Published in Mar Drugs on April 10, 2012
Protective effects of astaxanthin on ConA-induced autoimmune hepatitis by the JNK/p-JNK pathway-mediated inhibition of autophagy and apoptosis. PLoS One (2015) 0.92
Astaxanthin inhibits apoptosis in alveolar epithelial cells type II in vivo and in vitro through the ROS-dependent mitochondrial signalling pathway. J Cell Mol Med (2014) 0.89
Marine Carotenoids against Oxidative Stress: Effects on Human Health. Mar Drugs (2015) 0.87
Astaxanthin treatment confers protection against oxidative stress in U937 cells stimulated with lipopolysaccharide reducing O2- production. PLoS One (2014) 0.87
Astaxanthin as a Potential Neuroprotective Agent for Neurological Diseases. Mar Drugs (2015) 0.82
Carotenoids from Marine Microalgae: A Valuable Natural Source for the Prevention of Chronic Diseases. Mar Drugs (2015) 0.81
Modulation of cytokine production by drugs with antiepileptic or mood stabilizer properties in anti-CD3- and anti-Cd40-stimulated blood in vitro. Oxid Med Cell Longev (2014) 0.81
Anti-inflammatory Effect of Astaxanthin on the Sickness Behavior Induced by Diabetes Mellitus. Cell Mol Neurobiol (2015) 0.78
Astaxanthin Inhibits Expression of Retinal Oxidative Stress and Inflammatory Mediators in Streptozotocin-Induced Diabetic Rats. PLoS One (2016) 0.77
Carotenoids: biochemistry, pharmacology and treatment. Br J Pharmacol (2016) 0.76
Multiple Mechanisms of Anti-Cancer Effects Exerted by Astaxanthin. Mar Drugs (2015) 0.76
Potential Anti-Atherosclerotic Properties of Astaxanthin. Mar Drugs (2016) 0.75
FlexPro MD, a Mixture of Krill Oil, Astaxanthin, and Hyaluronic Acid, Suppresses Lipopolysaccharide-Induced Inflammatory Cytokine Production Through Inhibition of NF-κB. J Med Food (2016) 0.75
Astaxanthin protects against early burn-wound progression in rats by attenuating oxidative stress-induced inflammation and mitochondria-related apoptosis. Sci Rep (2017) 0.75
Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B. Proc Natl Acad Sci U S A (1989) 11.76
Autophagy in immunity and inflammation. Nature (2011) 11.16
Oxidative stress, inflammation, and cancer: how are they linked? Free Radic Biol Med (2010) 7.31
The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. Mol Cell (2002) 5.84
Inflammation and cardiovascular disease mechanisms. Am J Clin Nutr (2006) 3.09
IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide. J Immunol (2003) 2.77
Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: role of lipid peroxidation, DNA damage, and repair. Langenbecks Arch Surg (2006) 1.93
A SHPing tale: perspectives on the regulation of SHP-1 and SHP-2 tyrosine phosphatases by the C-terminal tail. Cell Signal (2005) 1.58
Potential health-promoting effects of astaxanthin: a high-value carotenoid mostly from microalgae. Mol Nutr Food Res (2010) 1.52
Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans. Nutr Metab (Lond) (2010) 1.29
Inhibition of low-density lipoprotein oxidation by astaxanthin. J Atheroscler Thromb (2000) 1.21
Crystal structure of the catalytic domain of protein-tyrosine phosphatase SHP-1. J Biol Chem (1998) 1.18
Administration of natural astaxanthin increases serum HDL-cholesterol and adiponectin in subjects with mild hyperlipidemia. Atherosclerosis (2009) 1.12
Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype. Lab Invest (2009) 1.10
Targeting protein tyrosine phosphatases for anticancer drug discovery. Curr Pharm Des (2010) 1.10
Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress. J Nutr Biochem (2009) 1.06
SHP-1 in cell-cycle regulation. Anticancer Agents Med Chem (2011) 1.05
Astaxanthin, oxidative stress, inflammation and cardiovascular disease. Future Cardiol (2009) 1.04
Marine carotenoids and cardiovascular risk markers. Mar Drugs (2011) 1.03
The role of monocytes and inflammation in the pathophysiology of heart failure. Eur J Heart Fail (2011) 1.03
Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds. J Med Chem (2008) 1.03
Antiinflammatory effects in THP-1 cells treated with verbascoside. Phytother Res (2010) 1.02
Oxidative stress up-regulates IL-8 and TNF-alpha synthesis by human dendritic cells. Eur J Immunol (1998) 1.01
Modulation of macrophage infiltration and inflammatory activity by the phosphatase SHP-1 in virus-induced demyelinating disease. J Virol (2008) 1.01
Importance of post-transcriptional regulation of chemokine genes by oxidative stress. Biochem J (2001) 0.98
Molecular mechanisms underlying SHP-1 gene expression. Eur J Biochem (2002) 0.94
Atherosclerosis: a classic inflammatory disease. Int J Immunopathol Pharmacol (2012) 0.93
Synthetic peptides containing ITIM-like sequences of IREM-1 inhibit BAFF-mediated regulation of interleukin-8 expression and phagocytosis through SHP-1 and/or PI3K. Immunology (2011) 0.84
Interferon-beta treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1. Clin Immunol (2009) 0.83
IL-10, an inflammatory/inhibitory cytokine, but not always. Immunol Lett (2003) 1.76
Chronic treatment with rosuvastatin modulates nitric oxide synthase expression and reduces ischemia-reperfusion injury in rat hearts. Cardiovasc Res (2005) 1.64
Neurologic soft signs in schizophrenic patients treated with conventional and atypical antipsychotics. J Clin Psychopharmacol (2005) 1.49
Marine carotenoids and cardiovascular risk markers. Mar Drugs (2011) 1.03
Antiinflammatory effects in THP-1 cells treated with verbascoside. Phytother Res (2010) 1.02
Tumor necrosis factor alpha (TNF-alpha) activates Jak1/Stat3-Stat5B signaling through TNFR-1 in human B cells. Cell Growth Differ (2002) 1.02
Carotenoids and vitamins C and E in the prevention of cardiovascular disease. Int J Vitam Nutr Res (2012) 1.01
Dysregulation of chemo-cytokine production in schizophrenic patients versus healthy controls. BMC Neurosci (2011) 1.01
Novel phytonutrient contributors to antioxidant protection against cardiovascular disease. Nutrition (2012) 0.97
Age-related death-survival balance in myocardium: an immunohistochemical and biochemical study. Mech Ageing Dev (2002) 0.94
Inducible nitric oxide synthase and heme oxygenase-1 in rat heart: direct effect of chronic exposure to hypoxia. Ann Clin Lab Sci (2003) 0.93
Licocalchone-C extracted from Glycyrrhiza glabra inhibits lipopolysaccharide-interferon-γ inflammation by improving antioxidant conditions and regulating inducible nitric oxide synthase expression. Molecules (2011) 0.92
Extremely low frequency electromagnetic field and wound healing: implication of cytokines as biological mediators. Eur Cytokine Netw (2013) 0.92
Activity of matrix metallo proteinases (MMPs) and the tissue inhibitor of MMP (TIMP)-1 in electromagnetic field-exposed THP-1 cells. J Cell Physiol (2012) 0.92
Left ventricular wall stress as a direct correlate of cardiomyocyte apoptosis in patients with severe dilated cardiomyopathy. Am Heart J (2003) 0.92
Phenotype modulation in cultures of vascular smooth muscle cells from diabetic rats: association with increased nitric oxide synthase expression and superoxide anion generation. J Cell Physiol (2003) 0.90
Trimetazidine improves post-ischemic recovery by preserving endothelial nitric oxide synthase expression in isolated working rat hearts. Nitric Oxide (2006) 0.86
Modulation of MCP-1 and iNOS by 50-Hz sinusoidal electromagnetic field. Nitric Oxide (2006) 0.86
Simvastatin attenuates expression of cytokine-inducible nitric-oxide synthase in embryonic cardiac myoblasts. J Biol Chem (2005) 0.86
Biological functional relevance of asymmetric dimethylarginine (ADMA) in cardiovascular disease. Int J Mol Sci (2013) 0.86
Enhanced adherence of human uremic erythrocytes to vascular endothelium: role of phosphatidylserine exposure. Kidney Int (2002) 0.86
Novel aminobenzyl-acetamidine derivative modulate the differential regulation of NOSs in LPS induced inflammatory response: role of PI3K/Akt pathway. Biochim Biophys Acta (2012) 0.86
Mitochondria as an easy target to oxidative stress events in Parkinson's disease. CNS Neurol Disord Drug Targets (2012) 0.85
Interleukin-17 and the interleukin-17 family member network. Allergy Asthma Proc (2004) 0.83
The biological effects of ivabradine in cardiovascular disease. Molecules (2012) 0.82
Interleukin-6 and mast cells. Allergy Asthma Proc (2002) 0.82
The biological evaluation of ADMA/SDMA and eNOS in patients with ACHF. Front Biosci (Elite Ed) (2013) 0.81
Adherence of uremic erythrocytes to vascular endothelium decreases endothelial nitric oxide synthase expression. Kidney Int (2005) 0.80
Stimulation of CCL2 (MCP-1) and CCL2 mRNA by substance P in LAD2 human mast cells. Transl Res (2009) 0.80
A comparison of bovine bone and hydroxyapatite scaffolds during initial bone regeneration: an in vitro evaluation. Implant Dent (2013) 0.79
The role of inducible nitric oxide synthase and haem oxygenase 1 in growth and development of dental tissue'. Cell Biochem Funct (2011) 0.79
Positive correlation between serum interleukin-1β and state anger in rugby athletes. Aggress Behav (2012) 0.79
Human gingival fibroblasts stress response to HEMA: A role for protein kinase C α. J Biomed Mater Res A (2012) 0.79
PKC-δ signalling pathway is involved in H9c2 cells differentiation. Differentiation (2010) 0.79
BNP and iNOS in decompensated chronic heart failure: a linear correlation. Front Biosci (Elite Ed) (2012) 0.79
The effect of pharmacological treatment on ADMA in patients with heart failure. Front Biosci (Elite Ed) (2011) 0.79
Synthesis of a novel cyclic prodrug of S-allyl-glutathione able to attenuate LPS-induced ROS production through the inhibition of MAPK pathways in U937 cells. Mol Pharm (2014) 0.79
MCP-1 and MIP-2 expression and production in BB diabetic rat: effect of chronic hypoxia. Mol Cell Biochem (2005) 0.79
Synthesis, biological evaluation, and docking studies of N-substituted acetamidines as selective inhibitors of inducible nitric oxide synthase. J Med Chem (2009) 0.79
A glutathione derivative with chelating and in vitro neuroprotective activities: synthesis, physicochemical properties, and biological evaluation. ChemMedChem (2013) 0.79
Selective inhibition of inducible nitric oxide synthase by derivatives of acetamidine. Med Chem (2012) 0.78
N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase. Bioorg Med Chem Lett (2010) 0.78
Selective inhibition of iNOS by benzyl- and dibenzyl derivatives of N-(3-aminobenzyl)acetamidine. ChemMedChem (2011) 0.77
Gingival endothelial and inducible nitric oxide synthase levels during orthodontic treatment: a cross-sectional study. Angle Orthod (2004) 0.77
Effect of chronic hypoxia on inducible nitric oxide synthase expression in rat myocardial tissue. Exp Biol Med (Maywood) (2003) 0.77
Thymopentin down-regulates both activity and expression of iNOS in blood cells of Sézary syndrome patients. Nitric Oxide (2012) 0.77
The biological effect of pharmacological treatment on dimethylaminohydrolases (DDAH-1) and cationic amino acid transporter-1 (CAT-1) expression in patients with acute congestive heart failure. Microvasc Res (2011) 0.76
Nitric oxide-mediated cytotoxic effect induced by zoledronic acid treatment on human gingival fibroblasts. Clin Oral Investig (2014) 0.76
Analysis of genomic methylation level using micellar electrokinetic chromatography with UV detection. Electrophoresis (2013) 0.75