Published in Cancer Res on April 15, 2005
Regulation of the actin cytoskeleton in cancer cell migration and invasion. Biochim Biophys Acta (2006) 4.27
Cortactin in tumor invasiveness. Cancer Lett (2008) 1.88
Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases. Biochim Biophys Acta (2012) 1.39
Cortactin: a multifunctional regulator of cellular invasiveness. Cell Adh Migr (2011) 1.36
Cortactin in cell migration and cancer at a glance. J Cell Sci (2012) 1.34
AFAP-110 is overexpressed in prostate cancer and contributes to tumorigenic growth by regulating focal contacts. J Clin Invest (2007) 1.30
Clathrin-independent pathways of endocytosis. Cold Spring Harb Perspect Biol (2014) 1.25
Regulation of invasive behavior by vascular endothelial growth factor is HEF1-dependent. Oncogene (2010) 1.19
Prognostic significance of cortactin levels in head and neck squamous cell carcinoma: comparison with epidermal growth factor receptor status. Br J Cancer (2008) 1.01
I-BAR protein antagonism of endocytosis mediates directional sensing during guided cell migration. J Cell Biol (2010) 1.00
Mtss1 regulates epidermal growth factor signaling in head and neck squamous carcinoma cells. Oncogene (2011) 0.97
Cortactin is a sensitive biomarker relative to the poor prognosis of human hepatocellular carcinoma. World J Surg Oncol (2013) 0.95
PI(3,5)P2 controls endosomal branched actin dynamics by regulating cortactin-actin interactions. J Cell Biol (2015) 0.94
Cortactin expression confers a more malignant phenotype to gastric cancer SGC-7901 cells. World J Gastroenterol (2014) 0.89
Protein kinase Cdelta and calmodulin regulate epidermal growth factor receptor recycling from early endosomes through Arp2/3 complex and cortactin. Mol Biol Cell (2007) 0.89
Cortactin modulates RhoA activation and expression of Cip/Kip cyclin-dependent kinase inhibitors to promote cell cycle progression in 11q13-amplified head and neck squamous cell carcinoma cells. Mol Cell Biol (2010) 0.85
Down-regulation of c-Cbl by morphine accounts for persistent ERK1/2 signaling in delta-opioid receptor-expressing HEK293 cells. J Biol Chem (2009) 0.84
Cortactin is a substrate of activated Cdc42-associated kinase 1 (ACK1) during ligand-induced epidermal growth factor receptor downregulation. PLoS One (2012) 0.84
An eQTL-based method identifies CTTN and ZMAT3 as pemetrexed susceptibility markers. Hum Mol Genet (2011) 0.83
Cortactin promotes exosome secretion by controlling branched actin dynamics. J Cell Biol (2016) 0.83
Cortactin overexpression results in sustained epidermal growth factor receptor signaling by preventing ligand-induced receptor degradation in human carcinoma cells. Breast Cancer Res (2005) 0.80
Monitoring the dynamics of Src activity in response to anti-invasive dasatinib treatment at a subcellular level using dual intravital imaging. Cell Adh Migr (2014) 0.78
Altered trafficking of mutated growth factor receptors and their associated molecules: implication for human cancers. Cell Logist (2014) 0.76
Association between genetic polymorphisms in cortactin and susceptibility to gastric cancer. Ann Surg Treat Res (2015) 0.75
Cortactin promotes colorectal cancer cell proliferation by activating the EGFR-MAPK pathway. Oncotarget (2016) 0.75
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature (2012) 8.31
Epidermal growth factor receptor: mechanisms of activation and signalling. Exp Cell Res (2003) 6.43
Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha. Cell (2002) 4.92
Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nat Cell Biol (2003) 4.25
Dual-specificity phosphatases: critical regulators with diverse cellular targets. Biochem J (2009) 3.98
Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Cell (2010) 2.91
Forward and reverse genetics through derivation of haploid mouse embryonic stem cells. Cell Stem Cell (2011) 2.69
Ligand-induced dimer-tetramer transition during the activation of the cell surface epidermal growth factor receptor-A multidimensional microscopy analysis. J Biol Chem (2005) 2.54
Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Science (2009) 2.47
A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Cell (2010) 2.37
Temporal regulation of EGF signalling networks by the scaffold protein Shc1. Nature (2013) 2.33
Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes. Mol Cell Biol (2005) 2.20
Cyclin D1, EMS1 and 11q13 amplification in breast cancer. Breast Cancer Res Treat (2003) 2.14
A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton. J Biol Chem (2003) 1.99
Improved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice. EMBO J (2004) 1.97
PI3K pathway activation in breast cancer is associated with the basal-like phenotype and cancer-specific mortality. Int J Cancer (2010) 1.89
Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14. Mol Cell (2005) 1.84
Cell cycle control in breast cancer cells. J Cell Biochem (2006) 1.68
Nedd4 controls animal growth by regulating IGF-1 signaling. Sci Signal (2008) 1.67
Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life. Mol Cell Biol (2007) 1.63
Tyrosine phosphorylation profiling reveals the signaling network characteristics of Basal breast cancer cells. Cancer Res (2010) 1.62
Function, regulation and pathological roles of the Gab/DOS docking proteins. Cell Commun Signal (2009) 1.59
RANKL/RANK-beyond bones. J Mol Med (Berl) (2011) 1.34
Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein. J Biol Chem (2005) 1.32
The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor AG1478 increases the formation of inactive untethered EGFR dimers. Implications for combination therapy with monoclonal antibody 806. J Biol Chem (2006) 1.30
The tumor-specific de2-7 epidermal growth factor receptor (EGFR) promotes cells survival and heterodimerizes with the wild-type EGFR. Oncogene (2004) 1.28
PI3K(p110 alpha) protects against myocardial infarction-induced heart failure: identification of PI3K-regulated miRNA and mRNA. Arterioscler Thromb Vasc Biol (2010) 1.24
Identification of the epitope for the epidermal growth factor receptor-specific monoclonal antibody 806 reveals that it preferentially recognizes an untethered form of the receptor. J Biol Chem (2004) 1.23
Antitumor efficacy of cytotoxic drugs and the monoclonal antibody 806 is enhanced by the EGF receptor inhibitor AG1478. Proc Natl Acad Sci U S A (2003) 1.20
Aberrant expression of cortactin in head and neck squamous cell carcinoma cells is associated with enhanced cell proliferation and resistance to the epidermal growth factor receptor inhibitor gefitinib. Cancer Res (2007) 1.14
PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2. EMBO J (2002) 1.14
Nonsense mediated decay resistant mutations are a source of expressed mutant proteins in colon cancer cell lines with microsatellite instability. PLoS One (2010) 1.12
Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells. Development (2013) 1.11
PAK is essential for RAS-induced upregulation of cyclin D1 during the G1 to S transition. Cell Cycle (2004) 1.10
Identification of novel non-phosphorylated ligands, which bind selectively to the SH2 domain of Grb7. J Biol Chem (2002) 1.10
Antibodies specifically targeting a locally misfolded region of tumor associated EGFR. Proc Natl Acad Sci U S A (2009) 1.07
Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. EMBO J (2008) 1.06
Imprinted genes that regulate early mammalian growth are coexpressed in somatic stem cells. PLoS One (2011) 1.06
Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B-Raf. Int J Cancer (2009) 1.04
Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasis. Mol Endocrinol (2009) 1.04
Growth factor receptor-bound protein 14 undergoes light-dependent intracellular translocation in rod photoreceptors: functional role in retinal insulin receptor activation. Biochemistry (2009) 1.04
KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling. Biochim Biophys Acta (2008) 1.02
Adapter protein connections: the MRL and Grb7 protein families. Growth Factors (2005) 1.02
Epidermal growth factor receptor: association of extracellular domain negatively regulates intracellular kinase activation in the absence of ligand. Growth Factors (2003) 1.01
Overexpression of the oncogenic signal transducer Gab2 occurs early in breast cancer development. Int J Cancer (2010) 1.01
Annexin A6 stimulates the membrane recruitment of p120GAP to modulate Ras and Raf-1 activity. Oncogene (2005) 1.01
Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling. Proc Natl Acad Sci U S A (2005) 1.00
Disruption of the growth hormone--signal transducer and activator of transcription 5--insulinlike growth factor 1 axis severely aggravates liver fibrosis in a mouse model of cholestasis. Hepatology (2010) 1.00
Involvement of Lyn and the atypical kinase SgK269/PEAK1 in a basal breast cancer signaling pathway. Cancer Res (2013) 0.98
Solution structure of the human Grb7-SH2 domain/erbB2 peptide complex and structural basis for Grb7 binding to ErbB2. J Biomol NMR (2003) 0.98
p27(Kip1) induces quiescence and growth factor insensitivity in tamoxifen-treated breast cancer cells. Cancer Res (2003) 0.98
PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis. Cancer Res (2011) 0.97
Growth factor receptor-bound protein 14: a new modulator of photoreceptor-specific cyclic-nucleotide-gated channel. EMBO Rep (2010) 0.97
Molecular determinants of Grb14-mediated inhibition of insulin signaling. Mol Endocrinol (2009) 0.97
Grb10 regulates the development of fiber number in skeletal muscle. FASEB J (2012) 0.96
Grb7-based molecular therapeutics in cancer. Expert Rev Mol Med (2003) 0.96
TCPTP regulates SFK and STAT3 signaling and is lost in triple-negative breast cancers. Mol Cell Biol (2012) 0.93
Grb10 deletion enhances muscle cell proliferation, differentiation and GLUT4 plasma membrane translocation. J Cell Physiol (2014) 0.93
Functional effects of glycosylation at Asn-579 of the epidermal growth factor receptor. Biochemistry (2005) 0.93
Global characterization of signalling networks associated with tamoxifen resistance in breast cancer. FEBS J (2013) 0.91
Protein kinase Cdelta and calmodulin regulate epidermal growth factor receptor recycling from early endosomes through Arp2/3 complex and cortactin. Mol Biol Cell (2007) 0.89
Targeting the human kinome for cancer therapy: current perspectives. Crit Rev Oncog (2012) 0.87
Gab2 regulates cytoskeletal organization and migration of mammary epithelial cells by modulating RhoA activation. Mol Biol Cell (2010) 0.87
Cortactin modulates RhoA activation and expression of Cip/Kip cyclin-dependent kinase inhibitors to promote cell cycle progression in 11q13-amplified head and neck squamous cell carcinoma cells. Mol Cell Biol (2010) 0.85
Phosphoproteomic profiling identifies focal adhesion kinase as a mediator of docetaxel resistance in castrate-resistant prostate cancer. Mol Cancer Ther (2013) 0.85
Hormonal regulation of the Grb14 signal modulator and its role in cell cycle progression of MCF-7 human breast cancer cells. J Cell Physiol (2005) 0.84
Respiratory inductive plethysmography as a method for measuring ventilatory parameters in conscious, non-restrained dogs. J Pharmacol Toxicol Methods (2010) 0.84
RON is not a prognostic marker for resectable pancreatic cancer. BMC Cancer (2012) 0.83
DUSP26 negatively affects the proliferation of epithelial cells, an effect not mediated by dephosphorylation of MAPKs. Biochim Biophys Acta (2010) 0.82
The PDZ-binding motif of MCC is phosphorylated at position -1 and controls lamellipodia formation in colon epithelial cells. Biochim Biophys Acta (2012) 0.82
Docking proteins. FEBS J (2010) 0.81
Loss of STARD10 expression identifies a group of poor prognosis breast cancers independent of HER2/Neu and triple negative status. Int J Cancer (2010) 0.81
How to Grb2 a Gab. Structure (2009) 0.81
Profiling the tyrosine phosphoproteome of different mouse mammary tumour models reveals distinct, model-specific signalling networks and conserved oncogenic pathways. Breast Cancer Res (2014) 0.79
Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling. J Proteome Res (2013) 0.78
The role of disulfide bonds in the structure and function of murine epidermal growth factor (mEGF). Growth Factors (2005) 0.77
Signalling through the grapevine. EMBO Rep (2012) 0.77
A mouse model to identify cooperating signaling pathways in cancer. Nat Methods (2012) 0.76
Macrophage-colony stimulating factor is required for the production of neutrophil-promoting activity by mouse embryo fibroblasts deficient in G-CSF and GM-CSF. J Leukoc Biol (2007) 0.76
New insights into signalling networks regulating breast cancer stem cells. Breast Cancer Res (2012) 0.75
Professor Robert Sutherland FAA, AO (1947-2012). Horm Mol Biol Clin Investig (2013) 0.75
Distinction at the leading edge of the cell. Bioessays (2005) 0.75