PubRank

Sandy Chang

Author PubWeight™ 88.37‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 2005 14.21
2 Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell 2004 8.16
3 Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres. Cell 2006 4.13
4 Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice. Nat Genet 2003 3.61
5 Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation. Cell 2008 3.42
6 Telomere dysfunction provokes regional amplification and deletion in cancer genomes. Cancer Cell 2002 3.06
7 Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis. EMBO J 2007 2.61
8 Telomere dysfunction and tumour suppression: the senescence connection. Nat Rev Cancer 2008 2.54
9 Control of chromosome stability by the beta-TrCP-REST-Mad2 axis. Nature 2008 2.46
10 Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance. Mol Cell 2009 2.29
11 Multiple roles for MRE11 at uncapped telomeres. Nature 2009 2.18
12 TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA. Nature 2011 2.17
13 Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence. EMBO Rep 2007 1.96
14 Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons. Mol Biol Cell 2011 1.86
15 Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway. Genes Dev 2005 1.84
16 The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres. EMBO J 2010 1.83
17 Tumor-specific low molecular weight forms of cyclin E induce genomic instability and resistance to p21, p27, and antiestrogens in breast cancer. Cancer Res 2004 1.70
18 POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination. EMBO J 2006 1.66
19 CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion. EMBO J 2012 1.65
20 Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenita. Mol Cell Biol 2008 1.46
21 WRN at telomeres: implications for aging and cancer. J Cell Sci 2007 1.36
22 Overexpression of the low molecular weight cyclin E in transgenic mice induces metastatic mammary carcinomas through the disruption of the ARF-p53 pathway. Cancer Res 2007 1.32
23 SNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repair. EMBO J 2010 1.32
24 Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. Clin Cancer Res 2010 1.31
25 The RAG2 C terminus suppresses genomic instability and lymphomagenesis. Nature 2011 1.24
26 Critical and distinct roles of p16 and telomerase in regulating the proliferative life span of normal human prostate epithelial progenitor cells. J Biol Chem 2008 1.23
27 BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice. PLoS Genet 2010 1.18
28 The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection. Nat Struct Mol Biol 2011 1.18
29 SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres. Cell Rep 2013 1.13
30 A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms. Nat Struct Mol Biol 2011 1.06
31 Block of T cell development in P53-deficient mice accelerates development of lymphomas with characteristic RAG-dependent cytogenetic alterations. Cancer Cell 2006 1.03
32 Role of telomeres and telomerase in genomic instability, senescence and cancer. Lab Invest 2007 1.02
33 The mINO80 chromatin remodeling complex is required for efficient telomere replication and maintenance of genome stability. Cell Res 2013 0.96
34 Evidence that senescent human prostate epithelial cells enhance tumorigenicity: cell fusion as a potential mechanism and inhibition by p16INK4a and hTERT. Int J Cancer 2008 0.91
35 Functional characterization of human CTC1 mutations reveals novel mechanisms responsible for the pathogenesis of the telomere disease Coats plus. Aging Cell 2013 0.90
36 Essential roles for Pot1b in HSC self-renewal and survival. Blood 2011 0.89
37 Dual roles of telomere dysfunction in initiation and suppression of tumorigenesis. Exp Cell Res 2008 0.89
38 Single strand DNA binding proteins 1 and 2 protect newly replicated telomeres. Cell Res 2013 0.88
39 Defending the end zone: studying the players involved in protecting chromosome ends. FEBS Lett 2010 0.86
40 The telomeric protein SNM1B/Apollo is required for normal cell proliferation and embryonic development. Aging Cell 2010 0.85
41 RPA and POT1: friends or foes at telomeres? Cell Cycle 2012 0.82
42 Probing the telomere damage response. Methods Mol Biol 2011 0.80
43 p16(INK4a) protects against dysfunctional telomere-induced ATR-dependent DNA damage responses. J Clin Invest 2013 0.80
44 The telomere protein tankyrase 1 regulates DNA damage responses at telomeres. Aging (Albany NY) 2010 0.79
45 Cytogenetic analysis of telomere dysfunction. Methods Mol Biol 2011 0.79