T cell tolerance and immunity to commensal bacteria.

Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation. Immunity (2014) 2.20

Oral Delivery of a Novel Recombinant Streptococcus mitis Vector Elicits Robust Vaccine Antigen-Specific Oral Mucosal and Systemic Antibody Responses and T Cell Tolerance. PLoS One (2015) 1.41

A single-amino-acid change in murine norovirus NS1/2 is sufficient for colonic tropism and persistence. J Virol (2012) 1.37

MyD88 Adaptor-Dependent Microbial Sensing by Regulatory T Cells Promotes Mucosal Tolerance and Enforces Commensalism. Immunity (2015) 1.17

Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status. Nat Commun (2014) 1.05

The mucosal immune system of fish: the evolution of tolerating commensals while fighting pathogens. Fish Shellfish Immunol (2013) 1.01

Regulatory T cells in autoimmune neuroinflammation. Immunol Rev (2014) 1.00

Whole genome gene expression meta-analysis of inflammatory bowel disease colon mucosa demonstrates lack of major differences between Crohn's disease and ulcerative colitis. PLoS One (2013) 0.98

Conventional CD4+ T cells regulate IL-22-producing intestinal innate lymphoid cells. Mucosal Immunol (2014) 0.97

Regulatory T cells: new keys for further unlocking the enigma of fetal tolerance and pregnancy complications. J Immunol (2014) 0.92

Competition for antigen between Th1 and Th2 responses determines the timing of the immune response switch during Mycobaterium avium subspecies paratuberulosis infection in ruminants. PLoS Comput Biol (2014) 0.91

The Role of Intestinal Microbiota in Acute Graft-versus-Host Disease. J Immunol Res (2015) 0.83

The interplay between the intestinal microbiota and the immune system. Clin Res Hepatol Gastroenterol (2014) 0.81

In vivo induction of regulatory T cells for immune tolerance in hemophilia. Cell Immunol (2015) 0.78

Border maneuvers: deployment of mucosal immune defenses against Toxoplasma gondii. Mucosal Immunol (2014) 0.78

Commensal microbes drive intestinal inflammation by IL-17-producing CD4+ T cells through ICOSL and OX40L costimulation in the absence of B7-1 and B7-2. Proc Natl Acad Sci U S A (2014) 0.77

Role of the gastrointestinal ecosystem in the development of type 1 diabetes. Pediatr Diabetes (2015) 0.76

T lymphocytes control microbial composition by regulating the abundance of Vibrio in the zebrafish gut. Gut Microbes (2014) 0.76

Intestinal microbiota and chronic constipation. Springerplus (2016) 0.75

Modulation of Cytokine Secretion Allows CD4 T Cells Secreting IL-10 and IL-17 to Simultaneously Participate in Maintaining Tolerance and Immunity. PLoS One (2015) 0.75

Human Gut Symbiont Roseburia hominis Promotes and Regulates Innate Immunity. Front Immunol (2017) 0.75

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med (2003) 26.05

Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity (2005) 23.00

Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell (2009) 20.29

Induction of colonic regulatory T cells by indigenous Clostridium species. Science (2010) 16.71

An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell (2005) 15.46

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med (2007) 15.17

Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science (2007) 12.79

A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol (2005) 11.48

Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe (2008) 11.08

Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc Natl Acad Sci U S A (2010) 9.81

Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J Immunol (2010) 9.72

CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science (2005) 8.97

The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity (2009) 8.95

Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity (2010) 8.90

Inflammatory bowel disease. N Engl J Med (2009) 8.62

Genetics and pathogenesis of inflammatory bowel disease. Nature (2011) 7.79

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature (2010) 6.87

Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature (2011) 6.43

Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity (2008) 6.08

The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science (2011) 6.01

All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J Exp Med (2007) 5.96

Th17 and regulatory T cells in mediating and restraining inflammation. Cell (2010) 5.89

Peripheral education of the immune system by colonic commensal microbiota. Nature (2011) 5.80

Immune adaptations that maintain homeostasis with the intestinal microbiota. Nat Rev Immunol (2010) 5.57

Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature (2011) 5.41

IgA response to symbiotic bacteria as a mediator of gut homeostasis. Cell Host Microbe (2007) 5.18

Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature (2010) 5.16

Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10. Nat Immunol (2007) 5.14

Intestinal bacterial colonization induces mutualistic regulatory T cell responses. Immunity (2011) 4.86

Control of intestinal inflammation by regulatory T cells. Immunol Rev (2001) 4.73

Extrathymically generated regulatory T cells control mucosal TH2 inflammation. Nature (2012) 4.33

Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice. Gastroenterology (2007) 3.82

A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. Immunity (2011) 3.76

Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. J Exp Med (2005) 3.70

Innate immune recognition of infected apoptotic cells directs T(H)17 cell differentiation. Nature (2009) 3.25

Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells. Immunity (2008) 3.25

OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset. J Exp Med (1990) 3.23

Inflammatory bowel disease: an immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus. Infect Immun (1997) 3.21

Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response. Nature (2009) 3.18

Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha. Immunity (2011) 3.06

CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease. J Exp Med (1998) 3.01

Expression of Helios in peripherally induced Foxp3+ regulatory T cells. J Immunol (2011) 2.80

A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota. Proc Natl Acad Sci U S A (2009) 2.77

Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine. Nature (2012) 2.76

Helios expression is a marker of T cell activation and proliferation. PLoS One (2011) 2.55

Selection of regulatory T cells in the thymus. Nat Rev Immunol (2012) 2.51

Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions. Eur J Immunol (2009) 2.21

TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo. J Exp Med (2010) 2.20

Gut flora antigens are not important in the maintenance of regulatory T cell heterogeneity and homeostasis. Eur J Immunol (2007) 2.12

Influence of intestinal bacteria on induction of regulatory T cells: lessons from a transfer model of colitis. Gut (2005) 1.95

Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitis. J Exp Med (2010) 1.86

Impaired regulatory T cell function in germ-free mice. Eur J Immunol (2006) 1.48

Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor-specified peripheral niche constraints. J Exp Med (2010) 1.41

Adaptive immunity in the host-microbiota dialog. Mucosal Immunol (2010) 1.31

The role of infection in the aetiology of inflammatory bowel disease. J Gastroenterol (2010) 1.26

Immune responses of TLR5(+) lamina propria dendritic cells in enterobacterial infection. J Gastroenterol (2009) 1.25

Regulatory T-cell differentiation versus clonal deletion of autoreactive thymocytes. Immunol Cell Biol (2010) 1.22

Induction of Treg cells in the mouse colonic mucosa: a central mechanism to maintain host-microbiota homeostasis. Semin Immunol (2011) 0.90

Peripheral education of the immune system by colonic commensal microbiota. Nature (2011) 5.80

A two-step process for thymic regulatory T cell development. Immunity (2008) 4.29

Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire. Immunity (2008) 3.56

Intraclonal competition limits the fate determination of regulatory T cells in the thymus. Nat Immunol (2009) 3.38

Antigen-specific peripheral shaping of the natural regulatory T cell population. J Exp Med (2008) 2.68

A broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self. Immunity (2012) 2.10

Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancer. J Immunol (2009) 1.75

Pancreatic adenocarcinoma induces bone marrow mobilization of myeloid-derived suppressor cells which promote primary tumor growth. Cancer Immunol Immunother (2012) 1.55

Comparative analysis of regulatory and effector T cells in progressively growing versus rejecting tumors of similar origins. Cancer Res (2006) 1.39

CD28 facilitates the generation of Foxp3(-) cytokine responsive regulatory T cell precursors. J Immunol (2010) 1.19

Rare development of Foxp3+ thymocytes in the CD4+CD8+ subset. J Immunol (2009) 1.14

Becoming self-aware: the thymic education of regulatory T cells. Curr Opin Immunol (2010) 1.12

Targeting of B and T lymphocyte associated (BTLA) prevents graft-versus-host disease without global immunosuppression. J Exp Med (2010) 1.03

Thymic and peripheral differentiation of regulatory T cells. Adv Immunol (2011) 0.95

T-cell selection and intestinal homeostasis. Immunol Rev (2014) 0.92

CTLA4Ig inhibits effector T cells through regulatory T cells and TGF-β. J Immunol (2013) 0.92

Cutting edge: MHC class II expression by pulmonary nonhematopoietic cells plays a critical role in controlling local inflammatory responses. J Immunol (2010) 0.88

Lack of adiponectin leads to increased lymphocyte activation and increased disease severity in a mouse model of multiple sclerosis. Eur J Immunol (2013) 0.87

T cell immunodominance is dictated by the positively selecting self-peptide. Elife (2014) 0.86

Pillars article: development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. 1993. Science 260(5107): 547-549. J Immunol (2008) 0.79