Published in J Med Chem on May 31, 2012
Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review). Int J Oncol (2015) 0.90
SPLINTS: small-molecule protein ligand interface stabilizers. Curr Opin Struct Biol (2016) 0.82
Small molecule substrate phosphorylation site inhibitors of protein kinases: approaches and challenges. ACS Chem Biol (2014) 0.82
Targeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor, ARQ 092. PLoS One (2015) 0.82
Synthesis and Anti-inflammatory Evaluation of Novel Benzimidazole and Imidazopyridine Derivatives. ACS Med Chem Lett (2012) 0.79
SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1. Oncotarget (2016) 0.77
Efficient and cost effective production of active-form human PKB using silkworm larvae. Sci Rep (2014) 0.75
Structural basis of autoregulatory scaffolding by apoptosis signal-regulating kinase 1. Proc Natl Acad Sci U S A (2017) 0.75
Inhibition of inflammation and oxidative stress by an imidazopyridine derivative X22 prevents heart injury from obesity. J Cell Mol Med (2016) 0.75
Solutions for a cultivated planet. Nature (2011) 20.11
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med (2013) 19.87
Land clearing and the biofuel carbon debt. Science (2008) 15.51
Global food demand and the sustainable intensification of agriculture. Proc Natl Acad Sci U S A (2011) 12.97
Energy. Beneficial biofuels--the food, energy, and environment trilemma. Science (2009) 9.27
Carbon-negative biofuels from low-input high-diversity grassland biomass. Science (2006) 6.86
Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. Cancer Cell (2004) 4.98
The immunological synapse balances T cell receptor signaling and degradation. Science (2003) 4.94
A mechanistic role for cardiac myocyte apoptosis in heart failure. J Clin Invest (2003) 3.96
CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility. Science (2003) 3.61
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell (2004) 3.43
TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism. Nature (2006) 3.04
A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer. Proc Natl Acad Sci U S A (2006) 2.86
A comparative study of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) on the effect of proliferation and differentiation of rat osteoblasts in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2009) 2.67
Association of increased interferon-inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus. Arthritis Rheum (2006) 2.50
Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation. Science (2012) 2.50
Genetic diversity and population structure of teosinte. Genetics (2005) 2.31
Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2. Nat Struct Biol (2003) 2.23
ARQ 197, a novel and selective inhibitor of the human c-Met receptor tyrosine kinase with antitumor activity. Mol Cancer Ther (2010) 2.18
Podocytes use FcRn to clear IgG from the glomerular basement membrane. Proc Natl Acad Sci U S A (2008) 2.12
Berlin Heart EXCOR pediatric ventricular assist device for bridge to heart transplantation in US children. Circulation (2013) 2.07
Evaluation of procalcitonin, C-reactive protein, interleukin-6 & serum amyloid A as diagnostic biomarkers of bacterial infection in febrile patients. Indian J Med Res (2015) 2.06
EP-2104R: a fibrin-specific gadolinium-Based MRI contrast agent for detection of thrombus. J Am Chem Soc (2008) 1.98
Natural and anthropogenic ethanol sources inNorth America and potential atmospheric impacts of ethanol fuel use. Environ Sci Technol (2012) 1.96
The Fap1 fimbrial adhesin is a glycoprotein: antibodies specific for the glycan moiety block the adhesion of Streptococcus parasanguis in an in vitro tooth model. Mol Microbiol (2002) 1.88
Glycosylation and biogenesis of a family of serine-rich bacterial adhesins. Microbiology (2009) 1.84
A yolk-shell design for stabilized and scalable li-ion battery alloy anodes. Nano Lett (2012) 1.79
A serine-rich glycoprotein of Streptococcus sanguis mediates adhesion to platelets via GPIb. Br J Haematol (2005) 1.79
Interconnected silicon hollow nanospheres for lithium-ion battery anodes with long cycle life. Nano Lett (2011) 1.76
Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1. Biochem Pharmacol (2009) 1.75
Collagen-targeted MRI contrast agent for molecular imaging of fibrosis. Angew Chem Int Ed Engl (2007) 1.75
Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin. J Clin Invest (2006) 1.66
Bedside technique to detect misplaced subclavian vein catheter in internal jugular vein. Ann Card Anaesth (2010) 1.62
Sensitive and specific molecular detection of Burkholderia pseudomallei, the causative agent of melioidosis, in the soil of tropical northern Australia. Appl Environ Microbiol (2007) 1.62
Vitrectomy for optic disk pit with macular schisis and outer retinal dehiscence. Retina (2012) 1.60
Association of tumor necrosis factor alpha polymorphism, but not the shared epitope, with increased radiographic progression in a seropositive rheumatoid arthritis inception cohort. Arthritis Rheum (2006) 1.55
Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility. PLoS Genet (2011) 1.49
The nuclear receptor tailless is required for neurogenesis in the adult subventricular zone. Genes Dev (2008) 1.46
Investigating the role of secA2 in secretion and glycosylation of a fimbrial adhesin in Streptococcus parasanguis FW213. Mol Microbiol (2004) 1.45
Discovery of a novel mode of protein kinase inhibition characterized by the mechanism of inhibition of human mesenchymal-epithelial transition factor (c-Met) protein autophosphorylation by ARQ 197. J Biol Chem (2011) 1.45
Hyoid bone fracture from a gunshot wound. J Trauma (2003) 1.44
A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus. Hum Mol Genet (2008) 1.43
Optimizing staging for hepatocellular carcinoma before liver transplantation: A retrospective analysis of the UNOS/OPTN database. Liver Transpl (2006) 1.41
Blockade of invasion and metastasis of breast cancer cells via targeting CXCR4 with an artificial microRNA. Biochem Biophys Res Commun (2007) 1.40
Oligo(N-aryl glycines): a new twist on structured peptoids. J Am Chem Soc (2008) 1.37
Thin, flexible secondary Li-ion paper batteries. ACS Nano (2010) 1.34
Protective role of 1,25(OH)2 vitamin D3 in the mucosal injury and epithelial barrier disruption in DSS-induced acute colitis in mice. BMC Gastroenterol (2012) 1.32
Simultaneous detection of human enterovirus 71 and coxsackievirus A16 in clinical specimens by multiplex real-time PCR with an internal amplification control. Arch Virol (2008) 1.31
Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality. J Biol Chem (2003) 1.26
Psammaplins from the sponge Pseudoceratina purpurea: inhibition of both histone deacetylase and DNA methyltransferase. J Org Chem (2003) 1.25
Interaction between two putative glycosyltransferases is required for glycosylation of a serine-rich streptococcal adhesin. J Bacteriol (2007) 1.22
Analysis on factors related to rabies epidemic in China from 2007-2011. Virol Sin (2012) 1.22
Performance enhancement of metal nanowire transparent conducting electrodes by mesoscale metal wires. Nat Commun (2013) 1.21
A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus. Proc Natl Acad Sci U S A (2005) 1.21
Microporous metal-organic framework with potential for carbon dioxide capture at ambient conditions. Nat Commun (2012) 1.19
Breast cancer-derived bone metastasis can be effectively reduced through specific c-MET inhibitor tivantinib (ARQ 197) and shRNA c-MET knockdown. Mol Cancer Ther (2011) 1.18
Symmetrical MnO2-carbon nanotube-textile nanostructures for wearable pseudocapacitors with high mass loading. ACS Nano (2011) 1.18
Extubation in the operating room after congenital heart surgery in children. J Thorac Cardiovasc Surg (2008) 1.18
Phosphoinositol phosphatase SHIP2 promotes cancer development and metastasis coupled with alterations in EGF receptor turnover. Carcinogenesis (2007) 1.16
Mice deleted for fatty acid transport protein 5 have defective bile acid conjugation and are protected from obesity. Gastroenterology (2006) 1.16
1,3-Bis(4-methoxy-phen-yl)imidazolidium chloride monohydrate. Acta Crystallogr Sect E Struct Rep Online (2008) 1.15
A novel glucosyltransferase is required for glycosylation of a serine-rich adhesin and biofilm formation by Streptococcus parasanguinis. J Biol Chem (2010) 1.14
Histone methyltransferase G9a contributes to H3K27 methylation in vivo. Cell Res (2010) 1.14
Chemical modification of paclitaxel (Taxol) reduces P-glycoprotein interactions and increases permeation across the blood-brain barrier in vitro and in situ. J Med Chem (2005) 1.14
Improving the performance of lithium-sulfur batteries by conductive polymer coating. ACS Nano (2011) 1.14
Role of interstitial cells of Cajal in motility disorders of the bowel. Am J Gastroenterol (2003) 1.13
Microscopic colitis-defining incidence rates and risk factors: a population-based study. Clin Gastroenterol Hepatol (2008) 1.13
Non-invasive assessment of small airway remodelling in smokers. COPD (2010) 1.13
Anxiety symptoms among Chinese nurses and the associated factors: a cross sectional study. BMC Psychiatry (2012) 1.13
Biofuels and biodiversity. Ecol Appl (2011) 1.12
Structural insights into serine-rich fimbriae from Gram-positive bacteria. J Biol Chem (2010) 1.09
A new small molecule specifically inhibits the cariogenic bacterium Streptococcus mutans in multispecies biofilms. Antimicrob Agents Chemother (2011) 1.08
Gas6 and the Tyro 3 receptor tyrosine kinase subfamily regulate the phagocytic function of Sertoli cells. Reproduction (2008) 1.08
Out of the ground: aerial and exotic habitats of the melioidosis bacterium Burkholderia pseudomallei in grasses in Australia. Environ Microbiol (2011) 1.08
Occupational stress and its related factors among university teachers in China. J Occup Health (2011) 1.07
Determinants of Rab5 interaction with the N terminus of early endosome antigen 1. J Biol Chem (2002) 1.07
Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1). Proc Natl Acad Sci U S A (2010) 1.07
Discovery of an opioid kappa receptor selective pure antagonist from a library of N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphans. J Med Chem (2002) 1.06
The impact of portopulmonary hypertension on intraoperative right ventricular function of living donor liver transplant recipients. Anesth Analg (2013) 1.06
DNA methyl transferase inhibiting halogenated monoterpenes from the Madagascar red marine alga Portieria hornemannii. J Nat Prod (2006) 1.06
The in vitro metabolism of bupropion revisited: concentration dependent involvement of cytochrome P450 2C19. Xenobiotica (2010) 1.04
Enhanced H2 adsorption in isostructural metal-organic frameworks with open metal sites: strong dependence of the binding strength on metal ions. J Am Chem Soc (2008) 1.04
Rapid detection of a highly virulent Chinese-type isolate of Porcine Reproductive and Respiratory Syndrome Virus by real-time reverse transcriptase PCR. J Virol Methods (2008) 1.03
A conserved domain of previously unknown function in Gap1 mediates protein-protein interaction and is required for biogenesis of a serine-rich streptococcal adhesin. Mol Microbiol (2008) 1.03
SecA2 is distinct from SecA in immunogenic specificity, subcellular distribution and requirement for membrane anchoring in Streptococcus parasanguis. FEMS Microbiol Lett (2006) 1.03
Association of IRF5 polymorphisms with activation of the interferon alpha pathway. Ann Rheum Dis (2009) 1.02
Adenoviral vector-based strategies for cancer therapy. Curr Drug ther (2009) 1.02
Comparison of oral paracetamol versus ibuprofen in premature infants with patent ductus arteriosus: a randomized controlled trial. PLoS One (2013) 1.02
Comparative analysis of vector biodistribution, persistence and gene expression following intravenous delivery of bovine, porcine and human adenoviral vectors in a mouse model. Virology (2009) 1.02
Combination therapy with vidaza and entinostat suppresses tumor growth and reprograms the epigenome in an orthotopic lung cancer model. Cancer Res (2011) 1.01
A systematic evaluation of the compatibility of histones containing methyl-lysine analogues with biochemical reactions. Cell Res (2009) 1.01
New high T(c) multiferroics KBiFe₂O₅ with narrow band gap and promising photovoltaic effect. Sci Rep (2013) 1.00
High expression of obesity-linked phosphatase SHIP2 in invasive breast cancer correlates with reduced disease-free survival. Tumour Biol (2008) 1.00
A conserved C-terminal 13-amino-acid motif of Gap1 is required for Gap1 function and necessary for the biogenesis of a serine-rich glycoprotein of Streptococcus parasanguinis. Infect Immun (2008) 0.99
Comparison of cardiovascular risk factors between prehypertension and hypertension in a Mongolian population, Inner Mongolia, China. Circ J (2008) 0.99