Published in Science on December 23, 2010
Interactions between the microbiota and the immune system. Science (2012) 10.45
The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science (2013) 8.53
Genetics and pathogenesis of inflammatory bowel disease. Nature (2011) 7.79
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature (2013) 7.51
The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine. Science (2011) 7.07
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature (2013) 6.77
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature (2013) 6.45
The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science (2011) 6.01
Gut immune maturation depends on colonization with a host-specific microbiota. Cell (2012) 5.91
Peripheral education of the immune system by colonic commensal microbiota. Nature (2011) 5.80
Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment. Genome Biol (2012) 5.66
Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. Elife (2013) 5.49
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature (2013) 5.47
The gut microbiota--masters of host development and physiology. Nat Rev Microbiol (2013) 5.25
Reciprocal interactions of the intestinal microbiota and immune system. Nature (2012) 4.42
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science (2015) 4.23
Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature (2011) 4.07
The gut microbiota in IBD. Nat Rev Gastroenterol Hepatol (2012) 3.88
The microbiome in infectious disease and inflammation. Annu Rev Immunol (2012) 3.76
Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice. Proc Natl Acad Sci U S A (2011) 3.55
Commensal bacteria calibrate the activation threshold of innate antiviral immunity. Immunity (2012) 3.47
Role of the microbiota in immunity and inflammation. Cell (2014) 3.43
Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis. Science (2014) 3.13
Antibiotic treatment expands the resistance reservoir and ecological network of the phage metagenome. Nature (2013) 3.02
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. J Exp Med (2012) 2.97
NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer. J Clin Invest (2013) 2.96
Microbiota-mediated colonization resistance against intestinal pathogens. Nat Rev Immunol (2013) 2.89
Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma. EMBO Rep (2012) 2.83
Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota. Nature (2013) 2.75
Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. Immunity (2014) 2.69
TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination. Immunity (2014) 2.59
Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism. Sci Transl Med (2013) 2.47
Fecal microbiota transplantation and emerging applications. Nat Rev Gastroenterol Hepatol (2011) 2.47
Role of the commensal microbiota in normal and pathogenic host immune responses. Cell Host Microbe (2011) 2.46
A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes. Immunity (2015) 2.35
The impact of perinatal immune development on mucosal homeostasis and chronic inflammation. Nat Rev Immunol (2011) 2.29
The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci U S A (2014) 2.22
Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation. Immunity (2014) 2.20
The airway microbiome in patients with severe asthma: Associations with disease features and severity. J Allergy Clin Immunol (2015) 2.20
Coinfection. Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation. Science (2014) 2.19
Emerging molecular insights into the interaction between probiotics and the host intestinal mucosa. Nat Rev Microbiol (2011) 2.15
Recent progress in Bacillus subtilis sporulation. FEMS Microbiol Rev (2011) 2.12
Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site. Immunity (2015) 2.12
The human gut microbiome as a screening tool for colorectal cancer. Cancer Prev Res (Phila) (2014) 2.08
Intestinal commensal microbes as immune modulators. Cell Host Microbe (2012) 2.07
Beyond pattern recognition: five immune checkpoints for scaling the microbial threat. Nat Rev Immunol (2012) 2.04
Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion. Science (2017) 2.03
Commensal bacteria protect against food allergen sensitization. Proc Natl Acad Sci U S A (2014) 2.02
Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora. Immunity (2013) 2.01
Acute gastrointestinal infection induces long-lived microbiota-specific T cell responses. Science (2012) 2.01
Environmental and ecological factors that shape the gut bacterial communities of fish: a meta-analysis. Mol Ecol (2012) 2.01
Metagenomics and personalized medicine. Cell (2011) 2.00
Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation. Am J Physiol Gastrointest Liver Physiol (2012) 1.98
Significance of the microbiome in obstructive lung disease. Thorax (2012) 1.97
Memory regulatory T cells reside in human skin. J Clin Invest (2014) 1.95
MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of RORγ⁺ regulatory T cells. Science (2015) 1.95
The microbiome and rheumatoid arthritis. Nat Rev Rheumatol (2011) 1.91
Oral tolerance to food protein. Mucosal Immunol (2012) 1.90
The intestinal microbiome in early life: health and disease. Front Immunol (2014) 1.90
House dust exposure mediates gut microbiome Lactobacillus enrichment and airway immune defense against allergens and virus infection. Proc Natl Acad Sci U S A (2013) 1.88
Intestinal colonization resistance. Immunology (2013) 1.85
Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis. Nat Commun (2016) 1.84
Computational meta'omics for microbial community studies. Mol Syst Biol (2013) 1.84
Plasmacytoid dendritic cells mediate anti-inflammatory responses to a gut commensal molecule via both innate and adaptive mechanisms. Cell Host Microbe (2014) 1.84
Role of "Western diet" in inflammatory autoimmune diseases. Curr Allergy Asthma Rep (2014) 1.79
Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn's disease. Gut (2015) 1.76
Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children. J Allergy Clin Immunol (2014) 1.75
Aquaporin 4-specific T cells in neuromyelitis optica exhibit a Th17 bias and recognize Clostridium ABC transporter. Ann Neurol (2012) 1.75
Innate lymphoid cell interactions with microbiota: implications for intestinal health and disease. Immunity (2012) 1.73
MyD88 signaling in T cells directs IgA-mediated control of the microbiota to promote health. Cell Host Microbe (2015) 1.73
Medicines from microbiota. Nat Biotechnol (2013) 1.72
From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines. Nat Immunol (2012) 1.70
Regulatory T cells in nonlymphoid tissues. Nat Immunol (2013) 1.69
Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella. Cell Host Microbe (2016) 1.69
Identifying gut microbe-host phenotype relationships using combinatorial communities in gnotobiotic mice. Sci Transl Med (2014) 1.69
Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon. PLoS Pathog (2012) 1.68
Gut biogeography of the bacterial microbiota. Nat Rev Microbiol (2015) 1.66
Engineered antigen-specific human regulatory T cells: immunosuppression of FVIII-specific T- and B-cell responses. Blood (2014) 1.65
Antibiotics in early life alter the gut microbiome and increase disease incidence in a spontaneous mouse model of autoimmune insulin-dependent diabetes. PLoS One (2015) 1.63
In vivo imaging and tracking of host-microbiota interactions via metabolic labeling of gut anaerobic bacteria. Nat Med (2015) 1.62
An update on the use and investigation of probiotics in health and disease. Gut (2013) 1.62
Metatranscriptomics of the human oral microbiome during health and disease. MBio (2014) 1.60
GPR15-mediated homing controls immune homeostasis in the large intestine mucosa. Science (2013) 1.58
Modulation of immune homeostasis by commensal bacteria. Curr Opin Microbiol (2011) 1.57
CD4CD8αα lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease. PLoS Biol (2014) 1.56
Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery. Nat Med (2017) 1.55
Bacteria and host interactions in the gut epithelial barrier. Nat Chem Biol (2011) 1.54
Airway microbiome dynamics in exacerbations of chronic obstructive pulmonary disease. J Clin Microbiol (2014) 1.53
Experimental inflammatory bowel disease: insights into the host-microbiota dialog. Immunity (2011) 1.53
Intestinal microbial diversity during early-life colonization shapes long-term IgE levels. Cell Host Microbe (2013) 1.51
Exploring host-microbiota interactions in animal models and humans. Genes Dev (2013) 1.51
Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice. Proc Natl Acad Sci U S A (2016) 1.50
Myeloid dendritic cells isolated from tissues of SIV-infected Rhesus macaques promote the induction of regulatory T cells. AIDS (2012) 1.50
Time for a gut check: evidence for the hypothesis that HLA-B27 predisposes to ankylosing spondylitis by altering the microbiome. Arthritis Rheum (2011) 1.50
An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes. Immunity (2012) 1.50
Tissue adaptation of regulatory and intraepithelial CD4⁺ T cells controls gut inflammation. Science (2016) 1.49
Subgingival microbial communities in Leukocyte Adhesion Deficiency and their relationship with local immunopathology. PLoS Pathog (2015) 1.49
Diversity of Intestinal Clostridium coccoides Group in the Japanese Population, as Demonstrated by Reverse Transcription-Quantitative PCR. PLoS One (2015) 1.48
Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin. Cell Host Microbe (2017) 1.44
The intestinal microbiota in health and disease. Curr Opin Gastroenterol (2012) 1.43
Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci U S A (2007) 20.60
Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell (2009) 20.29
The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol (2009) 13.87
Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe (2008) 11.08
Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity (2008) 9.82
Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc Natl Acad Sci U S A (2010) 9.81
Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J Immunol (2010) 9.72
The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity (2009) 8.95
Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity (2010) 8.90
Interactions between commensal intestinal bacteria and the immune system. Nat Rev Immunol (2004) 8.45
Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses. Immunity (2008) 5.82
Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10. Nat Immunol (2007) 5.14
Low counts of Faecalibacterium prausnitzii in colitis microbiota. Inflamm Bowel Dis (2009) 4.72
Homeostasis and inflammation in the intestine. Cell (2010) 4.60
Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse. Immunity (2006) 4.02
Oxazolone colitis: A murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4. J Exp Med (1998) 3.50
Regulatory T cells reinforce intestinal homeostasis. Immunity (2009) 3.27
Differential roles of segmented filamentous bacteria and clostridia in development of the intestinal immune system. Infect Immun (1999) 3.03
Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-beta-bearing regulatory cells. J Immunol (2005) 3.00
Lactobacillus reuteri-induced regulatory T cells protect against an allergic airway response in mice. Am J Respir Crit Care Med (2008) 2.39
Characterization of clostridia isolated from faeces of limited flora mice and their effect on caecal size when associated with germ-free mice. Lab Anim (1985) 2.12
Gut flora antigens are not important in the maintenance of regulatory T cell heterogeneity and homeostasis. Eur J Immunol (2007) 2.12
Authentic matrix vesicles contain active metalloproteases (MMP). a role for matrix vesicle-associated MMP-13 in activation of transforming growth factor-beta. J Biol Chem (2001) 1.96
Bacterial strain-specific induction of Foxp3+ T regulatory cells is protective in murine allergy models. Clin Exp Allergy (2010) 1.73
16S rRNA gene sequence-based analysis of clostridia related to conversion of germfree mice to the normal state. J Appl Microbiol (2009) 1.34
Toll-like receptor signalling. Nat Rev Immunol (2004) 34.74
Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell (2009) 20.29
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science (2003) 17.57
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol (2007) 16.21
TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature (2008) 14.26
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature (2007) 13.56
IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature (2005) 13.23
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol (2002) 13.10
Comparative metagenomics revealed commonly enriched gene sets in human gut microbiomes. DNA Res (2007) 13.08
MicroRNA-155 is induced during the macrophage inflammatory response. Proc Natl Acad Sci U S A (2007) 11.42
Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev (2006) 10.24
Cell type-specific involvement of RIG-I in antiviral response. Immunity (2005) 9.37
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell (2002) 9.10
Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity (2010) 8.90
ATP drives lamina propria T(H)17 cell differentiation. Nature (2008) 8.02
IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat Rev Immunol (2006) 7.98
Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J Exp Med (2005) 7.87
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature (2013) 7.51
Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. J Immunol (2002) 7.07
T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. Immunity (2006) 6.93
IRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity (2002) 6.85
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature (2013) 6.77
The IRF family transcription factors in immunity and oncogenesis. Annu Rev Immunol (2008) 6.60
Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Invest (2002) 6.48
Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76. Nat Immunol (2005) 6.48
Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology (2004) 6.47
Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature (2010) 6.44
Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature (2005) 6.14
Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol (2005) 6.13
Gut immune maturation depends on colonization with a host-specific microbiota. Cell (2012) 5.91
Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature (2011) 5.83
Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature (2005) 5.56
Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol (2002) 5.48
Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. Nature (2005) 5.37
Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors. Immunity (2006) 5.36
Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A (2010) 5.10
Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. Immunity (2012) 4.98
Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J Exp Med (2008) 4.95
TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol (2003) 4.94
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Nature (2004) 4.92
Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature (2002) 4.81
Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence. Nature (2003) 4.80
Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches. Science (2009) 4.80
Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin. Nat Immunol (2008) 4.78
Mincle is an ITAM-coupled activating receptor that senses damaged cells. Nat Immunol (2008) 4.66
Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells. Int Immunol (2004) 4.59
Activation of rac and cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells. Mol Cell Biol (2002) 4.50
RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta. Nature (2002) 4.44
Type I interferon production enhances susceptibility to Listeria monocytogenes infection. J Exp Med (2004) 4.34
MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus. Immunity (2006) 4.28
Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity. Proc Natl Acad Sci U S A (2009) 4.25
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat Immunol (2003) 4.25
Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma. Immunity (2008) 4.21
LXR-dependent gene expression is important for macrophage survival and the innate immune response. Cell (2004) 4.20
Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells. Nat Immunol (2006) 4.15
The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. J Exp Med (2004) 4.14
Blockade of chronic type I interferon signaling to control persistent LCMV infection. Science (2013) 4.14
The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors. Nat Immunol (2007) 4.12
Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling. Nat Immunol (2006) 4.01
Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. Nat Immunol (2008) 3.91
DUBA: a deubiquitinase that regulates type I interferon production. Science (2007) 3.88
HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses. Nature (2009) 3.86
Activity of Rho-family GTPases during cell division as visualized with FRET-based probes. J Cell Biol (2003) 3.85
Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. Immunity (2010) 3.66
Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut. Immunity (2008) 3.64
Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1. Nat Immunol (2012) 3.57
STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury. J Neurosci (2008) 3.44
IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J Clin Invest (2010) 3.40
SOCS-1 participates in negative regulation of LPS responses. Immunity (2002) 3.39
PI3K integrates the action of insulin and leptin on hypothalamic neurons. J Clin Invest (2005) 3.34
Role of hepatic STAT3 in brain-insulin action on hepatic glucose production. Cell Metab (2006) 3.34
Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. Proc Natl Acad Sci U S A (2003) 3.29
Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages. Sci Transl Med (2011) 3.27