applications. Adv Drug Deliv Rev (2012) 0.99

Role of sphingolipids in murine radiation-induced lung injury: protection by sphingosine 1-phosphate analogs. FASEB J (2011) 0.98

Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma. Blood (2014) 0.96

Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse. J Clin Invest (2013) 0.96

Effect of irradiation on microvascular endothelial cells of parotid glands in the miniature pig. Int J Radiat Oncol Biol Phys (2010) 0.96

Sphingolipid content of human adipose tissue: relationship to adiponectin and insulin resistance. Obesity (Silver Spring) (2012) 0.95

S1P lyase regulates DNA damage responses through a novel sphingolipid feedback mechanism. Cell Death Dis (2011) 0.95

Inhibition of cytokine signaling in human retinal endothelial cells through downregulation of sphingomyelinases by docosahexaenoic acid. Invest Ophthalmol Vis Sci (2010) 0.95

Selective irradiation of the vascular endothelium has no effect on the survival of murine intestinal crypt stem cells. Proc Natl Acad Sci U S A (2006) 0.94

Microbubble and ultrasound radioenhancement of bladder cancer. Br J Cancer (2012) 0.94

Defining a role for sphingosine kinase 1 in p53-dependent tumors. Oncogene (2011) 0.94

Membrane signaling induced by high doses of ionizing radiation in the endothelial compartment. Relevance in radiation toxicity. Int J Mol Sci (2013) 0.93

The membrane targeted apoptosis modulators erucylphosphocholine and erucylphosphohomocholine increase the radiation response of human glioblastoma cell lines in vitro. Radiat Oncol (2006) 0.92

Mechanisms of radiation toxicity in transformed and non-transformed cells. Int J Mol Sci (2013) 0.92

Alpha particles induce apoptosis through the sphingomyelin pathway. Radiat Res (2011) 0.91

Role of Acid Sphingomyelinase in Shifting the Balance Between Proinflammatory and Reparative Bone Marrow Cells in Diabetic Retinopathy. Stem Cells (2016) 0.89

Pancreatic cancer and SBRT: A new potential option? Rep Pract Oncol Radiother (2015) 0.88

Metronomic small molecule inhibitor of Bcl-2 (TW-37) is antiangiogenic and potentiates the antitumor effect of ionizing radiation. Int J Radiat Oncol Biol Phys (2010) 0.88

Spinal ceramide and neuronal apoptosis in morphine antinociceptive tolerance. Neurosci Lett (2009) 0.88

Discovery and evaluation of inhibitors of human ceramidase. Mol Cancer Ther (2011) 0.87

Novel drugs to ameliorate gastrointestinal normal tissue radiation toxicity in clinical practice: what is emerging from the laboratory? Curr Opin Support Palliat Care (2012) 0.87

Therapeutic Implications for Overcoming Radiation Resistance in Cancer Therapy. Int J Mol Sci (2015) 0.86

Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation. Sci Signal (2015) 0.85

Lysophosphatidate induces chemo-resistance by releasing breast cancer cells from taxol-induced mitotic arrest. PLoS One (2011) 0.85

Epigallocatechin-3-gallate (EGCG) protects skin cells from ionizing radiation via heme oxygenase-1 (HO-1) overexpression. J Radiat Res (2014) 0.85

Ultrasound-activated microbubble cancer therapy: ceramide production leading to enhanced radiation effect in vitro. Technol Cancer Res Treat (2012) 0.84

Aerobic training in rats increases skeletal muscle sphingomyelinase and serine palmitoyltransferase activity, while decreasing ceramidase activity. Lipids (2010) 0.84

Targeting sphingolipid metabolism in head and neck cancer: rational therapeutic potentials. Expert Opin Ther Targets (2010) 0.84

Space radiation-associated lung injury in a murine model. Am J Physiol Lung Cell Mol Physiol (2014) 0.84

Genetic and epigenetic features in radiation sensitivity Part I: cell signalling in radiation response. Eur J Nucl Med Mol Imaging (2005) 0.84

The potential of radiotherapy to enhance the efficacy of renal cell carcinoma therapy. Oncoimmunology (2015) 0.83

p53-independent early and late apoptosis is mediated by ceramide after exposure of tumor cells to photon or carbon ion irradiation. BMC Cancer (2013) 0.83

Ionizing radiation potentiates dihydroartemisinin-induced apoptosis of A549 cells via a caspase-8-dependent pathway. PLoS One (2013) 0.82

Tamoxifen magnifies therapeutic impact of ceramide in human colorectal cancer cells independent of p53. Biochem Pharmacol (2013) 0.82

Ultrasound-stimulated microbubble enhancement of radiation treatments: endothelial cell function and mechanism. Oncoscience (2015) 0.80

Combining Bevacizumab with Radiation or Chemoradiation for Solid Tumors: A Review of the Scientific Rationale, and Clinical Trials. Curr Angiogenes (2012) 0.80

A novel radioprotective function for the mitochondrial tumor suppressor protein Fus1. Cell Death Dis (2013) 0.80

Ceramide alters endothelial cell permeability by a nonapoptotic mechanism. Br J Pharmacol (2005) 0.80

The Rationale for Targeted Therapies and Stereotactic Radiosurgery in the Treatment of Brain Metastases. Oncologist (2016) 0.79

The endothelial deprotection hypothesis for lupus pathogenesis: the dual role of C1q as a mediator of clearance and regulator of endothelial permeability. F1000Res (2015) 0.79

Solenopsin A and analogs exhibit ceramide-like biological activity. Vasc Cell (2015) 0.79

P-glycoprotein antagonists confer synergistic sensitivity to short-chain ceramide in human multidrug-resistant cancer cells. Exp Cell Res (2011) 0.79

Gold nanoparticle induced vasculature damage in radiotherapy: Comparing protons, megavoltage photons, and kilovoltage photons. Med Phys (2015) 0.79

Biology of high single doses of IORT: RBE, 5 R's, and other biological aspects. Radiat Oncol (2017) 0.79

Exploring the link between ceramide and ionizing radiation. Glycoconj J (2014) 0.78

Local and systemic pathogenesis and consequences of regimen-induced inflammatory responses in patients with head and neck cancer receiving chemoradiation. Mediators Inflamm (2014) 0.78

Understanding the Pathophysiology and Challenges of Development of Medical Countermeasures for Radiation-Induced Vascular/Endothelial Cell Injuries: Report of a NIAID Workshop, August 20, 2015. Radiat Res (2016) 0.77

To combine or not combine: the role of radiotherapy and targeted agents in the treatment for renal cell carcinoma. World J Urol (2013) 0.77

Low-dose photon irradiation alters cell differentiation via activation of hIK channels. Pflugers Arch (2014) 0.77

Differential activation of NF-κB and nitric oxide in lymphocytes regulates in vitro and in vivo radiosensitivity. Mutat Res (2010) 0.77

Towards novel radiosensitizing agents: the role of cytosolic PLA2α in combined modality cancer therapy. Future Med Chem (2011) 0.77

Ionizing radiations increase the activity of the cell surface glycohydrolases and the plasma membrane ceramide content. Glycoconj J (2012) 0.77

Expression of blood serum proteins and lymphocyte differentiation clusters after chronic occupational exposure to ionizing radiation. Radiat Environ Biophys (2014) 0.76

CHK1 regulates NF-κB signaling upon DNA damage in p53- deficient cells and associated tumor-derived microvesicles. Oncotarget (2016) 0.76

Differential protection by wildtype vs. organelle-specific Bcl-2 suggests a combined requirement of both the ER and mitochondria in ceramide-mediated caspase-independent programmed cell death. Radiat Oncol (2009) 0.76

Extracellular matrix proteins modulate antimigratory and apoptotic effects of Doxorubicin. Chemother Res Pract (2012) 0.76

Stereotactic body radiation therapy as a derivative of stereotactic radiosurgery: clinically independent but with enduring common themes. J Clin Oncol (2014) 0.76

The radiobiological targets of SBRT: tumor cells or endothelial cells? Ann Transl Med (2015) 0.76

p38 mitogen-activated protein kinase/activator protein-1 involved in serum deprivation-induced human alkaline ceramidase 2 upregulation. Biomed Rep (2014) 0.76

Simvastatin ameliorates ionizing radiation-induced apoptosis in the thymus by activating the AKT/sirtuin 1 pathway in mice. Int J Mol Med (2017) 0.75

Oxygen and Perfusion Kinetics in Response to Fractionated Radiation Therapy in FaDu Head and Neck Cancer Xenografts Are Related to Treatment Outcome. Int J Radiat Oncol Biol Phys (2016) 0.75

New Aspects of Silibinin Stereoisomers and their 3-O-galloyl Derivatives on Cytotoxicity and Ceramide Metabolism in Hep G2 hepatocarcinoma Cell Line. Iran J Pharm Res (2016) 0.75

A comparison of robotic arm versus gantry linear accelerator stereotactic body radiation therapy for prostate cancer. Res Rep Urol (2016) 0.75

Challenges of Using High-Dose Fractionation Radiotherapy in Combination Therapy. Front Oncol (2016) 0.75

Dynamics of ceramide generation and metabolism in response to fenretinide--Diversity within and among leukemia. Leuk Res (2015) 0.75

Radiation-Induced Microvascular Injury as a Mechanism of Salivary Gland Hypofunction and Potential Target for Radioprotectors. Radiat Res (2016) 0.75

Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science (2003) 7.86

High-dose, single-fraction image-guided intensity-modulated radiotherapy for metastatic spinal lesions. Int J Radiat Oncol Biol Phys (2008) 3.78

Metastasis after radical prostatectomy or external beam radiotherapy for patients with clinically localized prostate cancer: a comparison of clinical cohorts adjusted for case mix. J Clin Oncol (2010) 3.76

High-dose intensity modulated radiation therapy for prostate cancer: early toxicity and biochemical outcome in 772 patients. Int J Radiat Oncol Biol Phys (2002) 2.65

Crypt base columnar stem cells in small intestines of mice are radioresistant. Gastroenterology (2012) 2.31

Influence of local tumor control on distant metastases and cancer related mortality after external beam radiotherapy for prostate cancer. J Urol (2008) 2.30

ATM regulates target switching to escalating doses of radiation in the intestines. Nat Med (2005) 2.28

Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation. PLoS One (2011) 1.86

Long-term results of conformal radiotherapy for prostate cancer: impact of dose escalation on biochemical tumor control and distant metastases-free survival outcomes. Int J Radiat Oncol Biol Phys (2008) 1.85

Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans. Science (2008) 1.83

Cytolytic T cells induce ceramide-rich platforms in target cell membranes to initiate graft-versus-host disease. Blood (2009) 1.67

Normalization of serum testosterone levels in patients treated with neoadjuvant hormonal therapy and three-dimensional conformal radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys (2002) 1.67

Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells. Cell Signal (2010) 1.60

Ultra-high dose (86.4 Gy) IMRT for localized prostate cancer: toxicity and biochemical outcomes. Int J Radiat Oncol Biol Phys (2007) 1.54

Predictors of biochemical outcome with salvage conformal radiotherapy after radical prostatectomy for prostate cancer. J Clin Oncol (2003) 1.51

PKCalpha activation downregulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo. Cancer Biol Ther (2009) 1.48

Caspase-dependent and -independent activation of acid sphingomyelinase signaling. J Biol Chem (2005) 1.44

Bax and Bak do not exhibit functional redundancy in mediating radiation-induced endothelial apoptosis in the intestinal mucosa. Int J Radiat Oncol Biol Phys (2008) 1.34

Microvascular function regulates intestinal crypt response to radiation. Cancer Res (2003) 1.30

Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing irradiation. Nat Genet (2004) 1.29

Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine. FEBS Lett (2007) 1.29

Pretreatment nomogram that predicts 5-year probability of metastasis following three-dimensional conformal radiation therapy for localized prostate cancer. J Clin Oncol (2003) 1.27

Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes. Genomics (2002) 1.22

Tumor control outcomes after hypofractionated and single-dose stereotactic image-guided intensity-modulated radiotherapy for extracranial metastases from renal cell carcinoma. Int J Radiat Oncol Biol Phys (2011) 1.16

Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in mice. J Clin Invest (2012) 1.15

Accurate setup of paraspinal patients using a noninvasive patient immobilization cradle and portal imaging. Med Phys (2005) 1.13

Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery. PLoS One (2010) 1.13

Predictors of local control after single-dose stereotactic image-guided intensity-modulated radiotherapy for extracranial metastases. Int J Radiat Oncol Biol Phys (2010) 1.13

Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer. Nat Med (2003) 1.12

Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring. Nat Med (2002) 1.12

Whole pelvic radiotherapy for prostate cancer using 3D conformal and intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys (2005) 1.12

From IMRT to IGRT: frontierland or neverland? Radiother Oncol (2006) 1.11

IMRT of large fields: whole-abdomen irradiation. Int J Radiat Oncol Biol Phys (2002) 1.09

Intensity-modulated radiotherapy. Cancer J (2002) 1.07

Sphingosine-1-phosphate activates the AKT pathway to protect small intestines from radiation-induced endothelial apoptosis. Cancer Res (2010) 1.07

Down-regulation of ATM protein sensitizes human prostate cancer cells to radiation-induced apoptosis. J Biol Chem (2005) 1.03

Intensity-modulated radiation therapy for prostate cancer. Semin Radiat Oncol (2002) 1.02

Impact of stromal sensitivity on radiation response of tumors implanted in SCID hosts revisited. Cancer Res (2010) 1.01

Technological advances in external-beam radiation therapy for the treatment of localized prostate cancer. Semin Oncol (2003) 1.00

Risk group dependence of dose-response for biopsy outcome after three-dimensional conformal radiation therapy of prostate cancer. Radiother Oncol (2002) 1.00

Involvement of membrane signaling in the bystander effect in irradiated cells. Cancer Res (2002) 0.99

Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery. PLoS One (2010) 0.97

Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes. Cancer Res (2010) 0.96

Timing of lethality from gastrointestinal syndrome in mice revisited. Int J Radiat Oncol Biol Phys (2009) 0.95

A CERTain role for ceramide in taxane-induced cell death. Cancer Cell (2007) 0.95

Improved biochemical disease-free survival of men younger than 60 years with prostate cancer treated with high dose conformal external beam radiotherapy. J Urol (2003) 0.94

Image-fusion of MR spectroscopic images for treatment planning of gliomas. Med Phys (2006) 0.94

A ceramide-binding C1 domain mediates kinase suppressor of ras membrane translocation. Cell Physiol Biochem (2009) 0.93

Adenoviral transduction of human acid sphingomyelinase into neo-angiogenic endothelium radiosensitizes tumor cure. PLoS One (2013) 0.87

Education and training for radiation scientists: radiation research program and American Society of Therapeutic Radiology and Oncology Workshop, Bethesda, Maryland, May 12-14, 2003. Radiat Res (2003) 0.86

Host acid sphingomyelinase regulates microvascular function not tumor immunity. Cancer Res (2004) 0.83

Comparison of kilovoltage cone-beam computed tomography with megavoltage projection pairs for paraspinal radiosurgery patient alignment and position verification. Int J Radiat Oncol Biol Phys (2008) 0.83

Kinase suppressor of Ras transphosphorylates c-Raf-1. Biochem Biophys Res Commun (2009) 0.82

Downregulation of KSR1 in pancreatic cancer xenografts by antisense oligonucleotide correlates with tumor drug uptake. Cancer Biol Ther (2008) 0.80

A study of the effects of internal organ motion on dose escalation in conformal prostate treatments. Radiother Oncol (2003) 0.76

Correction: Targeting Homologous Recombination in Notch-Driven C. elegans Stem Cell and Human Tumors. PLoS One (2016) 0.75

Correction: Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation. PLoS One (2015) 0.75

Advances in translational radiation oncology: from molecular signaling to cancer cure. Int J Radiat Oncol Biol Phys (2004) 0.75