PubRank

Alan Aderem

Author PubWeight™ 199.80‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. Nat Immunol 2006 9.64
2 Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 2004 9.40
3 Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4. Nature 2006 6.28
4 Systems biology of vaccination for seasonal influenza in humans. Nat Immunol 2011 6.09
5 Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat Immunol 2010 6.05
6 Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome. Proc Natl Acad Sci U S A 2010 5.59
7 Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility. Nat Immunol 2003 5.18
8 Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry. Genome Biol 2004 4.91
9 Pyogenic bacterial infections in humans with IRAK-4 deficiency. Science 2003 4.80
10 The evolution of vertebrate Toll-like receptors. Proc Natl Acad Sci U S A 2005 4.42
11 Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation. N Engl J Med 2008 4.16
12 Caspase-11 protects against bacteria that escape the vacuole. Science 2013 4.01
13 Function of C/EBPdelta in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals. Nat Immunol 2009 3.60
14 Caspase-1-induced pyroptotic cell death. Immunol Rev 2011 3.47
15 Evasion of Toll-like receptor 5 by flagellated bacteria. Proc Natl Acad Sci U S A 2005 3.35
16 A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. J Exp Med 2003 3.30
17 Uncovering a macrophage transcriptional program by integrating evidence from motif scanning and expression dynamics. PLoS Comput Biol 2008 3.02
18 Pseudomonas aeruginosa activates caspase 1 through Ipaf. Proc Natl Acad Sci U S A 2008 2.99
19 Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection. J Immunol 2008 2.87
20 The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells. J Immunol 2003 2.73
21 Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses. Nat Immunol 2012 2.72
22 A common human TLR1 polymorphism regulates the innate immune response to lipopeptides. Eur J Immunol 2007 2.71
23 The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2. Proc Natl Acad Sci U S A 2006 2.63
24 Staphylococcus aureus evades lysozyme-based peptidoglycan digestion that links phagocytosis, inflammasome activation, and IL-1beta secretion. Cell Host Microbe 2010 2.49
25 TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE. J Exp Med 2006 2.44
26 Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo. Immunity 2009 2.44
27 TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system. Semin Immunopathol 2007 2.42
28 Polymorphisms in TLR2 are associated with increased viral shedding and lesional rate in patients with genital herpes simplex virus Type 2 infection. J Infect Dis 2007 2.33
29 Memory T cell RNA rearrangement programmed by heterogeneous nuclear ribonucleoprotein hnRNPLL. Immunity 2008 2.13
30 Cutting edge: a Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling. J Immunol 2003 2.02
31 Systems biology of innate immunity. Immunol Rev 2009 1.87
32 A 2020 vision for vaccines against HIV, tuberculosis and malaria. Nature 2011 1.80
33 Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2. J Immunol 2010 1.77
34 Lipidomic profiling of influenza infection identifies mediators that induce and resolve inflammation. Cell 2013 1.69
35 Transcription factor expression in lipopolysaccharide-activated peripheral-blood-derived mononuclear cells. Proc Natl Acad Sci U S A 2007 1.63
36 Serpin 2a is induced in activated macrophages and conjugates to a ubiquitin homolog. J Immunol 2002 1.60
37 Leishmania promotes its own virulence by inducing expression of the host immune inhibitory ligand CD200. Cell Host Microbe 2011 1.59
38 Cutting edge: Tlr5-/- mice are more susceptible to Escherichia coli urinary tract infection. J Immunol 2007 1.57
39 A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin. J Exp Med 2007 1.51
40 Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women. PLoS One 2009 1.49
41 Merck Ad5/HIV induces broad innate immune activation that predicts CD8⁺ T-cell responses but is attenuated by preexisting Ad5 immunity. Proc Natl Acad Sci U S A 2012 1.46
42 A FOXO3-IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses. Nature 2012 1.44
43 Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles. PLoS Pathog 2008 1.41
44 Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection. AIDS 2007 1.39
45 Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease. Proc Natl Acad Sci U S A 2005 1.39
46 Myeloid differentiation primary response gene (88)- and toll-like receptor 2-deficient mice are susceptible to infection with aerosolized Legionella pneumophila. J Infect Dis 2006 1.34
47 Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy. J Infect Dis 2008 1.34
48 Paired Ig-like receptors bind to bacteria and shape TLR-mediated cytokine production. J Immunol 2007 1.29
49 Generation of diversity in the innate immune system: macrophage heterogeneity arises from gene-autonomous transcriptional probability of individual inducible genes. J Immunol 2002 1.28
50 Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophila. J Immunol 2007 1.28
51 The NLRP3 inflammasome detects encephalomyocarditis virus and vesicular stomatitis virus infection. J Virol 2011 1.27
52 A new triggering receptor expressed on myeloid cells (Trem) family member, Trem-like 4, binds to dead cells and is a DNAX activation protein 12-linked marker for subsets of mouse macrophages and dendritic cells. J Immunol 2009 1.26
53 ATF3, an adaptive-response gene, enhances TGF{beta} signaling and cancer-initiating cell features in breast cancer cells. J Cell Sci 2010 1.23
54 Genome-wide histone acetylation data improve prediction of mammalian transcription factor binding sites. Bioinformatics 2010 1.22
55 A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus. Proc Natl Acad Sci U S A 2005 1.21
56 CD4+ T cells and toll-like receptors recognize Salmonella antigens expressed in bacterial surface organelles. Infect Immun 2005 1.20
57 Bright field microscopy as an alternative to whole cell fluorescence in automated analysis of macrophage images. PLoS One 2009 1.19
58 Activating transcription factor 3 is a negative regulator of allergic pulmonary inflammation. J Exp Med 2008 1.18
59 ATF3 protects against atherosclerosis by suppressing 25-hydroxycholesterol-induced lipid body formation. J Exp Med 2012 1.15
60 Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses. Proc Natl Acad Sci U S A 2011 1.13
61 ATF3 regulates MCMV infection in mice by modulating IFN-gamma expression in natural killer cells. Proc Natl Acad Sci U S A 2008 1.13
62 A microfluidic device for multiplexed protein detection in nano-liter volumes. Anal Biochem 2008 1.12
63 The Innate Immune Database (IIDB). BMC Immunol 2008 1.11
64 Differential role of MyD88 in macrophage-mediated responses to opportunistic fungal pathogens. Infect Immun 2003 1.11
65 miR-451 regulates dendritic cell cytokine responses to influenza infection. J Immunol 2012 1.08
66 Leishmania major activates IL-1 alpha expression in macrophages through a MyD88-dependent pathway. Microbes Infect 2002 1.07
67 Simvastatin augments lipopolysaccharide-induced proinflammatory responses in macrophages by differential regulation of the c-Fos and c-Jun transcription factors. J Immunol 2004 1.06
68 Gangliosides act as co-receptors for Salmonella enteritidis FliC and promote FliC induction of human beta-defensin-2 expression in Caco-2 cells. J Biol Chem 2004 1.03
69 Activation of the NLRP3 inflammasome by intracellular poly I:C. FEBS Lett 2010 1.02
70 Genetic variation of the human urinary tract innate immune response and asymptomatic bacteriuria in women. PLoS One 2009 1.00
71 Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages. Proc Natl Acad Sci U S A 2009 1.00
72 Antigen expression determines adenoviral vaccine potency independent of IFN and STING signaling. J Clin Invest 2015 0.99
73 Generation of a Listeria vaccine strain by enhanced caspase-1 activation. Eur J Immunol 2011 0.99
74 A systems biology approach to understanding atherosclerosis. EMBO Mol Med 2010 0.97
75 Host susceptibility and clinical outcomes in toll-like receptor 5-deficient patients with typhoid fever in Vietnam. J Infect Dis 2005 0.96
76 Control of parasitophorous vacuole expansion by LYST/Beige restricts the intracellular growth of Leishmania amazonensis. PLoS Pathog 2008 0.94
77 Characterizing the connectivity of poly-ubiquitin chains by selected reaction monitoring mass spectrometry. Mol Biosyst 2010 0.94
78 The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12. Infect Immun 2008 0.93
79 A key role for ATF3 in regulating mast cell survival and mediator release. Blood 2010 0.92
80 A systems view of host defense. Nat Biotechnol 2009 0.91
81 Characterization of innate responses to influenza virus infection in a novel lung type I epithelial cell model. J Gen Virol 2013 0.91
82 Differential host response, rather than early viral replication efficiency, correlates with pathogenicity caused by influenza viruses. PLoS One 2013 0.91
83 The toll-like receptor signaling molecule Myd88 contributes to pancreatic beta-cell homeostasis in response to injury. PLoS One 2009 0.90
84 Inhibitory receptor paired Ig-like receptor B is exploited by Staphylococcus aureus for virulence. J Immunol 2012 0.89
85 Age-dependent signature of metallothionein expression in primary CD4 T cell responses is due to sustained zinc signaling. Rejuvenation Res 2008 0.89
86 Systems-level analysis of innate immunity. Annu Rev Immunol 2014 0.88
87 Hyper-IgE syndrome is not associated with defects in several candidate toll-like receptor pathway genes. Hum Immunol 2005 0.86
88 Cutting edge: microRNA regulation of macrophage fusion into multinucleated giant cells. J Immunol 2012 0.86
89 Systems approaches to dissecting immunity. Curr Top Microbiol Immunol 2013 0.82
90 Amphiphysin IIm is required for survival of Chlamydia pneumoniae in macrophages. J Exp Med 2004 0.81
91 Corrigendum: Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. Nature 2015 0.81
92 Overcoming limitations in the systems vaccinology approach: a pathway for accelerated HIV vaccine development. Curr Opin HIV AIDS 2012 0.80
93 Phagocytic cells. Immunol Rev 2007 0.77
94 Editorial overview. System immunology. Semin Immunol 2013 0.77
95 Alan Aderem: from molecules to megabytes. Interviewed by Nicole LeBrasseur. J Cell Biol 2008 0.75
96 Vaccines. Editorial overview. Curr Opin Immunol 2012 0.75
97 Alan Aderem. Interview with Asher Mullard. Nat Rev Drug Discov 2011 0.75