Published in ChemMedChem on May 29, 2012
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Mutation of Tyr137 of the universal Escherichia coli fimbrial adhesin FimH relaxes the tyrosine gate prior to mannose binding. IUCrJ (2017) 0.75
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Design, synthesis and biological evaluation of mannosyl triazoles as FimH antagonists. Bioorg Med Chem (2011) 0.98
Antiadhesion therapy for urinary tract infections--a balanced PK/PD profile proved to be key for success. J Med Chem (2012) 0.95
Peripheral lipopolysaccharide administration transiently affects expression of brain-derived neurotrophic factor, corticotropin and proopiomelanocortin in mouse brain. Neurosci Lett (2007) 0.94
Synthesis of sialic acid derivatives as ligands for the myelin-associated glycoprotein (MAG). Bioorg Med Chem (2007) 0.93
From a library of MAG antagonists to nanomolar CD22 ligands. ChemMedChem (2011) 0.92
Stabilization of branched oligosaccharides: Lewis(x) benefits from a nonconventional C-H···O hydrogen bond. J Am Chem Soc (2013) 0.92
Epitope mapping of sialyl Lewis(x) bound to E-selectin using saturation transfer difference NMR experiments. Glycobiology (2003) 0.89
AcquaAlta: a directional approach to the solvation of ligand-protein complexes. J Chem Inf Model (2011) 0.88
Preorganization of the Bioactive Conformation of Sialyl Lewis(X) Analogues Correlates with Their Affinity to E-Selectin. Angew Chem Int Ed Engl (2001) 0.88
Sensitivity enhancement in saturation transfer difference (STD) experiments through optimized excitation schemes. Magn Reson Chem (2007) 0.88
Trivalent, Gal/GalNAc-containing ligands designed for the asialoglycoprotein receptor. Bioorg Med Chem (2008) 0.87
Glycomimetic drugs--a new source of therapeutic opportunities. Discov Med (2009) 0.87
Consistent bioactive conformation of the Neu5Acalpha(2-->3)Gal epitope upon lectin binding. Chembiochem (2008) 0.87
Chemical development of intracellular protein heterodimerizers. Chem Biol (2013) 0.86
Molecular cloning and functional expression of a novel Helicobacter pylori alpha-1,4 fucosyltransferase. Glycobiology (2005) 0.85
Low molecular weight antagonists of the myelin-associated glycoprotein: synthesis, docking, and biological evaluation. J Med Chem (2010) 0.85
Pre-organization of the core structure of E-selectin antagonists. Chemistry (2011) 0.85
FimH antagonists: bioisosteres to improve the in vitro and in vivo PK/PD profile. J Med Chem (2015) 0.85
Examination of the biological role of the alpha(2-->6)-linked sialic acid in gangliosides binding to the myelin-associated glycoprotein (MAG). J Med Chem (2009) 0.84
Extraction and analysis of intact glucosinolates--a validated pressurized liquid extraction/liquid chromatography-mass spectrometry protocol for Isatis tinctoria, and qualitative analysis of other cruciferous plants. J Chromatogr A (2007) 0.83
Nanomolar E-selectin antagonists with prolonged half-lives by a fragment-based approach. J Am Chem Soc (2013) 0.83
Sialyl Lewis(x): a "pre-organized water oligomer"? Angew Chem Int Ed Engl (2012) 0.83
Probing small-molecule binding to cytochrome P450 2D6 and 2C9: An in silico protocol for generating toxicity alerts. ChemMedChem (2010) 0.82
Design, synthesis and evaluation of monovalent ligands for the asialoglycoprotein receptor (ASGP-R). Bioorg Med Chem (2009) 0.82
Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals. J Med Chem (2005) 0.81
A fragment-based in situ combinatorial approach to identify high-affinity ligands for unknown binding sites. Angew Chem Int Ed Engl (2010) 0.81
Target Selectivity of FimH Antagonists. J Med Chem (2012) 0.81
High affinity sialoside ligands of myelin associated glycoprotein. Bioorg Med Chem Lett (2011) 0.81
Expression of the carbohydrate recognition domain of FimH and development of a competitive binding assay. Anal Biochem (2010) 0.80
Exploring the free-energy landscape of carbohydrate-protein complexes: development and validation of scoring functions considering the binding-site topology. J Comput Aided Mol Des (2014) 0.80
From the ganglioside GQ1balpha to glycomimetic antagonists of the myelin-associated glycoprotein (MAG). Chimia (Aarau) (2010) 0.79
Antagonists of the myelin-associated glycoprotein: a new class of tetrasaccharide mimics. Bioorg Med Chem (2006) 0.79
Design, synthesis, biological evaluation, and modeling of a non-carbohydrate antagonist of the myelin-associated glycoprotein. Bioorg Med Chem (2010) 0.79
Binding epitopes of gangliosides to their neuronal receptor, myelin-associated glycoprotein, from saturation transfer difference NMR. Chembiochem (2008) 0.79
Predicting the toxic potential of drugs and chemicals in silico: a model for the peroxisome proliferator-activated receptor gamma (PPAR gamma). Toxicol Lett (2007) 0.79
A flow cytometry-based assay for screening FimH antagonists. Assay Drug Dev Technol (2011) 0.78
Mimetics of the tri- and tetrasaccharide epitope of GQ1balpha as myelin-associated glycoprotein (MAG) ligands. Bioorg Med Chem (2007) 0.78
New sialyl Lewis(x) mimic containing an alpha-substituted beta(3)-amino acid spacer. Carbohydr Res (2007) 0.77
Comparative epitope mapping with saturation transfer difference NMR of sialyl Lewis(a) compounds and derivatives bound to a monoclonal antibody. J Med Chem (2005) 0.77
Development of an aggregation assay to screen FimH antagonists. J Microbiol Methods (2010) 0.77
Kinetic and thermodynamic properties of MAG antagonists. Carbohydr Res (2010) 0.77
Probing the carbohydrate recognition domain of E-selectin: the importance of the acid orientation in sLex mimetics. Bioorg Med Chem (2009) 0.77
Kinetic properties of carbohydrate-lectin interactions: FimH antagonists. ChemMedChem (2013) 0.77
"Add-on" domains of Drosophila β1,4-N-acetylgalactosaminyltransferase B in the stem region and its pilot protein. Cell Mol Life Sci (2011) 0.77
Simulating alpha/beta selectivity at the human thyroid hormone receptor: consensus scoring using multidimensional QSAR. ChemMedChem (2007) 0.76
Mixed-model QSAR at the glucocorticoid receptor: predicting the binding mode and affinity of psychotropic drugs. ChemMedChem (2009) 0.76
SIGLEC-4 (MAG) Antagonists: From the Natural Carbohydrate Epitope to Glycomimetics. Top Curr Chem (2015) 0.76
In vivo evaluation of FimH antagonists - a novel class of antimicrobials for the treatment of urinary tract infection. Chimia (Aarau) (2012) 0.76
E- and P-selectin: differences, similarities and implications for the design of P-selectin antagonists. Chimia (Aarau) (2011) 0.76