A key role for NF-κB transcription factor c-Rel in T-lymphocyte-differentiation and effector functions.

PubWeight™: 0.85‹?›

🔗 View Article (PMC 3310234)

Published in Clin Dev Immunol on March 06, 2012

Authors

Alexander Visekruna1, Anton Volkov, Ulrich Steinhoff

Author Affiliations

1: Institute for Medical Microbiology and Hygiene, Philipps University of Marburg, Hans Meerwein Strasse 2, 35032 Marburg, Germany. alexander.visekruna@staff.uni-marburg.de

Articles cited by this

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity (2006) 29.29

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science (2006) 27.49

Signaling to NF-kappaB. Genes Dev (2004) 19.78

The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science (2002) 13.86

T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity (2007) 13.29

Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol (2009) 11.76

The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol (2004) 10.85

Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity (2008) 10.26

Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity (2008) 9.61

Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity (2009) 9.28

FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol (2010) 8.73

Bcl6 mediates the development of T follicular helper cells. Science (2009) 8.50

Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J Exp Med (2006) 7.76

Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science (2001) 7.66

A critical role for IL-21 in regulating immunoglobulin production. Science (2002) 7.09

Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity (2009) 6.87

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature (2010) 6.87

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature (2010) 6.44

Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature (2011) 6.43

A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity (2008) 6.41

Crosstalk in NF-κB signaling pathways. Nat Immunol (2011) 6.05

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev (1995) 5.51

Stimulus specificity of gene expression programs determined by temporal control of IKK activity. Science (2005) 5.14

IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses. J Exp Med (2010) 4.65

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J Exp Med (2010) 4.04

Interleukin-23 drives intestinal inflammation through direct activity on T cells. Immunity (2010) 3.51

Regulation of tissue homeostasis by NF-kappaB signalling: implications for inflammatory diseases. Nat Rev Immunol (2009) 3.51

Effector T cell plasticity: flexibility in the face of changing circumstances. Nat Immunol (2010) 3.12

Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology. Biochem J (2004) 3.01

Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome. Immunity (2009) 2.84

IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease. J Exp Med (2011) 2.74

NF-kappa B RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses. J Exp Med (1997) 2.66

Th17 T cells: linking innate and adaptive immunity. Semin Immunol (2007) 2.54

Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages. Proc Natl Acad Sci U S A (2000) 2.36

Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor. Immunity (2009) 2.35

Mature T cells depend on signaling through the IKK complex. Immunity (2003) 2.21

IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype. Proc Natl Acad Sci U S A (2008) 2.13

Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery. PLoS Biol (2009) 2.07

The interleukin-23 axis in intestinal inflammation. Immunol Rev (2008) 2.06

Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation. J Clin Invest (2002) 1.96

c-Rel regulates interleukin 12 p70 expression in CD8(+) dendritic cells by specifically inducing p35 gene transcription. J Exp Med (2001) 1.92

c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells. J Exp Med (2009) 1.85

Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor. Proc Natl Acad Sci U S A (1996) 1.79

Essential roles of c-Rel in TLR-induced IL-23 p19 gene expression in dendritic cells. J Immunol (2007) 1.77

New insights into NF-kappaB regulation and function. Trends Immunol (2008) 1.73

Hierarchies of NF-κB target-gene regulation. Nat Immunol (2011) 1.71

IkappaBbeta acts to inhibit and activate gene expression during the inflammatory response. Nature (2010) 1.68

Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha. Mol Cell Biol (2001) 1.66

c-Rel is required for chromatin remodeling across the IL-2 gene promoter. J Immunol (2003) 1.64

Differential requirement of PKC-theta in the development and function of natural regulatory T cells. Mol Immunol (2008) 1.63

Roles of the NF-kappaB pathway in lymphocyte development and function. Cold Spring Harb Perspect Biol (2009) 1.63

The Th17 immune response is controlled by the Rel-RORγ-RORγ T transcriptional axis. J Exp Med (2011) 1.50

A proximal kappaB site in the IL-23 p19 promoter is responsible for RelA- and c-Rel-dependent transcription. J Immunol (2007) 1.49

c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function. Int Immunol (1999) 1.48

Calcium-dependent activation of interleukin-21 gene expression in T cells. J Biol Chem (2005) 1.47

A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation. Genes Dev (2005) 1.45

The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity. Nat Immunol (2011) 1.45

Proteasome-mediated degradation of IkappaBalpha and processing of p105 in Crohn disease and ulcerative colitis. J Clin Invest (2006) 1.45

Genome-wide analysis of gene expression in T cells to identify targets of the NF-kappa B transcription factor c-Rel. J Immunol (2007) 1.43

Cutting edge: CD28 and c-Rel-dependent pathways initiate regulatory T cell development. J Immunol (2010) 1.41

CARMA1 controls an early checkpoint in the thymic development of FoxP3+ regulatory T cells. J Immunol (2009) 1.40

Differential role for c-Rel and C/EBPbeta/delta in TLR-mediated induction of proinflammatory cytokines. J Immunol (2009) 1.38

Prevention of experimental colitis by a selective inhibitor of the immunoproteasome. J Immunol (2010) 1.36

The Rel subunit of NF-kappaB-like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populations. EMBO J (1996) 1.34

Targeting the proteasome: partial inhibition of the proteasome by bortezomib or deletion of the immunosubunit LMP7 attenuates experimental colitis. Gut (2010) 1.34

Differential requirement for NF-kappa B family members in control of helminth infection and intestinal inflammation. J Immunol (2002) 1.31

IkappaB family members function by different mechanisms. J Biol Chem (2001) 1.23

T cell-intrinsic expression of c-Rel regulates Th1 cell responses essential for resistance to Toxoplasma gondii. J Immunol (2004) 1.23

Cutting edge: identification of c-Rel-dependent and -independent pathways of IL-12 production during infectious and inflammatory stimuli. J Immunol (2002) 1.18

CD4+ and CD8+ T cell survival is regulated differentially by protein kinase Ctheta, c-Rel, and protein kinase B. J Immunol (2007) 1.18

The NF-κB transcription factor c-Rel is required for Th17 effector cell development in experimental autoimmune encephalomyelitis. J Immunol (2011) 1.15

c-Rel is crucial for the induction of Foxp3(+) regulatory CD4(+) T cells but not T(H)17 cells. Eur J Immunol (2010) 1.14

Distinctions between c-Rel and other NF-kappaB proteins in immunity and disease. Bioessays (2003) 1.11

CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cells. J Biol Chem (2007) 1.11

High levels of susceptibility and T helper 2 response in MyD88-deficient mice infected with Leishmania major are interleukin-4 dependent. Infect Immun (2003) 1.10

Regulation of the IL-21 gene by the NF-κB transcription factor c-Rel. J Immunol (2010) 1.10

Mice lacking the transcription factor subunit Rel can clear an influenza infection and have functional anti-viral cytotoxic T cells but do not develop an optimal antibody response. Int Immunol (1999) 1.07

c-Rel-dependent priming of naive T cells by inflammatory cytokines. Immunity (2005) 1.07

The death domain of NF-kappa B1 p105 is essential for signal-induced p105 proteolysis. J Biol Chem (2002) 1.06

c-Rel is essential for the development of innate and T cell-induced colitis. J Immunol (2008) 1.00

Bioinformatic analysis reveals cRel as a regulator of a subset of interferon-stimulated genes. J Interferon Cytokine Res (2008) 0.99

NF-κB–inducing kinase plays an essential T cell–intrinsic role in graft-versus-host disease and lethal autoimmunity in mice. J Clin Invest (2011) 0.97

IRF-1 and NF-kappaB p50/cRel bind to distinct regions of the proximal murine IL-12 p35 promoter during costimulation with IFN-gamma and LPS. Mol Immunol (2006) 0.93

Selective loss of c-Rel compromises dendritic cell activation of T lymphocytes. Cell Immunol (2003) 0.92

Identification of new Rel/NFkappaB regulatory networks by focused genome location analysis. Cell Cycle (2009) 0.92

The roles of c-rel and interleukin-2 in tolerance: a molecular explanation of self-nonself discrimination. Immunol Cell Biol (2010) 0.90

Inhibitor of kappa B epsilon (IκBε) is a non-redundant regulator of c-Rel-dependent gene expression in murine T and B cells. PLoS One (2011) 0.89

Activation of IL-2 receptor alpha-chain gene by individual members of the rel oncogene family in association with serum response factor. J Immunol (1995) 0.87

Degradation of proto-oncoprotein c-Rel by the ubiquitin-proteasome pathway. J Biol Chem (1998) 0.83

c-Rel promotes type 1 and type 17 immune responses during Leishmania major infection. Eur J Immunol (2011) 0.83

Kickstarting Foxp3 with c-Rel. Immunity (2009) 0.81

Articles by these authors

Poor correlation between BCG vaccination-induced T cell responses and protection against tuberculosis. Proc Natl Acad Sci U S A (2007) 2.62

TLR-activated B cells suppress T cell-mediated autoimmunity. J Immunol (2008) 2.25

MyD88/TLR9 mediated immunopathology and gut microbiota dynamics in a novel murine model of intestinal graft-versus-host disease. Gut (2010) 1.93

Signaling via the MyD88 adaptor protein in B cells suppresses protective immunity during Salmonella typhimurium infection. Immunity (2010) 1.75

Proteasome-mediated degradation of IkappaBalpha and processing of p105 in Crohn disease and ulcerative colitis. J Clin Invest (2006) 1.45

Targeting the proteasome: partial inhibition of the proteasome by bortezomib or deletion of the immunosubunit LMP7 attenuates experimental colitis. Gut (2010) 1.34

Syk tyrosine kinase participates in beta1-integrin signaling and inflammatory responses in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol (2004) 1.21

c-Rel is crucial for the induction of Foxp3(+) regulatory CD4(+) T cells but not T(H)17 cells. Eur J Immunol (2010) 1.14

Immunity against HIV/AIDS, malaria, and tuberculosis during co-infections with neglected infectious diseases: recommendations for the European Union research priorities. PLoS Negl Trop Dis (2008) 1.10

Immunoproteasomes are essential for clearance of Listeria monocytogenes in nonlymphoid tissues but not for induction of bacteria-specific CD8+ T cells. J Immunol (2006) 1.02

Link between organ-specific antigen processing by 20S proteasomes and CD8(+) T cell-mediated autoimmunity. J Exp Med (2002) 1.00

Differential expression of spleen tyrosine kinase Syk isoforms in tissues: Effects of the microbial flora. Histochem Cell Biol (2006) 0.95

Comparative expression analysis and characterization of 20S proteasomes in human intestinal tissues: The proteasome pattern as diagnostic tool for IBD patients. Inflamm Bowel Dis (2009) 0.93

Antitopes define preferential proteasomal cleavage site usage. J Biol Chem (2008) 0.92

rKLO8, a novel Leishmania donovani - derived recombinant immunodominant protein for sensitive detection of visceral leishmaniasis in Sudan. PLoS Negl Trop Dis (2013) 0.91

Immune regulation by B cells and antibodies a view towards the clinic. Adv Immunol (2008) 0.89

c-Rel promotes type 1 and type 17 immune responses during Leishmania major infection. Eur J Immunol (2011) 0.83

The proteasome system in infection: impact of β5 and LMP7 on composition, maturation and quantity of active proteasome complexes. PLoS One (2012) 0.82

Promiscuous peptide recognition of an autoreactive CD8(+) T-cell clone is responsible for autoimmune intestinal pathology. J Autoimmun (2002) 0.80

Lack of microbiota reduces innate responses and enhances adaptive immunity against Listeria monocytogenes infection. Eur J Immunol (2014) 0.79

β5i subunit deficiency of the immunoproteasome leads to reduced Th2 response in OVA induced acute asthma. PLoS One (2013) 0.79

Expression of catalytic proteasome subunits in the gut of patients with Crohn's disease. Int J Colorectal Dis (2009) 0.79

Association between activation of atypical NF-kappaB1 p105 signaling pathway and nuclear beta-catenin accumulation in colorectal carcinoma. Mol Carcinog (2010) 0.77

Autistic effector T cells in mice with a point mutation in the LAT adaptor fail to respond to Listeria monocytogenes infection. Int Immunol (2005) 0.76

Restricted expression of C-type lectin-like natural killer receptors by CD8 T cells in the murine small intestine. Immunology (2008) 0.75

Exacerbated colitis associated with elevated levels of activated CD4+ T cells in TCRalpha chain transgenic mice. Gastroenterology (2004) 0.75