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1
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A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25.
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Nature
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2008
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16.10
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2
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Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry.
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Proc Natl Acad Sci U S A
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2005
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8.10
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3
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A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma.
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Am J Hum Genet
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2009
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5.62
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4
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The American Association for Thoracic Surgery guidelines for lung cancer screening using low-dose computed tomography scans for lung cancer survivors and other high-risk groups.
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J Thorac Cardiovasc Surg
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2012
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4.68
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5
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Predictive accuracy of the Liverpool Lung Project risk model for stratifying patients for computed tomography screening for lung cancer: a case-control and cohort validation study.
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Ann Intern Med
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2012
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3.45
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6
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Occupational exposure to crystalline silica and risk of lung cancer: a multicenter case-control study in Europe.
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Epidemiology
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2007
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2.60
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7
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Lung cancer risk prediction to select smokers for screening CT--a model based on the Italian COSMOS trial.
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Cancer Prev Res (Phila)
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2011
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1.98
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8
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Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals.
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Int J Epidemiol
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2009
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1.97
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9
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Hypomethylation of retrotransposable elements correlates with genomic instability in non-small cell lung cancer.
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Int J Cancer
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2009
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1.94
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10
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Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls.
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Hum Mol Genet
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2012
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1.77
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11
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A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.
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PLoS Genet
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2011
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1.68
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12
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Informed conditioning on clinical covariates increases power in case-control association studies.
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PLoS Genet
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2012
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1.57
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13
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Lung cancer risk prediction: a tool for early detection.
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Int J Cancer
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2007
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1.51
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14
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Expression profiling of primary non-small cell lung cancer for target identification.
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Oncogene
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2002
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1.51
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15
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International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways.
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Cancer Epidemiol Biomarkers Prev
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2008
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1.51
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16
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A prognostic DNA methylation signature for stage I non-small-cell lung cancer.
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J Clin Oncol
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2013
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1.47
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17
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DNA methylation epigenotypes in breast cancer molecular subtypes.
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Breast Cancer Res
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2010
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1.44
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18
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Monosomy 3 in uveal melanoma: correlation with clinical and histologic predictors of survival.
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Invest Ophthalmol Vis Sci
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2003
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1.34
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19
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Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene.
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Cancer Res
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2008
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1.28
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20
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Previous lung diseases and lung cancer risk: a pooled analysis from the International Lung Cancer Consortium.
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Am J Epidemiol
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2012
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1.27
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21
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Methylation enrichment pyrosequencing: combining the specificity of MSP with validation by pyrosequencing.
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Nucleic Acids Res
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2006
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1.25
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22
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Downregulation of the KIP family members p27(KIP1) and p57(KIP2) by SKP2 and the role of methylation in p57(KIP2) inactivation in nonsmall cell lung cancer.
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Int J Cancer
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2006
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1.21
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23
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Cytosine methylation profiles as a molecular marker in non-small cell lung cancer.
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Cancer Res
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2006
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1.21
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24
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RHBDF2 mutations are associated with tylosis, a familial esophageal cancer syndrome.
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Am J Hum Genet
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2012
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1.18
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25
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SHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer in plasma.
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J Thorac Oncol
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2011
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1.17
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26
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The UK Lung Screen (UKLS): demographic profile of first 88,897 approaches provides recommendations for population screening.
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Cancer Prev Res (Phila)
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2014
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1.16
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27
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p16 Promoter methylation is a potential predictor of malignant transformation in oral epithelial dysplasia.
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Cancer Epidemiol Biomarkers Prev
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2008
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1.13
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28
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SHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer based on bronchial aspirates.
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BMC Cancer
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2010
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1.12
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29
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Development of The American Association for Thoracic Surgery guidelines for low-dose computed tomography scans to screen for lung cancer in North America: recommendations of The American Association for Thoracic Surgery Task Force for Lung Cancer Screening and Surveillance.
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J Thorac Cardiovasc Surg
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2012
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1.11
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30
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UHRF1-mediated tumor suppressor gene inactivation in nonsmall cell lung cancer.
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Cancer
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2010
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1.09
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31
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Increased risk of lung cancer in individuals with a family history of the disease: a pooled analysis from the International Lung Cancer Consortium.
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Eur J Cancer
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2012
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1.07
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32
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Expression of tumor-derived vascular endothelial growth factor and its receptors is associated with outcome in early squamous cell carcinoma of the lung.
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J Clin Oncol
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2012
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1.06
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33
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Performance evaluation of the DNA methylation biomarker SHOX2 for the aid in diagnosis of lung cancer based on the analysis of bronchial aspirates.
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Int J Oncol
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2011
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1.06
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34
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DNA methylation biomarkers offer improved diagnostic efficiency in lung cancer.
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Cancer Res
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2012
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1.05
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35
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Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer Consortium.
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Carcinogenesis
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2012
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1.05
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36
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Is previous respiratory disease a risk factor for lung cancer?
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Am J Respir Crit Care Med
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2014
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1.04
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37
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DNA methylation of the homeobox genes PITX2 and SHOX2 predicts outcome in non-small-cell lung cancer patients.
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Diagn Mol Pathol
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2012
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1.04
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38
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Down-regulation of the cytoglobin gene, located on 17q25, in tylosis with oesophageal cancer (TOC): evidence for trans-allele repression.
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Hum Mol Genet
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2006
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1.02
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39
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Frequent genetic and epigenetic abnormalities contribute to the deregulation of cytoglobin in non-small cell lung cancer.
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Hum Mol Genet
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2006
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1.01
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40
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Generation of a non-small cell lung cancer transcriptome microarray.
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BMC Med Genomics
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2008
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1.01
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41
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Incorporation of a genetic factor into an epidemiologic model for prediction of individual risk of lung cancer: the Liverpool Lung Project.
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Cancer Prev Res (Phila)
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2010
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1.01
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42
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Prognostic value of TP53, KRAS and EGFR mutations in nonsmall cell lung cancer: the EUELC cohort.
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Eur Respir J
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2012
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1.01
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43
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CpG island methylation phenotype (CIMP) in oral cancer: associated with a marked inflammatory response and less aggressive tumour biology.
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Oral Oncol
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2007
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1.00
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44
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Epigenetic biomarkers in lung cancer.
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Cancer Lett
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2012
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1.00
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45
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Asthma and lung cancer risk: a systematic investigation by the International Lung Cancer Consortium.
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Carcinogenesis
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2011
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0.99
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46
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TPL2 kinase is a suppressor of lung carcinogenesis.
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Proc Natl Acad Sci U S A
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2013
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0.99
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47
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Novel microsatellite markers and single nucleotide polymorphisms refine the tylosis with oesophageal cancer (TOC) minimal region on 17q25 to 42.5 kb: sequencing does not identify the causative gene.
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Hum Genet
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2004
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0.96
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48
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The role of pyrosequencing in head and neck cancer epigenetics: correlation of quantitative methylation data with gene expression.
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Arch Otolaryngol Head Neck Surg
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2008
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0.96
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49
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Exposure to secondhand tobacco smoke and lung cancer by histological type: a pooled analysis of the International Lung Cancer Consortium (ILCCO).
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Int J Cancer
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2014
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0.95
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50
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A novel type of p53 pathway dysfunction in chronic lymphocytic leukemia resulting from two interacting single nucleotide polymorphisms within the p21 gene.
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Cancer Res
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2009
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0.93
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51
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Cytoglobin: biochemical, functional and clinical perspective of the newest member of the globin family.
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Cell Mol Life Sci
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2011
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0.93
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52
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Neuroglobin and myoglobin in non-small cell lung cancer: expression, regulation and prognosis.
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Lung Cancer
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2011
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0.92
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53
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Associations between genes for killer immunoglobulin-like receptors and their ligands in patients with solid tumors.
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Hum Immunol
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2010
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0.92
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54
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Fragile histidine triad gene inactivation in lung cancer: the European Early Lung Cancer project.
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Am J Respir Crit Care Med
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2008
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0.92
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55
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Cytoglobin has bimodal: tumour suppressor and oncogene functions in lung cancer cell lines.
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Hum Mol Genet
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2013
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0.91
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56
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Seizure 6-like (SEZ6L) gene and risk for lung cancer.
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Cancer Res
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2007
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0.91
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57
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Sample size determination in clinical proteomic profiling experiments using mass spectrometry for class comparison.
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Proteomics
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2009
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0.91
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58
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Defining high-risk individuals in a population-based molecular-epidemiological study of lung cancer.
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Int J Oncol
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2006
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0.91
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59
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Quantitative methylation analysis of resection margins and lymph nodes in oral squamous cell carcinoma.
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Br J Oral Maxillofac Surg
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2007
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0.90
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60
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Associated Links Among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer: A Pooled Analysis in the International Lung Cancer Consortium.
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EBioMedicine
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2015
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0.90
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61
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Effect modification of the association of cumulative exposure and cancer risk by intensity of exposure and time since exposure cessation: a flexible method applied to cigarette smoking and lung cancer in the SYNERGY Study.
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Am J Epidemiol
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2013
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0.89
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62
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Characterization of a 500 kb region on 17q25 and the exclusion of candidate genes as the familial Tylosis Oesophageal Cancer (TOC) locus.
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Oncogene
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2002
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0.89
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63
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The role of DNA methylation as biomarkers in the clinical management of lung cancer.
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Expert Rev Respir Med
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2013
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0.89
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64
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Glycine-extended gastrin promotes the growth of lung cancer.
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Cancer Res
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2004
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0.89
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65
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E-cigarettes and cancer patients.
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J Thorac Oncol
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2014
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0.89
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66
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In-depth analysis of molecular alterations within normal and tumour tissue from an entire bronchial tree.
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Int J Oncol
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2003
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0.89
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67
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Loss of heterozygosity on chromosome 17p predicts neoplastic progression in Barrett's esophagus.
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J Gastroenterol Hepatol
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2003
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0.89
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68
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Three different subsite classification systems for carcinomas in the proximity of the GEJ, but is it all one disease?
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J Gastroenterol Hepatol
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2004
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0.87
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69
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Global DNA hypomethylation-induced ΔNp73 transcriptional activation in non-small cell lung cancer.
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Cancer Lett
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2011
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0.86
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70
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Pleiotropic associations of risk variants identified for other cancers with lung cancer risk: the PAGE and TRICL consortia.
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J Natl Cancer Inst
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2014
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0.85
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71
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A T2517C polymorphism in the GSTM4 gene is associated with risk of developing lung cancer.
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Lung Cancer
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2002
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0.84
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72
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Cancer diagnosis in first-degree relatives and non-small cell lung cancer risk: results from a multi-centre case-control study in Europe.
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Eur J Cancer
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2009
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0.83
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73
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Epigenetic silencing of the endothelin-B receptor gene in non-small cell lung cancer.
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Int J Oncol
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2009
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0.80
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74
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Education and lung cancer among never smokers.
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Epidemiology
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2014
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0.80
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75
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Prognostic value of hTERT mRNA expression in surgical samples of lung cancer patients: the European Early Lung Cancer Project.
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Int J Oncol
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2010
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0.79
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76
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Progressive lung cancer determined by expression profiling and transcriptional regulation.
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Int J Oncol
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0.79
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77
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Sp1 binds to the external promoter of the p73 gene and induces the expression of TAp73gamma in lung cancer.
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FEBS J
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2010
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0.79
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78
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p53 status correlates with the differential expression of the DNA mismatch repair protein MSH2 in non-small cell lung carcinoma.
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Int J Cancer
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2002
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0.79
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79
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Lung cancer risk among bricklayers in a pooled analysis of case-control studies.
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Int J Cancer
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2014
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0.78
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80
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Use of lung cancer risk models in planning research and service programs in CT screening for lung cancer.
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Expert Rev Anticancer Ther
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2009
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0.78
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81
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Physical and transcript map of the minimally deleted region III on 17p implicated in the early development of Barrett's oesophageal adenocarcinoma.
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Oncogene
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2003
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0.78
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82
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A novel in silico reverse-transcriptomics-based identification and blood-based validation of a panel of sub-type specific biomarkers in lung cancer.
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BMC Genomics
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2013
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0.77
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83
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Detection of DNA methylation changes in body fluids.
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Adv Genet
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2010
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0.77
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84
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A global approach to cancer-screening trials.
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Lancet Oncol
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2008
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0.77
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85
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Tobacco money: up in smoke?
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Lancet
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2002
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0.75
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Thorax
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2013
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0.75
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87
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In response. Predictive accuracy of the Liverpool Lung Project risk model.
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Ann Intern Med
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2013
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0.75
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88
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Measurement methods and algorithms for the management of solid nodules.
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J Thorac Imaging
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2012
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0.75
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89
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A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma.
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Am J Hum Genet
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2011
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0.75
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90
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Lung cancer screening with low dose computed tomography.
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BMJ
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2014
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91
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Lung Cancer Among Firefighters: Smoking-Adjusted Risk Estimates in a Pooled Analysis of Case-Control Studies.
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J Occup Environ Med
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2016
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0.75
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