Published in Proc Natl Acad Sci U S A on December 16, 2008
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet (2012) 4.13
Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection. Nat Med (2010) 3.81
Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage. Immunity (2010) 3.24
Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism. Nucl Recept Signal (2009) 3.19
Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors. Immunity (2009) 2.89
Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria. Immunity (2012) 2.87
The origins, function, and regulation of T follicular helper cells. J Exp Med (2012) 2.59
The development and fate of follicular helper T cells defined by an IL-21 reporter mouse. Nat Immunol (2012) 2.14
Transcriptional regulatory networks in Th17 cell differentiation. Curr Opin Immunol (2009) 2.12
Interferon regulatory factor 4 sustains CD8(+) T cell expansion and effector differentiation. Immunity (2013) 2.03
The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity. J Exp Med (2009) 1.95
Type 17 T helper cells-origins, features and possible roles in rheumatic disease. Nat Rev Rheumatol (2009) 1.90
Th17 cells: from precursors to players in inflammation and infection. Int Immunol (2009) 1.77
IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors. Nature (2010) 1.76
Ectopic lymphoid-like structures in infection, cancer and autoimmunity. Nat Rev Immunol (2014) 1.72
Effector and regulatory T-cell subsets in autoimmunity and tissue inflammation. Scand J Immunol (2010) 1.70
Cellular and molecular basis for the regulation of inflammation by TGF-beta. J Biochem (2010) 1.69
Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation. J Clin Invest (2011) 1.54
Understanding the development and function of T follicular helper cells. Cell Mol Immunol (2010) 1.40
Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice. J Clin Invest (2010) 1.40
Th17 cells in immunity and autoimmunity. Clin Dev Immunol (2013) 1.40
IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis. J Clin Invest (2012) 1.40
Translational mini-review series on Th17 cells: induction of interleukin-17 production by regulatory T cells. Clin Exp Immunol (2009) 1.37
Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation. Proc Natl Acad Sci U S A (2012) 1.32
The plasticity of human Treg and Th17 cells and its role in autoimmunity. Semin Immunol (2013) 1.29
Transcriptional regulation of follicular T-helper (Tfh) cells. Immunol Rev (2013) 1.28
Mechanisms underlying helper T-cell plasticity: implications for immune-mediated disease. J Allergy Clin Immunol (2013) 1.19
TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation. Proc Natl Acad Sci U S A (2012) 1.13
IRF4 and its regulators: evolving insights into the pathogenesis of inflammatory arthritis? Immunol Rev (2010) 1.12
Aryl hydrocarbon receptor-mediated induction of the microRNA-132/212 cluster promotes interleukin-17-producing T-helper cell differentiation. Proc Natl Acad Sci U S A (2013) 1.09
MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis. J Clin Invest (2015) 1.09
Interleukin-17: a promoter in colorectal cancer progression. Clin Dev Immunol (2013) 1.00
Transcriptional regulation of T helper 17 cell differentiation. Yonsei Med J (2010) 0.98
Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice. J Clin Invest (2011) 0.98
β-catenin/TCF-1 pathway in T cell development and differentiation. J Neuroimmune Pharmacol (2012) 0.97
IL-17A and Th17 cells in lung inflammation: an update on the role of Th17 cell differentiation and IL-17R signaling in host defense against infection. Clin Dev Immunol (2013) 0.97
Dual regulation of IRF4 function in T and B cells is required for the coordination of T-B cell interactions and the prevention of autoimmunity. J Exp Med (2012) 0.93
Complex interactions of transcription factors in mediating cytokine biology in T cells. Immunol Rev (2014) 0.93
Hyperactivation of nuclear factor of activated T cells 1 (NFAT1) in T cells attenuates severity of murine autoimmune encephalomyelitis. Proc Natl Acad Sci U S A (2010) 0.93
An atlas of mouse CD4(+) T cell transcriptomes. Biol Direct (2015) 0.93
Systems modeling of the role of interleukin-21 in the maintenance of effector CD4+ T cell responses during chronic Helicobacter pylori infection. MBio (2014) 0.92
Regulation and function of IL-17A- and IL-22-producing γδ T cells. Cell Mol Life Sci (2011) 0.91
Crucial role for TNF receptor-associated factor 2 (TRAF2) in regulating NFκB2 signaling that contributes to autoimmunity. Proc Natl Acad Sci U S A (2011) 0.91
Regulatory T cells and immune tolerance in the intestine. Cold Spring Harb Perspect Biol (2013) 0.88
Th17 Cell Plasticity and Functions in Cancer Immunity. Biomed Res Int (2015) 0.88
Epigenomic elements enriched in the promoters of autoimmunity susceptibility genes. Epigenetics (2013) 0.88
Critical role of TCF-1 in repression of the IL-17 gene. PLoS One (2011) 0.86
The biological and clinical importance of the 'new generation' cytokines in rheumatic diseases. Arthritis Res Ther (2009) 0.86
T-cell based immunotherapy in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunotherapy (2010) 0.86
A key role for NF-κB transcription factor c-Rel in T-lymphocyte-differentiation and effector functions. Clin Dev Immunol (2012) 0.85
Activation of OX40 augments Th17 cytokine expression and antigen-specific uveitis. Am J Pathol (2010) 0.85
Genome-wide regulatory analysis reveals that T-bet controls Th17 lineage differentiation through direct suppression of IRF4. J Immunol (2013) 0.85
The important role of T cells and receptor expression in Sjögren's syndrome. Scand J Immunol (2013) 0.84
IL-21 Signaling in Immunity. F1000Res (2016) 0.84
New insights into T cell biology and T cell-directed therapy for autoimmunity, inflammation, and immunosuppression. Ann N Y Acad Sci (2010) 0.84
IRAK-2 regulates IL-1-mediated pathogenic Th17 cell development in helminthic infection. PLoS Pathog (2011) 0.81
The Emerging Role of Interleukin-21 in Transplantation. J Clin Cell Immunol (2012) 0.81
The current concept of T (h) 17 cells and their expanding role in systemic lupus erythematosus. Arthritis (2011) 0.81
Regulation of IL-17 expression by the developmental pathway of CD4 T cells in the thymus. Mol Immunol (2010) 0.81
Helper T cell plasticity: impact of extrinsic and intrinsic signals on transcriptomes and epigenomes. Curr Top Microbiol Immunol (2014) 0.80
IL-6 activated integrated BATF/IRF4 functions in lymphocytes are T-bet-independent and reversed by subcutaneous immunotherapy. Sci Rep (2013) 0.79
Modulation of innate host factors by Mycobacterium avium complex in human macrophages includes interleukin 17. J Infect Dis (2012) 0.79
Aberrant ROCK activation promotes the development of type I diabetes in NOD mice. Cell Immunol (2010) 0.79
IL-10 Modulates Th17 Pathogenicity during Autoimmune Diseases. J Clin Cell Immunol (2016) 0.78
The interferon regulatory factors as novel potential targets in the treatment of cardiovascular diseases. Br J Pharmacol (2015) 0.78
Interferon Regulatory Factor 4 controls TH1 cell effector function and metabolism. Sci Rep (2016) 0.78
Cellular and Molecular Dynamics of Th17 Differentiation and its Developmental Plasticity in the Intestinal Immune Response. Front Immunol (2017) 0.77
Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAs. Front Genet (2015) 0.77
Role of Tyk-2 in Th9 and Th17 cells in allergic asthma. Sci Rep (2014) 0.77
The 4q27 locus and prostate cancer risk. BMC Cancer (2010) 0.76
IL-21 and IRF4: A complex partnership in immune and metabolic regulation. Diabetes (2014) 0.76
Interleukin-17 and type 17 helper T cells in cancer management and research. Immunotargets Ther (2014) 0.75
Marijuana-derived Δ-9-tetrahydrocannabinol suppresses Th1/Th17 cell-mediated delayed-type hypersensitivity through microRNA regulation. J Mol Med (Berl) (2016) 0.75
IFN regulatory factors 4 and 8 expression in the NOD mouse. Clin Dev Immunol (2011) 0.75
Cigarette smoke inhibits ROCK2 activation in T cells and modulates IL-22 production. Mol Immunol (2016) 0.75
Activated IL-1RI Signaling Pathway Induces Th17 Cell Differentiation via Interferon Regulatory Factor 4 Signaling in Patients with Relapsing-Remitting Multiple Sclerosis. Front Immunol (2016) 0.75
Advances of the interleukin-21 signaling pathway in immunity and angiogenesis. Biomed Rep (2016) 0.75
CREM Alpha Enhances IL-21 Production in T Cells In Vivo and In Vitro. Front Immunol (2016) 0.75
The Receptor for Advanced Glycation Endproducts Drives T Cell Survival and Inflammation in Type 1 Diabetes Mellitus. J Immunol (2016) 0.75
Transcription factor Foxo1 is essential for IL-9 induction in T helper cells. Nat Commun (2017) 0.75
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature (2006) 46.36
Control of regulatory T cell development by the transcription factor Foxp3. Science (2003) 40.32
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell (2006) 33.94
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity (2006) 29.29
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med (2003) 26.05
Transforming growth factor-beta induces development of the T(H)17 lineage. Nature (2006) 25.91
IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature (2007) 16.59
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol (2007) 16.21
IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol (2007) 14.99
Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature (2007) 14.28
TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature (2008) 14.26
T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity (2007) 13.29
T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol (2007) 12.20
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity (2007) 12.12
TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat Immunol (2007) 11.14
Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity (2008) 10.26
Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J Exp Med (2006) 7.76
The IRF family transcription factors in immunity and oncogenesis. Annu Rev Immunol (2008) 6.60
The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4. Nat Immunol (2007) 5.83
Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu Rev Immunol (2008) 4.90
IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem (2007) 4.77
Cytokine signaling modules in inflammatory responses. Immunity (2008) 4.09
Transcriptional regulation of Th17 cell differentiation. Semin Immunol (2007) 3.86
Alternative polyadenylation events contribute to the induction of NF-ATc in effector T cells. Immunity (1999) 3.69
Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression. J Exp Med (2002) 3.16
The molecular basis of IL-21-mediated proliferation. Blood (2007) 2.90
Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4. Proc Natl Acad Sci U S A (2002) 2.61
IL-27 inhibits the development of regulatory T cells via STAT3. Int Immunol (2007) 1.84
Roles of interferon-regulatory factors in T-helper-cell differentiation. Nat Rev Immunol (2005) 1.49
NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression. Proc Natl Acad Sci U S A (2005) 1.45
siRNA stabilization prolongs gene knockdown in primary T lymphocytes. Eur J Immunol (2008) 1.30
The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6. J Clin Invest (2008) 1.24
Regulation of IL-21 signaling by suppressor of cytokine signaling-1 (SOCS1) in CD8(+) T lymphocytes. Cell Signal (2006) 0.95
Interleukin-21 stimulates antigen uptake, protease activity, survival and induction of CD4+ T cell proliferation by murine macrophages. Clin Exp Immunol (2008) 0.91
The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4. Nat Immunol (2007) 5.83
IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics. Nature (2012) 4.04
Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells. Immunity (2010) 3.64
Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity. Proc Natl Acad Sci U S A (2011) 1.98
Thymic stromal lymphopoetin-induced expression of the endogenous inhibitory enzyme SLPI mediates recovery from colonic inflammation. Immunity (2011) 1.96
IL-27 inhibits the development of regulatory T cells via STAT3. Int Immunol (2007) 1.84
A Th17-like developmental process leads to CD8(+) Tc17 cells with reduced cytotoxic activity. Eur J Immunol (2009) 1.79
Lymphocyte-derived ACh regulates local innate but not adaptive immunity. Proc Natl Acad Sci U S A (2013) 1.78
Deregulated MHC class II transactivator expression leads to a strong Th2 bias in CD4+ T lymphocytes. J Immunol (2003) 1.54
IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis. J Clin Invest (2012) 1.40
Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation. Proc Natl Acad Sci U S A (2012) 1.32
IFN-gamma represses IL-4 expression via IRF-1 and IRF-2. Immunity (2002) 1.32
Increased lysis of stem cells but not their differentiated cells by natural killer cells; de-differentiation or reprogramming activates NK cells. PLoS One (2010) 1.28
The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6. J Clin Invest (2008) 1.24
c-Rel is crucial for the induction of Foxp3(+) regulatory CD4(+) T cells but not T(H)17 cells. Eur J Immunol (2010) 1.14
DNA methylation of TH1/TH2 cytokine genes affects sensitization and progress of experimental asthma. J Allergy Clin Immunol (2012) 1.14
The anti-microbial peptide LL-37 inhibits the activation of dendritic cells by TLR ligands. Int Immunol (2006) 1.13
CD161 expression characterizes a subpopulation of human regulatory T cells that produces IL-17 in a STAT3-dependent manner. Eur J Immunol (2013) 1.07
IRF4 regulates IL-17A promoter activity and controls RORγt-dependent Th17 colitis in vivo. Inflamm Bowel Dis (2011) 1.07
The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cells. Proc Natl Acad Sci U S A (2013) 1.07
IRF4 at the crossroads of effector T-cell fate decision. Eur J Immunol (2014) 1.04
Enhanced TCR-induced apoptosis in interferon regulatory factor 4-deficient CD4(+) Th cells. J Exp Med (2004) 1.04
Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1. J Clin Invest (2014) 0.96
TAp73 is required for spermatogenesis and the maintenance of male fertility. Proc Natl Acad Sci U S A (2014) 0.95
Tc9 cells, a new subset of CD8(+) T cells, support Th2-mediated airway inflammation. Eur J Immunol (2013) 0.92
rKLO8, a novel Leishmania donovani - derived recombinant immunodominant protein for sensitive detection of visceral leishmaniasis in Sudan. PLoS Negl Trop Dis (2013) 0.91
Crucial role for TNF receptor-associated factor 2 (TRAF2) in regulating NFκB2 signaling that contributes to autoimmunity. Proc Natl Acad Sci U S A (2011) 0.91
Systemic Th1 immunization of mice against Helicobacter pylori infection with CpG oligodeoxynucleotides as adjuvants does not protect from infection but enhances gastritis. Infect Immun (2004) 0.88
2-Methoxyestradiol inhibits experimental autoimmune encephalomyelitis through suppression of immune cell activation. Proc Natl Acad Sci U S A (2012) 0.87
IRF-1 gene variations influence IgE regulation and atopy. Am J Respir Crit Care Med (2007) 0.86
Differential production of macrophage inflammatory protein 1gamma (MIP-1gamma), lymphotactin, and MIP-2 by CD4(+) Th subsets polarized in vitro and in vivo. Infect Immun (2003) 0.86
Unlike αβ T cells, γδ T cells, LTi cells and NKT cells do not require IRF4 for the production of IL-17A and IL-22. Eur J Immunol (2012) 0.85
The role of NF-κB activation during protection against Leishmania infection. Int J Med Microbiol (2012) 0.84
c-Rel promotes type 1 and type 17 immune responses during Leishmania major infection. Eur J Immunol (2011) 0.83
Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells. Proc Natl Acad Sci U S A (2014) 0.82
Chronic prosthetic joint infection caused by Listeria monocytogenes. J Med Microbiol (2009) 0.81
IRF4 provides rations for cytotoxic CD8(+) T cell soldiers. Immunity (2013) 0.79
Helicobacter pylori polyclonally activates murine CD4(+) T cells in the absence of antigen-presenting cells. Eur J Immunol (2007) 0.77
Multidrug-resistance-associated protein 1 (Mrp1) is probably not required for murine Th cell activation. Int Immunol (2006) 0.75
Glutathione Primes T Cell Metabolism for Inflammation. Immunity (2017) 0.75
New nucleotide analogues with enhanced signal properties. Bioconjug Chem (2010) 0.75