Identification of HIV-1 inhibitors targeting the nucleocapsid protein.

PubWeight™: 0.85‹?›

🔗 View Article (PMC 3499629)

Published in J Med Chem on May 24, 2012

Authors

Sebastian Breuer1, Max W Chang, Jinyun Yuan, Bruce E Torbett

Author Affiliations

1: Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

Articles cited by this

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. J Biomol Screen (1999) 32.67

Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity. Eur J Biochem (2000) 8.76

New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. J Med Chem (2010) 6.54

A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening. J Med Chem (2002) 5.67

Structure of the HIV-1 nucleocapsid protein bound to the SL3 psi-RNA recognition element. Science (1998) 4.52

Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination. Proc Natl Acad Sci U S A (2006) 4.45

PA-457: a potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing. Proc Natl Acad Sci U S A (2003) 4.03

RNA is a structural element in retrovirus particles. Proc Natl Acad Sci U S A (2001) 3.45

Partial inhibition of the human immunodeficiency virus type 1 protease results in aberrant virus assembly and the formation of noninfectious particles. J Virol (1993) 2.96

NMR structure of the HIV-1 nucleocapsid protein bound to stem-loop SL2 of the psi-RNA packaging signal. Implications for genome recognition. J Mol Biol (2000) 2.89

HIV-1 nucleocapsid protein induces "maturation" of dimeric retroviral RNA in vitro. Proc Natl Acad Sci U S A (1996) 2.30

A novel one-step, highly sensitive fluorometric assay to evaluate cell-mediated cytotoxicity. J Immunol Methods (1998) 2.22

Inhibitors of HIV nucleocapsid protein zinc fingers as candidates for the treatment of AIDS. Science (1995) 2.16

Imaging the interaction of HIV-1 genomes and Gag during assembly of individual viral particles. Proc Natl Acad Sci U S A (2009) 2.08

The human immunodeficiency virus type 1 Gag polyprotein has nucleic acid chaperone activity: possible role in dimerization of genomic RNA and placement of tRNA on the primer binding site. J Virol (1999) 2.04

Chemical inactivation of retroviral infectivity by targeting nucleocapsid protein zinc fingers: a candidate SIV vaccine. AIDS Res Hum Retroviruses (1998) 1.97

Characterization of a putative alpha-helix across the capsid-SP1 boundary that is critical for the multimerization of human immunodeficiency virus type 1 gag. J Virol (2002) 1.96

NMR structure of stem-loop SL2 of the HIV-1 psi RNA packaging signal reveals a novel A-U-A base-triple platform. J Mol Biol (2000) 1.35

A general method for discovering inhibitors of protein-DNA interactions using photonic crystal biosensors. ACS Chem Biol (2008) 1.25

Properties, functions, and drug targeting of the multifunctional nucleocapsid protein of the human immunodeficiency virus. Adv Pharmacol (2007) 1.20

Proline residues within spacer peptide p1 are important for human immunodeficiency virus type 1 infectivity, protein processing, and genomic RNA dimer stability. J Virol (2002) 1.14

Targeting the viral nucleocapsid protein in anti-HIV-1 therapy. Mini Rev Med Chem (2008) 1.08

Specificity of acyl transfer from 2-mercaptobenzamide thioesters to the HIV-1 nucleocapsid protein. J Am Chem Soc (2007) 1.03

Properties and functions of the nucleocapsid protein in virus assembly. RNA Biol (2010) 1.02

In vitro identification and characterization of an early complex linking HIV-1 genomic RNA recognition and Pr55Gag multimerization. J Biol Chem (2004) 1.02

Small-molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transfer. Nat Chem Biol (2010) 0.96

Single point mutations in the zinc finger motifs of the human immunodeficiency virus type 1 nucleocapsid alter RNA binding specificities of the gag protein and enhance packaging and infectivity. J Virol (2005) 0.96

The relationship between HIV-1 genome RNA dimerization, virion maturation and infectivity. Nucleic Acids Res (2010) 0.95

Identification of HIV-1 nucleocapsid protein: nucleic acid antagonists with cellular anti-HIV activity. Biochem Biophys Res Commun (2002) 0.95

The next generation of HIV/AIDS drugs: novel and developmental antiHIV drugs and targets. Expert Rev Anti Infect Ther (2003) 0.95

Probing the topography of HIV-1 nucleocapsid protein with the alkylating agent N-ethylmaleimide. Biochemistry (1998) 0.93

Studies on the mechanism of inactivation of the HIV-1 nucleocapsid protein NCp7 with 2-mercaptobenzamide thioesters. J Med Chem (2005) 0.92

Retroviral RNA packaging. Biochem Soc Trans (1991) 0.92

A mimic of HIV-1 nucleocapsid protein impairs reverse transcription and displays antiviral activity. Proc Natl Acad Sci U S A (1999) 0.92

Real experiences of uHTS: a prototypic 1536-well fluorescence anisotropy-based uHTS screen and application of well-level quality control procedures. J Biomol Screen (2001) 0.91

Single DNA molecule stretching measures the activity of chemicals that target the HIV-1 nucleocapsid protein. Anal Biochem (2006) 0.88

Inhibition of HIV-1 by a peptide ligand of the genomic RNA packaging signal Psi. ChemMedChem (2008) 0.86

A cleavage enzyme-cytometric bead array provides biochemical profiling of resistance mutations in HIV-1 Gag and protease. Biochemistry (2011) 0.86

Identification by high throughput screening of small compounds inhibiting the nucleic acid destabilization activity of the HIV-1 nucleocapsid protein. Biochimie (2009) 0.85

A tryptophan-rich hexapeptide inhibits nucleic acid destabilization chaperoned by the HIV-1 nucleocapsid protein. Biochemistry (2006) 0.83

Identification of specific small molecule ligands for stem loop 3 ribonucleic acid of the packaging signal Psi of human immunodeficiency virus-1. J Med Chem (2009) 0.83

Nucleomimetic strategy for the inhibition of HIV-1 nucleocapsid protein NCp7 activities. Bioorg Med Chem Lett (1999) 0.77

Articles by these authors

C/EBPalpha binds and activates the PU.1 distal enhancer to induce monocyte lineage commitment. Blood (2007) 1.52

Conformational flexibility in the flap domains of ligand-free HIV protease. Acta Crystallogr D Biol Crystallogr (2007) 1.36

Virtual screening for HIV protease inhibitors: a comparison of AutoDock 4 and Vina. PLoS One (2010) 1.35

Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBP epsilon and PU.1. Blood (2002) 1.32

The transcription factor encyclopedia. Genome Biol (2012) 1.28

Developmental regulation of TREM2 and DAP12 expression in the murine CNS: implications for Nasu-Hakola disease. Neurochem Res (2008) 1.27

Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor. J Biol Chem (2004) 1.24

Alternative splicing of the human cyclin D-binding Myb-like protein (hDMP1) yields a truncated protein isoform that alters macrophage differentiation patterns. J Biol Chem (2003) 1.18

Is resistance futile? Curr Drug Targets Infect Disord (2003) 1.14

Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells. J Cell Sci (2009) 1.11

Zinc-finger nuclease editing of human cxcr4 promotes HIV-1 CD4(+) T cell resistance and enrichment. Mol Ther (2012) 1.10

Targeting and hematopoietic suppression of human CD34+ cells by measles virus. J Virol (2002) 1.10

The role of angiopoietins in the development of endothelial cells from cord blood CD34+ progenitors. Blood (2004) 1.09

Mystery solved: VSV-G-LVs do not allow efficient gene transfer into unstimulated T cells, B cells, and HSCs because they lack the LDL receptor. Blood (2014) 1.06

PU.1 is linking the glycolytic enzyme HK3 in neutrophil differentiation and survival of APL cells. Blood (2012) 1.03

Contribution of T-cell receptor repertoire breadth to the dominance of epitope-specific CD8+ T-lymphocyte responses. J Virol (2006) 1.00

Assessment of FIV-C infection of cats as a function of treatment with the protease inhibitor, TL-3. Retrovirology (2004) 0.97

Accessory mutations maintain stability in drug-resistant HIV-1 protease. J Mol Biol (2011) 0.96

The class I HLA repertoire of pancreatic islets comprises the nonclassical class Ib antigen HLA-G. Diabetes (2006) 0.96

HIC1 tumour suppressor gene is suppressed in acute myeloid leukaemia and induced during granulocytic differentiation. Br J Haematol (2008) 0.95

The death-associated protein kinase 2 is up-regulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cells. J Leukoc Biol (2007) 0.95

Small molecule regulation of protein conformation by binding in the Flap of HIV protease. ACS Chem Biol (2013) 0.94

Structural insights into the mechanisms of drug resistance in HIV-1 protease NL4-3. J Mol Biol (2005) 0.93

A copper(I)-catalyzed 1,2,3-triazole azide-alkyne click compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variant. J Med Chem (2008) 0.92

Modulation of drug resistance by artificial transcription factors. Mol Cancer Ther (2008) 0.91

Structures of manganese polysulfides: mass-selected photodissociation and density functional calculations. Dalton Trans (2011) 0.90

CLEC5A (MDL-1) is a novel PU.1 transcriptional target during myeloid differentiation. Mol Immunol (2010) 0.88

Photoelectron spectroscopy and density functional calculations of CuSi(n)- (n = 4-18) clusters. J Chem Phys (2012) 0.88

The proteome of mouse brain microvessel membranes and basal lamina. J Cereb Blood Flow Metab (2011) 0.87

Altered gag polyprotein cleavage specificity of feline immunodeficiency virus/human immunodeficiency virus mutant proteases as demonstrated in a cell-based expression system. J Virol (2006) 0.87

Resolution and prevention of feline immunodeficiency virus-induced neurological deficits by treatment with the protease inhibitor TL-3. J Virol (2004) 0.87

Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3. Retrovirology (2007) 0.87

Identification of broad-based HIV-1 protease inhibitors from combinatorial libraries. Biochem J (2010) 0.87

Inhibition of GATE-16 attenuates ATRA-induced neutrophil differentiation of APL cells and interferes with autophagosome formation. Biochem Biophys Res Commun (2013) 0.87

Switching-on survival and repair response programs in islet transplants by bone marrow-derived vasculogenic cells. Diabetes (2008) 0.86

A cleavage enzyme-cytometric bead array provides biochemical profiling of resistance mutations in HIV-1 Gag and protease. Biochemistry (2011) 0.86

Rapid deep sequencing of patient-derived HIV with ion semiconductor technology. J Virol Methods (2013) 0.85

Transcriptional regulation of MIR29B by PU.1 (SPI1) and MYC during neutrophil differentiation of acute promyelocytic leukaemia cells. Br J Haematol (2011) 0.84

Identification and characterization of 177 unreported genes associated with liver regeneration. Genomics Proteomics Bioinformatics (2004) 0.81

Targeting CD8+ T-cell tolerance for cancer immunotherapy. Immunotherapy (2014) 0.81

A specific protein disorder catalyzer of HIV-1 Nef. Bioorg Med Chem (2011) 0.81

Nucleocapsid Protein: A Desirable Target for Future Therapies Against HIV-1. Curr Top Microbiol Immunol (2015) 0.81

Generation of infectious feline immunodeficiency virus (FIV) encoding FIV/human immunodeficiency virus chimeric protease. J Virol (2010) 0.81

Mechanical properties and failure mechanisms of graphene under a central load. Chemphyschem (2014) 0.80

The tumor suppressor gene DAPK2 is induced by the myeloid transcription factors PU.1 and C/EBPα during granulocytic differentiation but repressed by PML-RARα in APL. J Leukoc Biol (2013) 0.80

BIRC6 (APOLLON) is down-regulated in acute myeloid leukemia and its knockdown attenuates neutrophil differentiation. Exp Hematol Oncol (2012) 0.80

Improved health and survival of FIV-infected cats is associated with the presence of autoantibodies to the primary receptor, CD134. Proc Natl Acad Sci U S A (2009) 0.79

Safety and efficacy of a tCD25 preselective combination anti-HIV lentiviral vector in human hematopoietic stem and progenitor cells. Stem Cells (2015) 0.79

The actin-binding protein CORO1A is a novel PU.1 (SPI1)- and CEBPA-regulated gene with significantly lower expression in APL and CEBPA-mutated AML patients. Br J Haematol (2012) 0.78

Heat shock protein 90AB1 and hyperthermia rescue infectivity of HIV with defective cores. Virology (2012) 0.78

Structural basis for drug and substrate specificity exhibited by FIV encoding a chimeric FIV/HIV protease. Acta Crystallogr D Biol Crystallogr (2011) 0.78

HIV-1 determinants of thrombocytopenia at the stage of CD34+ progenitor cell differentiation in vivo lie in the viral envelope gp120 V3 loop region. Virology (2010) 0.75

Role of the mammalian target of rapamycin pathway in lentiviral vector transduction of hematopoietic stem cells. Curr Opin Hematol (2015) 0.75

Erratum: Structural isomerism in gold nanoparticles revealed by X-ray crystallography. Nat Commun (2015) 0.75

Rescue of multi-lineage hematopoiesis during HIV-1 infection by human c-mpl gene transfer and reconstitution of CD34+ progenitor cells in vivo. J Stem Cells (2009) 0.75

Large scale of identification of differentially expressed genes in the regenerating rat liver after SISPH. Sci China C Life Sci (2005) 0.75

Tunable thermal transport and mechanical properties of graphyne heterojunctions. Phys Chem Chem Phys (2016) 0.75

Preface. Curr Top Microbiol Immunol (2015) 0.75

The Response to Burn Injury in Mice With Human Hematolymphoid Systems. Ann Surg (2016) 0.75