SdhE is a conserved protein required for flavinylation of succinate dehydrogenase in bacteria.

PubWeight™: 1.04‹?› | Rank: Top 15%

🔗 View Article (PMC 3365757)

Published in J Biol Chem on April 03, 2012

Authors

Matthew B McNeil1, James S Clulow, Nabil M Wilf, George P C Salmond, Peter C Fineran

Author Affiliations

1: Department of Microbiology and Immunology, University of Otago, Dunedin 9054, New Zealand.

Articles citing this

In vivo protein interactions and complex formation in the Pectobacterium atrosepticum subtype I-F CRISPR/Cas System. PLoS One (2012) 1.07

Alternative pyrimidine biosynthesis protein ApbE is a flavin transferase catalyzing covalent attachment of FMN to a threonine residue in bacterial flavoproteins. J Biol Chem (2013) 0.91

Flavinylation and assembly of succinate dehydrogenase are dependent on the C-terminal tail of the flavoprotein subunit. J Biol Chem (2012) 0.90

A Serratia marcescens PigP homolog controls prodigiosin biosynthesis, swarming motility and hemolysis and is regulated by cAMP-CRP and HexS. PLoS One (2013) 0.90

Emerging concepts in the flavinylation of succinate dehydrogenase. Biochim Biophys Acta (2013) 0.84

Structural basis for malfunction in complex II. J Biol Chem (2012) 0.82

Catalytic mechanisms of complex II enzymes: a structural perspective. Biochim Biophys Acta (2012) 0.81

A 14.7 kDa protein from Francisella tularensis subsp. novicida (named FTN_1133), involved in the response to oxidative stress induced by organic peroxides, is not endowed with thiol-dependent peroxidase activity. PLoS One (2014) 0.80

Genomewide landscape of gene-metabolome associations in Escherichia coli. Mol Syst Biol (2017) 0.78

Evolution of Pectobacterium Bacteriophage ΦM1 To Escape Two Bifunctional Type III Toxin-Antitoxin and Abortive Infection Systems through Mutations in a Single Viral Gene. Appl Environ Microbiol (2017) 0.78

Binding of the Covalent Flavin Assembly Factor to the Flavoprotein Subunit of Complex II. J Biol Chem (2015) 0.77

Draft Genome Sequence of Serratia sp. Strain ATCC 39006, a Model Bacterium for Analysis of the Biosynthesis and Regulation of Prodigiosin, a Carbapenem, and Gas Vesicles. Genome Announc (2013) 0.77

Agaricus meleagris pyranose dehydrogenase: influence of covalent FAD linkage on catalysis and stability. Arch Biochem Biophys (2014) 0.77

Sequence diversity and conservation in factors influencing succinate dehydrogenase flavinylation. Plant Signal Behav (2012) 0.76

Redox state of flavin adenine dinucleotide drives substrate binding and product release in Escherichia coli succinate dehydrogenase. Biochemistry (2015) 0.76

CRISPR-Cas gene-editing reveals RsmA and RsmC act through FlhDC to repress the SdhE flavinylation factor and control motility and prodigiosin production in Serratia. Microbiology (2016) 0.75

The Assembly Factor SDHAF2 Is Dispensable for Flavination of the Catalytic Subunit of Mitochondrial Complex II in Breast Cancer Cells. J Biol Chem (2016) 0.75

Structural and biochemical analyses reveal insights into covalent flavinylation of the Escherichia coli Complex II homolog quinol:fumarate reductase. J Biol Chem (2017) 0.75

Articles cited by this

MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Mol Biol Evol (2007) 168.76

Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Mol Syst Biol (2006) 40.15

The Pfam protein families database. Nucleic Acids Res (2009) 37.98

STRING 8--a global view on proteins and their functional interactions in 630 organisms. Nucleic Acids Res (2008) 20.62

The genome sequence of Rickettsia prowazekii and the origin of mitochondria. Nature (1998) 12.53

Linking genome and proteome by mass spectrometry: large-scale identification of yeast proteins from two dimensional gels. Proc Natl Acad Sci U S A (1996) 8.10

Blue native PAGE. Nat Protoc (2006) 8.04

Tricine-SDS-PAGE. Nat Protoc (2006) 7.89

The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A (2003) 5.13

The MicrobesOnline Web site for comparative genomics. Genome Res (2005) 4.48

Architecture of succinate dehydrogenase and reactive oxygen species generation. Science (2003) 4.40

The genus Serratia. Annu Rev Microbiol (1978) 3.85

SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma. Science (2009) 3.72

'Conserved hypothetical' proteins: prioritization of targets for experimental study. Nucleic Acids Res (2004) 3.50

Identifying protein function--a call for community action. PLoS Biol (2004) 2.99

The biosynthesis and regulation of bacterial prodiginines. Nat Rev Microbiol (2006) 2.36

Function and structure of complex II of the respiratory chain. Annu Rev Biochem (2003) 1.99

Regulation of succinate dehydrogenase (sdhCDAB) operon expression in Escherichia coli in response to carbon supply and anaerobiosis: role of ArcA and Fnr. Mol Microbiol (1995) 1.89

The phylogeny of proteobacteria: relationships to other eubacterial phyla and eukaryotes. FEMS Microbiol Rev (2000) 1.82

Anticancer and immunosuppressive properties of bacterial prodiginines. Future Microbiol (2007) 1.52

Bacterial electron transport chains. Annu Rev Biochem (1988) 1.51

A GntR family transcriptional regulator (PigT) controls gluconate-mediated repression and defines a new, independent pathway for regulation of the tripyrrole antibiotic, prodigiosin, in Serratia. Microbiology (2005) 1.41

Biosynthesis of tripyrrole and beta-lactam secondary metabolites in Serratia: integration of quorum sensing with multiple new regulatory components in the control of prodigiosin and carbapenem antibiotic production. Mol Microbiol (2005) 1.36

What's in a covalent bond? On the role and formation of covalently bound flavin cofactors. FEBS J (2009) 1.35

Covalent attachment of flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) to enzymes: the current state of affairs. Protein Sci (1998) 1.34

Succinate dehydrogenase--a comparative review. Microbiol Rev (1981) 1.34

Riboflavin uptake and FAD synthesis in Saccharomyces cerevisiae mitochondria: involvement of the Flx1p carrier in FAD export. J Biol Chem (2003) 1.34

Structures and proton-pumping strategies of mitochondrial respiratory enzymes. Annu Rev Biophys Biomol Struct (2001) 1.30

SDHAF2 (PGL2-SDH5) and hereditary head and neck paraganglioma. Clin Cancer Res (2011) 1.22

Virulence and prodigiosin antibiotic biosynthesis in Serratia are regulated pleiotropically by the GGDEF/EAL domain protein, PigX. J Bacteriol (2007) 1.21

Integrated regulation involving quorum sensing, a two-component system, a GGDEF/EAL domain protein and a post-transcriptional regulator controls swarming and RhlA-dependent surfactant biosynthesis in Serratia. Environ Microbiol (2008) 1.16

Covalent attachment of FAD to the yeast succinate dehydrogenase flavoprotein requires import into mitochondria, presequence removal, and folding. J Biol Chem (1996) 1.07

The covalent FAD of monoamine oxidase: structural and functional role and mechanism of the flavinylation reaction. Antioxid Redox Signal (2001) 1.06

Kinetic analysis of growth rate, ATP, and pigmentation suggests an energy-spilling function for the pigment prodigiosin of Serratia marcescens. J Bacteriol (2008) 0.98

PigZ, a TetR/AcrR family repressor, modulates secondary metabolism via the expression of a putative four-component resistance-nodulation-cell-division efflux pump, ZrpADBC, in Serratia sp. ATCC 39006. Mol Microbiol (2008) 0.98

The PhoBR two-component system regulates antibiotic biosynthesis in Serratia in response to phosphate. BMC Microbiol (2009) 0.95

Droplet enrichment factors of pigmented and nonpigmented Serratia marcescens: possible selective function for prodigiosin. Appl Environ Microbiol (1985) 0.94

The covalent attachment of FAD to the flavoprotein of Saccharomyces cerevisiae succinate dehydrogenase is not necessary for import and assembly into mitochondria. Eur J Biochem (1994) 0.92

Covalent cofactor attachment to proteins: cytochrome c biogenesis. Biochem Soc Trans (2005) 0.89

Covalent cofactor binding to flavoenzymes requires specific effectors. Eur J Biochem (1989) 0.88

Crystal structure of the YgfY from Escherichia coli, a protein that may be involved in transcriptional regulation. Proteins (2005) 0.87

Covalent flavinylation of vanillyl-alcohol oxidase is an autocatalytic process. FEBS J (2008) 0.86

PigS and PigP regulate prodigiosin biosynthesis in Serratia via differential control of divergent operons, which include predicted transporters of sulfur-containing molecules. J Bacteriol (2010) 0.85

Supramolecular organizations in the aerobic respiratory chain of Escherichia coli. Biochimie (2010) 0.84

Succinate dehydrogenase mutants of Bacillus subtilis lacking covalently bound flavin in the flavoprotein subunit. Eur J Biochem (1983) 0.80

Articles by these authors

The phage abortive infection system, ToxIN, functions as a protein-RNA toxin-antitoxin pair. Proc Natl Acad Sci U S A (2009) 2.69

The biosynthesis and regulation of bacterial prodiginines. Nat Rev Microbiol (2006) 2.36

Phosphate availability regulates biosynthesis of two antibiotics, prodigiosin and carbapenem, in Serratia via both quorum-sensing-dependent and -independent pathways. Mol Microbiol (2003) 1.83

Quorum sensing coordinates brute force and stealth modes of infection in the plant pathogen Pectobacterium atrosepticum. PLoS Pathog (2008) 1.66

Cytotoxic chromosomal targeting by CRISPR/Cas systems can reshape bacterial genomes and expel or remodel pathogenicity islands. PLoS Genet (2013) 1.63

Viral evasion of a bacterial suicide system by RNA-based molecular mimicry enables infectious altruism. PLoS Genet (2012) 1.62

The Serratia gene cluster encoding biosynthesis of the red antibiotic, prodigiosin, shows species- and strain-dependent genome context variation. Microbiology (2004) 1.57

Csy4 is responsible for CRISPR RNA processing in Pectobacterium atrosepticum. RNA Biol (2011) 1.52

Anticancer and immunosuppressive properties of bacterial prodiginines. Future Microbiol (2007) 1.52

CRISPRTarget: bioinformatic prediction and analysis of crRNA targets. RNA Biol (2013) 1.46

A generalized transducing phage (phiIF3) for the genomically sequenced Serratia marcescens strain Db11: a tool for functional genomics of an opportunistic human pathogen. Microbiology (2006) 1.44

A GntR family transcriptional regulator (PigT) controls gluconate-mediated repression and defines a new, independent pathway for regulation of the tripyrrole antibiotic, prodigiosin, in Serratia. Microbiology (2005) 1.41

Identification and classification of bacterial Type III toxin-antitoxin systems encoded in chromosomal and plasmid genomes. Nucleic Acids Res (2012) 1.40

Advances in bacteriophage-mediated control of plant pathogens. Int J Microbiol (2012) 1.40

Biosynthesis of tripyrrole and beta-lactam secondary metabolites in Serratia: integration of quorum sensing with multiple new regulatory components in the control of prodigiosin and carbapenem antibiotic production. Mol Microbiol (2005) 1.36

Biosynthesis of the red antibiotic, prodigiosin, in Serratia: identification of a novel 2-methyl-3-n-amyl-pyrrole (MAP) assembly pathway, definition of the terminal condensing enzyme, and implications for undecylprodigiosin biosynthesis in Streptomyces. Mol Microbiol (2005) 1.33

Biotechnological exploitation of bacteriophage research. Trends Biotechnol (2006) 1.33

Function and regulation of clustered regularly interspaced short palindromic repeats (CRISPR) / CRISPR associated (Cas) systems. Viruses (2012) 1.27

Quorum sensing, virulence and secondary metabolite production in plant soft-rotting bacteria. Philos Trans R Soc Lond B Biol Sci (2007) 1.25

A processed noncoding RNA regulates an altruistic bacterial antiviral system. Nat Struct Mol Biol (2011) 1.24

The regulation of virulence in phytopathogenic Erwinia species: quorum sensing, antibiotics and ecological considerations. Antonie Van Leeuwenhoek (2002) 1.21

Nonenzymatic turnover of an Erwinia carotovora quorum-sensing signaling molecule. J Bacteriol (2002) 1.21

Virulence and prodigiosin antibiotic biosynthesis in Serratia are regulated pleiotropically by the GGDEF/EAL domain protein, PigX. J Bacteriol (2007) 1.21

Balancing at survival's edge: the structure and adaptive benefits of prokaryotic toxin-antitoxin partners. Curr Opin Struct Biol (2011) 1.20

Synthesis and stability of small molecule probes for Pseudomonas aeruginosa quorum sensing modulation. Org Biomol Chem (2004) 1.18

Regulation and biosynthesis of carbapenem antibiotics in bacteria. Nat Rev Microbiol (2005) 1.17

Integrated regulation involving quorum sensing, a two-component system, a GGDEF/EAL domain protein and a post-transcriptional regulator controls swarming and RhlA-dependent surfactant biosynthesis in Serratia. Environ Microbiol (2008) 1.16

Identification of the central quorum sensing regulator of virulence in the enteric phytopathogen, Erwinia carotovora: the VirR repressor. Mol Microbiol (2006) 1.14

luxS mutants of Serratia defective in autoinducer-2-dependent 'quorum sensing' show strain-dependent impacts on virulence and production of carbapenem and prodigiosin. Microbiology (2004) 1.09

Metabolic and regulatory engineering of Serratia marcescens: mimicking phage-mediated horizontal acquisition of antibiotic biosynthesis and quorum-sensing capacities. Microbiology (2006) 1.09

Combating multidrug-resistant bacteria: current strategies for the discovery of novel antibacterials. Angew Chem Int Ed Engl (2013) 1.09

Bacterial biosynthetic gene clusters encoding the anti-cancer haterumalide class of molecules: biogenesis of the broad spectrum antifungal and anti-oomycete compound, oocydin A. J Biol Chem (2012) 1.08

In vivo protein interactions and complex formation in the Pectobacterium atrosepticum subtype I-F CRISPR/Cas System. PLoS One (2012) 1.07

Citrobacter rodentium is an unstable pathogen showing evidence of significant genomic flux. PLoS Pathog (2011) 1.05

Quorum sensing in Erwinia species. Anal Bioanal Chem (2006) 1.05

A widely conserved molecular switch controls quorum sensing and symbiosis island transfer in Mesorhizobium loti through expression of a novel antiactivator. Mol Microbiol (2012) 1.04

A quorum-sensing molecule acts as a morphogen controlling gas vesicle organelle biogenesis and adaptive flotation in an enterobacterium. Proc Natl Acad Sci U S A (2011) 1.02

The Nep1-like proteins-a growing family of microbial elicitors of plant necrosis. Mol Plant Pathol (2004) 1.01

Genome sequence of a new Streptomyces coelicolor generalized transducing bacteriophage, ΦCAM. J Virol (2012) 1.01

Ribonucleases in bacterial toxin-antitoxin systems. Biochim Biophys Acta (2013) 1.00

A generalized transducing phage for the murine pathogen Citrobacter rodentium. Microbiology (2007) 1.00

PigZ, a TetR/AcrR family repressor, modulates secondary metabolism via the expression of a putative four-component resistance-nodulation-cell-division efflux pump, ZrpADBC, in Serratia sp. ATCC 39006. Mol Microbiol (2008) 0.98

Genetic and proteomic analysis of the role of luxS in the enteric phytopathogen, Erwinia carotovora. Mol Plant Pathol (2006) 0.97

A widespread bacteriophage abortive infection system functions through a Type IV toxin-antitoxin mechanism. Nucleic Acids Res (2014) 0.97

The PhoBR two-component system regulates antibiotic biosynthesis in Serratia in response to phosphate. BMC Microbiol (2009) 0.95

Quorum sensing has an unexpected role in virulence in the model pathogen Citrobacter rodentium. EMBO Rep (2007) 0.95

The Pseudomonas aeruginosa generalized transducing phage phiPA3 is a new member of the phiKZ-like group of 'jumbo' phages, and infects model laboratory strains and clinical isolates from cystic fibrosis patients. Microbiology (2010) 0.94

The RNA chaperone, Hfq, controls two luxR-type regulators and plays a key role in pathogenesis and production of antibiotics in Serratia sp. ATCC 39006. Environ Microbiol (2011) 0.92

Identification of bacteriophages for biocontrol of the kiwifruit canker phytopathogen Pseudomonas syringae pv. actinidiae. Appl Environ Microbiol (2014) 0.92

N-Acetylglucosamine-dependent biofilm formation in Pectobacterium atrosepticum is cryptic and activated by elevated c-di-GMP levels. Microbiology (2011) 0.92

Selectivity and self-assembly in the control of a bacterial toxin by an antitoxic noncoding RNA pseudoknot. Proc Natl Acad Sci U S A (2012) 0.91

Carbapenem antibiotic biosynthesis in Erwinia carotovora is regulated by physiological and genetic factors modulating the quorum sensing-dependent control pathway. Mol Microbiol (2005) 0.90

The stationary phase sigma factor, RpoS, regulates the production of a carbapenem antibiotic, a bioactive prodigiosin and virulence in the enterobacterial pathogen Serratia sp. ATCC 39006. Microbiology (2011) 0.89

DsbA plays a critical and multifaceted role in the production of secreted virulence factors by the phytopathogen Erwinia carotovora subsp. atroseptica. J Biol Chem (2008) 0.87

CRISPR-Cas systems preferentially target the leading regions of MOBF conjugative plasmids. RNA Biol (2013) 0.86

A new evaluation of our life-support system. EMBO Rep (2003) 0.86

Structure-activity relationships of Erwinia carotovora quorum sensing signaling molecules. Bioorg Med Chem Lett (2005) 0.86

The Serratia LuxR family regulator CarR 39006 activates transcription independently of cognate quorum sensing signals. Mol Microbiol (2011) 0.86

PigS and PigP regulate prodigiosin biosynthesis in Serratia via differential control of divergent operons, which include predicted transporters of sulfur-containing molecules. J Bacteriol (2010) 0.85

Novel configurations of type I and II CRISPR-Cas systems in Corynebacterium diphtheriae. Microbiology (2013) 0.85

Chromosomal targeting by CRISPR-Cas systems can contribute to genome plasticity in bacteria. Mob Genet Elements (2013) 0.85

RNA-seq reveals the RNA binding proteins, Hfq and RsmA, play various roles in virulence, antibiotic production and genomic flux in Serratia sp. ATCC 39006. BMC Genomics (2013) 0.84

A multi-repeat adhesin of the phytopathogen, Pectobacterium atrosepticum, is secreted by a Type I pathway and is subject to complex regulation involving a non-canonical diguanylate cyclase. Mol Microbiol (2011) 0.83

Two mobile Pectobacterium atrosepticum prophages modulate virulence. FEMS Microbiol Lett (2010) 0.82

Discovery of a quorum sensing modulator pharmacophore by 3D small-molecule microarray screening. Org Biomol Chem (2010) 0.82

YgfX (CptA) is a multimeric membrane protein that interacts with the succinate dehydrogenase assembly factor SdhE (YgfY). Microbiology (2013) 0.82

Prokaryotic assembly factors for the attachment of flavin to complex II. Biochim Biophys Acta (2012) 0.82

The subtype I-F CRISPR-Cas system influences pathogenicity island retention in Pectobacterium atrosepticum via crRNA generation and Csy complex formation. Biochem Soc Trans (2013) 0.82

Complete genome sequence of Serratia plymuthica bacteriophage ΦMAM1. J Virol (2012) 0.82

Virulence in Pectobacterium atrosepticum is regulated by a coincidence circuit involving quorum sensing and the stress alarmone, (p)ppGpp. Mol Microbiol (2013) 0.82

The conserved RGxxE motif of the bacterial FAD assembly factor SdhE is required for succinate dehydrogenase flavinylation and activity. Biochemistry (2013) 0.82

Can boron get bacteria talking? Trends Biochem Sci (2002) 0.82

Mutations in rpsL that confer streptomycin resistance show pleiotropic effects on virulence and the production of a carbapenem antibiotic in Erwinia carotovora. Microbiology (2010) 0.81

Identification of genes in the VirR regulon of Pectobacterium atrosepticum and characterization of their roles in quorum sensing-dependent virulence. Environ Microbiol (2012) 0.81

Quorum sensing-controlled buoyancy through gas vesicles: Intracellular bacterial microcompartments for environmental adaptation. Commun Integr Biol (2012) 0.81

A promiscuous antitoxin of bacteriophage T4 ensures successful viral replication. Mol Microbiol (2012) 0.80

RelA-dependent (p)ppGpp production controls exoenzyme synthesis in Erwinia carotovora subsp. atroseptica. J Bacteriol (2007) 0.80

Engineering of new prodigiosin-based biosensors of Serratia for facile detection of short-chain N-acyl homoserine lactone quorum-sensing molecules. Environ Microbiol Rep (2010) 0.80

Reverse engineering gene regulatory networks related to quorum sensing in the plant pathogen Pectobacterium atrosepticum. Methods Mol Biol (2010) 0.79

A metabolic regulator modulates virulence and quorum sensing signal production in Pectobacterium atrosepticum. Mol Plant Microbe Interact (2013) 0.78

Intra-species bacterial quorum sensing studied at single cell level in a double droplet trapping system. Int J Mol Sci (2013) 0.78

Disruption of the copper efflux pump (CopA) of Serratia marcescens ATCC 274 pleiotropically affects copper sensitivity and production of the tripyrrole secondary metabolite, prodigiosin. J Ind Microbiol Biotechnol (2005) 0.78

Computational Detection of CRISPR/crRNA Targets. Methods Mol Biol (2015) 0.77

Draft Genome Sequence of Serratia sp. Strain ATCC 39006, a Model Bacterium for Analysis of the Biosynthesis and Regulation of Prodigiosin, a Carbapenem, and Gas Vesicles. Genome Announc (2013) 0.77