Published in J Vis Exp on March 28, 2012
Inner ear supporting cells protect hair cells by secreting HSP70. J Clin Invest (2013) 1.10
MYC gene delivery to adult mouse utricles stimulates proliferation of postmitotic supporting cells in vitro. PLoS One (2012) 0.88
Live imaging the phagocytic activity of inner ear supporting cells in response to hair cell death. Cell Death Differ (2015) 0.86
SoxC transcription factors are essential for the development of the inner ear. Proc Natl Acad Sci U S A (2015) 0.78
Heat shock protein-mediated protection against Cisplatin-induced hair cell death. J Assoc Res Otolaryngol (2014) 0.77
Regeneration of sensory hair cells after acoustic trauma. Science (1988) 2.84
Hair cell regeneration after acoustic trauma in adult Coturnix quail. Science (1988) 2.65
Hair cell regeneration in the avian auditory epithelium. Int J Dev Biol (2007) 1.96
Apoptotic death of hair cells in mammalian vestibular sensory epithelia. Hear Res (2000) 1.66
Caspase activation in hair cells of the mouse utricle exposed to neomycin. J Neurosci (2002) 1.55
Inhibition of caspases prevents ototoxic and ongoing hair cell death. J Neurosci (2002) 1.46
Caspase inhibitors, but not c-Jun NH2-terminal kinase inhibitor treatment, prevent cisplatin-induced hearing loss. Cancer Res (2004) 1.39
Using the zebrafish lateral line to screen for ototoxicity. J Assoc Res Otolaryngol (2008) 1.26
Identification of FDA-approved drugs and bioactives that protect hair cells in the zebrafish (Danio rerio) lateral line and mouse (Mus musculus) utricle. J Assoc Res Otolaryngol (2009) 1.22
Caspase inhibitors promote vestibular hair cell survival and function after aminoglycoside treatment in vivo. J Neurosci (2003) 1.22
Cisplatin-induced hair cell death requires STAT1 and is attenuated by epigallocatechin gallate. J Neurosci (2009) 1.18
Damage-induced activation of ERK1/2 in cochlear supporting cells is a hair cell death-promoting signal that depends on extracellular ATP and calcium. J Neurosci (2008) 1.16
The adult mouse utricle as an in vitro preparation for studies of ototoxic-drug-induced sensory hair cell death. Brain Res (2006) 1.14
JNK signaling in neomycin-induced vestibular hair cell death. Hear Res (2006) 1.10
Supporting cells eliminate dying sensory hair cells to maintain epithelial integrity in the avian inner ear. J Neurosci (2010) 1.08
Hsp70 inhibits aminoglycoside-induced hair cell death and is necessary for the protective effect of heat shock. J Assoc Res Otolaryngol (2008) 1.08
Caspase inhibitors prevent cisplatin-induced apoptosis of auditory sensory cells. Neuroreport (1998) 1.02
Hsp70 inhibits aminoglycoside-induced hearing loss and cochlear hair cell death. Cell Stress Chaperones (2009) 1.02
Expression of fractalkine receptor CX3CR1 on cochlear macrophages influences survival of hair cells following ototoxic injury. J Assoc Res Otolaryngol (2009) 1.02
Supporting cell division is not required for regeneration of auditory hair cells after ototoxic injury in vitro. J Assoc Res Otolaryngol (2010) 1.00
A novel technique for inducing local inner ear damage. Hear Res (2003) 0.98
Sensory hair cell death and regeneration: two halves of the same equation. Curr Opin Otolaryngol Head Neck Surg (2004) 0.90
Celastrol inhibits aminoglycoside-induced ototoxicity via heat shock protein 32. Cell Death Dis (2011) 0.85
Neomycin-induced hair cell death and rapid regeneration in the lateral line of zebrafish (Danio rerio). J Assoc Res Otolaryngol (2003) 2.43
Doxorubicin pretreatment sensitizes prostate cancer cell lines to TRAIL induced apoptosis which correlates with the loss of c-FLIP expression. Cancer Biol Ther (2002) 1.96
Mechanisms of hair cell death and protection. Curr Opin Otolaryngol Head Neck Surg (2005) 1.65
Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway. Cancer Res (2010) 1.43
Sorafenib activates CD95 and promotes autophagy and cell death via Src family kinases in gastrointestinal tumor cells. Mol Cancer Ther (2010) 1.31
Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms. Mol Pharmacol (2009) 1.29
Using the zebrafish lateral line to screen for ototoxicity. J Assoc Res Otolaryngol (2008) 1.26
Identification of FDA-approved drugs and bioactives that protect hair cells in the zebrafish (Danio rerio) lateral line and mouse (Mus musculus) utricle. J Assoc Res Otolaryngol (2009) 1.22
Hair cell death in the avian basilar papilla: characterization of the in vitro model and caspase activation. J Assoc Res Otolaryngol (2002) 1.19
Developmental differences in susceptibility to neomycin-induced hair cell death in the lateral line neuromasts of zebrafish (Danio rerio). Hear Res (2003) 1.12
JNK signaling in neomycin-induced vestibular hair cell death. Hear Res (2006) 1.10
Inner ear supporting cells protect hair cells by secreting HSP70. J Clin Invest (2013) 1.10
MDA-7/IL-24-induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK-dependent mechanism. Mol Cancer Ther (2009) 1.08
Hsp70 inhibits aminoglycoside-induced hair cell death and is necessary for the protective effect of heat shock. J Assoc Res Otolaryngol (2008) 1.08
Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma. Mol Cancer Ther (2013) 1.05
Doxorubicin increases the effectiveness of Apo2L/TRAIL for tumor growth inhibition of prostate cancer xenografts. BMC Cancer (2005) 1.04
The role of protein synthesis in cell cycling and cancer. Mol Oncol (2009) 1.03
Inhibition of superoxide generation upon T-cell receptor engagement rescues Mart-1(27-35)-reactive T cells from activation-induced cell death. Cancer Res (2009) 1.03
Hsp70 inhibits aminoglycoside-induced hearing loss and cochlear hair cell death. Cell Stress Chaperones (2009) 1.02
The role of TNF-α in inflammatory olfactory loss. Laryngoscope (2011) 0.97
Lead roles for supporting actors: critical functions of inner ear supporting cells. Hear Res (2013) 0.97
Round window gentamicin application: an inner ear hair cell damage protocol for the mouse. Hear Res (2004) 0.95
Oxidative stress and lymphocyte persistence: implications in immunotherapy. Adv Cancer Res (2009) 0.93
T cells expanded in presence of IL-15 exhibit increased antioxidant capacity and innate effector molecules. Cytokine (2011) 0.92
Polymer-enhanced adenoviral transduction of CAR-negative bladder cancer cells. Mol Pharm (2009) 0.91
Doxorubicin generates a proapoptotic phenotype by phosphorylation of elongation factor 2. Free Radic Biol Med (2007) 0.90
Sound preconditioning therapy inhibits ototoxic hearing loss in mice. J Clin Invest (2013) 0.89
17-allylamino-17-demethoxygeldanamycin and MEK1/2 inhibitors kill GI tumor cells via Ca2+-dependent suppression of GRP78/BiP and induction of ceramide and reactive oxygen species. Mol Cancer Ther (2010) 0.86
Gene therapy for sensorineural hearing loss. Ear Hear (2015) 0.85
Enhanced apoptosis of glioma cell lines is achieved by co-delivering FasL-GFP and TRAIL with a complex Ad5 vector. Cancer Gene Ther (2003) 0.84
Oxidative stress sensitizes bladder cancer cells to TRAIL mediated apoptosis by down-regulating anti-apoptotic proteins. J Urol (2009) 0.83
Targeting the short form of cFLIP by RNA interference is sufficient to enhance TRAIL sensitivity in PC3 prostate carcinoma cells. Cancer Biol Ther (2006) 0.83
Restoring synaptic connections in the inner ear after noise damage. N Engl J Med (2015) 0.81
Histone deacetylase inhibitors restore cell surface expression of the coxsackie adenovirus receptor and enhance CMV promoter activity in castration-resistant prostate cancer cells. Prostate Cancer (2012) 0.80
Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure. Hear Res (2010) 0.79
In vitro efficacy of Fas ligand gene therapy for the treatment of bladder cancer. Cancer Gene Ther (2005) 0.79
Transformation, translation and TRAIL: an unexpected intersection. Cytokine Growth Factor Rev (2008) 0.78
Heat shock protein-mediated protection against Cisplatin-induced hair cell death. J Assoc Res Otolaryngol (2014) 0.77
An orthotopic bladder cancer model for gene delivery studies. J Vis Exp (2013) 0.76
Illuminating TRAIL gene therapy. Cancer Biol Ther (2006) 0.76
Adenoviral infectivity of exfoliated viable cells in urine: implications for the detection of bladder cancer. BMC Cancer (2011) 0.75
Hearing Loss after Round Window Surgery in Mice Is due to Middle Ear Effusion. Audiol Neurootol (2017) 0.75