Published in Crit Rev Oncog on January 01, 2012
Targeted-capture massively-parallel sequencing enables robust detection of clinically informative mutations from formalin-fixed tumours. Sci Rep (2013) 0.97
RLIMS-P: an online text-mining tool for literature-based extraction of protein phosphorylation information. Database (Oxford) (2014) 0.96
Postmortem brain: an underutilized substrate for studying severe mental illness. Neuropsychopharmacology (2013) 0.91
Targeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies? Immunol Rev (2015) 0.88
ACK1 tyrosine kinase: targeted inhibition to block cancer cell proliferation. Cancer Lett (2013) 0.87
Fluorescence lifetime imaging of biosensor peptide phosphorylation in single live cells. Angew Chem Int Ed Engl (2013) 0.85
PBK/TOPK enhances aggressive phenotype in prostate cancer via β-catenin-TCF/LEF-mediated matrix metalloproteinases production and invasion. Oncotarget (2015) 0.80
PAS kinase is activated by direct SNF1-dependent phosphorylation and mediates inhibition of TORC1 through the phosphorylation and activation of Pbp1. Mol Biol Cell (2014) 0.80
A comprehensive protein-protein interactome for yeast PAS kinase 1 reveals direct inhibition of respiration through the phosphorylation of Cbf1. Mol Biol Cell (2014) 0.78
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature (2012) 8.31
Dual-specificity phosphatases: critical regulators with diverse cellular targets. Biochem J (2009) 3.98
Temporal regulation of EGF signalling networks by the scaffold protein Shc1. Nature (2013) 2.33
Cyclin D1, EMS1 and 11q13 amplification in breast cancer. Breast Cancer Res Treat (2003) 2.14
A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton. J Biol Chem (2003) 1.99
Improved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice. EMBO J (2004) 1.97
PI3K pathway activation in breast cancer is associated with the basal-like phenotype and cancer-specific mortality. Int J Cancer (2010) 1.89
Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14. Mol Cell (2005) 1.84
Cell cycle control in breast cancer cells. J Cell Biochem (2006) 1.68
Nedd4 controls animal growth by regulating IGF-1 signaling. Sci Signal (2008) 1.67
Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life. Mol Cell Biol (2007) 1.63
Tyrosine phosphorylation profiling reveals the signaling network characteristics of Basal breast cancer cells. Cancer Res (2010) 1.62
Function, regulation and pathological roles of the Gab/DOS docking proteins. Cell Commun Signal (2009) 1.59
Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein. J Biol Chem (2005) 1.32
PI3K(p110 alpha) protects against myocardial infarction-induced heart failure: identification of PI3K-regulated miRNA and mRNA. Arterioscler Thromb Vasc Biol (2010) 1.24
Aberrant expression of cortactin in head and neck squamous cell carcinoma cells is associated with enhanced cell proliferation and resistance to the epidermal growth factor receptor inhibitor gefitinib. Cancer Res (2007) 1.14
PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2. EMBO J (2002) 1.14
Cortactin overexpression inhibits ligand-induced down-regulation of the epidermal growth factor receptor. Cancer Res (2005) 1.11
Identification of novel non-phosphorylated ligands, which bind selectively to the SH2 domain of Grb7. J Biol Chem (2002) 1.10
Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. EMBO J (2008) 1.06
Imprinted genes that regulate early mammalian growth are coexpressed in somatic stem cells. PLoS One (2011) 1.06
Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasis. Mol Endocrinol (2009) 1.04
Growth factor receptor-bound protein 14 undergoes light-dependent intracellular translocation in rod photoreceptors: functional role in retinal insulin receptor activation. Biochemistry (2009) 1.04
KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling. Biochim Biophys Acta (2008) 1.02
Adapter protein connections: the MRL and Grb7 protein families. Growth Factors (2005) 1.02
Overexpression of the oncogenic signal transducer Gab2 occurs early in breast cancer development. Int J Cancer (2010) 1.01
Annexin A6 stimulates the membrane recruitment of p120GAP to modulate Ras and Raf-1 activity. Oncogene (2005) 1.01
Involvement of Lyn and the atypical kinase SgK269/PEAK1 in a basal breast cancer signaling pathway. Cancer Res (2013) 0.98
Solution structure of the human Grb7-SH2 domain/erbB2 peptide complex and structural basis for Grb7 binding to ErbB2. J Biomol NMR (2003) 0.98
p27(Kip1) induces quiescence and growth factor insensitivity in tamoxifen-treated breast cancer cells. Cancer Res (2003) 0.98
Growth factor receptor-bound protein 14: a new modulator of photoreceptor-specific cyclic-nucleotide-gated channel. EMBO Rep (2010) 0.97
Molecular determinants of Grb14-mediated inhibition of insulin signaling. Mol Endocrinol (2009) 0.97
Grb7-based molecular therapeutics in cancer. Expert Rev Mol Med (2003) 0.96
Grb10 regulates the development of fiber number in skeletal muscle. FASEB J (2012) 0.96
TCPTP regulates SFK and STAT3 signaling and is lost in triple-negative breast cancers. Mol Cell Biol (2012) 0.93
Grb10 deletion enhances muscle cell proliferation, differentiation and GLUT4 plasma membrane translocation. J Cell Physiol (2014) 0.93
Global characterization of signalling networks associated with tamoxifen resistance in breast cancer. FEBS J (2013) 0.91
Protein kinase Cdelta and calmodulin regulate epidermal growth factor receptor recycling from early endosomes through Arp2/3 complex and cortactin. Mol Biol Cell (2007) 0.89
Gab2 regulates cytoskeletal organization and migration of mammary epithelial cells by modulating RhoA activation. Mol Biol Cell (2010) 0.87
Cortactin modulates RhoA activation and expression of Cip/Kip cyclin-dependent kinase inhibitors to promote cell cycle progression in 11q13-amplified head and neck squamous cell carcinoma cells. Mol Cell Biol (2010) 0.85
Phosphoproteomic profiling identifies focal adhesion kinase as a mediator of docetaxel resistance in castrate-resistant prostate cancer. Mol Cancer Ther (2013) 0.85
Hormonal regulation of the Grb14 signal modulator and its role in cell cycle progression of MCF-7 human breast cancer cells. J Cell Physiol (2005) 0.84
RON is not a prognostic marker for resectable pancreatic cancer. BMC Cancer (2012) 0.83
The PDZ-binding motif of MCC is phosphorylated at position -1 and controls lamellipodia formation in colon epithelial cells. Biochim Biophys Acta (2012) 0.82
DUSP26 negatively affects the proliferation of epithelial cells, an effect not mediated by dephosphorylation of MAPKs. Biochim Biophys Acta (2010) 0.82
Docking proteins. FEBS J (2010) 0.81
Loss of STARD10 expression identifies a group of poor prognosis breast cancers independent of HER2/Neu and triple negative status. Int J Cancer (2010) 0.81
How to Grb2 a Gab. Structure (2009) 0.81
Profiling the tyrosine phosphoproteome of different mouse mammary tumour models reveals distinct, model-specific signalling networks and conserved oncogenic pathways. Breast Cancer Res (2014) 0.79
Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling. J Proteome Res (2013) 0.78
Signalling through the grapevine. EMBO Rep (2012) 0.77
New insights into signalling networks regulating breast cancer stem cells. Breast Cancer Res (2012) 0.75
Professor Robert Sutherland FAA, AO (1947-2012). Horm Mol Biol Clin Investig (2013) 0.75
Distinction at the leading edge of the cell. Bioessays (2005) 0.75