Published in Trends Neurosci on August 18, 2016
Rust on the Brain from Microbleeds and Its Relevance to Alzheimer Studies: Invited Commentary on Cacciottolo Neurobiology of Aging, 2016. J Alzheimers Dis Parkinsonism (2016) 0.78
Epidermal growth factor prevents APOE4 and amyloid-beta-induced cognitive and cerebrovascular deficits in female mice. Acta Neuropathol Commun (2016) 0.77
Towards Personalized Intervention for Alzheimer's Disease. Genomics Proteomics Bioinformatics (2016) 0.76
Does selection for short sleep duration explain human vulnerability to Alzheimer's disease? Evol Med Public Health (2017) 0.75
Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol (2013) 6.18
Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol (2010) 5.76
Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation. Am J Hum Genet (1985) 3.81
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature (2012) 3.80
Gender differences in the regulation of blood pressure. Hypertension (2001) 3.78
Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery. Nat Med (2009) 2.76
Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism. Am J Hum Genet (2000) 2.62
Sporadic cerebral amyloid angiopathy revisited: recent insights into pathophysiology and clinical spectrum. J Neurol Neurosurg Psychiatry (2011) 2.32
Prevalence and severity of microbleeds in a memory clinic setting. Neurology (2006) 2.29
Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS. J Lipid Res (2008) 2.28
Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model. J Neurosci (2005) 2.17
Blood-brain barrier breakdown in the aging human hippocampus. Neuron (2015) 2.17
Sex differences in the clinical manifestations of Alzheimer disease pathology. Arch Gen Psychiatry (2005) 2.08
Apolipoprotein E alleles as risk factors in Alzheimer's disease. Annu Rev Med (1996) 2.04
Microbleed topography, leukoaraiosis, and cognition in probable Alzheimer disease from the Sunnybrook dementia study. Arch Neurol (2008) 2.03
Blood-brain barrier permeability is increased in normal-appearing white matter in patients with lacunar stroke and leucoaraiosis. J Neurol Neurosurg Psychiatry (2009) 1.97
Cerebral microbleeds: prevalence and associations with cardiovascular risk factors in the Framingham Study. Stroke (2004) 1.96
Superficial siderosis: a potential diagnostic marker of cerebral amyloid angiopathy in Alzheimer disease. Stroke (2008) 1.89
Hippocampal atrophy rates and CSF biomarkers in elderly APOE2 normal subjects. Neurology (2010) 1.86
Brain microbleeds and Alzheimer's disease: innocent observation or key player? Brain (2011) 1.82
Evolution in health and medicine Sackler colloquium: Evolution of the human lifespan and diseases of aging: roles of infection, inflammation, and nutrition. Proc Natl Acad Sci U S A (2009) 1.79
Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls. Am J Pathol (2005) 1.77
Cerebral microbleeds are associated with worse cognitive function: the Rotterdam Scan Study. Neurology (2012) 1.63
Cerebral amyloid angiopathy with and without hemorrhage: evidence for different disease phenotypes. Neurology (2015) 1.61
Blood-brain barrier permeability abnormalities in vascular cognitive impairment. Stroke (2011) 1.60
APOE distribution in world populations with new data from India and the UK. Ann Hum Biol (2006) 1.59
Apolipoprotein E markedly facilitates age-dependent cerebral amyloid angiopathy and spontaneous hemorrhage in amyloid precursor protein transgenic mice. J Neurosci (2003) 1.58
Patients with Alzheimer disease with multiple microbleeds: relation with cerebrospinal fluid biomarkers and cognition. Stroke (2009) 1.57
Superficial siderosis in the general population. Neurology (2009) 1.52
Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E. Proc Natl Acad Sci U S A (2001) 1.51
Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy. Ann Neurol (2010) 1.50
Two distal downstream enhancers direct expression of the human apolipoprotein E gene to astrocytes in the brain. J Neurosci (2001) 1.38
Risk factors for β-amyloid deposition in healthy aging: vascular and genetic effects. JAMA Neurol (2013) 1.36
Microvascular pathology in the aging human brain: evidence that senile plaques are sites of microhaemorrhages. Neurobiol Aging (2006) 1.34
APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease. J Biol Chem (2012) 1.34
Topography of dilated perivascular spaces in subjects from a memory clinic cohort. Neurology (2013) 1.33
The biphasic relationship between regional brain senile plaque and neurofibrillary tangle distributions: modification by age, sex, and APOE polymorphism. Ann N Y Acad Sci (2004) 1.29
Cerebrovascular dysfunction in amyloid precursor protein transgenic mice: contribution of soluble and insoluble amyloid-beta peptide, partial restoration via gamma-secretase inhibition. J Neurosci (2008) 1.27
Endothelial nitric oxide gene haplotypes and risk of cerebral small-vessel disease. Stroke (2004) 1.25
White matter hyperintensities, cognitive impairment and dementia: an update. Nat Rev Neurol (2015) 1.23
Pathogenesis of cerebral microbleeds: In vivo imaging of amyloid and subcortical ischemic small vessel disease in 226 individuals with cognitive impairment. Ann Neurol (2013) 1.22
Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides. J Biol Inorg Chem (2004) 1.21
APOE and cholesterol homeostasis in Alzheimer's disease. Trends Mol Med (2010) 1.15
Gender, sex steroid hormones, and Alzheimer's disease. Horm Behav (2012) 1.14
The role of positive selection in determining the molecular cause of species differences in disease. BMC Evol Biol (2008) 1.11
Dense-core senile plaques in the Flemish variant of Alzheimer's disease are vasocentric. Am J Pathol (2002) 1.11
Association of APOE genotype with carotid atherosclerosis in men and women: the Framingham Heart Study. J Lipid Res (2004) 1.10
Sex differences in β-amyloid accumulation in 3xTg-AD mice: role of neonatal sex steroid hormone exposure. Brain Res (2010) 1.08
Apolipoprotein E genotype and cerebral amyloid angiopathy-related hemorrhage. Ann N Y Acad Sci (2000) 1.08
Transient exposure of neonatal female mice to testosterone abrogates the sexual dimorphism of abdominal aortic aneurysms. Circ Res (2012) 1.07
Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease. J Cereb Blood Flow Metab (2016) 1.05
Cerebral microbleeds: different prevalence, topography, and risk factors depending on dementia diagnosis—the Karolinska Imaging Dementia Study. AJNR Am J Neuroradiol (2014) 1.04
Inflammatory biomarkers, cerebral microbleeds, and small vessel disease: Framingham Heart Study. Neurology (2015) 1.03
Sex steroids, APOE genotype and the innate immune system. Neurobiol Aging (2005) 1.02
Associations between cerebral small-vessel disease and Alzheimer disease pathology as measured by cerebrospinal fluid biomarkers. JAMA Neurol (2014) 1.02
Mild cognitive impairment as a predictor of falls in community-dwelling older people. Am J Geriatr Psychiatry (2012) 1.01
Interactions between amyloid-β and hemoglobin: implications for amyloid plaque formation in Alzheimer's disease. PLoS One (2012) 0.99
Human apolipoprotein E4 targeted replacement mice show increased prevalence of intracerebral hemorrhage associated with vascular amyloid deposition. J Stroke Cerebrovasc Dis (2008) 0.99
Resveratrol supplementation: Where are we now and where should we go? Ageing Res Rev (2015) 0.98
Angiogenesis in the embryonic CNS: a new twist on an old tale. Cell Adh Migr (2008) 0.98
Genetics of cerebral amyloid angiopathy: systematic review and meta-analysis. J Neurol Neurosurg Psychiatry (2013) 0.97
Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection. Aging Cell (2015) 0.97
Microbleeds relate to altered amyloid-β metabolism in Alzheimer's disease. Neurobiol Aging (2011) 0.96
Constraints on the coevolution of contemporary human males and females. Proc Biol Sci (2012) 0.96
Rodent Abeta(1-42) exhibits oxidative stress properties similar to those of human Abeta(1-42): Implications for proposed mechanisms of toxicity. J Alzheimers Dis (2004) 0.96
Gender differences in hypertension: myths and reality. Curr Hypertens Rep (2013) 0.95
Hemoglobin promotes Abeta oligomer formation and localizes in neurons and amyloid deposits. Neurobiol Dis (2004) 0.94
APOEε2 is associated with milder clinical and pathological Alzheimer disease. Ann Neurol (2015) 0.94
Strictly lobar microbleeds are associated with executive impairment in patients with ischemic stroke or transient ischemic attack. Stroke (2013) 0.93
What initiates the formation of senile plaques? The origin of Alzheimer-like dementias in capillary haemorrhages. Med Hypotheses (2008) 0.93
Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice. Proc Natl Acad Sci U S A (2015) 0.92
Conceptual frameworks and mouse models for studying sex differences in physiology and disease: why compensation changes the game. Exp Neurol (2014) 0.92
Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice. J Gerontol A Biol Sci Med Sci (2014) 0.91
Microbleeds, Mortality, and Stroke in Alzheimer Disease: The MISTRAL Study. JAMA Neurol (2015) 0.90
High frequency of apolipoprotein E epsilon 2 in patients with cerebral hemorrhage due to cerebral amyloid angiopathy. Ann Neurol (1996) 0.90
Cerebral amyloid angiopathy: progressive disruption of the neurovascular unit. Stroke (2008) 0.90
Human apolipoprotein E ɛ4 expression impairs cerebral vascularization and blood-brain barrier function in mice. J Cereb Blood Flow Metab (2014) 0.90
Effect of the apolipoprotein E epsilon4 allele on white matter hyperintensities in dementia. Stroke (2000) 0.89
Neuroprotective Sirtuin ratio reversed by ApoE4. Proc Natl Acad Sci U S A (2013) 0.89
Cerebral white matter lesions are not associated with apoE genotype but with age and female sex in Alzheimer's disease. J Neurol Neurosurg Psychiatry (2000) 0.88
The apolipoprotein E (APOE) gene appears functionally monomorphic in chimpanzees (Pan troglodytes). PLoS One (2012) 0.87
Activation of PPARδ prevents endothelial dysfunction induced by overexpression of amyloid-β precursor protein. Cardiovasc Res (2012) 0.87
Cerebral Microbleeds, CSF p-Tau, and Cognitive Decline: Significance of Anatomic Distribution. AJNR Am J Neuroradiol (2015) 0.87
Cortical microinfarcts on 3T MRI: Clinical correlates in memory-clinic patients. Alzheimers Dement (2015) 0.87
Prevalence of cortical superficial siderosis in patients with cognitive impairment. J Neurol (2013) 0.86
APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice. Mol Neurodegener (2015) 0.85
Brain pathologies in extreme old age. Neurobiol Aging (2015) 0.84
Apolipoprotein E4 influences growth and cognitive responses to micronutrient supplementation in shantytown children from northeast Brazil. Clinics (Sao Paulo) (2012) 0.84
Apolipoprotein E plays a key role against cryptosporidial infection in transgenic undernourished mice. PLoS One (2014) 0.84
Incidental Cerebral Microbleeds and Cerebral Blood Flow in Elderly Individuals. JAMA Neurol (2015) 0.83
The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer's disease of humans and mice. Neurobiol Aging (2015) 0.83
Cortical superficial siderosis: a marker of vascular amyloid in patients with cognitive impairment. Neurology (2015) 0.83
Endothelial cells and human cerebral small vessel disease. Brain Pathol (2015) 0.83
Lobar microbleeds are associated with a decline in executive functioning in older adults. Cerebrovasc Dis (2014) 0.82
Effects of oxidative stress on amyloid precursor protein processing in rat and human platelets. Platelets (2012) 0.82
Association of ApoE polymorphisms with prevalent hypertension in 1406 older adults: the Bambuí Health Aging Study (BHAS). Braz J Med Biol Res (2008) 0.82
Bosentan preserves endothelial function in mice overexpressing APP. Neurobiol Aging (2006) 0.82
Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice. Acta Neuropathol Commun (2014) 0.81
Comment on: Brain Microbleeds and Alzheimer's Disease: Innocent Observation or Key Player? : Cordonnier C, van der Flier WM. Brain. 2011;134:335-44. Clin Neuroradiol (2011) 0.81