Transient exposure of neonatal female mice to testosterone abrogates the sexual dimorphism of abdominal aortic aneurysms.

PubWeight™: 1.07‹?› | Rank: Top 10%

🔗 View Article (PMC 3518797)

Published in Circ Res on April 26, 2012

Authors

Xuan Zhang1, Sean E Thatcher, Debra L Rateri, Dennis Bruemmer, Richard Charnigo, Alan Daugherty, Lisa A Cassis

Author Affiliations

1: Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536-0200, USA.

Articles citing this

Mineralocorticoid receptor agonists induce mouse aortic aneurysm formation and rupture in the presence of high salt. Arterioscler Thromb Vasc Biol (2013) 1.53

Depletion of endothelial or smooth muscle cell-specific angiotensin II type 1a receptors does not influence aortic aneurysms or atherosclerosis in LDL receptor deficient mice. PLoS One (2012) 0.96

Novel mechanisms of abdominal aortic aneurysms. Curr Atheroscler Rep (2012) 0.95

Loss of Timp3 gene leads to abdominal aortic aneurysm formation in response to angiotensin II. J Biol Chem (2012) 0.89

Regional variation in aortic AT1b receptor mRNA abundance is associated with contractility but unrelated to atherosclerosis and aortic aneurysms. PLoS One (2012) 0.86

GenTAC registry report: gender differences among individuals with genetically triggered thoracic aortic aneurysm and dissection. Am J Med Genet A (2013) 0.85

Associations of ApoAI and ApoB-containing lipoproteins with AngII-induced abdominal aortic aneurysms in mice. Arterioscler Thromb Vasc Biol (2015) 0.84

Exogenous 17-β estradiol administration blunts progression of established angiotensin II-induced abdominal aortic aneurysms in female ovariectomized mice. Biol Sex Differ (2015) 0.84

The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer's disease of humans and mice. Neurobiol Aging (2015) 0.83

Castration of male mice prevents the progression of established angiotensin II-induced abdominal aortic aneurysms. J Vasc Surg (2014) 0.82

Apolipoprotein E and Sex Bias in Cerebrovascular Aging of Men and Mice. Trends Neurosci (2016) 0.81

Attenuation of aortic aneurysms with stem cells from different genders. J Surg Res (2015) 0.78

Hypertension overrides the protective effect of female hormones on the development of aortic aneurysm secondary to Alk5 deficiency via ERK activation. Am J Physiol Heart Circ Physiol (2014) 0.77

Sex-specific aging in flies, worms, and missing great-granddads. Cell (2014) 0.76

Recent developments in vascular biology. Circ Res (2014) 0.75

Pharmacologic blockade and genetic deletion of androgen receptor attenuates aortic aneurysm formation. J Vasc Surg (2016) 0.75

Sex Hormones and Sex Chromosomes Cause Sex Differences in the Development of Cardiovascular Diseases. Arterioscler Thromb Vasc Biol (2017) 0.75

Sex Differences in Vascular Physiology and Pathophysiology: Estrogen and Androgen Signaling in Health and Disease. Am J Physiol Heart Circ Physiol (2017) 0.75

Sex, pregnancy and aortic disease in Marfan syndrome. PLoS One (2017) 0.75

Articles cited by this

Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science (2006) 10.25

LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature (2005) 8.53

Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. J Clin Invest (2000) 6.84

Developmental basis of vascular smooth muscle diversity. Arterioscler Thromb Vasc Biol (2007) 4.09

Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat Cell Biol (2007) 3.89

Risk factors for abdominal aortic aneurysms: a 7-year prospective study: the Tromsø Study, 1994-2001. Circulation (2009) 3.86

Analysis of risk factors for abdominal aortic aneurysm in a cohort of more than 3 million individuals. J Vasc Surg (2010) 3.45

Prevalence and associations of abdominal aortic aneurysm detected through screening. Aneurysm Detection and Management (ADAM) Veterans Affairs Cooperative Study Group. Ann Intern Med (1997) 3.08

Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure. Proc Natl Acad Sci U S A (2002) 3.03

Aortic dissection precedes formation of aneurysms and atherosclerosis in angiotensin II-infused, apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol (2003) 3.02

The organizational-activational hypothesis as the foundation for a unified theory of sexual differentiation of all mammalian tissues. Horm Behav (2009) 2.97

Chronic angiotensin II infusion promotes atherogenesis in low density lipoprotein receptor -/- mice. Ann N Y Acad Sci (1999) 2.91

Prevalence of and risk factors for abdominal aortic aneurysms in a population-based study : The Tromsø Study. Am J Epidemiol (2001) 2.48

Abdominal aortic aneurysm: pathogenesis and implications for management. Arterioscler Thromb Vasc Biol (2006) 2.43

TGF-beta activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II-infused mice. J Clin Invest (2010) 2.32

Risk factors for aneurysm rupture in patients kept under ultrasound surveillance. UK Small Aneurysm Trial Participants. Ann Surg (1999) 2.27

Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms. Nat Med (2009) 2.24

Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT1A receptor. Circulation (2004) 2.04

Temporally controlled somatic mutagenesis in smooth muscle. Genesis (2000) 2.01

Bone marrow transplantation reveals that recipient AT1a receptors are required to initiate angiotensin II-induced atherosclerosis and aneurysms. Arterioscler Thromb Vasc Biol (2006) 1.85

AT1b receptor predominantly mediates contractions in major mouse blood vessels. Circ Res (2003) 1.84

Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE-/- mice. Clin Sci (Lond) (2010) 1.78

Endothelial cell-specific deficiency of Ang II type 1a receptors attenuates Ang II-induced ascending aortic aneurysms in LDL receptor-/- mice. Circ Res (2011) 1.78

Orchidectomy, but not ovariectomy, regulates angiotensin II-induced vascular diseases in apolipoprotein E-deficient mice. Endocrinology (2004) 1.76

Smoking, atherosclerosis and risk of abdominal aortic aneurysm. Eur Heart J (1997) 1.68

Obesity promotes inflammation in periaortic adipose tissue and angiotensin II-induced abdominal aortic aneurysm formation. Arterioscler Thromb Vasc Biol (2009) 1.59

Aneurysms of the abdominal aorta in older adults. The Rotterdam Study. Am J Epidemiol (1995) 1.59

Smooth muscle lineage diversity in the chick embryo. Two types of aortic smooth muscle cell differ in growth and receptor-mediated transcriptional responses to transforming growth factor-beta. Dev Biol (1996) 1.56

Abdominal aortic aneurysms: fresh insights from a novel animal model of the disease. Vasc Med (2002) 1.48

Risk factors for asymptomatic abdominal aortic aneurysm: systematic review and meta-analysis of population-based screening studies. Eur J Public Health (2004) 1.45

Differential response of mesoderm- and neural crest-derived smooth muscle to TGF-beta1: regulation of c-myb and alpha1 (I) procollagen genes. Exp Cell Res (1997) 1.38

Epigenetic control of sexual differentiation of the bed nucleus of the stria terminalis. Endocrinology (2009) 1.35

Obesity, adipokines, and abdominal aortic aneurysm: Health in Men study. Circulation (2007) 1.31

Androgen increases AT1a receptor expression in abdominal aortas to promote angiotensin II-induced AAAs in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol (2008) 1.29

The role of the renin-angiotensin system in aortic aneurysmal diseases. Curr Hypertens Rep (2008) 1.28

Smokers' relative risk for aortic aneurysm compared with other smoking-related diseases: a systematic review. J Vasc Surg (2003) 1.25

Whole genome expression analysis within the angiotensin II-apolipoprotein E deficient mouse model of abdominal aortic aneurysm. BMC Genomics (2009) 1.22

The neonatal testosterone surge: a comparative study. Arch Int Physiol Biochim Biophys (1992) 1.22

Angiotensin II induces a region-specific hyperplasia of the ascending aorta through regulation of inhibitor of differentiation 3. Circ Res (2009) 1.20

Sex chromosome effects unmasked in angiotensin II-induced hypertension. Hypertension (2010) 1.19

Imprinting of female offspring with testosterone results in insulin resistance and changes in body fat distribution at adult age in rats. J Clin Invest (1998) 1.12

Abdominal aortic aneurysm surgery in a district general hospital: a 15-years experience. Ann Vasc Surg (2007) 1.09

Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension. Hypertension (2011) 1.06

Testosterone levels in plasma and testes of neonatal mice. J Steroid Biochem (1988) 1.04

Screening for abdominal aortic aneurysms and associated risk factors in a general population. Eur J Vasc Endovasc Surg (1995) 0.99

Ruptured abdominal aortic aneurysm in a well-defined geographic area. J Vasc Surg (2002) 0.99

Effects of caspase inhibitor on angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol (2010) 0.98

Novel genetic mechanisms for aortic aneurysms. Curr Atheroscler Rep (2010) 0.91

Sex chromosome complement contributes to sex differences in bradycardic baroreflex response. Hypertension (2011) 0.87

Differential neonatal testosterone imprinting of GH-dependent liver proteins and genes in female mice. J Endocrinol (2010) 0.82

Genetic variants of the Renin Angiotensin system: effects on atherosclerosis in experimental models and humans. Curr Atheroscler Rep (2010) 0.77

Articles by these authors

Use of nonsteroidal antiinflammatory drugs: an update for clinicians: a scientific statement from the American Heart Association. Circulation (2007) 3.27

Aortic dissection precedes formation of aneurysms and atherosclerosis in angiotensin II-infused, apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol (2003) 3.02

Mouse models of abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol (2004) 2.94

Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice. J Clin Invest (2007) 2.73

Translating molecular discoveries into new therapies for atherosclerosis. Nature (2008) 2.67

Abdominal aortic aneurysm: pathogenesis and implications for management. Arterioscler Thromb Vasc Biol (2006) 2.43

Vitamin E inhibits abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol (2005) 2.42

Biphasic roles for soluble guanylyl cyclase (sGC) in platelet activation. Blood (2011) 2.27

The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance. Cell Metab (2010) 2.26

Glutathione depletion prevents diet-induced obesity and enhances insulin sensitivity. Obesity (Silver Spring) (2011) 2.12

Activation of the systemic and adipose renin-angiotensin system in rats with diet-induced obesity and hypertension. Am J Physiol Regul Integr Comp Physiol (2004) 2.11

Differential effects of doxycycline, a broad-spectrum matrix metalloproteinase inhibitor, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol (2003) 2.10

Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT1A receptor. Circulation (2004) 2.04

ANG II infusion promotes abdominal aortic aneurysms independent of increased blood pressure in hypercholesterolemic mice. Am J Physiol Heart Circ Physiol (2009) 2.01

Rapid dilation of the abdominal aorta during infusion of angiotensin II detected by noninvasive high-frequency ultrasonography. J Vasc Surg (2006) 1.91

Polychlorinated biphenyl-77 induces adipocyte differentiation and proinflammatory adipokines and promotes obesity and atherosclerosis. Environ Health Perspect (2008) 1.86

Bone marrow transplantation reveals that recipient AT1a receptors are required to initiate angiotensin II-induced atherosclerosis and aneurysms. Arterioscler Thromb Vasc Biol (2006) 1.85

A new glucagon and GLP-1 co-agonist eliminates obesity in rodents. Nat Chem Biol (2009) 1.79

Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice. Am J Physiol Regul Integr Comp Physiol (2011) 1.79

Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE-/- mice. Clin Sci (Lond) (2010) 1.78

Endothelial cell-specific deficiency of Ang II type 1a receptors attenuates Ang II-induced ascending aortic aneurysms in LDL receptor-/- mice. Circ Res (2011) 1.78

Interleukin-18 enhances atherosclerosis in apolipoprotein E(-/-) mice through release of interferon-gamma. Circ Res (2002) 1.77

Orchidectomy, but not ovariectomy, regulates angiotensin II-induced vascular diseases in apolipoprotein E-deficient mice. Endocrinology (2004) 1.76

Coplanar polychlorinated biphenyls impair glucose homeostasis in lean C57BL/6 mice and mitigate beneficial effects of weight loss on glucose homeostasis in obese mice. Environ Health Perspect (2012) 1.73

Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans. Sci Transl Med (2013) 1.72

Telomerase activation in atherosclerosis and induction of telomerase reverse transcriptase expression by inflammatory stimuli in macrophages. Arterioscler Thromb Vasc Biol (2010) 1.70

Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice. J Clin Invest (2008) 1.70

Urokinase-type plasminogen activator deficiency in bone marrow-derived cells augments rupture of angiotensin II-induced abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol (2011) 1.65

Impact of drug-eluting stents on outcomes of patients with end-stage renal disease undergoing percutaneous coronary revascularization. J Invasive Cardiol (2006) 1.61

Depletion of natural killer cell function decreases atherosclerosis in low-density lipoprotein receptor null mice. Arterioscler Thromb Vasc Biol (2004) 1.60

Obesity promotes inflammation in periaortic adipose tissue and angiotensin II-induced abdominal aortic aneurysm formation. Arterioscler Thromb Vasc Biol (2009) 1.59

Interleukin-4 deficiency decreases atherosclerotic lesion formation in a site-specific manner in female LDL receptor-/- mice. Arterioscler Thromb Vasc Biol (2002) 1.58

IFN-gamma deficiency exerts gender-specific effects on atherogenesis in apolipoprotein E-/- mice. J Interferon Cytokine Res (2002) 1.58

Proinflammatory properties of coplanar PCBs: in vitro and in vivo evidence. Toxicol Appl Pharmacol (2002) 1.58

NR4A orphan nuclear receptors: transcriptional regulators of gene expression in metabolism and vascular biology. Arterioscler Thromb Vasc Biol (2010) 1.53

Mineralocorticoid receptor agonists induce mouse aortic aneurysm formation and rupture in the presence of high salt. Arterioscler Thromb Vasc Biol (2013) 1.53

Intensive glycemic control and cardiovascular disease: an update. Nat Rev Cardiol (2010) 1.52

Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin. J Clin Invest (2012) 1.51

Development of experimental designs for atherosclerosis studies in mice. Methods (2005) 1.51

The NR4A orphan nuclear receptor NOR1 is induced by platelet-derived growth factor and mediates vascular smooth muscle cell proliferation. J Biol Chem (2006) 1.48

Abdominal aortic aneurysms: fresh insights from a novel animal model of the disease. Vasc Med (2002) 1.48

Group X secretory phospholipase A(2) augments angiotensin II-induced inflammatory responses and abdominal aortic aneurysm formation in apoE-deficient mice. Atherosclerosis (2010) 1.48

A brief, clinic-based, safer sex intervention for heterosexual African American men newly diagnosed with an STD: a randomized controlled trial. Am J Public Health (2009) 1.46

Prolonged infusion of angiotensin II in apoE(-/-) mice promotes macrophage recruitment with continued expansion of abdominal aortic aneurysm. Am J Pathol (2011) 1.43

Is there an association between external cardioversions and long-term mortality and morbidity? Insights from the Atrial Fibrillation Follow-up Investigation of Rhythm Management study. Circ Arrhythm Electrophysiol (2011) 1.42

Interferon-gamma and the interferon-inducible chemokine CXCL10 protect against aneurysm formation and rupture. Circulation (2009) 1.40

COX-2 up-regulation and vascular smooth muscle contractile hyperreactivity in spontaneous diabetic db/db mice. Cardiovasc Res (2005) 1.37

Liver x receptor agonists inhibit cytokine-induced osteopontin expression in macrophages through interference with activator protein-1 signaling pathways. Circ Res (2005) 1.34

Role of the renin-angiotensin system in the development of abdominal aortic aneurysms in animals and humans. Ann N Y Acad Sci (2006) 1.32

Androgen increases AT1a receptor expression in abdominal aortas to promote angiotensin II-induced AAAs in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol (2008) 1.29

The role of the renin-angiotensin system in aortic aneurysmal diseases. Curr Hypertens Rep (2008) 1.28

The renin-angiotensin system: a target of and contributor to dyslipidemias, altered glucose homeostasis, and hypertension of the metabolic syndrome. Am J Physiol Heart Circ Physiol (2012) 1.24

Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteries. Circ Res (2004) 1.24

Local adipose tissue renin-angiotensin system. Curr Hypertens Rep (2008) 1.23

Peroxisome proliferator-activated receptor gamma: implications for cardiovascular disease. Hypertension (2004) 1.22

PGE(2) is generated by specific COX-2 activity and increases VEGF production in COX-2-expressing human pancreatic cancer cells. Biochem Biophys Res Commun (2003) 1.22

Pioglitazone-induced reductions in atherosclerosis occur via smooth muscle cell-specific interaction with PPAR{gamma}. Circ Res (2010) 1.22

Dietary fat interacts with PCBs to induce changes in lipid metabolism in mice deficient in low-density lipoprotein receptor. Environ Health Perspect (2005) 1.21

Adipocyte deficiency of angiotensinogen prevents obesity-induced hypertension in male mice. Hypertension (2012) 1.21

Reduction in ABCG1 in Type 2 diabetic mice increases macrophage foam cell formation. J Biol Chem (2006) 1.21

Mechanisms of abdominal aortic aneurysm formation. Curr Atheroscler Rep (2002) 1.20

ACE2 is expressed in mouse adipocytes and regulated by a high-fat diet. Am J Physiol Regul Integr Comp Physiol (2008) 1.20

Angiotensin II induces a region-specific hyperplasia of the ascending aorta through regulation of inhibitor of differentiation 3. Circ Res (2009) 1.20