Published in Cell on October 03, 2008
Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis. Nat Rev Mol Cell Biol (2010) 5.35
Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair. Cell (2008) 4.26
The MRE11 complex: starting from the ends. Nat Rev Mol Cell Biol (2011) 3.83
BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair. Genes Dev (2011) 3.47
DNA end resection: many nucleases make light work. DNA Repair (Amst) (2009) 3.28
Pathways of mammalian replication fork restart. Nat Rev Mol Cell Biol (2010) 3.26
PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination. EMBO J (2009) 2.99
Origin of chromosomal translocations in lymphoid cancer. Cell (2010) 2.94
DNA resection in eukaryotes: deciding how to fix the break. Nat Struct Mol Biol (2010) 2.81
Mechanisms of double-strand break repair in somatic mammalian cells. Biochem J (2009) 2.68
Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells. Nat Struct Mol Biol (2009) 2.64
Multiple roles for MRE11 at uncapped telomeres. Nature (2009) 2.18
Mre11-Rad50-Xrs2 and Sae2 promote 5' strand resection of DNA double-strand breaks. Nat Struct Mol Biol (2010) 2.14
Multiple functions of MRN in end-joining pathways during isotype class switching. Nat Struct Mol Biol (2009) 2.05
Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks. EMBO J (2010) 2.04
Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks. DNA Repair (Amst) (2010) 1.96
DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell (2013) 1.93
RPA antagonizes microhomology-mediated repair of DNA double-strand breaks. Nat Struct Mol Biol (2014) 1.82
DNA damage sensing by the ATM and ATR kinases. Cold Spring Harb Perspect Biol (2013) 1.72
Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates. Mol Cell (2009) 1.70
Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks. PLoS Genet (2011) 1.66
Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks. Nucleic Acids Res (2009) 1.66
SOSS complexes participate in the maintenance of genomic stability. Mol Cell (2009) 1.63
Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells. Proc Natl Acad Sci U S A (2013) 1.62
Palindromic gene amplification--an evolutionarily conserved role for DNA inverted repeats in the genome. Nat Rev Cancer (2009) 1.62
Cell cycle-dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of nonhomologous end joining (NHEJ) in G1 and resection-mediated inhibition of NHEJ in G2. Mol Cell Biol (2009) 1.60
Focus on histone variant H2AX: to be or not to be. FEBS Lett (2010) 1.56
Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites. J Cell Biol (2009) 1.55
The MRN complex in double-strand break repair and telomere maintenance. FEBS Lett (2010) 1.53
MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks. J Exp Med (2009) 1.50
Crystal structure of the Mre11-Rad50-ATPγS complex: understanding the interplay between Mre11 and Rad50. Genes Dev (2011) 1.45
DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints. Trends Cell Biol (2010) 1.44
Making the best of the loose ends: Mre11/Rad50 complexes and Sae2 promote DNA double-strand break resection. DNA Repair (Amst) (2010) 1.42
Enhanced cellular radiosensitivity induced by cofilin-1 over-expression is associated with reduced DNA repair capacity. Int J Radiat Biol (2013) 1.42
Links between mutant p53 and genomic instability. J Cell Biochem (2012) 1.41
DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking. Proc Natl Acad Sci U S A (2013) 1.41
A mouse PRMT1 null allele defines an essential role for arginine methylation in genome maintenance and cell proliferation. Mol Cell Biol (2009) 1.40
MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX. J Biol Chem (2009) 1.39
Limiting the persistence of a chromosome break diminishes its mutagenic potential. PLoS Genet (2009) 1.38
Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions. DNA Repair (Amst) (2012) 1.37
RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks. Nat Struct Mol Biol (2011) 1.36
Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS. Genes Dev (2009) 1.36
The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links. Nucleic Acids Res (2009) 1.30
Mre11: roles in DNA repair beyond homologous recombination. Nat Struct Mol Biol (2009) 1.28
Probing PML body function in ALT cells reveals spatiotemporal requirements for telomere recombination. Proc Natl Acad Sci U S A (2009) 1.27
Regulatory networks integrating cell cycle control with DNA damage checkpoints and double-strand break repair. Philos Trans R Soc Lond B Biol Sci (2011) 1.27
The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair. PLoS Genet (2013) 1.27
Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection. EMBO J (2009) 1.24
Loss of ATM kinase activity leads to embryonic lethality in mice. J Cell Biol (2012) 1.23
End resection at double-strand breaks: mechanism and regulation. Cold Spring Harb Perspect Biol (2014) 1.21
Aggressive chronic lymphocytic leukemia with elevated genomic complexity is associated with multiple gene defects in the response to DNA double-strand breaks. Clin Cancer Res (2010) 1.18
CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1. Nucleic Acids Res (2010) 1.16
Exonuclease function of human Mre11 promotes deletional nonhomologous end joining. J Biol Chem (2009) 1.16
The impact of environmental stress on male reproductive development in plants: biological processes and molecular mechanisms. Plant Cell Environ (2013) 1.16
Characteristics of DNA-binding proteins determine the biological sensitivity to high-linear energy transfer radiation. Nucleic Acids Res (2010) 1.15
Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway? Trends Biochem Sci (2015) 1.13
Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair. Adv Immunol (2014) 1.11
Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2. Nat Struct Mol Biol (2012) 1.10
The ATM signaling network in development and disease. Front Genet (2013) 1.09
Physical interaction between replication protein A (RPA) and MRN: involvement of RPA2 phosphorylation and the N-terminus of RPA1. Biochemistry (2009) 1.07
CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination. EMBO Rep (2012) 1.07
RAD50 and NBS1 form a stable complex functional in DNA binding and tethering. Nucleic Acids Res (2009) 1.05
Non-homologous end joining: emerging themes and unanswered questions. DNA Repair (Amst) (2014) 1.05
MRN and the race to the break. Chromosoma (2009) 1.04
Human Ku70/80 protein blocks exonuclease 1-mediated DNA resection in the presence of human Mre11 or Mre11/Rad50 protein complex. J Biol Chem (2011) 1.04
PTIP regulates 53BP1 and SMC1 at the DNA damage sites. J Biol Chem (2009) 1.04
Structural and functional insights into DNA-end processing by the archaeal HerA helicase-NurA nuclease complex. Nucleic Acids Res (2011) 1.02
DNA double-strand break signaling and human disorders. Genome Integr (2010) 1.00
The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation. Cell Res (2011) 0.99
ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control. J Biol Chem (2011) 0.98
Mre11 nuclease activity and Ctp1 regulate Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at double-strand breaks. Mol Cell Biol (2010) 0.98
Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex. J Biol Chem (2013) 0.96
PHS1 regulates meiotic recombination and homologous chromosome pairing by controlling the transport of RAD50 to the nucleus. Proc Natl Acad Sci U S A (2009) 0.95
Biochemical characterization of bacteriophage T4 Mre11-Rad50 complex. J Biol Chem (2010) 0.95
The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks. Mol Biol Cell (2013) 0.94
Fanconi anemia group J helicase and MRE11 nuclease interact to facilitate the DNA damage response. Mol Cell Biol (2013) 0.93
The RING finger protein RNF8 ubiquitinates Nbs1 to promote DNA double-strand break repair by homologous recombination. J Biol Chem (2012) 0.93
Repair of chromosomal RAG-mediated DNA breaks by mutant RAG proteins lacking phosphatidylinositol 3-like kinase consensus phosphorylation sites. J Immunol (2011) 0.92
DNA replication and homologous recombination factors: acting together to maintain genome stability. Chromosoma (2013) 0.92
Coincident resection at both ends of random, γ-induced double-strand breaks requires MRX (MRN), Sae2 (Ctp1), and Mre11-nuclease. PLoS Genet (2013) 0.92
Effects of tumor-suppressor lysyl oxidase propeptide on prostate cancer xenograft growth and its direct interactions with DNA repair pathways. Oncogene (2014) 0.91
DNA repair by the MRN complex: break it to make it. Cell (2008) 0.91
The role of MRN in the S-phase DNA damage checkpoint is independent of its Ctp1-dependent roles in double-strand break repair and checkpoint signaling. Mol Biol Cell (2009) 0.90
Mechanism and regulation of DNA end resection in eukaryotes. Crit Rev Biochem Mol Biol (2016) 0.88
Bcl2 inhibits recruitment of Mre11 complex to DNA double-strand breaks in response to high-linear energy transfer radiation. Nucleic Acids Res (2015) 0.88
EXD2 promotes homologous recombination by facilitating DNA end resection. Nat Cell Biol (2016) 0.88
Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms. Hum Mol Genet (2013) 0.88
MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA. Biol Open (2012) 0.88
Insight into the mechanism of inhibition of adeno-associated virus by the Mre11/Rad50/Nbs1 complex. J Virol (2014) 0.87
ATR signaling at a glance. J Cell Sci (2009) 0.87
Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phase. Nucleic Acids Res (2012) 0.87
ATP hydrolysis by RAD50 protein switches MRE11 enzyme from endonuclease to exonuclease. J Biol Chem (2011) 0.87
ATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to Adaptor. Biomolecules (2015) 0.86
BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres. EMBO J (2015) 0.86
Defending the end zone: studying the players involved in protecting chromosome ends. FEBS Lett (2010) 0.86
Mre11 modulates the fidelity of fusion between short telomeres in human cells. Nucleic Acids Res (2011) 0.86
Dual functions of Nbs1 in the repair of DNA breaks and proliferation ensure proper V(D)J recombination and T-cell development. Mol Cell Biol (2010) 0.85
A hypomorphic Artemis human disease allele causes aberrant chromosomal rearrangements and tumorigenesis. Hum Mol Genet (2010) 0.85
NFBD1/MDC1 regulates Cav1 and Cav2 independently of DNA damage and p53. Mol Cancer Res (2011) 0.85
The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress. Cell Death Differ (2015) 0.84
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature (2003) 20.13
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Human CtIP promotes DNA end resection. Nature (2007) 10.63
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The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder. Cell (1999) 5.44
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Yeast DNA ligase IV mediates non-homologous DNA end joining. Nature (1997) 4.34
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Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Nat Genet (2000) 4.30
The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements. Cell (2002) 4.23
The RAG proteins and V(D)J recombination: complexes, ends, and transposition. Annu Rev Immunol (2000) 4.17
Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. Nat Cell Biol (2007) 4.14
Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex. Mol Cell (2007) 3.86
Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase. Cell (2001) 3.81
DNA damage-dependent nuclear dynamics of the Mre11 complex. Mol Cell Biol (2001) 3.78
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DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes. Mol Cell (1998) 2.97
Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination. EMBO J (1998) 2.94
Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice. Curr Biol (2001) 2.72
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Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis. EMBO J (2007) 2.61
Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells. Nucleic Acids Res (1997) 2.58
The Mre11 nuclease is not required for 5' to 3' resection at multiple HO-induced double-strand breaks. Mol Cell Biol (2004) 2.46
Alteration of N-terminal phosphoesterase signature motifs inactivates Saccharomyces cerevisiae Mre11. Genetics (1998) 2.32
Defective DNA repair and increased genomic instability in Artemis-deficient murine cells. J Exp Med (2003) 1.98
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Arrested replication fork processing: interplay between checkpoints and recombination. DNA Repair (Amst) (2007) 1.65
Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control. Genes Dev (2005) 1.61
Evidence that the ATR/Chk1 pathway maintains normal replication fork progression during unperturbed S phase. Cell Cycle (2006) 1.53
Mutations in Mre11 phosphoesterase motif I that impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex stability in addition to nuclease activity. Genetics (2005) 1.48
Role of the nuclease activity of Saccharomyces cerevisiae Mre11 in repair of DNA double-strand breaks in mitotic cells. Genetics (2004) 1.43
The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor. Genes Dev (2005) 1.37
Rad50 depletion impacts upon ATR-dependent DNA damage responses. Hum Mol Genet (2005) 1.36
Structural and functional analysis of Mre11-3. Nucleic Acids Res (2004) 1.28
The NBS1-ATM connection revisited. Cell Cycle (2007) 1.22
A nanomachine for making ends meet: MRN is a flexing scaffold for the repair of DNA double-strand breaks. Mol Cell (2005) 0.90
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell (2005) 14.21
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature (2006) 11.86
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Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Cell (2003) 5.26
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc Natl Acad Sci U S A (2002) 5.07
Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell (2002) 4.29
Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres. Cell (2006) 4.13
Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice. Nat Genet (2003) 3.61
Telomere dysfunction provokes regional amplification and deletion in cancer genomes. Cancer Cell (2002) 3.06
Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation. Cancer Res (2007) 2.97
Calorie restriction alters mitochondrial protein acetylation. Aging Cell (2009) 2.73
The role of DNA breaks in genomic instability and tumorigenesis. Immunol Rev (2003) 2.72
Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis. EMBO J (2007) 2.61
Telomere dysfunction and tumour suppression: the senescence connection. Nat Rev Cancer (2008) 2.54
Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. Cell (2012) 2.54
Control of chromosome stability by the beta-TrCP-REST-Mad2 axis. Nature (2008) 2.46
Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance. Mol Cell (2009) 2.29
Multiple roles for MRE11 at uncapped telomeres. Nature (2009) 2.18
TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA. Nature (2011) 2.17
Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice. Mol Cell (2003) 2.08
Multiple functions of MRN in end-joining pathways during isotype class switching. Nat Struct Mol Biol (2009) 2.05
Defective DNA repair and increased genomic instability in Artemis-deficient murine cells. J Exp Med (2003) 1.98
The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability. Cell Cycle (2009) 1.97
Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence. EMBO Rep (2007) 1.96
Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons. Mol Biol Cell (2011) 1.86
Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability. Genes Dev (2004) 1.84
Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway. Genes Dev (2005) 1.84
The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres. EMBO J (2010) 1.83
Tumor-specific low molecular weight forms of cyclin E induce genomic instability and resistance to p21, p27, and antiestrogens in breast cancer. Cancer Res (2004) 1.70
Proapoptotic BID is required for myeloid homeostasis and tumor suppression. Genes Dev (2003) 1.70
Genetic p53 deficiency partially rescues the adrenocortical dysplasia phenotype at the expense of increased tumorigenesis. Cancer Cell (2009) 1.67
POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination. EMBO J (2006) 1.66
Mammalian Rif1 contributes to replication stress survival and homology-directed repair. J Cell Biol (2009) 1.66
CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion. EMBO J (2012) 1.65
Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells. Proc Natl Acad Sci U S A (2004) 1.53
Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenita. Mol Cell Biol (2008) 1.46
The Polycomb group protein EZH2 impairs DNA repair in breast epithelial cells. Neoplasia (2005) 1.42
Rad50 depletion impacts upon ATR-dependent DNA damage responses. Hum Mol Genet (2005) 1.36
WRN at telomeres: implications for aging and cancer. J Cell Sci (2007) 1.36
Overexpression of the low molecular weight cyclin E in transgenic mice induces metastatic mammary carcinomas through the disruption of the ARF-p53 pathway. Cancer Res (2007) 1.32
SNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repair. EMBO J (2010) 1.32
Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. Clin Cancer Res (2010) 1.31
Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression. Mol Cell Biol (2005) 1.31
Switch recombination and somatic hypermutation are controlled by the heavy chain 3' enhancer region. J Exp Med (2009) 1.29
DNA double-strand break repair: a relentless hunt uncovers new prey. Cell (2006) 1.27
The RAG2 C terminus suppresses genomic instability and lymphomagenesis. Nature (2011) 1.24
Critical and distinct roles of p16 and telomerase in regulating the proliferative life span of normal human prostate epithelial progenitor cells. J Biol Chem (2008) 1.23
Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation. Blood (2009) 1.19
Chfr and RNF8 synergistically regulate ATM activation. Nat Struct Mol Biol (2011) 1.19
BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice. PLoS Genet (2010) 1.18
The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection. Nat Struct Mol Biol (2011) 1.18
SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres. Cell Rep (2013) 1.13
Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2. Nat Struct Mol Biol (2012) 1.10
Impact of a hypomorphic Artemis disease allele on lymphocyte development, DNA end processing, and genome stability. J Exp Med (2009) 1.07
A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms. Nat Struct Mol Biol (2011) 1.06
Block of T cell development in P53-deficient mice accelerates development of lymphomas with characteristic RAG-dependent cytogenetic alterations. Cancer Cell (2006) 1.03
Role of telomeres and telomerase in genomic instability, senescence and cancer. Lab Invest (2007) 1.02
Tpp1/Acd maintains genomic stability through a complex role in telomere protection. Chromosome Res (2008) 0.99
The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation. Cell Res (2011) 0.99
A deletion at the mouse Xist gene exposes trans-effects that alter the heterochromatin of the inactive X chromosome and the replication time and DNA stability of both X chromosomes. Genetics (2006) 0.98
C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress. PLoS Genet (2012) 0.96
The mINO80 chromatin remodeling complex is required for efficient telomere replication and maintenance of genome stability. Cell Res (2013) 0.96
Role for PKC δ in Fenretinide-Mediated Apoptosis in Lymphoid Leukemia Cells. J Signal Transduct (2010) 0.94
Evidence that senescent human prostate epithelial cells enhance tumorigenicity: cell fusion as a potential mechanism and inhibition by p16INK4a and hTERT. Int J Cancer (2008) 0.91
Functional characterization of human CTC1 mutations reveals novel mechanisms responsible for the pathogenesis of the telomere disease Coats plus. Aging Cell (2013) 0.90
Essential roles for Pot1b in HSC self-renewal and survival. Blood (2011) 0.89
Dual roles of telomere dysfunction in initiation and suppression of tumorigenesis. Exp Cell Res (2008) 0.89
Single strand DNA binding proteins 1 and 2 protect newly replicated telomeres. Cell Res (2013) 0.88
Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms. Hum Mol Genet (2013) 0.88
Epicatechin-rich cocoa polyphenol inhibits Kras-activated pancreatic ductal carcinoma cell growth in vitro and in a mouse model. Int J Cancer (2012) 0.88
Defending the end zone: studying the players involved in protecting chromosome ends. FEBS Lett (2010) 0.86
BMI1 polycomb group protein acts as a master switch for growth and death of tumor cells: regulates TCF4-transcriptional factor-induced BCL2 signaling. PLoS One (2013) 0.86
Dysregulated TCL1 requires the germinal center and genome instability for mature B-cell transformation. Blood (2006) 0.86
A hypomorphic Artemis human disease allele causes aberrant chromosomal rearrangements and tumorigenesis. Hum Mol Genet (2010) 0.85
The telomeric protein SNM1B/Apollo is required for normal cell proliferation and embryonic development. Aging Cell (2010) 0.85
Bax and BH3-domain-only proteins in p53-mediated apoptosis. Front Biosci (2002) 0.83
Analysis of induced pluripotent stem cells from a BRCA1 mutant family. Stem Cell Reports (2013) 0.83
RPA and POT1: friends or foes at telomeres? Cell Cycle (2012) 0.82
Hematopoietic stem cells are acutely sensitive to Acd shelterin gene inactivation. J Clin Invest (2013) 0.81
Probing the telomere damage response. Methods Mol Biol (2011) 0.80
p16(INK4a) protects against dysfunctional telomere-induced ATR-dependent DNA damage responses. J Clin Invest (2013) 0.80
Expression of BCR/ABL p210 from a knockin allele enhances bone marrow engraftment without inducing neoplasia. Cell Rep (2013) 0.80
Cytogenetic analysis of telomere dysfunction. Methods Mol Biol (2011) 0.79
The telomere protein tankyrase 1 regulates DNA damage responses at telomeres. Aging (Albany NY) (2010) 0.79
Oncogenic Myc translocations are independent of chromosomal location and orientation of the immunoglobulin heavy chain locus. Proc Natl Acad Sci U S A (2012) 0.79