Back pocket flexibility provides group II p21-activated kinase (PAK) selectivity for type I 1/2 kinase inhibitors.

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Published in J Med Chem on February 04, 2014

Authors

Steven T Staben1, Jianwen A Feng, Karen Lyle, Marcia Belvin, Jason Boggs, Jason D Burch, Ching-ching Chua, Haifeng Cui, Antonio G DiPasquale, Lori S Friedman, Christopher Heise, Hartmut Koeppen, Adrian Kotey, Robert Mintzer, Angela Oh, David Allen Roberts, Lionel Rouge, Joachim Rudolph, Christine Tam, Weiru Wang, Yisong Xiao, Amy Young, Yamin Zhang, Klaus P Hoeflich

Author Affiliations

1: Department of Discovery Chemistry, ‡Department of Translational Oncology, △Department of Pathology, §Department of Drug Metabolism and Pharmacokinetics, ∥Department of Biochemical and Cellular Pharmacology, and ⊥Department of Structural Biology, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.

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