The actin-severing protein cofilin is downstream of neuregulin signaling and is essential for Schwann cell myelination.

PubWeight™: 0.93‹?›

🔗 View Article (PMC 3490500)

Published in J Neurosci on April 11, 2012

Authors

Nicklaus Sparrow1, Maria Elisa Manetti, Marga Bott, Tiffany Fabianac, Alejandra Petrilli, Margaret Longest Bates, Mary Bartlett Bunge, Stephen Lambert, Cristina Fernandez-Valle

Author Affiliations

1: Burnett School of Biomedical Science, College of Medicine, University of Central Florida, Orlando, Florida 32827, USA.

Articles citing this

Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases. Neuron (2014) 1.30

CaMKIIβ regulates oligodendrocyte maturation and CNS myelination. J Neurosci (2013) 1.00

Retrograde BMP signaling modulates rapid activity-dependent synaptic growth via presynaptic LIM kinase regulation of cofilin. J Neurosci (2014) 0.99

Integrative mechanisms of oriented neuronal migration in the developing brain. Annu Rev Cell Dev Biol (2013) 0.99

LIM domain kinases as potential therapeutic targets for neurofibromatosis type 2. Oncogene (2013) 0.92

The CT20 peptide causes detachment and death of metastatic breast cancer cells by promoting mitochondrial aggregation and cytoskeletal disruption. Cell Death Dis (2014) 0.84

Requirement of cAMP signaling for Schwann cell differentiation restricts the onset of myelination. PLoS One (2015) 0.83

Mapping genetically controlled neural circuits of social behavior and visuo-motor integration by a preliminary examination of atypical deletions with Williams syndrome. PLoS One (2014) 0.80

Activation of sodium-dependent glutamate transporters regulates the morphological aspects of oligodendrocyte maturation via signaling through calcium/calmodulin-dependent kinase IIβ's actin-binding/-stabilizing domain. Glia (2014) 0.77

Nanoparticles carrying neurotrophin-3-modified Schwann cells promote repair of sciatic nerve defects. Neural Regen Res (2013) 0.77

The proteome profiles of the olfactory bulb of juvenile, adult and aged rats - an ontogenetic study. Proteome Sci (2015) 0.77

Cofilin-1 and Other ADF/Cofilin Superfamily Members in Human Malignant Cells. Int J Mol Sci (2016) 0.76

Putative miRNAs for the diagnosis of dyslexia, dyspraxia, and specific language impairment. Epigenetics (2013) 0.75

Articles cited by this

Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat Cell Biol (1999) 6.18

Axonal neuregulin-1 regulates myelin sheath thickness. Science (2004) 6.09

Rho GTPases and the control of cell behaviour. Biochem Soc Trans (2005) 5.38

Cofilin promotes actin polymerization and defines the direction of cell motility. Science (2004) 5.12

Studies on cultured rat Schwann cells. I. Establishment of purified populations from cultures of peripheral nerve. Brain Res (1979) 4.39

Neuregulin-1 type III determines the ensheathment fate of axons. Neuron (2005) 4.19

ADF/cofilin: a functional node in cell biology. Trends Cell Biol (2010) 3.95

Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin. Cell (2002) 3.83

Actin-depolymerizing factor and cofilin-1 play overlapping roles in promoting rapid F-actin depolymerization in mammalian nonmuscle cells. Mol Biol Cell (2004) 3.15

Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics. Nat Cell Biol (2004) 3.12

Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. J Biol Chem (2000) 2.99

Spatial and temporal control of cofilin activity is required for directional sensing during chemotaxis. Curr Biol (2006) 2.86

Cofilin phosphatases and regulation of actin dynamics. Curr Opin Cell Biol (2005) 2.66

EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells. J Cell Biol (2007) 2.48

Inhibition of the interactions of cofilin, destrin, and deoxyribonuclease I with actin by phosphoinositides. J Biol Chem (1990) 2.35

Cofilin determines the migration behavior and turning frequency of metastatic cancer cells. J Cell Biol (2007) 2.26

14-3-3 regulates actin dynamics by stabilizing phosphorylated cofilin. Curr Biol (2002) 2.00

The cofilin activity cycle in lamellipodia and invadopodia. J Cell Biochem (2009) 1.99

Elevated phosphatidylinositol 3,4,5-trisphosphate in glia triggers cell-autonomous membrane wrapping and myelination. J Neurosci (2010) 1.93

Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin. J Biol Chem (2001) 1.93

Beta1 integrin activates Rac1 in Schwann cells to generate radial lamellae during axonal sorting and myelination. J Cell Biol (2007) 1.77

mDia2 regulates actin and focal adhesion dynamics and organization in the lamella for efficient epithelial cell migration. J Cell Sci (2007) 1.73

Integrin beta4 regulates migratory behavior of keratinocytes by determining laminin-332 organization. J Biol Chem (2006) 1.55

Neuregulin-1, a key axonal signal that drives Schwann cell growth and differentiation. Glia (2008) 1.45

ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration. J Cell Biol (2008) 1.37

Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors. Mol Cancer Ther (2008) 1.31

Selective inhibition of the epidermal growth factor and HER2/neu receptors by tyrphostins. J Biol Chem (1993) 1.27

Association of beta 1 integrin with focal adhesion kinase and paxillin in differentiating Schwann cells. J Neurosci (2000) 1.26

Rho kinase regulates schwann cell myelination and formation of associated axonal domains. J Neurosci (2004) 1.24

Anti-beta 1 integrin antibody inhibits Schwann cell myelination. J Neurobiol (1994) 1.17

Actin plays a role in both changes in cell shape and gene-expression associated with Schwann cell myelination. J Neurosci (1997) 1.15

Direct stimulation of receptor-controlled phospholipase D1 by phospho-cofilin. EMBO J (2007) 1.14

Mechanisms of gradient detection: a comparison of axon pathfinding with eukaryotic cell migration. Int Rev Cytol (2007) 1.09

Conserved F-actin dynamics and force transmission at cell adhesions. Curr Opin Cell Biol (2010) 1.06

Rho-associated kinase-dependent contraction of stress fibres and the organization of focal adhesions. J R Soc Interface (2010) 1.05

New concepts in phospholipase D signaling in inflammation and cancer. ScientificWorldJournal (2010) 1.01

Phosphorylation of the NF2 tumor suppressor in Schwann cells is mediated by Cdc42-Pak and requires paxillin binding. Mol Cell Neurosci (2006) 1.00

Neuregulin and laminin stimulate phosphorylation of the NF2 tumor suppressor in Schwann cells by distinct protein kinase A and p21-activated kinase-dependent pathways. Oncogene (2007) 0.97

Coronin 2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway. J Cell Sci (2009) 0.96

An EGR2/CITED1 transcription factor complex and the 14-3-3sigma tumor suppressor are involved in regulating ErbB2 expression in a transgenic-mouse model of human breast cancer. Mol Cell Biol (2007) 0.93

Inter-regulatory dynamics of phospholipase D and the actin cytoskeleton. Biochim Biophys Acta (2009) 0.93

Schwannomin/merlin promotes Schwann cell elongation and influences myelin segment length. Mol Cell Neurosci (2010) 0.89

Cultured Schwann cells assemble normal-appearing basal lamina only when they ensheathe axons. Dev Biol (1989) 0.88

Articles by these authors

cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury. Nat Med (2004) 3.65

Immunogenicity of a monovalent 2009 influenza A(H1N1) vaccine in infants and children: a randomized trial. JAMA (2009) 3.32

Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes. Proc Natl Acad Sci U S A (2004) 2.88

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity. Nat Med (2011) 2.87

Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans? Nat Med (2007) 2.29

Identification of a conserved ankyrin-binding motif in the family of sodium channel alpha subunits. J Biol Chem (2003) 2.22

Schwann cell but not olfactory ensheathing glia transplants improve hindlimb locomotor performance in the moderately contused adult rat thoracic spinal cord. J Neurosci (2002) 1.98

Functional recovery in traumatic spinal cord injury after transplantation of multineurotrophin-expressing glial-restricted precursor cells. J Neurosci (2005) 1.75

Transplantation of Schwann cells and/or olfactory ensheathing glia into the contused spinal cord: Survival, migration, axon association, and functional recovery. Glia (2007) 1.60

Mutant huntingtin and mitochondrial dysfunction. Trends Neurosci (2008) 1.59

The burden of influenza in children. Curr Opin Infect Dis (2007) 1.44

Endogenous Nkx2.2+/Olig2+ oligodendrocyte precursor cells fail to remyelinate the demyelinated adult rat spinal cord in the absence of astrocytes. Exp Neurol (2005) 1.41

Anti-CD11d monoclonal antibody treatment for rat spinal cord compression injury. Exp Neurol (2010) 1.40

S-Nitrosylation of DRP1 does not affect enzymatic activity and is not specific to Alzheimer's disease. J Alzheimers Dis (2010) 1.26

Transplantation of Schwann cells and olfactory ensheathing glia after spinal cord injury: does pretreatment with methylprednisolone and interleukin-10 enhance recovery? J Neurotrauma (2004) 1.21

New vascular tissue rapidly replaces neural parenchyma and vessels destroyed by a contusion injury to the rat spinal cord. Exp Neurol (2002) 1.21

Genetic dysmyelination alters the molecular architecture of the nodal region. J Neurosci (2002) 1.19

A novel combined Haemophilus influenzae type b-Neisseria meningitidis serogroups C and Y-tetanus-toxoid conjugate vaccine is immunogenic and induces immune memory when co-administered with DTPa-HBV-IPV and conjugate pneumococcal vaccines in infants. Vaccine (2007) 1.17

Labeled Schwann cell transplantation: cell loss, host Schwann cell replacement, and strategies to enhance survival. Glia (2006) 1.17

Transduced Schwann cells promote axon growth and myelination after spinal cord injury. Exp Neurol (2007) 1.13

Equivalence of nasal and oronasal masks during initial CPAP titration for obstructive sleep apnea syndrome. Sleep (2011) 1.12

Delayed transplantation of olfactory ensheathing glia promotes sparing/regeneration of supraspinal axons in the contused adult rat spinal cord. J Neurotrauma (2003) 1.11

Local ERM activation and dynamic growth cones at Schwann cell tips implicated in efficient formation of nodes of Ranvier. J Cell Biol (2003) 1.10

Combination of engineered Schwann cell grafts to secrete neurotrophin and chondroitinase promotes axonal regeneration and locomotion after spinal cord injury. J Neurosci (2014) 1.08

A re-assessment of minocycline as a neuroprotective agent in a rat spinal cord contusion model. Brain Res (2008) 1.08

The role of proteoglycans in Schwann cell/astrocyte interactions and in regeneration failure at PNS/CNS interfaces. Mol Cell Neurosci (2005) 1.08

Lentiviral vector-mediated transduction of neural progenitor cells before implantation into injured spinal cord and brain to detect their migration, deliver neurotrophic factors and repair tissue. Restor Neurol Neurosci (2005) 1.06

Purified adult ensheathing glia fail to myelinate axons under culture conditions that enable Schwann cells to form myelin. J Neurosci (2002) 1.04

Combinatorial strategies with Schwann cell transplantation to improve repair of the injured spinal cord. Neurosci Lett (2009) 1.03

Endothelial cell loss is not a major cause of neuronal and glial cell death following contusion injury of the spinal cord. Exp Neurol (2006) 1.00

Phosphorylation of the NF2 tumor suppressor in Schwann cells is mediated by Cdc42-Pak and requires paxillin binding. Mol Cell Neurosci (2006) 1.00

Methylprednisolone and interleukin-10 reduce gray matter damage in the contused Fischer rat thoracic spinal cord but do not improve functional outcome. J Neurotrauma (2002) 0.99

Non-antagonistic relationship between mitogenic factors and cAMP in adult Schwann cell re-differentiation. Glia (2009) 0.98

Schwann cell transplantation: a repair strategy for spinal cord injury? Prog Brain Res (2012) 0.96

A new target for amyloid beta toxicity validated by standard and high-throughput electrophysiology. PLoS One (2010) 0.96

Basic fibroblast growth factor promotes neuronal survival but not behavioral recovery in the transected and Schwann cell implanted rat thoracic spinal cord. J Neurotrauma (2004) 0.95

Demonstrating efficacy in preclinical studies of cellular therapies for spinal cord injury - how much is enough? Exp Neurol (2013) 0.94

Muscle injection of AAV-NT3 promotes anatomical reorganization of CST axons and improves behavioral outcome following SCI. J Neurotrauma (2009) 0.94

Brain-derived neurotrophic factor released from engineered mesenchymal stem cells attenuates glutamate- and hydrogen peroxide-mediated death of staurosporine-differentiated RGC-5 cells. Exp Eye Res (2009) 0.93

Invariant mantling of growth cones by Schwann cell precursors characterize growing peripheral nerve fronts. Glia (2006) 0.92

A re-assessment of erythropoietin as a neuroprotective agent following rat spinal cord compression or contusion injury. Exp Neurol (2008) 0.91

Enkurin is a novel calmodulin and TRPC channel binding protein in sperm. Dev Biol (2004) 0.90

Nuclear factor-κB activation in Schwann cells regulates regeneration and remyelination. Glia (2012) 0.89

Skin incision induces expression of axonal regeneration-related genes in adult rat spinal sensory neurons. J Pain (2010) 0.89

Schwannomin/merlin promotes Schwann cell elongation and influences myelin segment length. Mol Cell Neurosci (2010) 0.89

Improved immunocytochemical identification of neural, endothelial, and inflammatory cell types in paraffin-embedded injured adult rat spinal cord. J Neurosci Methods (2004) 0.88

Schwann cell transplantation for spinal cord injury repair: its significant therapeutic potential and prospectus. Rev Neurosci (2015) 0.88

Node of Ranvier formation on motoneurons in vitro. Biomaterials (2009) 0.88

Direct gene therapy for repair of the spinal cord. J Neurotrauma (2006) 0.87

Forskolin increases neuregulin receptors in human Schwann cells without increasing receptor mRNA. Glia (2005) 0.87

Asymmetric ERM activation at the Schwann cell process tip is required in axon-associated motility. J Cell Physiol (2007) 0.86

Inhibition of tumour necrosis factor-alpha by antisense targeting produces immunophenotypical and morphological changes in injury-activated microglia and macrophages. Eur J Neurosci (2004) 0.86

Fabrication of growth factor- and extracellular matrix-loaded, gelatin-based scaffolds and their biocompatibility with Schwann cells and dorsal root ganglia. Biomaterials (2012) 0.85

Permissive Schwann cell graft/spinal cord interfaces for axon regeneration. Cell Transplant (2013) 0.85

From animal models to humans: strategies for promoting CNS axon regeneration and recovery of limb function after spinal cord injury. J Neurol Phys Ther (2005) 0.85

Derivation of sensory neurons and neural crest stem cells from human neural progenitor hNP1. Biomaterials (2013) 0.85

Combining neurotrophin-transduced schwann cells and rolipram to promote functional recovery from subacute spinal cord injury. Cell Transplant (2012) 0.84

Formation of a beta1 integrin signaling complex in Schwann cells is independent of rho. Glia (2003) 0.83

Inhibition of SIRT2 in merlin/NF2-mutant Schwann cells triggers necrosis. Oncotarget (2013) 0.82

Rat Cortical Oligodendrocyte-Embryonic Motoneuron Co-Culture: An In Vitro Axon-Oligodendrocyte Interaction Model. J Biomater Tissue Eng (2012) 0.82

A multifunctional neurotrophin with reduced affinity to p75NTR enhances transplanted Schwann cell survival and axon growth after spinal cord injury. Exp Neurol (2013) 0.81

Tissue engineering the monosynaptic circuit of the stretch reflex arc with co-culture of embryonic motoneurons and proprioceptive sensory neurons. Biomaterials (2012) 0.81

Contact tracing of in-flight measles exposures: lessons from an outbreak investigation and case series, Australia, 2010. Western Pac Surveill Response J (2011) 0.81

CTF meeting 2012: Translation of the basic understanding of the biology and genetics of NF1, NF2, and schwannomatosis toward the development of effective therapies. Am J Med Genet A (2014) 0.81

Serum and forskolin cooperate to promote G1 progression in Schwann cells by differentially regulating cyclin D1, cyclin E1, and p27Kip expression. Glia (2007) 0.81

A calpain inhibitor enhances the survival of Schwann cells in vitro and after transplantation into the injured spinal cord. J Neurotrauma (2010) 0.81

Small Molecule Induction of Human Umbilical Stem Cells into MBP-positive Oligodendrocytes in a Defined Three-Dimensional Environment. ACS Chem Neurosci (2011) 0.80

The assessment of adeno-associated vectors as potential intrinsic treatments for brainstem axon regeneration. J Gene Med (2012) 0.80

Three-year antibody persistence and safety after a single dose of combined haemophilus influenzae type b (Hib)-Neisseria meningitidis serogroup C-tetanus toxoid conjugate vaccine in Hib-primed toddlers. Pediatr Infect Dis J (2013) 0.79

Stability of the tumor suppressor merlin depends on its ability to bind paxillin LD3 and associate with β1 integrin and actin at the plasma membrane. Biol Open (2012) 0.78

Immediate and longer term immunogenicity of a single dose of the combined haemophilus influenzae type B-Neisseria meningitidis serogroup C-tetanus toxoid conjugate vaccine in primed toddlers 12 to 18 months of age. Pediatr Infect Dis J (2011) 0.78

Immunogenicity and safety of measles-mumps-rubella and varicella vaccines coadministered with a fourth dose of Haemophilus influenzae type b and Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine in toddlers: a pooled analysis of randomized trials. Hum Vaccin Immunother (2012) 0.77

Group A Streptococcal Carriage and Seroepidemiology in Children up to 10 Years of Age in Australia. Pediatr Infect Dis J (2015) 0.77

Rapid assessment of internodal myelin integrity in central nervous system tissue. J Neurosci Res (2010) 0.76

DTPa-HBV-IPV vaccine for primary vaccination of infants. J Paediatr Child Health (2007) 0.76

Measuring anisotropic cell motility on curved substrates. J Biophotonics (2012) 0.76

Paralysis research: Promoting nerve fiber protection, growth and functional recovery by cyclic AMP and cell transplantation. Discov Med (2004) 0.75

Human coronavirus nomenclature. Pediatr Infect Dis J (2006) 0.75

Is this really an ethical evaluation of HPV vaccination policy in Australia? Aust N Z J Public Health (2012) 0.75

Surveillance of viral pathogens in Australia: respiratory syncytial virus. Commun Dis Intell Q Rep (2003) 0.75

The evolution of HIV education for nurses in Australia. J Assoc Nurses AIDS Care (2013) 0.75

The mumps outbreak that wasn't. Aust N Z J Public Health (2002) 0.75

Development of a highly detailed virtual model eye. Ophthalmic Surg Lasers Imaging (2006) 0.75

Estimating influenza vaccine effectiveness in an outbreak when anti-viral medications were used as a control measure. Aust N Z J Public Health (2005) 0.75