The dynamics of protein phosphorylation in bacterial chemotaxis.

PubWeight™: 2.81‹?› | Rank: Top 1%

🔗 View Article (PMID 2261645)

Published in Cell on December 21, 1990

Authors

K A Borkovich1, M I Simon

Author Affiliations

1: Division of Biology, California Institute of Technology, Pasadena 91125.

Articles citing this

Receptor sensitivity in bacterial chemotaxis. Proc Natl Acad Sci U S A (2001) 5.90

The two-component signaling pathway of bacterial chemotaxis: a molecular view of signal transduction by receptors, kinases, and adaptation enzymes. Annu Rev Cell Dev Biol (1997) 4.99

Phosphorylation of bacterial response regulator proteins by low molecular weight phospho-donors. Proc Natl Acad Sci U S A (1992) 4.88

Diversity in chemotaxis mechanisms among the bacteria and archaea. Microbiol Mol Biol Rev (2004) 3.15

Crosslinking snapshots of bacterial chemoreceptor squads. Proc Natl Acad Sci U S A (2004) 3.09

Determination of transmembrane protein structure by disulfide cross-linking: the Escherichia coli Tar receptor. Proc Natl Acad Sci U S A (1992) 2.94

Attenuation of sensory receptor signaling by covalent modification. Proc Natl Acad Sci U S A (1992) 2.90

Computer simulation of the phosphorylation cascade controlling bacterial chemotaxis. Mol Biol Cell (1993) 2.78

How signals are heard during bacterial chemotaxis: protein-protein interactions in sensory signal propagation. J Bacteriol (2000) 2.76

Signal processing in complex chemotaxis pathways. Nat Rev Microbiol (2011) 2.52

Direct visualization of Escherichia coli chemotaxis receptor arrays using cryo-electron microscopy. Proc Natl Acad Sci U S A (2007) 2.51

Constitutively signaling fragments of Tsr, the Escherichia coli serine chemoreceptor. J Bacteriol (1994) 2.47

Biphasic control logic of HAMP domain signalling in the Escherichia coli serine chemoreceptor. Mol Microbiol (2011) 2.08

Liberation of an interaction domain from the phosphotransfer region of CheA, a signaling kinase of Escherichia coli. Proc Natl Acad Sci U S A (1994) 2.06

Genetic evidence for interaction between the CheW and Tsr proteins during chemoreceptor signaling by Escherichia coli. J Bacteriol (1991) 2.04

Receptor-mediated protein kinase activation and the mechanism of transmembrane signaling in bacterial chemotaxis. EMBO J (1997) 1.99

The smaller of two overlapping cheA gene products is not essential for chemotaxis in Escherichia coli. J Bacteriol (1995) 1.69

Computer analysis of the binding reactions leading to a transmembrane receptor-linked multiprotein complex involved in bacterial chemotaxis. Mol Biol Cell (1995) 1.62

Phosphorylation site of NtrC, a protein phosphatase whose covalent intermediate activates transcription. J Bacteriol (1992) 1.60

Aspartate and maltose-binding protein interact with adjacent sites in the Tar chemotactic signal transducer of Escherichia coli. J Bacteriol (1992) 1.55

Chemotaxis is required for virulence and competitive fitness of the bacterial wilt pathogen Ralstonia solanacearum. J Bacteriol (2006) 1.53

Chimeric chemoreceptors in Escherichia coli: signaling properties of Tar-Tap and Tap-Tar hybrids. J Bacteriol (1998) 1.49

Bacterial chemotaxis signaling complexes: formation of a CheA/CheW complex enhances autophosphorylation and affinity for CheY. Proc Natl Acad Sci U S A (1991) 1.47

Comparison in vitro of a high- and a low-abundance chemoreceptor of Escherichia coli: similar kinase activation but different methyl-accepting activities. J Bacteriol (1998) 1.47

Polar clustering of the chemoreceptor complex in Escherichia coli occurs in the absence of complete CheA function. J Bacteriol (2000) 1.43

The carboxy-terminal portion of the CheA kinase mediates regulation of autophosphorylation by transducer and CheW. J Bacteriol (1993) 1.43

A model of excitation and adaptation in bacterial chemotaxis. Biophys J (1995) 1.40

DcrA, a c-type heme-containing methyl-accepting protein from Desulfovibrio vulgaris Hildenborough, senses the oxygen concentration or redox potential of the environment. J Bacteriol (1994) 1.37

Chemotactic signal integration in bacteria. Proc Natl Acad Sci U S A (1995) 1.36

Chemotaxis in a gliding bacterium. Proc Natl Acad Sci U S A (1998) 1.30

Nutrient-sensing mechanisms across evolution. Cell (2015) 1.30

Isolation and characterization of nonchemotactic CheZ mutants of Escherichia coli. J Bacteriol (2000) 1.26

In different organisms, the mode of interaction between two signaling proteins is not necessarily conserved. Proc Natl Acad Sci U S A (2004) 1.18

Chemotaxis in Bacillus subtilis requires either of two functionally redundant CheW homologs. J Bacteriol (1994) 1.14

Chemotactic signaling by the P1 phosphorylation domain liberated from the CheA histidine kinase of Escherichia coli. J Bacteriol (1996) 1.13

The short form of CheA couples chemoreception to CheA phosphorylation. J Bacteriol (1994) 1.10

CheV: CheW-like coupling proteins at the core of the chemotaxis signaling network. Trends Microbiol (2010) 1.09

In vivo and in vitro characterization of Escherichia coli protein CheZ gain- and loss-of-function mutants. J Bacteriol (1996) 1.09

Activation of the phosphosignaling protein CheY. I. Analysis of the phosphorylated conformation by 19F NMR and protein engineering. J Biol Chem (1993) 1.09

CheR- and CheB-dependent chemosensory adaptation system of Rhodobacter sphaeroides. J Bacteriol (2001) 1.08

Myxococcus xanthus fibril appendages are essential for excitation by a phospholipid attractant. Proc Natl Acad Sci U S A (2000) 1.07

Genetic analysis of the catalytic domain of the chemotaxis-associated histidine kinase CheA. J Bacteriol (1997) 1.05

CheA-receptor interaction sites in bacterial chemotaxis. J Mol Biol (2012) 1.05

Coexpression of the long and short forms of CheA, the chemotaxis histidine kinase, by members of the family Enterobacteriaceae. J Bacteriol (1997) 1.04

Mutational analysis of the chemoreceptor-coupling domain of the Escherichia coli chemotaxis signaling kinase CheA. J Bacteriol (2006) 1.04

Bacterial chemotaxis: the early years of molecular studies. Annu Rev Microbiol (2012) 1.01

Protein histidine kinases: assembly of active sites and their regulation in signaling pathways. Curr Opin Microbiol (2010) 0.98

Phosphorylation and dephosphorylation among Dif chemosensory proteins essential for exopolysaccharide regulation in Myxococcus xanthus. J Bacteriol (2010) 0.98

A fragment liberated from the Escherichia coli CheA kinase that blocks stimulatory, but not inhibitory, chemoreceptor signaling. J Bacteriol (1997) 0.95

Mutational analysis of the transmembrane helix 2-HAMP domain connection in the Escherichia coli aspartate chemoreceptor tar. J Bacteriol (2010) 0.95

Ligand and antagonist driven regulation of the Vibrio cholerae quorum-sensing receptor CqsS. Mol Microbiol (2012) 0.94

Functional analysis of nine putative chemoreceptor proteins in Sinorhizobium meliloti. J Bacteriol (2006) 0.91

Mutational activation of CheA, the protein kinase in the chemotaxis system of Escherichia coli. J Bacteriol (1994) 0.89

PAS/poly-HAMP signalling in Aer-2, a soluble haem-based sensor. Mol Microbiol (2010) 0.86

Site-specific and synergistic stimulation of methylation on the bacterial chemotaxis receptor Tsr by serine and CheW. BMC Microbiol (2005) 0.86

Influence of attractants and repellents on methyl group turnover on methyl-accepting chemotaxis proteins of Bacillus subtilis and role of CheW. J Bacteriol (1992) 0.83

The two active sites of Thermotoga maritima CheA dimers bind ATP with dramatically different affinities. Biochemistry (2009) 0.83

Elucidation of the multiple roles of CheD in Bacillus subtilis chemotaxis. Mol Microbiol (2012) 0.80

Identification of an anchor residue for CheA-CheY interactions in the chemotaxis system of Escherichia coli. J Bacteriol (2011) 0.80

Preformed Soluble Chemoreceptor Trimers That Mimic Cellular Assembly States and Activate CheA Autophosphorylation. Biochemistry (2015) 0.78

Structural insight into the low affinity between Thermotoga maritima CheA and CheB compared to their Escherichia coli/Salmonella typhimurium counterparts. Int J Biol Macromol (2011) 0.75

Conformational Transitions that Enable Histidine Kinase Autophosphorylation and Receptor Array Integration. J Mol Biol (2015) 0.75

Coordinated regulation of multiple flagellar motors by the Escherichia coli chemotaxis system. Biophysics (Nagoya-shi) (2012) 0.75

An insight into the interaction mode between CheB and chemoreceptor from two crystal structures of CheB methylesterase catalytic domain. Biochem Biophys Res Commun (2011) 0.75

Signaling complexes control the chemotaxis kinase by altering its apparent rate constant of autophosphorylation. Protein Sci (2017) 0.75

Articles by these authors

Robust perfect adaptation in bacterial chemotaxis through integral feedback control. Proc Natl Acad Sci U S A (2000) 7.67

Phosphorylation of three proteins in the signaling pathway of bacterial chemotaxis. Cell (1988) 7.56

Signal transduction pathways involving protein phosphorylation in prokaryotes. Annu Rev Biochem (1991) 6.84

Expression of flagellar genes carried by bacteriophage lambda. Nature (1976) 5.14

Sensory transducers of E. coli are composed of discrete structural and functional domains. Cell (1983) 4.90

Bacterial flagella. Annu Rev Microbiol (1977) 4.77

Protein phosphorylation is involved in bacterial chemotaxis. Proc Natl Acad Sci U S A (1987) 4.70

Transmembrane signal transduction in bacterial chemotaxis involves ligand-dependent activation of phosphate group transfer. Proc Natl Acad Sci U S A (1989) 4.66

Histidine phosphorylation and phosphoryl group transfer in bacterial chemotaxis. Nature (1988) 4.46

Transposition of structural genes to an expression sequence on a linear plasmid causes antigenic variation in the bacterium Borrelia hermsii. Nature (1985) 4.41

Transposon-facilitated DNA sequencing. Proc Natl Acad Sci U S A (1991) 4.29

Structure of the serine chemoreceptor in Escherichia coli. Nature (1983) 4.03

Stable propagation of cosmid sized human DNA inserts in an F factor based vector. Nucleic Acids Res (1992) 3.97

Construction and characterization of a human bacterial artificial chromosome library. Genomics (1996) 3.91

Homologies between signal transducing G proteins and ras gene products. Science (1984) 3.85

Flagellar assembly mutants in Escherichia coli. J Bacteriol (1972) 3.81

Antigenic variation is associated with DNA rearrangements in a relapsing fever Borrelia. Cell (1985) 3.78

Chromosomal sublocalization of human c-myb and c-fes cellular onc genes. Nature (1983) 3.77

Conserved aspartate residues and phosphorylation in signal transduction by the chemotaxis protein CheY. Proc Natl Acad Sci U S A (1990) 3.72

Hin-mediated site-specific recombination requires two 26 bp recombination sites and a 60 bp recombinational enhancer. Cell (1985) 3.69

Structure of CheA, a signal-transducing histidine kinase. Cell (1999) 3.68

The entry of diphtheria toxin into the mammalian cell cytoplasm: evidence for lysosomal involvement. J Cell Biol (1980) 3.64

Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase. EMBO J (1990) 3.62

Repetitive segmental structure of the transducin beta subunit: homology with the CDC4 gene and identification of related mRNAs. Proc Natl Acad Sci U S A (1986) 3.59

A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell (2001) 3.52

Chimeric chemosensory transducers of Escherichia coli. Proc Natl Acad Sci U S A (1985) 3.38

Host protein requirements for in vitro site-specific DNA inversion. Cell (1986) 3.31

Diphtheria toxin forms transmembrane channels in planar lipid bilayers. Proc Natl Acad Sci U S A (1981) 3.17

Participation of the protein Go in multiple aspects of behavior in C. elegans. Science (1995) 3.12

Slowed recovery of rod photoresponse in mice lacking the GTPase accelerating protein RGS9-1. Nature (2000) 3.11

Bacterial flagella: polarity of elongation. Science (1970) 3.05

Nucleotide sequence corresponding to five chemotaxis genes in Escherichia coli. J Bacteriol (1986) 3.04

Determination of transmembrane protein structure by disulfide cross-linking: the Escherichia coli Tar receptor. Proc Natl Acad Sci U S A (1992) 2.94

New unified nomenclature for the flagellar genes of Escherichia coli and Salmonella typhimurium. Microbiol Rev (1988) 2.90

Attenuation of sensory receptor signaling by covalent modification. Proc Natl Acad Sci U S A (1992) 2.90

Primary structure of the M subunit of the reaction center from Rhodopseudomonas sphaeroides. Proc Natl Acad Sci U S A (1983) 2.87

Protein histidine kinases and signal transduction in prokaryotes and eukaryotes. Trends Genet (1994) 2.85

Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase. Proc Natl Acad Sci U S A (1999) 2.83

Computer simulation of the phosphorylation cascade controlling bacterial chemotaxis. Mol Biol Cell (1993) 2.78

Isolation of the gene encoding the Hin recombinational enhancer binding protein. Proc Natl Acad Sci U S A (1988) 2.76

Defective platelet activation in G alpha(q)-deficient mice. Nature (1997) 2.67

Primary structure of the L subunit of the reaction center from Rhodopseudomonas sphaeroides. Proc Natl Acad Sci U S A (1984) 2.65

Prolonged photoresponses in transgenic mouse rods lacking arrestin. Nature (1997) 2.64

Histidine and aspartate phosphorylation: two-component systems and the limits of homology. Trends Biochem Sci (1994) 2.54

Increased susceptibility to light damage in an arrestin knockout mouse model of Oguchi disease (stationary night blindness) Invest Ophthalmol Vis Sci (1999) 2.53

G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates. Proc Natl Acad Sci U S A (1990) 2.52

Subunits beta gamma of heterotrimeric G protein activate beta 2 isoform of phospholipase C. Nature (1992) 2.47

Localization of proteins controlling motility and chemotaxis in Escherichia coli. J Bacteriol (1977) 2.47

Sequence of the alpha subunit of photoreceptor G protein: homologies between transducin, ras, and elongation factors. Science (1985) 2.46

G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C. J Biol Chem (1995) 2.41

Mechanisms of rhodopsin inactivation in vivo as revealed by a COOH-terminal truncation mutant. Science (1995) 2.39

Mutants defective in bacterial chemotaxis show modified protein phosphorylation. Cell (1988) 2.34

Multiple electrophoretic forms of methyl-accepting chemotaxis proteins generated by stimulus-elicited methylation in Escherichia coli. J Bacteriol (1980) 2.29

Vascular system defects and impaired cell chemokinesis as a result of Galpha13 deficiency. Science (1997) 2.28

Mutations in a C. elegans Gqalpha gene disrupt movement, egg laying, and viability. Neuron (1996) 2.23

Protein phosphorylation in chemotaxis and two-component regulatory systems of bacteria. J Biol Chem (1989) 2.18

Assembly and function of a quaternary signal transduction complex monitored by surface plasmon resonance. Nature (1993) 2.16

G protein multiplicity in eukaryotic signal transduction systems. Biochemistry (1988) 2.14

Rapid and reproducible deactivation of rhodopsin requires multiple phosphorylation sites. Neuron (2000) 2.13

Isolation and characterization of a cDNA clone for the gamma subunit of bovine retinal transducin. Proc Natl Acad Sci U S A (1984) 2.12

Intermolecular complementation of the kinase activity of CheA. Mol Microbiol (1993) 2.08

Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase. Proc Natl Acad Sci U S A (1994) 2.04

Hyphal development in Neurospora crassa: involvement of a two-component histidine kinase. Proc Natl Acad Sci U S A (1996) 2.03

Fis binding to the recombinational enhancer of the Hin DNA inversion system. Genes Dev (1987) 2.02

Pulsed field gel electrophoresis. Biotechniques (1989) 2.02

Spatial relationship of the Fis binding sites for Hin recombinational enhancer activity. Nature (1987) 2.02

G protein-coupled signal transduction pathways for interleukin-8. Science (1993) 2.01

Characterization of Escherichia coli chemotaxis receptor mutants with null phenotypes. J Bacteriol (1986) 1.98

The response regulators CheB and CheY exhibit competitive binding to the kinase CheA. Biochemistry (1995) 1.97

Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice. EMBO J (1998) 1.96

Synthesis of bacterial flagella. II. PBS1 transduction of flagella-specific markers in Bacillus subtilis. J Bacteriol (1969) 1.92

Tissue-specific and developmental regulation of rod opsin chimeric genes in transgenic mice. Neuron (1991) 1.88

Cloning of the Vibrio harveyi luciferase genes: use of a synthetic oligonucleotide probe. Proc Natl Acad Sci U S A (1983) 1.88

Distinct forms of the beta subunit of GTP-binding regulatory proteins identified by molecular cloning. Proc Natl Acad Sci U S A (1987) 1.87

Measurement by quantitative PCR of changes in HPRT, PGK-1, PGK-2, APRT, MTase, and Zfy gene transcripts during mouse spermatogenesis. Nucleic Acids Res (1990) 1.86

Division mutants of Bacillus subtilis: isolation and PBS1 transduction of division-specific markers. J Bacteriol (1971) 1.85

Recoverin regulates light-dependent phosphodiesterase activity in retinal rods. J Gen Physiol (2004) 1.82

Synthesis of a sequence-specific DNA-cleaving peptide. Science (1987) 1.78

G protein beta gamma subunits synthesized in Sf9 cells. Functional characterization and the significance of prenylation of gamma. J Biol Chem (1992) 1.75

Purification from Sf9 cells and characterization of recombinant Gq alpha and G11 alpha. Activation of purified phospholipase C isozymes by G alpha subunits. J Biol Chem (1993) 1.74

Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets. J Cell Biol (1999) 1.72

Nucleotide binding by the histidine kinase CheA. Nat Struct Biol (2001) 1.72

Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse. Proc Natl Acad Sci U S A (1989) 1.70

Activation of phospholipase C by the alpha subunits of the Gq and G11 proteins in transfected Cos-7 cells. J Biol Chem (1992) 1.70

Nucleotide sequence of the luxA gene of Vibrio harveyi and the complete amino acid sequence of the alpha subunit of bacterial luciferase. J Biol Chem (1985) 1.70

Expression of CheA fragments which define domains encoding kinase, phosphotransfer, and CheY binding activities. Biochemistry (1993) 1.68

Activation of the phosphosignaling protein CheY. II. Analysis of activated mutants by 19F NMR and protein engineering. J Biol Chem (1993) 1.68

Gz, a guanine nucleotide-binding protein with unique biochemical properties. J Biol Chem (1990) 1.67

A G protein gamma subunit shares homology with ras proteins. Science (1989) 1.66

Chromosomal mapping of the mink cell focus-inducing and xenotropic env gene family in the mouse. Proc Natl Acad Sci U S A (1983) 1.65

Characterization of G-protein alpha subunits in the Gq class: expression in murine tissues and in stromal and hematopoietic cell lines. Proc Natl Acad Sci U S A (1991) 1.63

The hybrid histidine kinase DokA is part of the osmotic response system of Dictyostelium. EMBO J (1996) 1.62

Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking Galphaq. Proc Natl Acad Sci U S A (1997) 1.62

Melanopsin signalling in mammalian iris and retina. Nature (2011) 1.61

Cloning of the C-terminal cytoplasmic fragment of the tar protein and effects of the fragment on chemotaxis of Escherichia coli. J Bacteriol (1988) 1.60

COS1, a two-component histidine kinase that is involved in hyphal development in the opportunistic pathogen Candida albicans. Proc Natl Acad Sci U S A (1998) 1.59

Purification and partial characterization of Bacillus subtilis Flagellar hooks. J Bacteriol (1971) 1.58

Mice lacking G-protein receptor kinase 1 have profoundly slowed recovery of cone-driven retinal responses. J Neurosci (2000) 1.57